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Sasambo Journal of Pharmacy

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Published by Universitas Mataram

ISSN : 27232824 EISSN : 27232832 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sasambo Journal of Pharmacy (p-ISSN: 2723-2824; e-ISSN: 2723-2832) is a scientific journal publishing original articles research in pharmaceutical science. The Journal is managed by the Pharmacy Study Program, Mataram University. Sasambo Journal of Pharmacy receives manuscripts in both English and Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutical Microbiology and Biotechnology, Community Pharmacy, Clinical Pharmacy, and Pharmaceutical Education

Arjuna Subject : Profesi Kesehatan - Farmasi

Articles 94 Documents

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Uji Aktivitas Antimikroba Ekstrak n-Butanol Madu Hutan (Apis nigrocincta) dari Kabupaten Selayar dengan Metode KLT-Bioautografi A.Suparlan Isya Syamsu
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Preliminary research has been conducted on the antimicrobial activity of n-Butanol extract of forest honey (Apis nigrocincta). This study aims to determine the antimicrobial activity of forest honey from Selayar Regency on the growth of test microbes, using the method of solid dilution with the test microbial Bacillus subtilis, Staphylococcus aureus, Streptococcus mutans, Pseudomonas aeruginosa, Salmonella typhi, Escherichia coli, Vibrio sp, Staphylococcus epidermidis, and Candida albicans against n-butanol extract from forest honey (Apis nigrocincta) at 1 mg/ml. The results obtained showed that n-butanol extract inhibited the growth of bacteria Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, and Staphylococcus aureus. To estimate the compounds that provide antimicrobial activity, the TLC-Bioautography test is performed. Obtained the best results from the separation of compounds by TLC using Chlorophorom eluate: Acetone (3: 1). The TLC-Bioautographic test results showed that the spots with an Rf value of 0.29 gave activity to Bacillus subtilis, Escherichia coli, and Staphylococcus epidermidis, and gave positive results on the appearance of flavonoid compounds.

Uji Efek Antiangiogenesis Menggunakan Metode Chorio Allantoic Membrane dari Ekstrak Etanol Daun Talas (Colocasia esculenta L. Schott) Muhammad Yusuf
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Antiangiogenesis berdasarkan ekstrak etanol in vivo daun talas ( Colocasia esculenta L. Schott) dengan metode Chorio Allantoic Membrane (CAM). Angiogenesis adalah proses informasi kapiler baru yang terkandung dalam sistem vaskular. Daun talas ( Colocasia esculenta L.Schott) mengandung flavonoid yang diduga memiliki efek antiangiogenesis. Penelitian bertujuan untuk melihat potensi antiangiogenesis ekstrak etanol daun talas ( Colocasia esculenta L. Schott) dengan metode Chorio Allantois Membrane (CAM) dan menentukan konsentrasi ekstrak daun talas ( Colocasia esculenta L. Schott) yang berpotensi sebagai antiangiogenesis. The Antiangiogenesis Chorio Allantoic Membrane(CAM) menggunakan telur ayam berumur 9 hari. Penelitian membagi telur menjadi 4 kelompok, satu kelompok kontrol tanpa perlakuan dan 3 kelompok sebagai kontrol pengobatan. Kelompok kontrol diperlakukan dengan konsentrasi 1 ug / ml, 10 mg / ml dan 100 mg / ml. Telur diinkubasi selama 72 jam. Penelitian dilakukan dengan skor semiquantitatif pengamatan makroskopik. Pada kelompok kontrol yang tidak diberi perlakuan mendapat skor 5 dan kelompok perlakuan pada konsentrasi 1 ug / ml mendapat skor 5, konsentrasi 10 ug / ml mendapat skor 1 dan konsentrasi 100 ug / ml mendapat skor 0. Hasil penelitian menunjukkan bahwa konsentrasi ekstrak yang diberikan Efek antiangiogenesis adalah pada konsentrasi 10 ug / ml dan 100 ug / ml dan konsentrasi ekstrak yang efektif menghambat antiangiogenesis pada konsentrasi 100 ug / ml. Dapat disimpulkan bahwa semakin besar jumlah konsentrasi ekstrak yang dimasukkan,

Isolasi Bakteri Rhizosfer Penghasil Antimikroba Pada Akar Tanaman Jeruk Nipis (Citrus aurantifolia Swingle) rusman hasanuddin
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Isolation of rhizosphere bacteria producing antimicrobial soil around the roots of the lime plant (Citrus aurantifolia Swingle). This study aims to obtain rhizosphere bacterial isolates originating from the soil around the roots of the Lime Plant (citrus aurantifolia Swingle) which can be used as antimicrobials. The research method was taken from the soil around the roots of the Lime plant and then diluted with dilutions of 10-1, 10-2, 10-3 to 10-5 dilution, then poured on NA media containing test microbes. The resulting isolates were then purified and coded JS-1, JS-2, JS-3. Microscopic examination results added 2 gram-negative bacterial isolates namely JS-1 and JS-3, while 1 gram-positive bacterial isolate was JS-2. The resulting isolate was then fermented with NB medium which produced supernatant and biomass, the supernatant was tested antimicrobial which produced active compounds of rhizosphere bacteria (JS-1 and JS-3) from the root soil of the Lime plant have the ability as an antimicrobial activity against Staphylococcus aureus, Escherichia Candida albicans coli and fungal test

Skirining fitokimia ekstrak etanol kulit buah sirsak (Annona muricata Linn) dan uji aktivitas antioksidan dengan metode DPPH Nur Alim; Nurul Jummah; Agus Sangka Pratama; Nurdiyanti Nurdiyanti
Sasambo Journal of Pharmacy Vol. 2 No. 2 (2021): September
Publisher : Universitas Mataram

Phytochemical screening research on the ethanol extract of soursop (Annona muricata Linn) peel and antioxidant activity was tested using the DPPH method. The purpose of this study was to determine several classes of compounds found in soursop rind and to determine the antioxidant activity of ethanol extract of soursop rind against DPPH free radicals. The results showed ethanol extract of positive soursop fruit skin containing flavonoids, tannins, and terpenoids. of soursop fruit skin extract was carried out by DPPH method results obtained IC50 value of 192.13 µg / mL ± 5.198137 which was categorized as weak.

Microbial pattern of urinary catheterization infection at Wahidin Sudirohusodo Hospital Muhammad Akmal Sukara; Nasir Djide; Nasrum Massi
Sasambo Journal of Pharmacy Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

Infectious disease still remains a serious problem in Indonesia and worldwide, it leads to use of uncontrollable anti-microbial treatment with cause to drug resistance. With unsupported condition for using a sensitivity test prior to antimicrobial treatment, a common guide for choosing an antimicrobial agent for infection of specific specimen is needed. The aims of this research is to determine the pattern of bacteria, more specific specimen is urine. This research was an observational Experimental consecutive sampling study, sample for this research were taken from inpatient room of Wahidin Sudirohusodo Hospital of Makassar during 2019-2020. The largest number of pathogenic bacteria that potentially becoming infection agent in inpatient room of Wahidin Sudirohusodo Makassar was E.coli, P.Aureginosa and Acinetobacter. Most of antimicrobial found in range of 61-70 years Old, and there was no significant relationship between sex and infections Sickness

Formulasi dan evaluasi karakter fisik sediaan gel ekstrak etanol daun salam (Syzygium polyanthum) Lalu Mukhlis Maqbul Sani; Windah Anugrah Subaidah; Yayuk Andayani
Sasambo Journal of Pharmacy Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

Abstrak: Bay leaves (Syzygium polyanthum) are known to have antioxidant effects that can neutralize free radicals found in the skin. The objectives of this research are to formulate the ethanol extract of bay leaves into gel formulation and evaluate the physical properties of gel formulation. Ethanol extract of bay leaves was obtained through the maceration method with 70 % ethanol as a solvent. The thick ethanol extract of bay leaves was formulated into gel formulation with CMC – Na as a gelling agent, glycerin as a humectant, methyl paraben as a preservative, and aquadest as a solvent. After the freeze-thaw test was done, there was no change found in organoleptic but there were changes in pH, spreadability, and adhesion. The pH of gel preparation before being in storage was 5 and after being in storage was 6. In the spreadability, gel formulation spread 5,5 cm before being in the storage, and 5,1 cm after being in the storage. Gel adhesion has a sticky time of 8.35 seconds before in being storage and 8.45 seconds after being in storage.

Analisis perencanaan dan pengadaan guna menjamin ketersediaan obat di rumah sakit Rafiastiana Capritasari; Dwiky Ramadhani Kurniawati
Sasambo Journal of Pharmacy Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

Management of drug is one of the factors which contribute to the quality of hospital services. This study aimed at finding out drug planning in Pharmacy Unit of Adelia Surgical Hospital by using ABC analysis method. This research is qualitative descriptive study involving informants. Primary data were collected by interview with respondents and secondary data report of general drugs purchased period of May 2018 – May 2019. The Result using ABC analysis indicate that there are 23 (17,42%) kindof drugs in group A, 35 (26,52%) in group B and 74 (56,06%) in grup C. Group A if in the event of an excess or deficiency will couse harm to the hospital. ABC analysis method will effectively improve hospital drug consumption plan.

Optimasi formula sampo ekstrak daun pacar air (Impatiens balsamina L.) dengan kombinasi natrium lauril sulfat dan cocamide DEA Dila Ayu Lestari; Yohanes Juliantoni; Raisya Hasina
Sasambo Journal of Pharmacy Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

Dandruff is an anomalous condition characterized by excessive exfoliation of the horny layer from the scalp. The leaves of the water henna plant (Impatiens balsamina L.) are one of the natural ingredients that have anti-dandruff properties, so they can be used as an active ingredient in making dandruff shampoo. The water henna leaves were extracted using the maceration method with ethanol 96%. Apart from the active ingredients, shampoo also has an important component, namely surfactants. The surfactant used in this study was a combination of sodium lauryl sulfate and cocamide DEA. The purpose of this study was to optimize the surfactant formula of sodium lauryl sulfate and cocamide DEA in water henna leaf extract shampoo. This research was a laboratory experimental research. Formula optimization was done through the Simplex Latice Design (SLD) method approach by making eight formulas. All formulas were evaluated for their physical properties including the foam height test and pH test. The data obtained were processed with Design Expert® software. Based on the physical evaluation of the water henna leaf extract shampoo, the results of the high foam test were 10,025 cm and a pH of 6,12. The results of the acceptability test of shampoo preparations including the parameters of color, smell, texture and viscosity received a fairly good response with the acquisition of values 3,1, 3,3, 3,9 and 4 with information 1 (very dislike), 2 (dislike), 3 (quite like), 4 (like) and 5 (really like). The optimum formula for the shampoo consisting of 5% water henna leaf extract, 1,1863% sodium lauryl sulfate, 19,814% cocamide DEA, 3% CMC, 0,5% citric acid, 0,5% methyl paraben, 0,15% menthol and distilled water had physical properties that meet the requirements of a good shampoo preparation.

Profil penggunaan obat antidiabetes pada pasien diabetes mellitus tipe 2 di instalasi rawat jalan RSUD Provinsi NTB tahun 2018 Baiq Sofianti Annisa; Candra Eka Puspitasari; Siti Rahmatul Aini
Sasambo Journal of Pharmacy Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

Diabetes mellitus (DM) is a disorder of insulin secretion, insulin action or both, which are characterized by blood glucose levels > 200 mg/dl and / or fasting blood glucose levels > 126 mg/dl. In 2017 Indonesia was recorded as the sixth largest country with DM in the world. The most common classification of diabetes is type 2 DM with an incidence 90-95%. The study aimed to determine the profile of antidiabetic use in type 2 DM patients at the outpatient installation of RSUD Provinsi NTB in 2018. This study used cross sectional design retrospectively with purposive sampling method for the period January-December 2018. The results showed that in 112 patients, 195 antidiabetic agents were prescribed. The antidiabetic prescribed were metformin (33.85%), glimepirid (25.13%), aspart insulin (13.33%), insulin detemir (8.21%), pioglitazone (6.67%), insulin glargine (6.67%), glyclazide (1.54%), gliquidone (1.54%), acarbose (1.54), regular insulin (1.03%), and insulin lispro (0.51%). Overall, antidiabetic use was in accordance with the guideline recommendations. Further research is needed regarding the review of prescriptions and detailed indications in order to increase rationality of drug use, reduce morbidity and mortality and reduce medical costs.

Skrining fitokimia pada tanaman penyembuh luka di Lombok Timur Fidrus Affandy; Dyke Gita Wirasisya; Nisa Isneni Hanifa
Sasambo Journal of Pharmacy Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

The ethnomedicinal study which conducted in East Lombok revealed 5 potentially plants that have wound healing properties (Jatropha multifida L., Stachytarpheta jamaicensis (L.) Vahl, Centella asiatica (L.) Urban, Euphorbia pulcherrima Willd, and Angelica keiskei). The five plants have been no further research related to the presence of compounds that have activity in wound healing. This study aims to screen the plants secondary metabolites from above plants. The sample was maserated with 96% solvent methanol. The viscous extract was determined by physical characterization including consistency and color as well as chemical characterization, namely the phytochemical screening test. The results showed that the five plants contained flavonoids, phenolics, saponins, and steroids, except for Stachytarpheta jamaicensis (L.) Vahl showed negative results for saponins and Angelica keiskei showed negative results for steroid compounds. Keywords: phytochemical screening, total phenolic content, wound healing herbs, East Lombok

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Yayuk Andayani

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+6281936732708

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Jl. Majapahit No. 62 Mataram

Location
Kota mataram,

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INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Yayuk Andayani

Contact Email sjp@unram.ac.id

Phone +6281936732708

Journal Mail Official sjp@unram.ac.id

Editorial Address Jl. Majapahit No. 62 Mataram

Location Kota mataram, Nusa tenggara barat INDONESIA

Abstract

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Abstract

Contact Name
Yayuk Andayani

Contact Email
sjp@unram.ac.id

Phone
+6281936732708

Journal Mail Official
sjp@unram.ac.id

Editorial Address
Jl. Majapahit No. 62 Mataram

Location
Kota mataram,

Nusa tenggara barat

INDONESIA