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Marcellino Rudyanto
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marcellino-r@ff.unair.ac.id
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bikfar@ff.unair.ac.id
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Department Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Airlangga Surabaya, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia
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Berkala Ilmiah Kimia Farmasi
Published by Universitas Airlangga
ISSN : 23028270     EISSN : 28081048     DOI : http://dx.doi.org/10.20473/bikfar.v8i2.31763
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology
to facilitate interaction, discussion, and updating of research ideas in the fields of pharmacy, Pharmaceutical Chemistry, Medicinal Chemistry, Drug Development, Organic synthesis, Analytical chemistry, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Nutraceutical / functional foods.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 5 Documents
 1 
Search results for , issue "Vol. 10 No. 2 (2023): December" : 5 Documents clear
Synthesis of Methyl 3-(4-hydroxyphenyl) acrylate using Domestic Microwave Irradiation at 200 Watt Power Moch Davit Abdul Majid; Ekowati, Juni; Purwanto, Bambang Tri
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i2.38479

Abstract

In this study, a methylation reaction was carried out for the p-coumaric acid compound using potassium carbonate as a base and dimethyl carbonate as a methylation agent with acetone as a solvent. The methylation reaction was carried out using microwave irradiation from microwave domestic with a power of 200 watts. The purity test was carried out on a TLC plate using three different eluents and produced a single stain that was different from the initial compound. The phenol functional group tested with FeCl3 reagent showed a positive purple color. Compound identification was done using an FT-IR spectrophotometer and a 1H-NMR spectrometer. In the synthesized FT-IR spectrum, there was an absorption of the ester group at wave numbers 1671 cm-1 (C=O group) and 1243 cm-1 (C-O group), there was a band at 3378 cm-1 indicating the presence of the phenol group. There were differences in fingerprint results in the FT-IR spectrum of the p-coumaric acid compound and the results of the methylation reaction. The 1H-NMR spectrum confirmed the presence of three methyl ester protons of the carboxylic acid and the phenolic OH. This indicated that the synthesis produced a compound, namely methyl (E)-3-(4-hydroxyphenyl) acrylate. Keywords: methyl (E) 3-(4hydroxyphenyl) acrylate), p-coumaric acid, Potasium Carbonate, Microwave Irradiation, Synthesis
Potential of Collagen as an Active Ingredient in Cosmetics Denayu Pebrianti; Mikhael Ardi Kristiawan; Rima Hidayatul Qoiriyah; Siti Nur Kholisah; Aulia Hanin Fakhira; Laila Nur Azizah; Cindi Dia Rakhmawati; Muhammad Hilal Salim; Aviatus Solikhah; Rohana Ayu Pramesti; Rika Putri Septiawati; Melanny Ika Sulistyowati; Muh. Agus Syamsur Rijal
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i2.46518

Abstract

Skin was the part of the outer body that was most often exposed to external factors, especially ultraviolet radiation. The skin had an important role in supporting the appearance so that it could affect human social life. Skin aging was a process of decreasing the body's physiological functions that could not be avoided. The aging process of the skin could be caused by a decrease in collagen density and replacement of essential structural proteins so that the skin loses its integrity and elasticity. Collagen was the most abundant protein in humans which could be found in bones, muscles, skin and tendons. Several studies had shown that damaged collagen fibers could be replaced by new fibers when collagen production was stimulated, which was why many cosmetic industries were competing to develop the use of collagen. Collagen had shown potential as an antioxidant, skin moisturizer, and anti-aging. Therefore, this article examined the benefits of collagen, especially in the cosmetic field. This article also discussed the sources of collagen with the best properties as active ingredients for skin care products. Keywords:  Collagen, Cosmetics, Antioxidants, Moisturizers, Anti-Aging
Validation of Analytical Method of Testing Cefotaxime Sodium in Injection Powder Preparation by High-Performance Liquid Chromatography Aneu Aryani Pratiwi; Dikdik Mulyadi; Devi Indah Anwar
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i2.47179

Abstract

Cefotaxime sodium was an antibiotic drug included in the third-generation cephalosporin group. The aim of this research was to validate the method used for the analysis of cefotaxime sodium injection powder using HPLC. Parameters performed in this study included system suitability, selectivity, linearity, accuracy, precision, robustness, Limit of Detection (LOD), and Limit of Quantitation (LOQ). In this study, the mobile phase used was phosphate buffer pH 6,25 with methanol in the ratios of (30:70), (40:60), (50:50), (60:40), and (70:30) v/v. The analysis was carried out using a 150 × 4,6 mm 5μm C18 column and phosphate buffer pH 6,25 with methanol (40:60) v/v as a mobile phase with a flow rate of 1 mL/min, and a detector at a wavelength of 235 nm. The results showed that the system suitability test results met the requirements, with a plate number of 2288, a standard deviation of 0,93%, and a tailing factor of 1,3. The linearity results met the requirements of r ≥ 0,999 with LOD and LOQ values of 3,3894 ×10⁻⁴ mg/mL and 1,0271 ×10⁻³ mg/mL, respectively. The accuracy results obtained a recovery value of 99,30% and an RSD of 0,48%. Precision results of repeatability and intermediate precision had RSDs of 0,38% and 0,85%, respectively. Robustness test results obtained a recovery value of 100,25% and an RSD of 0,85%. The results showed that the recovery values (98-102%) and RSD ≤ 1,5% were in accordance with the validation requirements. It was concluded that the validation of the proposed method was recommended and could be used for routine analysis. Keywords:  Cefotaxime Sodium, Method Validation, HPLC
Color Stability and Antioxidant Activity of Red Roselle (Hibiscus Sabdariffa L.) Calyx Infuse Sholika Sari, Trisiyana; Kusumawati, Idha; Isnaeni, Isnaeni
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i2.51706

Abstract

The roselle flower (Hibiscus sabdariffa L.), was known as a potential functional food source because of its antioxidant and antibacterial properties. Apart from that, it was also used as a natural dye because of its red color. Antioxidant compounds in roselle flowers included neo-chlorogenic acid, chlorogenic acid, crypto- chlorogenic acid, routine, and isoquercitrin. The high content of these antioxidant compounds often causes color instability. For this reason, this research would analyzed the effect of temperature and long storage on color changes and the antioxidant activity of a red roselle flower infusion. Storage conditions were carried out with three temperature variations, namely cold temperature (2–8℃), cool temperature (8–15℃), and room temperature (15–30℃), with a long storage of 8 days. The stability parameters used were color changes and activity as an antioxidant. Color changes were measured using a chromameter, while the antioxidant activity was measured by the IC50 value using the DPPH method. The principle of this method was based on a purple color change reaction, which faded, and then the inhibitory intensity against DPPH was measured using UV-Vis spectrophotometer. It was found that the color values had significant differences visible from the first day storage at the room temperature (30℃), cool temperature (11℃), and cold temperature (6℃). Thus, there was an influence of temperature and long storage on the color change of boiled red roselle flower calyx. A significant decrease in activity was seen on the first day storage at room temperature (30℃) and third day storage at cool temperature (11℃). Meanwhile, at cold temperatures (6℃), there was no significant effect on the reduction in activity from boiling red roselle flower calyx for up to 8 days of storage. Keywords:  Red Rosela, Stability, Infuse, Color, Antioxidant
Analysis of Cyclamate Content in Unbranded Instant Herbal Medicinal Drink on Market in the City of Pamekasan Jamila, Nur; Rahman, Alief Putriana; Humaidi, Fauzan
Berkala Ilmiah Kimia Farmasi Vol. 10 No. 2 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v10i2.51955

Abstract

Jamu was one of the traditional medicines because most herbal medicine used natural ingredients or plants. One of the safety of herbal medicine was the absence of abuse such as the addition of artificial sweeteners in the form of cyclamate. Cyclamate was one of the artificial sweeteners that had a sweetness level 30 times higher than natural sweeteners. Excessive use of cyclamate could cause cancer and tumors. The purpose of this study was to determine the presence or absence of cyclamate content and levels in ready-to-drink herbal medicine without a brand sold in the Pamekasan City market. This research was conducted qualitatively with precipitation methods and quantitative with gravimetric methods. From qualitative research, the results of sample A found a white precipitate which indicated a positive sample containing cyclamate. While samples B and C found no deposits indicating that the sample was negative cyclamate. Furthermore, a positive sample was carried out quantitative testing. In determining cyclamate levels, sodium cyclamate levels in sample A were obtained at 4,8047 g/kg, so that the serving rate or per 1 bottle of herbal medicine contains 115,312 g/0,6 kg. This exceeded the threshold determined by BPOM Regulations which is 1,25 g/kg. The conclusion of this study was that 1 out of 3 positive samples contains cyclamate with levels that exceeded the threshold determined by BPOM RI No. 32 of 2019. Keywords:  Jamu, Cyclamat, Gravimetry

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