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Jurnal Farmanesia

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Published by Universitas Sari Mutiara Indonesia

ISSN : """" EISSN : 25282484 DOI : https://doi.org/10.51544/jf.v8i2

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmanesia dengan E-ISSN: 2528-2484 merupakan jurnal resmi yang diterbitkan oleh Program Studi S1 Farmasi Fakultas Farmasi dan Ilmu Kesehatan Universitas Sari Mutiara Indonesia, yang artikelnya dapat diakses dan diunduh secara online oleh publik (open access journal). Jurnal ini merupakan jurnal peer-review yang diterbitkan dua kali setahun dengan topik keunggulan hasil penelitian di bidang pelayanan dan praktik kefarmasian, teknologi farmasi, dan disiplin ilmu kesehatan yang berkaitan erat. Jurnal ini menerima teks bahasa Indonesia. Berikut ini adalah area penelitian yang menjadi fokus jurnal ini: 1. Farmakologi 2. Farmasetika 3. Biologi Farmasi 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 20 Documents

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Search results for , issue "Vol 8 No 2 (2021): Jurnal Farmanesia" : 20 Documents clear

AKTIVITAS PENGHAMBATAN ENZIM PROTEASE 6LU7 VIRUS SARS-COV-2OLEH SENYAWA FLAVONOID DARI TUMBUHAN GENUS ARTOCARPUS SECARA IN SILICO Adiansyah Adiansyah; Dumartina Hutauruk; Lastry Derliana Nainggolan
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

The genus Artocarpus is one of the genera of Moraceae plants, this genus consists of 50 species and 40 species of them are found in Indonesia. Several studies have reported that the flavonoid compounds contained in the genus Artocarpus have cytotoxic, antiproliferative, antimalarial, anti-inflammatory, and antioxidant properties. The purpose of this study was to determine the inhibitory activity of the protease enzyme 6LU7 of the SARS-COV-2 virus by flavonoid compounds from plants of the genus Artocarpus using the in-silico tethering method. The method used in the in-silico tethering process is carried out using the PLANTS program, validated using the Yasara program, and visualized using the Moe2008 program. The protein model of the 6LU7 Protease Enzyme was downloaded via the Protein Data Bank (PDB) with the code 6LU7. The results of this study indicate that the binding of flavonoid compounds from the genus Artocarpus to the expression of 6LU7 gives valid results in silico. The flavonoid compounds of the Artocarpus genus inhibited the 6LU7 enzyme protein with a higher docking value than each of the comparison drugs and produced 7 amino acid residues that were bound to each other. The conclusion of this study can be concluded that flavonoid compounds from the genus Artocarpus inhibit the expression of 6LU7 protein with a docking score close to the docking score of each comparison drug and 7 amino acid residues are bound to each other.

PEMBUATAN PATI DARI RIMPANG LENGKUAS, TEMULAWAK, TEMUKUNCI SERTA KARAKTERISASINYA Pandapotan Nasution; Suharyanisa Suharyanisa; Manahan Situmorang; Nurpita Putri Manihuruk
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

The rhizome is part of the plant for food reserves, including storing carbohydrates (starch), therefore rhizomes of Galangal, Curcuma, Fingerroot rhizome can be used as a source of starch. This study used an exploratory method which included isolation of starch from Galangal, Curcuma, Fingerroot Rhizome, macroscopic examination, microscopic examination, sample collection, sample processing, and examination of the characterization of starch. The results of starch characterization obtained yields for Galangal starch 2.6%, Curcuma starch 5.4%, Fingerroot rhizome starch 4.1%; determination of total ash content for Galangal starch 1.4%; Curcuma starch 2.0%, Fingerroot rhizome starch 1.0%; determination of drying shrinkage for 1.8% Galangal starch, 2.4% Curcuma starch, 3.2% Fingerroot rhizome starch; determination of acid-insoluble ash content for 0.6% Galangal starch, 0.7% Curcuma starch, 0.7%Fingerroot rhizome starch.

PENGGUNAAN EKSTRAK KELOPAK JANTUNG PISANG KEPOK (Musa acuminate L.) DALAM FORMULASI PEWARNA RAMBUT Cut Masyithah Thaib; Raissa Fitri; Siti Nurbaya; Aprili Yanti Simatupang
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Hair dye preparations are cosmetics used in hair makeup to color hair, either to restore the original hair color or change the original hair color to a new color. Kepok banana heart contains dyes and produces anthocyanins which are used as a safe food coloring. The purpose of this study was to determine that the leaf extract of the Kepok banana heart can be formulated as a hair dye and to determine the concentration of the banana flower extract that produces the best color. Kepok banana flower petals were extracted by maceration method using 96% ethanol, then concentrated to obtain Kepok banana flower petals extract. Hair dye preparations were made with a formula consisting of Kepok banana flower petals extract with various concentrations, namely: 2.5%, 5%, 7.5% and 10%. Staining is done by soaking for 1-4 hours. Observation of color stability was carried out by means of a stability test against 15 washings and exposure to the sun for 5 hours on colored hair, and a biological test (irritation). This study showed that the formula made with the extract of the petals of the Kepok banana heart can give a black color. The best staining was obtained from formula C, namely the extract of the petals of the banana heart of the Kepok banana with a concentration of 7.5% which produced a dark black color. The stability test for 15 washes and the stability test against the sunlight for 5 hours showed that there was no discoloration and no irritation to the skin. It can be concluded that Kepok banana flower petal extract can be used as hair dye.

KARAKTERISASI DAN SKRINING FITOKIMIA SERTA ANALISIS FLAVONOID DARI BUAH MENGKUDU (Morindacitrifolia L) SECARA KROMATOGRAFI LAPIS TIPIS Panal Sitorus; Suharyanisa Suharyanisa; Devina Chandra; Berton Sitanggang
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Noni fruit (Morindacitrifolia L.) is a medicinal plant that is well known by the people in Indonesia. Noni is efficacious as an immune enhancer, normalizes blood pressure, anti-cancer, analgesic, diabetes mellitus, heart disease, stroke, antimicrobial. To know the characteristics of simplicia and the class of compounds from the noni fruit as well as to analyze the flavonoid compounds contained in the noni fruit using the thin layer chromatography method. The flavonoid compounds were extracted by maceration using ethanol solvent and then the ethanol extract was tested by thin-layer chromatography using 1% HCl mobile phase and spotting with 1 N H2SO4 reagent and methanol pa (1: 1% v/v). Result of simplicia characterization of fruit Noni, obtained 1.32% water content, 38.41 % water soluble extract content, 16.7% ethanol soluble extract content, 6.09% total ash content, and 0.45 acid insoluble ash content. %. Noni fruit simplicia contains chemical compounds of alkaloids, tannins, flavonoids, triterpenoids/steroids, anthraquinones, saponins with phytochemical screening tests. The value of Rf from the analysis of noni fruit flavonoid compounds using the Thin Layer Chromatography method with 3 repetitions is 0.75; 0.68 and 0.62. This indicates the presence of flavonoid compounds in the noni fruit.

PENGARUH MINYAK KELAPA MURNI DAN MINYAK INTI SAWIT TERHADAP PERTUMBUHAN RAMBUT PADA KELINCI Monica Suryani; Christica Ilsana Surbakti; Novia Silvana Hadi
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Hair is something that comes out of the skin and has a shape like a thin thread. Hair has many things, including protection from the sun's function, adding beauty and color lines to the face, protecting the eyes from sweat, dirt and dust, and others. Hair is composed of a protein substance called keratin. To determine the VCO and PKO in the rate of growth activity and hair distribution rate. Extraction of PKO from palm kernel and VCO from the coconut fruit, characterization testing including fatty acids and squalene using the Gas Chromatography (GC) method, free fatty acids using the titration method with 0.01N KOH, and finally vitamin E using the Ultra Performance Liquid Chromatography (UPLC) method. smeared every 2 times a day. Tests for the distribution rate of hair growth and daily hair growth rate were carried out every 5th, 10th, 15th, 20th, 25th, 30th day. And weight considerations were made on the 30th day. compared to Pure Coconut Oil in hair growth in rabbits.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUNMANGKOKAN (Polyscias scutellaria) TERHADAP BAKTERI Propionibacterium acnes Siti Nurbaya; Dicky Yuswardi Wiratma; Elly Sitorus; Amaliah Insani
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Indonesia is a tropical country that has a variety of plants, one of which is the succulent plant (Polyscias Scutellaria). Mangkukan plant contains flavonoid compounds, alkaloids, saponins, polyphenols, fats. This study aimed to determine the antibacterial activity of the ethanol extract of the leaves of the Mangkokan (Polyscias Scutellaria) against Propionibacterium acnes bacteria. The tests were carried out through the stages of collecting materials, preparing simplicia, making an ethanolic extract of Mangkukan leaves, and testing the inhibitory power of basil leaves against Propionibacterium acnes bacteria. The manufacture of ethanolic extract of the leaves of the Mangkokan was carried out by the maceration method using 96% ethanol. Antibacterial activity testing was carried out using the agar diffusion method using disc paper. The results of the study based on the results of phytochemical screening showed that the simplicia and ethanol extract of the Mangkukan leaf contained alkaloids, flavonoids, glycosides, tannins, saponins, steroids/triterpenes. Meanwhile, the results of the antibacterial activity test of the ethanolic extract of the Mangkokan leaf have antibacterial properties against Propionibacterium acnes at extract concentrations of 30% (6.74 mm), .35% (6.84 mm), 40% (7.26 mm), 45% (7.32 mm), 50% (8.68 mm) with medium resistance zone. The positive control used 30 g chloramphenicol disc paper with an inhibition zone diameter of 21.89 and the negative control used 10% DMSO solution which had no inhibition zone. The ethanol extract of basil leaves has antibacterial activity against Propionibacterium acnes bacteria.

UJI AKTIVITAS ANTIOKSIDAN SEDIAAN GEL YANG MENGANDUNG EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J. R & G. Forst) DENGAN MENGGUNAKAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Wahyu Margi Sidoretno; Rosa Devitria; Harni Sepriyani
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Matoa (Pometia pinnata J.R & J. G. Forster) is one of the plants that can be used for traditional medicine. Based on several studies, it is stated that the ethanolic extract of matoa leaves has good antioxidant activity. This study aims to determine the antioxidant activity of gel preparations from the ethanolic extract of matoa (Pometia pinnata) leaves. Matoa leaf extract (Pometia pinnata) was prepared using maceration method with 96% ethanol as solvent. Then the extract was formulated into a gel with 4 formulations, namely F0 (no matoa leaf extract), FI (with 0.1% matoa leaf ethanol extract), FII (with 0.3% matoa leaf extract), FIII (with ethanol leaf matoa by 0.5%). Furthermore, the antioxidant activity test was carried out on the gel samples using the DPPH method (1,1-diphenyl-2-picrylhydrazyl) spectrophotometrically at a wavelength of 515 nm. The results of the antioxidant activity test showed that the percentage of inhibition of the 96% ethanol extract of matoa leaf (Pometia pinnata) was F0 40.34%, FI 55.187%, FII 61.703%, FIII 27.969%, and the percentage inhibition of vitamin C was 178.947%. So it can be said that the matoa leaf extract gel has antioxidant activity.

UJI AKTIVITAS ANTIBAKTERI DARI BLACK GARLIC DENGAN VARIASI WAKTU BERBEDA TERHADAP Streptococcusmutans PENYEBAB KARIES GIGI Vivi Purwandari; Jon Kenedy Marpaung; Suharyanisa Suharyanisa
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Dental cariesand gingivitis are the two mostcommon dental and oral diseases in human society. The main cause of both diseasesis a collection of bacteria bound in anorganicmatrix and firmlyattachedtothe tooth surface known as plaque. Black garlicis garlic that has been processed by fermentationat a certaintemperaturefor a long time, resulting in new compounds that have pharmacological effects showing broad antibiotic properties against gram-positiveand gram-negative bacteria, includingstrains that are multi-bacterial. Antibiotic resistance. The purpose of this study was to determine the antibacterial activity of black garlic against Streptococcus mutans bacteria and to determine the differences in the variation of the antibacterial fermentation time of blackgarlicon the antibacterial activity of Streptococcus mutans bacteria. The methodused in this study isanexperimentalmethod (experimentalresearch) to determine the effect of blackgarlic as anantibacterial against Streptococcusmutans. The resultsobtained fromthis study are blackgarlic extract containsalkal oids, flavonoids, tannins, andsaponins. Black garlic extract from variations of 7 days, 12 days, 15 days, and Chlorhexidine had an inhibitoryzone with a strong category while steriledistilled water had an inhibitionzone in the weakcategory.

FORMULASI SEDIAAN PEMBUATAN PELEMBAB BIBIR (LIP BALM) MENGGUNAKAN SARI BUAH PEPAYA(Carica papaya L.) Supartiningsih Supartiningsih; Siti Maimunah; Elly Sitorus; Sarah Lestari
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Lip balm adalah sediaan kosmetik perawatan pada bibir yang digunakan untuk melindungi bibir terhadap faktor lingkungan yang merugikan pada keadaan kelembaban udara yang rendah karena suhu yang terlalu dingin, mencegah penguapan air, serta melembabkan bibir agar tidak mudah kering dan pecah- pecah. Tanaman Buah Pepaya (Carica papaya L.) memiliki kandungan antrakuinon, saponin, lignin, glikosida dan tanin. Tujuan penelitian ini adalah untuk memformulasikan dan uji efektifitas sari buah pepaya pada konsentrasi 1%, 5% dan 9% pada sediaan pelembab bibir. Evaluasi sediaan pelembab bibir yaitu uji homogenitas, uji stabilitas, uji oles, uji daya sebar, uji daya lekat. Metode yang dilakukan dalam penelitian ini adalah bersifat eksperimental. Dari hasil penelitian dan pengujian yang telah dilakukan peneliti didapatkan hasil parameter uji daya lekat adalah (Blanko) 1 menit 10 detik, (F1) 1 menit 02 detik, (F2) 57,66 detik, dan (F3) 44,33 detik. Hasil dari pengujian parameter daya sebar memiliki rata-rata 4 cm, 5 cm, 6 cm dan 6 cm. Lip balm yang diformulasi dalam penelitian ini tidak melalui uji iritasi dikarenakan pandemic virus corona yang membuat peneliti tidak bisa menggunakan sukarelawan manusia. Peneliti juga tidak melalui uji kelembapan pada bibir sukarelawan demi menghidari penyebaran virus dan memenuhi protokol kesehatan.

HUBUNGAN PELAYANAN KEFARMASIAN TERHADAP KEPUASAN PASIEN PENGGUNA OBAT ANTI TUBERKULOSIS (OAT) DI UPT PUSKESMAS TITIPAPAN TAHUN 2021 Manurung, Kesaktian; Sinaga, Taruli Rohana; Thaib, Cut Masyithah; Monica, Yohana
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v8i2.2789

. Patient satisfaction is the match between expectations and the reality felt by the patient. Pharmaceutical service is a direct and responsible service to patients, related to pharmaceutical preparations with the aim of achieving definite results to improve the quality of life of patients. The purpose of this study was to determine the level of patient satisfaction at UPT Puskesmas Titipapan and to determine the relationship between pharmaceutical services and patient satisfaction at UPT Puskesmas Titipapan. The population in this study were OAT users who were treated at UPT Puskesmas Titipapan Medan during this study. With an average number of 31 patients per month. The number of samples in this study was determined using theformula in slovin order to obtain a sample of as many as respondents who visited the UPT Puskesmas Titipapan. This research is a descriptive research with quantitative methods. The type of approach used is a cross sectional design, namely a research design that collects data at one time to the sample. The results of this study were the level of patient satisfaction at the UPT Puskesmas Titipapan Medan, 71.0% of patients felt very satisfied. Of the 25 patients (80.6%) who received good service, 9 patients (29.0%) were satisfied. Based on the statistical analysis of these values indicate that the level of quality pharmaceutical services provided by the UPT Puskesmas TitipapanPengg Patients AgainstunaAnti- Tuberculosis Drugs (AOT) is less significant.

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Contact Name HENNY SYAPITRI

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Journal Mail Official ojs.usmindonesia19@gmail.com

Editorial Address http://e-journal.sari-mutiara.ac.id/index.php/2/Editorial-Team

Location Kota medan, Sumatera utara INDONESIA

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Contact Name
HENNY SYAPITRI

Contact Email
heny_syahfitri86@yahoo.com

Phone
+6285359022627

Journal Mail Official
ojs.usmindonesia19@gmail.com

Editorial Address
http://e-journal.sari-mutiara.ac.id/index.php/2/Editorial-Team

Location
Kota medan,

Sumatera utara

INDONESIA