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INDONESIA
Jurnal Farmanesia
Published by Universitas Sari Mutiara Indonesia
ISSN : """"     EISSN : 25282484     DOI : https://doi.org/10.51544/jf.v8i2
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmanesia dengan E-ISSN: 2528-2484 merupakan jurnal resmi yang diterbitkan oleh Program Studi S1 Farmasi Fakultas Farmasi dan Ilmu Kesehatan Universitas Sari Mutiara Indonesia, yang artikelnya dapat diakses dan diunduh secara online oleh publik (open access journal). Jurnal ini merupakan jurnal peer-review yang diterbitkan dua kali setahun dengan topik keunggulan hasil penelitian di bidang pelayanan dan praktik kefarmasian, teknologi farmasi, dan disiplin ilmu kesehatan yang berkaitan erat. Jurnal ini menerima teks bahasa Indonesia. Berikut ini adalah area penelitian yang menjadi fokus jurnal ini: 1. Farmakologi 2. Farmasetika 3. Biologi Farmasi 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 248 Documents
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PENGARUH MINYAK KELAPA MURNI DAN MINYAK INTI SAWIT TERHADAP PERTUMBUHAN RAMBUT PADA KELINCI Monica Suryani; Christica Ilsana Surbakti; Novia Silvana Hadi
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.717 KB) | DOI: 10.51544/jf.v8i2.2794

Abstract

Hair is something that comes out of the skin and has a shape like a thin thread. Hair has many things, including protection from the sun's function, adding beauty and color lines to the face, protecting the eyes from sweat, dirt and dust, and others. Hair is composed of a protein substance called keratin. To determine the VCO and PKO in the rate of growth activity and hair distribution rate. Extraction of PKO from palm kernel and VCO from the coconut fruit, characterization testing including fatty acids and squalene using the Gas Chromatography (GC) method, free fatty acids using the titration method with 0.01N KOH, and finally vitamin E using the Ultra Performance Liquid Chromatography (UPLC) method. smeared every 2 times a day. Tests for the distribution rate of hair growth and daily hair growth rate were carried out every 5th, 10th, 15th, 20th, 25th, 30th day. And weight considerations were made on the 30th day. compared to Pure Coconut Oil in hair growth in rabbits.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUNMANGKOKAN (Polyscias scutellaria) TERHADAP BAKTERI Propionibacterium acnes Siti Nurbaya; Dicky Yuswardi Wiratma; Elly Sitorus; Amaliah Insani
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (421.316 KB) | DOI: 10.51544/jf.v8i2.2795

Abstract

Indonesia is a tropical country that has a variety of plants, one of which is the succulent plant (Polyscias Scutellaria). Mangkukan plant contains flavonoid compounds, alkaloids, saponins, polyphenols, fats. This study aimed to determine the antibacterial activity of the ethanol extract of the leaves of the Mangkokan (Polyscias Scutellaria) against Propionibacterium acnes bacteria. The tests were carried out through the stages of collecting materials, preparing simplicia, making an ethanolic extract of Mangkukan leaves, and testing the inhibitory power of basil leaves against Propionibacterium acnes bacteria. The manufacture of ethanolic extract of the leaves of the Mangkokan was carried out by the maceration method using 96% ethanol. Antibacterial activity testing was carried out using the agar diffusion method using disc paper. The results of the study based on the results of phytochemical screening showed that the simplicia and ethanol extract of the Mangkukan leaf contained alkaloids, flavonoids, glycosides, tannins, saponins, steroids/triterpenes. Meanwhile, the results of the antibacterial activity test of the ethanolic extract of the Mangkokan leaf have antibacterial properties against Propionibacterium acnes at extract concentrations of 30% (6.74 mm), .35% (6.84 mm), 40% (7.26 mm), 45% (7.32 mm), 50% (8.68 mm) with medium resistance zone. The positive control used 30 g chloramphenicol disc paper with an inhibition zone diameter of 21.89 and the negative control used 10% DMSO solution which had no inhibition zone. The ethanol extract of basil leaves has antibacterial activity against Propionibacterium acnes bacteria.
UJI AKTIVITAS ANTIOKSIDAN SEDIAAN GEL YANG MENGANDUNG EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J. R & G. Forst) DENGAN MENGGUNAKAN METODE DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Wahyu Margi Sidoretno; Rosa Devitria; Harni Sepriyani
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.368 KB) | DOI: 10.51544/jf.v8i2.2796

Abstract

Matoa (Pometia pinnata J.R & J. G. Forster) is one of the plants that can be used for traditional medicine. Based on several studies, it is stated that the ethanolic extract of matoa leaves has good antioxidant activity. This study aims to determine the antioxidant activity of gel preparations from the ethanolic extract of matoa (Pometia pinnata) leaves. Matoa leaf extract (Pometia pinnata) was prepared using maceration method with 96% ethanol as solvent. Then the extract was formulated into a gel with 4 formulations, namely F0 (no matoa leaf extract), FI (with 0.1% matoa leaf ethanol extract), FII (with 0.3% matoa leaf extract), FIII (with ethanol leaf matoa by 0.5%). Furthermore, the antioxidant activity test was carried out on the gel samples using the DPPH method (1,1-diphenyl-2-picrylhydrazyl) spectrophotometrically at a wavelength of 515 nm. The results of the antioxidant activity test showed that the percentage of inhibition of the 96% ethanol extract of matoa leaf (Pometia pinnata) was F0 40.34%, FI 55.187%, FII 61.703%, FIII 27.969%, and the percentage inhibition of vitamin C was 178.947%. So it can be said that the matoa leaf extract gel has antioxidant activity.
UJI AKTIVITAS ANTIBAKTERI DARI BLACK GARLIC DENGAN VARIASI WAKTU BERBEDA TERHADAP Streptococcusmutans PENYEBAB KARIES GIGI Vivi Purwandari; Jon Kenedy Marpaung; Suharyanisa Suharyanisa
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (356.457 KB) | DOI: 10.51544/jf.v8i2.2797

Abstract

Dental cariesand gingivitis are the two mostcommon dental and oral diseases in human society. The main cause of both diseasesis a collection of bacteria bound in anorganicmatrix and firmlyattachedtothe tooth surface known as plaque. Black garlicis garlic that has been processed by fermentationat a certaintemperaturefor a long time, resulting in new compounds that have pharmacological effects showing broad antibiotic properties against gram-positiveand gram-negative bacteria, includingstrains that are multi-bacterial. Antibiotic resistance. The purpose of this study was to determine the antibacterial activity of black garlic against Streptococcus mutans bacteria and to determine the differences in the variation of the antibacterial fermentation time of blackgarlicon the antibacterial activity of Streptococcus mutans bacteria. The methodused in this study isanexperimentalmethod (experimentalresearch) to determine the effect of blackgarlic as anantibacterial against Streptococcusmutans. The resultsobtained fromthis study are blackgarlic extract containsalkal oids, flavonoids, tannins, andsaponins. Black garlic extract from variations of 7 days, 12 days, 15 days, and Chlorhexidine had an inhibitoryzone with a strong category while steriledistilled water had an inhibitionzone in the weakcategory.
FORMULASI SEDIAAN PEMBUATAN PELEMBAB BIBIR (LIP BALM) MENGGUNAKAN SARI BUAH PEPAYA(Carica papaya L.) Supartiningsih Supartiningsih; Siti Maimunah; Elly Sitorus; Sarah Lestari
Jurnal Farmanesia Vol 8 No 2 (2021): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (59.881 KB) | DOI: 10.51544/jf.v8i2.2833

Abstract

Lip balm adalah sediaan kosmetik perawatan pada bibir yang digunakan untuk melindungi bibir terhadap faktor lingkungan yang merugikan pada keadaan kelembaban udara yang rendah karena suhu yang terlalu dingin, mencegah penguapan air, serta melembabkan bibir agar tidak mudah kering dan pecah- pecah. Tanaman Buah Pepaya (Carica papaya L.) memiliki kandungan antrakuinon, saponin, lignin, glikosida dan tanin. Tujuan penelitian ini adalah untuk memformulasikan dan uji efektifitas sari buah pepaya pada konsentrasi 1%, 5% dan 9% pada sediaan pelembab bibir. Evaluasi sediaan pelembab bibir yaitu uji homogenitas, uji stabilitas, uji oles, uji daya sebar, uji daya lekat. Metode yang dilakukan dalam penelitian ini adalah bersifat eksperimental. Dari hasil penelitian dan pengujian yang telah dilakukan peneliti didapatkan hasil parameter uji daya lekat adalah (Blanko) 1 menit 10 detik, (F1) 1 menit 02 detik, (F2) 57,66 detik, dan (F3) 44,33 detik. Hasil dari pengujian parameter daya sebar memiliki rata-rata 4 cm, 5 cm, 6 cm dan 6 cm. Lip balm yang diformulasi dalam penelitian ini tidak melalui uji iritasi dikarenakan pandemic virus corona yang membuat peneliti tidak bisa menggunakan sukarelawan manusia. Peneliti juga tidak melalui uji kelembapan pada bibir sukarelawan demi menghidari penyebaran virus dan memenuhi protokol kesehatan.
PENGGUNAAN KULIT BATANG JAMBLANG (Syzygiumcumini) DALAM FORMULASI PEWARNA RAMBUT Karnerius Harefa; Artha Yuliana Sianipar; Siti Nurbaya; Sisca Mayryanisa
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Hair dye is a cosmetic used in hair makeup to color hair, either to restore the original hair color or change the original hair color to a new color. Jamblang bark contains dyes and produces tannins which are used to dye textiles. The purpose of this study was to determine that Jamblang bark extract could be formulated as a hair dye. Hair dye preparations contain Jamblang bark extract with concentrations of A (2.5%), B (5%), C (7.5%), and D (10%). Observation of color stability was carried out by means of a stability test against 15 washes and exposure in the sun for 5 hours on colored hair, then an irritation test was carried out. This study shows that a formula made with Jamblang bark extract can give hair a brown color. The longer the immersion of gray hair in hair dye preparations, the darker the resulting brown color at a concentration of C (7.5%). The results of stability tests against washing and sunlight showed that there was no change in hair color and did not cause skin irritation. Jamblang bark extract can be formulated as hair dye. The best dye was obtained from Formula C which consisted of 7.5% Jamblang stem bark extract producing a dark brown color.
SKRINING FITOKIMIA DAN UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL JAHE MERAH (Zingiber officinale Rosc. Var Rubrum) DAN EKSTRAK ETANOL JAHE PUTIH (Zingiber officinale Rosc. Var Officinarum) PADA MENCIT PUTIH JANTAN Siti Nurbaya; Yosy Cinthya Eriwaty Silalahi; Nurussakinah Nurussakinah; Trionaldo Purba
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

One of the medicinal plants is ginger. The ginger plant has properties in overcoming pain, but it is not yet known how big the percentage of the strength of the analgesic activity of the ginger plant is. The components consisting of oleoresin are a complete picture of the content of ginger, namely essential oils and fixed oils consisting of gingerol, shagaol, and resin. Mice were divided into eight treatment groups (CMC 0.5%, Acetosal, EEJM (Red Ginger Ethanol Extract) 100, EEJM 200, EEJP (White Ginger Ethanol Extract) 100, EEJP 200, Combination 100, Combination 200). orally. Animals were induced with 3% acetic acid. Pain is characterized by the emergence of stretching which is indicated by the abdomen touching the base of the footing and both pairs of legs being pulled back. Observe stretching at intervals of every 10 minutes for 90 minutes. The characterization of red ginger rhizome simplicia and white ginger rhizome has met the requirements set by the Indonesian Herbal Pharmacopoeia. The results of phytochemical screening showed that simplicia and extracts from red and white ginger rhizome contained alkaloids and triterpenoids/steroids. The results showed that all treatment groups had an analgesic effect, which was not significantly different from the acetosal treatment (P>0.01). The highest analgesic power and effectiveness was seen in the EEJM 200mg/kg BW treatment group.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN INSULIN (Smallanthussonchifolius) TERHADAP BAKTERI Bacillus cereus Kesaktian Manurung; Ahmad Ghazali; Ahmad Hafizullah; Ulfayani Mayasari
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Insulin leaves are known as one of the ingredients of traditional medicine. Insulin leaves contain potential substances such as tannins, alkaloids, flavonoids, saponins, and terpenoids which have antibacterial abilities. This study aims to determine the effectiveness of insulin leaf ethanol extract as an antibacterial. This research is an experimental study that includes the collection and processing of insulin leaf samples, examination of the characteristics of Simplisia, phytochemical screening, testing of the antibacterial diffusion method using a disk paper brace, and using the One Way ANOVA analysis method. The test results showed that the ethanol extract could inhibit bacterial growth at a concentration of 50 - 60% with an average resistor potential of 14.8 - 17.83 mm while Ampicillin as a comparison control averaged 33.62 mm. So that the ethanol extract of insulin leaves was effective in inhibiting the growth of Bacillus cereus bacteria with a minimum resistance concentration of 60 mg/ml. Keywords: Antibacterial, Bacillus cereus, insulin leaf extract
UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN BANGUN-BANGUN (Plectranthus amboinicus Lour.) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN Zuhairiah Zuhairiah; Yosy Cinthya Eriwaty Silalahi; Ahmad Hafizullah; Ariyanti Ariska
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Bangun-Bangun leaves contain phytochemical compounds such as phenolic compounds and flavonoids which have potential as antioxidant activity. This study aims to determine the antidiabetic activity of the ethanolic extract of Bangun-Bangun leaves on reducing blood glucose levels (KGD) of male white rats by using the glucose tolerance test method and the alloxan induction test. The study was conducted by grouping rats where each group consisted of 5 rats, the fasting KGD was measured. Then, a group I was given Na-CMC 1% BW, group II was given glibenclamide 0.45 mg/kg BW, group III was given EEDBB at a dose of 200 mg/kg BW, group IV was given EEDBB at a dose of 250 mg/kg BW and group V was given EEDBB dose of 300 mg/kg BW. In the glucose tolerance test, each group was given a 50% concentration of glucose solution. Furthermore, measurements of KGD were carried out at 30, 60, 90, and 120 minutes. In alloxan induction, 25 test animals weighing ±150-200 g that had been fasted were divided into 5 groups and then KGD was measured. The rats were then induced with a dose of 150 mg/kg BW of alloxan intraperitoneally. Diabetic rats were then given the test preparation orally for 15 consecutive days. Furthermore, glucose levels were measured on the 3rd, 5th, 7th, 9th, 11th, 13th, and 15th days. The results concluded that EEDBB can reduce blood glucose levels of male white rats induced by alloxan.
PENETAPAN KADAR FLAVONOID TOTAL DARI EKSTRAK ETANOL DAUN ANDALIMAN (Zanthoxylum acanthopodium DC.) Yettri Simarmata; Cut Masyithah Thaib; Siti Nurbaya; Martha Uli Oktavrina Rajagukguk
Jurnal Farmanesia Vol 4 No 1 (2017): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Flavonoids are a class of polyphenolic compounds that have an antioxidant effect by donating hydrogen atoms and linking them with metal ions. Most flavonoids are found in plants. One of the plants that contain lots of flavonoids is andaliman (Zanthoxylum acanthopodium DC). The purpose of this study was to determine the compounds contained in the Andaliman leaf and to determine the total flavonoid content of the Andaliman leaf extract. The type of research conducted was descriptive, including identification of plant material, collection of plant material, phytochemical screening, and examination of total flavonoids with visible ultraviolet spectrophotometry. Samples were taken from LobuSiregar village, Siborong-Borong, North Tapanuli. Andaliman leaf extract (Zanthoxylum acanthopodium DC) was obtained by the maceration method using 96% ethanol. Determination of total flavonoid content was carried out by the colorimetric method. The results of phytochemical screening showed the presence of alkaloids, flavonoids, tannins, and steroids. Determination of total flavonoid content calculated as quercetin with the regression equation y= 0.03278 X + 0.04086, and r = 0.99825. The measurement results of the total flavonoid content of the ethanol extract of Andaliman leaves were 39.65 ± 0.08 mg QE/g.

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