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INDONESIA
Jurnal Farmanesia
Published by Universitas Sari Mutiara Indonesia
ISSN : """"     EISSN : 25282484     DOI : https://doi.org/10.51544/jf.v8i2
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmanesia dengan E-ISSN: 2528-2484 merupakan jurnal resmi yang diterbitkan oleh Program Studi S1 Farmasi Fakultas Farmasi dan Ilmu Kesehatan Universitas Sari Mutiara Indonesia, yang artikelnya dapat diakses dan diunduh secara online oleh publik (open access journal). Jurnal ini merupakan jurnal peer-review yang diterbitkan dua kali setahun dengan topik keunggulan hasil penelitian di bidang pelayanan dan praktik kefarmasian, teknologi farmasi, dan disiplin ilmu kesehatan yang berkaitan erat. Jurnal ini menerima teks bahasa Indonesia. Berikut ini adalah area penelitian yang menjadi fokus jurnal ini: 1. Farmakologi 2. Farmasetika 3. Biologi Farmasi 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 248 Documents
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PEMERIKSAAN KADAR ASAM MERKAPTOASETAT DALAM SEDIAAN PENGERITING RAMBUT YANG BEREDAR DI SALON SEKITAR UNIVERSITAS SARI MUTIARA INDONESIA Nurbaya, Siti; Maimunah, Siti; Manurung, Kesaktian
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2731

Abstract

Cosmetics used for this purpose, such as curling hair, use hair curling preparations containing mercaptoacetic acid. Curling hair aims to change the structure of straight hair into wavy. The purpose of this study was to determine the levels of mercaptoacetic acid in hair curling preparations circulating in salons around Sari Mutiara University, Indonesia. The research was conducted on 3 types of samples determined by iodometric titration method using potassium iodide titer solution and starch indicator. The results of this study examined the levels of mercaptoacetic acid in hair curling preparations in samples A: 5,676%, B: 6,053%, C: 6,478%. These results indicate that the 3 types of samples meet the requirements in accordance with the decision of the POM RI No. HK.00.05.42.1018 the Year 2008 with a maximum level of 8.0%.
PENGARUH VARIASI KONSENTRASI HEMISELULOSA DALAM PEMBUATAN MIKROPARTIKEL Dalimunthe, Gabena Indrayani; Lubis, Minda Sari; Sitinjak, Iyustri Ririn
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2733

Abstract

Hemicellulose (corncob isolated) is a natural polymer that is nontoxic, mucoadhesive, biodegradable, biocompatible and has a low level of immunogenicity, so it is very good to be used as a drug carrier and in the development of pharmaceutical preparations. Hemicellulose in this study will be made in the size of microparticles, where the microparticles are preparations with a particle size of 1-1000 m. The microparticles in this study were encapsulated by varying the concentration of hemicellulose as a carrier combined with STPP (Sodium tripolyphosphate) as a cross-linker or as a crosslinking agent and Propylene Glycol (PG) as a solvent and metronidazole as a model drug. Variations in the concentration of hemicellulose made were 100 mg, 200 mg, 300 mg, 400 mg and 500 mg. The purpose of this study was to see how the effect of variations in hemicellulose concentration on particle size and the characterization of the formed microparticles. The microparticle characterization results obtained have particle sizes at F1= 453.36 m, F2= 635.93 m, F3= 717.32 m, F4= 893.22 m and F5= 918.57 m. The yield obtained at F1 = 80.29% , F2 = 82.50%, F3 = 90.47%, F4 = 87.65% and F5 = 90.75% while the solubility test results show that the microparticles are easily soluble in an atmosphere. alkaline and at high temperatures, while at low temperatures and acid conditions it is difficult to dissolve until practically insoluble.
PERBANDINGAN UJI AKTIVITAS ANTIDIABETES EKSTRAK DAUN LIDAH BUAYA DAN LIDAH MERTUA PADA MENCIT PUTIH JANTAN Sianipar, Artha Yuliana; Supartiningsih, Supartiningsih; Nasution, Pandapotan; Maimunah, Siti; Gloria, Rifka
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2734

Abstract

Diabetes mellitus (DM) is a disease whose prevalence is increasing from year to year. This increase was accompanied by an increase in the cost of treatment and the number of complications. The use of traditional medicine is an alternative for the community to control blood sugar levels (KGD). Considering that synthetic drugs have various side effects, one of the medicinal plants used as traditional medicine is aloe vera leaf and mother-in-law's tongue leaf which contain flavonoid compounds, alkaloids, tannins, saponins, and steroids/triterpenoids. The purpose of this study was to determine the antidiabetic activity of aloe vera leaf extract and mother-in-law's tongue and to compare the activities of the two. The results of the analysis of the glucose tolerance ANOVA test showed a significant difference in the percentage reduction at 60, 90, and 120 minutes for all treatment preparations. The alloxan induction test showed a significant difference in the percentage decrease from days 3, 5, 7, 9, 11, 13, and 15. Based on these results, it can be concluded that Aloe Vera Leaf Ethanol Extract (EEDLB) and LidahMertua Leaf Ethanol Extract (EEDLM) with each dose of 150 and 200 mg/kg BW and the combination of the two gave antidiabetic activity against mice as well as differences in effectiveness between samples of aloe vera leaf and LidahMertua leaf as well as a single dose with a combination.
UJI AKTIVITAS ANTIJAMUR EKSTRAK ETANOL KULIT BAWANG PUTIH (Allium sativum) DENGAN METODE DIFUSI CAKRAM Sitorus, Panal; Sinaga, Eka Margaret; Marpaung, Jon Kenedy; Vevariantina, Ayu
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2735

Abstract

Fungal infections rarely cause dangerous conditions, one of which is Candida albicans. The use of antifungal drugs for the treatment of infectious diseases caused by fungi is now quite a lot, but the problem faced now is the occurrence of side effects for users, such as allergies, to other toxic hazards. Garlic (Allium sativum) since antiquity has shown broad antibiotic properties against gram-positive and gram-negative bacteria, including against multi-antibiotic-resistant strains. The purpose of this study was to determine the antifungal activity and effectiveness of ethanol extract of garlic peel against the fungus Candida albicans. The results showed that the yield of fresh simplicia was 10%, the extract yield was 8%. Examination of simplicia characteristics resulted in water content of 7.98%, water-soluble extract content of 18.11%, ethanol-soluble extract content of 7.30%, ash content of 1.06%, and acid insoluble ash content of 0.27%. Phytochemical screening results stated that garlic peel simplicia contained secondary metabolites of alkaloids, flavonoids, and saponins. The results of the inhibition test against the fungus candida Albicans using ethanol extract of garlic peel found antifungal effectiveness on the fungus candida Albicans. The conclusion of this study is that the ethanolic extract of garlic peel at concentrations of 500%, 400%, 300%, 200%, and 100% was less effective against the fungus Candida albicans.
UJI AKTIVITAS ANTIOKSIDAN DALAM BEBERAPA MINUMAN YOGHURT DENGAN METODE DPPH (1,1-Diphenyl-2-Picryhydrazil) Simarmata, Yettrie; Sinaga, Eka Margaret; Silitonga, Maringan
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2736

Abstract

Antioxidants are chemical compounds that can donate one or more electrons (electron donors) to free radicals to inhibit oxidative reactions. One example that has the potential as an antioxidant is yogurt. Yogurt is a food that contains a number of live bacteria that have a beneficial effect on health because it has antioxidant, antimicrobial, antidiarrheal activity and can boost the immune system. There are several factors that can affect the antioxidant activity of yogurt including temperature, storage conditions, and additional ingredients used such as adding fruit flavors. The purpose of this study was to determine the antioxidant activity of probiotics from yogurt drinks with various brands. Samples were taken from supermarkets in Medan City with 3 different brands coded A, B, and C. The antioxidant activity was determined by the DPPH (1,1-diphenyl-2-picrylhydrazyl) method using a visible spectrophotometer measured at wavelengths. 516 nm. The results showed that there were two samples of yogurt drink coded A and B which were included in the strong category and code C samples were included in the weak category. Yogurt drink with brand code A has the strongest antioxidant activity compared to other brand yogurt drinks (B and C) with IC50 values from samples code A (80.52 ml), B (90.14 ml), and C (194, 81 ml).
PEMERIKSAAN ZAT WARNA MERAH PADA MINUMAN BOTOL YANG BEREDAR DI SEKITAR JALAN KAPTEN MUSLIM MEDAN SECARA KROMATOGRAFI KERTAS Silalahi, Yosy Cinthya Eriwaty; Wiratma, Dicky Yuswardi; Sianipar, Artha Yuliana
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2737

Abstract

Drinks are materials that are needed by living things, which are useful for survival. Therefore, many manufacturers are innovating with drinks, one of which is bottled drinks and adding colorants to drinks to attract buyers. The purpose of this study was to determine whether or not the use of red dye is not allowed in bottled drinks sold around Jalan Captain Muslim Medan. This study uses a descriptive method, namely by conducting examinations in the laboratory. Drinks that are red were taken as samples, namely as many as 5 samples. Samples were purified using wool absorption, followed by identification using paper chromatography compared with tables. The results of the observations showed that from the 5 samples tested, none of the bottled drinks containing red dye were prohibited.
FORMULASI SEDIAAN ANTISEPTIK DARI BUAH RIMBANG (Solanum torvum) SEBAGAI HAND SANITIZER Maimunah, Siti; Simarmata, Yettrie; Sinaga, Eka Margaret
Jurnal Farmanesia Vol 5 No 2 (2018): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v5i2.2738

Abstract

Rimbang fruit (Solanum torvum) has properties as a skin antiseptic. Rimbang fruit extract (Solanum torvum) which has been isolated has antibacterial activity against Staphylococcus aureus bacteria. This is because the Rimbang fruit extract (Solanum torvum) contains compounds such as solasonins, glucosides, saponins, and sterolins. Formulation and testing of antibacterial activity of hand sanitizer gel preparations of Rimbang fruit extract and evaluation of the physical quality of hand sanitizer preparations. Rimbang fruit extract was made by the maceration method using 70% ethanol. Then it was evaporated using a rotary evaporator and the remaining solvent was evaporated until a thick extract was formed. Testing of antibacterial activity by agar diffusion method using disc paper against Staphylococcus aureus by measuring the diameter of the zone of inhibition of bacterial growth. The concentration of Rimbang fruit extract and hand sanitizer gel formula used (F1) 0.5% and (F2) 1%; Evaluation of the physical quality of the hand sanitizer preparation includes organoleptic test, homogeneity test, and pH test. The results of the antibacterial activity test of Rimbang fruit extract against Staphylococcus aureus at a concentration of 0.5% with an inhibitory diameter of 5.2 mm. Meanwhile, the results of the gel hand sanitizer activity test of Rimbang fruit extract obtained the inhibition of Staphylococcus aureus bacteria at a concentration of 1% with a diameter of 9.0 mm.
FORMULASI KRIM ANTI-AGING DARI EKSTRAK KULIT BUAH JERUK LEMON (Citruslimon) Silalahi, Yosy Cinthya Eriwaty; Sinaga, Eka Margaret; Thaib, Cut Masyithah
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Anti-aging is a preparation that is useful for preventing or slowing down the effects of aging such as wrinkles, dark spots, rough skin, and enlarged pores. Lemon peel contains flavonoids, namely hesperidin which can prevent aging and can improve skin health. This study aims to formulate anti-aging cream preparations, test the anti-aging effect, and determine the best concentration of anti-aging cream from lemon peel extract. The concentration of lemon peel extract used as a cream ingredient are: 2.5%, 5%, 7.5%, 10%. The tests carried out were homogeneity test, determination of emulsion type, pH, stability observation, skin irritation test. The test was carried out for 4 weeks. The results showed that the anti-aging cream preparations produced were homogeneous and showed an o/w type. The pH test when the cream was made was: 6-7 and after 12 weeks of storage, it was: 5-7. Anti-aging cream preparations have shown a significant increase in skin effects after 1 week, 2 weeks, 3 weeks, and 4 weeks. F5 (10% cream) provides the best anti-aging effectiveness. Lemon peel extract can be formulated into an o/a cream preparation that is able to provide anti-aging effects on the skin. Formula 5 (F5) with a concentration of 10% lemon peel extract was the most.
KARAKTERISASI SIMPLISIA SKRINING FITOKIMIA DAN UJI TOKSISITAS EKSTRAK ETANOL HERBA BINTARO (Cerbera manghas L.) TERHADAP Artemia salina Leach Nasution, Haris Munandar; Fatimah, Cut; Syara, Nurdiani
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v6i1.2741

Abstract

The use of anticancer chemotherapy with chemicals has not given optimal results because the drug does not work specifically, in addition to attacking cancer cells it also damages normal cells. Bintaro (Cerbera mangha L.) is a wild plant that contains secondary metabolites which have been shown to have a wide range of therapeutic applications. Several studies have stated that Bintaro has activities as aanti cancer. The purpose of this researchto know the characteristics of Bintaro herb simplicia (Cerbera manghas L.) which can be determined using the procedures listed in the Materia Medika Indonesia book, knowing the class of secondary metabolites contained in the ethanol extract of bintaro herbs (Cerbera manghas L.), andknowing the level of toxicity of the ethanol extract of the herb bintaro (Cerbera manghas L.). The method used in this research is experimental with the post-test only controlled group design. The results of the characterization on the organoleptic test of Bintaro herb simplicia, namely the leaves are dark brown, the taste is slightly bitter then bitter, the stems are dark brown and shrinking, the smell is distinctive and tasteless, and the flowers are dark brown, characteristic odor and tasteless, after being ground to a powder. dark brown. The results of the microscopic test, the leaf herb simplicia samples obtained fragments, namely diasitic type stomata, spiral vessel fragments and upper epidermis fragments with palisade cells. As for the stem herbs, there were tissue fragments of sclerenchyma fibers, vessel fragments, parenchymal fragments with clumps of brown secretions. Sclereid fragments were found in the floral herb samples.6%, for determination of water-soluble extract content obtained = 20.06%, ethanol soluble extract content = 2.18%, total ash content = 12.62%, acid insoluble ash content = 6.11%. positive bintaro herbs contain compounds of alkaloids, flavonoids, steroids, tannins and saponins. From the calculation of the LC50 value, it can be concluded that the entanol extract of the Bintaro herb is included in the very toxic category with a value ofLC50 < 30 g/mlthat is9.35g/mL.
PENENTUAN KADAR BESI DI DALAM AIR SUMUR GALI PENDUDUK DI DESA KAMPUNG LALANG SECARA SPEKTROFOTOMETRI SINAR TAMPAK Thaib, Cut Masyithah; Sinaga, Eka Margaret; Purba, Dina Riani
Jurnal Farmanesia Vol 6 No 1 (2019): Jurnal Farmanesia
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jf.v6i1.2743

Abstract

Water is one of the sources of iron compound contaminants and the iron content in dug well water used as a water source is influenced by location and environment. The purpose of this study was to determine the iron content in dug well water used in daily life in the village of Kampung Lalang. Samples were taken from five different dug wells. Determination of iron content was carried out according to the spectrophotometric method in accordance with the procedures and spectrophotometers used in the chemical laboratory of the University of Sari Mutiara Indonesia. The results showed that of the 5 samples tested there were 2 samples containing iron compounds exceeding the levels of iron compounds set by the Ministry of Health of the Republic of Indonesia Number 907/MENKES/SK/VII/2002, the permissible levels of iron compounds, which should not be more than 0.3 mg/day. l. The iron content of 5 wells ranged from 0.2457 - 0.405 mg/l.

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