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Pharmacy Reports
Published by Indonesian Young Scientist Group
ISSN : -     EISSN : 27989798     DOI : https://doi.org/10.51511/pr.2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Pharmacy Reports is an open-access journal publishing peer-reviewed research in the pharmacy field, covering topics in pharmaceutics, biomedicine, pharmaceutical chemistry, bioinformatics, natural product, pharmacology and toxicology, and clinical pharmacy. Pharmacy Reports invites you to submit papers, covering topics in: pharmaceutics (pharmaceutical technology, drug delivery system), biomedicine (molecular biology, biochemistry, immunology, microbiology, biotechnology), pharmaceutical chemistry (analytical chemistry, medicinal chemistry: drug design, drug synthesis, pharmacochemistry, bioinformatic), natural product (fractionation, isolation, purification, and elucidation), pharmacology and toxicology (pharmacokinetics, toxicology), clinical pharmacy (therapeutic drug monitoring, adverse drug reaction, drug interaction), pharmaceutical industry, pharmacy education, community service related to pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 70 Documents
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Molecular docking of gallic acid as anti-photoaging in silico Dewi, Ni Kadek Diah Parwati; Suryadewi, Kadek Dinda; Fitriari, Diah Mawarni; Andini, Kadek Lia; Laksmiani, Ni Putu Linda
Pharmacy Reports Vol. 1 No. 2 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (333.053 KB) | DOI: 10.51511/pr.18

Abstract

Skin aging caused by excessive exposure to ultraviolet is known as photoaging. The mechanism underlying skin photoaging relates to collagen degradation in the extracellular matrix (ECM) by overexpression of matrix metalloproteinases-1 (MMP-1). Gallic acid is a phenolic antioxidant found in many types of plants and can be used as an anti-photoaging agent due to its antioxidant activity. This study aims to determine the potential effect of gallic acid as an anti-photoaging against MMP-1 using in silico molecular docking. The stages included gallic acid structure optimization using the HyperChem 8, preparation of protein target MMP-1 (PDB ID: 966C) using the Chimera1.10.1, validation the molecular docking protocol, and docking gallic acid on MMP-1 with the Autodock 1.5.6. The results showed that gallic acid had an affinity for MMP-1 with a binding energy of -6.0 kcal/mol. There are similar amino acid residues in hydrogen bonds between the native ligand RS2 with MMP-1 and gallic acid with MMP-1, namely ALA 182, LEU 181, and HIS 218. The results suggest that gallic acid has the potential as the anti-photoaging agent through the inhibition of the MMP-1 enzyme.
The potency of alpha-humulene as HER-2 inhibitor by molecular docking Putra, I Made Harimbawa; Pratama, I Putu Ari Anggara Catur; Putra, Komang Dian Aditya; Pradnyaswari, G. A. Desya; Laksmiani, Ni Putu Linda
Pharmacy Reports Vol. 2 No. 1 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (813.372 KB) | DOI: 10.51511/pr.19

Abstract

HER-2 overexpression is present in approximately 20% of breast cancer. This research aims to study the interactions of α-humulene to HER-2 protein by using in silico molecular docking. The experiment was carried out by HER-2 protein preparation (PDB ID 3PP0), docking validation, α-humulene optimization, and α-humulene docking. The results showed that α-humulene had binding energy of -7.50 kcal/mol, Van der Waals binding energy of -7.48 kcal/mol, and electrostatic energy of -0.02 kcal/mol. α-Humulene is potential as anti-breast cancer towards HER-2 in silico.
The potency of blumeatin and luteolin as caspase-1 inhibitor by molecular docking Pratama, I Putu Ari Anggara Catur; Putra, I Made Harimbawa; Pujasari, Luh Wayan Sita; Dewi, Komang Dian Merta Sari; Laksmiani, Ni Putu Linda
Pharmacy Reports Vol. 2 No. 1 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.097 KB) | DOI: 10.51511/pr.22

Abstract

COVID-19 infection induces inflammation by increasing cytokines such as IL-1b, IL-6, IL-18, IFN-γ, and TNF-α. IL-1b is generated by the involvement of caspase-1. Therefore, caspase-1 inhibitor can be potential for inflammation therapy caused by COVID-19 infection. This study aims to determine the potential of blumeatin and luteolin as anti-inflammatory agents by inhibiting caspase-1 using a molecular docking approach. This study was carried out by caspase-1 (PDB ID: 1RWK) preparation, blumeatin and luteolin structure optimization, docking protocol validation, and docking of blumeatin and luteolin on caspase-1. Bluematin and luteolin had a binding affinity of -5,63 kcal/mol and -5,93 kcal/mol, lower than Q158 native ligand (-3.92 kcal/mol). Similar amino acid residues in hydrogen bonds interaction were observed between Q158 native ligand, blumeatin, and luteolin with caspase-1 (GLN 283 and ARG 179). Blumeatin and luteolin are potentially anti-inflammation agents through the inhibition of the caspase-1 in silico.
Chlorogenic acid and kojic acid as anti-hyperpigmentation: in silico study Yudantara, I Made Agus; Cahyani, Ni Ketut Nitya; Saputra, Made Agus Widiana; Dewi, Ni Kadek Diah Parwati
Pharmacy Reports Vol. 1 No. 2 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.496 KB) | DOI: 10.51511/pr.23

Abstract

Hyperpigmentation is a skin problem caused by excessive melanin production due to continuous ultraviolet (UV) radiation. Kojic acid inhibiting melanin synthesis by tyrosinase enzyme is a prevalent treatment for hyperpigmentation. This study aims to determine the potential of chlorogenic acid and kojic acid as an anti-hyperpigmentation against tyrosinase using in silico molecular docking. The docking process involved optimizing chlorogenic acid and kojic acid structures, preparing tyrosinase protein (PDB ID: 5M8O), validating the molecular docking method, and docking of chlorogenic acid and kojic acid on tyrosinase. The binding energy of chlorogenic acid and kojic acid were -4.59 kcal/mol and -3.75 kcal/mol, while the binding energy of 0TR native ligand was -5.02 kcal/mol. The interaction of chlorogenic acid to tyrosinase involved ARG 321 and ARG 374 residues. The results suggest that chlorogenic acid and kojic acid has the potential as anti-hyperpigmentation agents through inhibition of the tyrosinase enzyme.
Antioxidant activity of fermented coffee beans Jelena, Jesslyn; Yustiantara, Putu Sanna
Pharmacy Reports Vol. 1 No. 2 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.084 KB) | DOI: 10.51511/pr.25

Abstract

A green coffee bean contains phenolic compounds with strong antioxidant activity, such as chlorogenic acid. Fermentation is one of the ways to increase the antioxidant activity of coffee beans by using microorganisms. This review aims to study the antioxidant activity of fermented green coffee beans and the factors involved in the fermentation process. We selected original research articles providing data on the antioxidant activity of fermented green coffee beans published from 2015 to 2021. Fermented green coffee beans shows stronger antioxidant activity compared to the controls. The amount of substrate, yeast (as a starter), and fermentation duration influence the antioxidant activity of the fermented green coffee beans. The fermented green coffee beans with yeast had significantly higher antioxidant activity than those in unfermented coffee.
In silico study of baicalin as an inhibitor of HER-2 receptor in breast cancer Kadek Adi Arya Wiranata; Made Agus Widiana Saputra; Ni Kadek Diah Parwati Dewi; Ni Ketut Nitya Cahyani
Pharmacy Reports Vol. 2 No. 1 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.171 KB) | DOI: 10.51511/pr.26

Abstract

Breast cancer is the second cause of female death in the world. Lapatinib targeting HER-2 is the common inhibitor for breast cancer therapy. This study reports the potential of baicalin as an inhibitor of HER-2 through in silico molecular docking. The study was conducted by structure optimization of baicalin and lapatinib, preparation of HER-2 (PDB ID: 3PP0) target protein, validation of the molecular docking method, and docking of baicalin and lapatinib. The results showed that baicalin had an affinity for HER-2 with a binding energy of -6.0 kcal/mol, while the binding energy of the 03Q native ligand and lapatinib to HER-2 was -4.79 kcal/mol and -3.98 kcal/mol, respectively. This finding indicated that baicalin is a potential breast anticancer through the inhibition of the HER-2 protein.
Sunscreen lip balm stick formulation containing a combination of virgin coconut oil and crude palm oil Nareswari, Tantri Liris; Syafitri, Erga; Nurjannah, Okta
Pharmacy Reports Vol. 2 No. 2 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.48

Abstract

Virgin coconut oil (VCO) and crude palm oil (CPO) are products of Indonesia’s natural wealth with significant antioxidant activity and potential as lip balm sticks to treat dry lips caused by sun exposure. This study aims to determine the formulation of lip balm stick preparations containing VCO and CPO that have sunscreen activity and acceptable physical characteristics. This study included the phases of testing, formulation of lip balm stick, sunscreen activity test, and evaluation of physical properties. The compositions were melted using a water bath, and the sunscreen’s efficacy was evaluated using UV-Vis spectrophotometry. VCO and CPO concentrations varied between 5%, 7.5%, 10%, 12.5%, and 15% (w/w). The F1 formula containing 5% VCO and 15% CPO (w/w) had the highest sun protection factor (SPF) value of 15.438. The evaluation of the formula activity test revealed that the higher the CPO content, the greater the sunscreen activity. Formula F1 has stable physical properties while stored at room temperature for 28 days. Formula F1 has a yellow color, chocolate scent, semi-solid consistency, homogeneous, 3.35 cm dispersion, 56 oC melting point, and 64-gram hardness. Formula F1 provides excellent sun protection and physical properties. It may be further evaluated as a lip balm stick sunscreen formulation for chapped lips.
The relationship between service quality and customer satisfaction: a case study at Nh Beji Pharmacy Budianto, Arif; Pradani, Dea Yulinestria; Rachmania, Nindita; Widiantoro, Edwin; Damanik, Alaris Darasito; Cahyono, Dwi
Pharmacy Reports Vol. 2 No. 1 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.6

Abstract

Customer satisfaction is a critical indicator of the quality of pharmaceutical services and products pharmacies provide. It holds strategic importance in the pharmacy sector, significantly influencing repeat patronage and referrals. Satisfied customers are more likely to recommend the pharmacy to others, which can substantially contribute to the business's long-term growth. This study identifies service variables at Nh Beji Pharmacy that enhance customer satisfaction and evaluates their impact on patients' loyalty and their propensity to refer new customers. By exploring the link between customer satisfaction, repeat business, and referrals, the study aims to highlight the value of customer-focused services in pharmacies. Through interviews with 55 patients randomly selected from service records and provided informed consent for the 2019-2020 period, the study identified seven service variables that significantly boost customer satisfaction at Nh Beji Pharmacy. The findings demonstrate a notable correlation between customer satisfaction and patients' willingness to return and recommend the pharmacy, underscoring the importance of prioritizing customer satisfaction in pharmaceutical service delivery.
Isatin come on the stage of CDK4/6 inhibitor Pradana, Radiktya Surya; Fareza, Muhammad Salman
Pharmacy Reports Vol. 2 No. 2 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.12

Abstract

Cyclin-dependent kinase (CDK) 4/6 inhibitors have significantly improved the prognosis for patients with hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer, including those with metastatic or advanced breast cancer (mBC/ABC). Recent research has focused on developing CDK4/6 inhibitors with diverse structural frameworks, including isatin-based compounds. Isatin and its derivatives have shown promise in inhibiting CDK4/6, with potential efficacy against breast cancer cell lines. Studies have also indicated that isatinyl-2-aminobenzoylhydrazone (ISABH) complexes, particularly those with transition metals like nickel (Ni-ISABH), exhibit strong binding affinities to CDK6 and fulfill key pharmacokinetic criteria.
Sensory evaluation of flavoring agent addition in soy-based beverage Pratiwi, Riyona Desvy; Rosyidi, Viddy Agustian; Zanjabilla, Sabighoh; Dewi, Kartika Sari; Novandra, Rio; Desvina, Della; Herawati, Heny
Pharmacy Reports Vol. 2 No. 1 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.46

Abstract

Soy-based beverages offer numerous health benefits, but the presence of lipoxygenases causes an unpleasant off-flavor sensation that hinders acceptability. The addition of a suitable flavoring agent has been shown to enhance the acceptability of soy-based beverages. This study aimed to investigate preferences towards two flavored variants of soy-based beverages: original chocolate made from cocoa powder and vanilla made from vanilla essence. Before comparing the sensory parameters, which included appearance, taste, odor, texture, and overall assessment, the ratio of basic components such as soy and cow milk powder, sugar, and maltodextrin was studied. Fifty-seven untrained panelists evaluated the three flavored variants of soy-based beverages. The chocolate-flavored soy-based beverage received a significantly higher score in taste, odor, texture, and overall assessment (α = 0.05). Hence, adding cocoa powder as a flavoring agent in soy-based beverages effectively improved the sensory attributes.

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