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Pharmacy Reports
Published by Indonesian Young Scientist Group
ISSN : -     EISSN : 27989798     DOI : https://doi.org/10.51511/pr.2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Pharmacy Reports is an open-access journal publishing peer-reviewed research in the pharmacy field, covering topics in pharmaceutics, biomedicine, pharmaceutical chemistry, bioinformatics, natural product, pharmacology and toxicology, and clinical pharmacy. Pharmacy Reports invites you to submit papers, covering topics in: pharmaceutics (pharmaceutical technology, drug delivery system), biomedicine (molecular biology, biochemistry, immunology, microbiology, biotechnology), pharmaceutical chemistry (analytical chemistry, medicinal chemistry: drug design, drug synthesis, pharmacochemistry, bioinformatic), natural product (fractionation, isolation, purification, and elucidation), pharmacology and toxicology (pharmacokinetics, toxicology), clinical pharmacy (therapeutic drug monitoring, adverse drug reaction, drug interaction), pharmaceutical industry, pharmacy education, community service related to pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 73 Documents
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Stability and efficacy of green solvent and natural excipient-based semisolid formulations compared with conventional formulations: a review Muh Fajar Fauzi; Eko Hidayaturrohman Khumaini
Pharmacy Reports Vol. 5 No. 3 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.118

Abstract

Semisolid dosage forms, including creams, gels, ointments, hydrogels, and emulgels, are widely used for topical drug delivery. Green solvent- and natural excipient-based systems have gained attention for their potential biocompatibility and reduced environmental burden, but their stability advantages over conventional formulations remain unclear. This systematic review with narrative synthesis evaluated 36 eligible studies from 1,000 records. Due to the methodological and clinical heterogeneity of the included studies, a narrative synthesis was conducted in place of quantitative pooling. Among 20 studies reporting direct comparative efficacy, 11 showed superior results for green or natural formulations, 7 reported equivalence, and 2 had mixed findings. Safety outcomes were generally comparable or more favorable for green formulations, with no serious adverse events linked to these systems. However, stability evidence was limited: only 9 studies reported stability-related parameters, and long-term or accelerated data were largely absent. While green solvent- and natural excipient-based semisolid formulations demonstrate promising efficacy and tolerability, current evidence does not establish that they are inherently more stable than conventional systems, and their translational readiness remains constrained by insufficient demonstration of reproducible formulation quality over time.
Cost of illness of breast cancer in Indonesia in 2024: an analysis from the payer perspective Sudewi Mukaromah Khoirunnisa; Didik Setiawan
Pharmacy Reports Vol. 6 No. 1 (2026): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.119

Abstract

Breast cancer imposes a substantial clinical and economic burden in Indonesia, particularly within the National Health Insurance system administered by BPJS Kesehatan. Understanding cost variation by disease severity and care type is therefore essential for efficient resource allocation. This retrospective observational study used BPJS Kesehatan claims data to estimate annual direct medical costs from the payer perspective, categorizing expenses into chemotherapy, radiotherapy, surgery, diagnostic procedures, and follow-up examinations. Costs were analyzed by outpatient versus inpatient care and inpatient severity levels (mild, moderate, severe). The total annual direct medical cost reached IDR 834.11 billion. Outpatient care accounted for the largest share of total expenditure, while inpatient care incurred substantially higher per-patient costs. Costs increased consistently with severity across all components, with chemotherapy, surgery, and radiotherapy identified as the main cost drivers, particularly in severe inpatient cases. Median cost differences between outpatient care and all inpatient severity levels were statistically significant (p<0.001). These findings highlight the significant financial burden of breast cancer on Indonesia’s national health insurance system, strongly influenced by disease severity and inpatient utilization, and underscore the importance of early detection and optimized outpatient care to improve efficiency and long-term sustainability of cancer care financing under Indonesia’s national health insurance system (JKN).
Optimizing a vaseline–lanolin ointment base for Momordica charantia extract using a simplex lattice design Muh Fajar Fauzi; Sarmoko; Tantri Liris Nareswari; Ahmad Bayu Satriawan; Nisa Yulianti Suprahman; Evi Kurniawaty
Pharmacy Reports Vol. 6 No. 1 (2026): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.126

Abstract

Topical delivery of Momordica charantia (bitter melon) extract is a promising approach for anti-inflammatory and antioxidant therapy, yet the performance of the dosage form depends strongly on the composition of the formulation base. This study aimed to optimize a two-component vaseline–lanolin ointment base for M. charantia extract using a simplex lattice mixture design. Five blends spanning the binary mixture space were prepared and characterized for viscosity, spreadability, adhesiveness, and pH. Polynomial mixture models were fitted to each response, model adequacy was assessed by analysis of variance and lack-of-fit testing, and a multi-response Derringer desirability function was applied to locate a compromise optimum, which was then verified experimentally. Increasing the lanolin proportion generally increased viscosity and adhesiveness but reduced spreadability, whereas higher vaseline fractions improved spreadability while maintaining pH within a skin-compatible range. The models showed good fit and predictive utility, and the selected blend (vaseline:lanolin = 70:30) met all predefined physical criteria, with observed responses showing no significant difference from predicted values. In conclusion, simplex lattice optimization efficiently guided the vaseline–lanolin ratio toward a base with favorable rheological properties, providing a useful and reproducible platform for incorporating M. charantia extract in future efficacy and stability studies.

Page 8 of 8 | Total Record : 73

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