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Pharmacy Reports
Published by Indonesian Young Scientist Group
ISSN : -     EISSN : 27989798     DOI : https://doi.org/10.51511/pr.2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Pharmacy Reports is an open-access journal publishing peer-reviewed research in the pharmacy field, covering topics in pharmaceutics, biomedicine, pharmaceutical chemistry, bioinformatics, natural product, pharmacology and toxicology, and clinical pharmacy. Pharmacy Reports invites you to submit papers, covering topics in: pharmaceutics (pharmaceutical technology, drug delivery system), biomedicine (molecular biology, biochemistry, immunology, microbiology, biotechnology), pharmaceutical chemistry (analytical chemistry, medicinal chemistry: drug design, drug synthesis, pharmacochemistry, bioinformatic), natural product (fractionation, isolation, purification, and elucidation), pharmacology and toxicology (pharmacokinetics, toxicology), clinical pharmacy (therapeutic drug monitoring, adverse drug reaction, drug interaction), pharmaceutical industry, pharmacy education, community service related to pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 70 Documents
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In vitro antibiofilm activity of eggshells derived nano-hydroxyapatite (nHA) against Staphylococcus aureus and Streptococcus mutans Suhaimi, Nursyamimi Nasuha; Tarmizi, Nur Hazirah; Zulkifli, Nur Farahim; Amana Allah, Nur Ili Aqilah; Harun, Fakhrul Aimanulhakim; Hanafee, Siti Nur’aisyah Muhamad; Zulkepli, Nur Ayunie; Salim, Fatimah; Mokhtar, Norehan
Pharmacy Reports Vol. 4 No. 3 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.84

Abstract

Dental caries, a highly prevalent oral health condition worldwide, is primarily driven by the biofilm-forming abilities of Staphylococcus aureus and Streptococcus mutans. The interest in eggshell extracts has grown in recent years due to their potential benefits for oral health. Therefore, this study investigated the potential of nano-hydroxyapatite (nHA) derived from eggshells in combating bacterial infections and inhibiting biofilm formation by the selected cariogenic bacteria. The antibacterial activity of the nano-hydroxyapatite extract was initially assessed using the agar well diffusion method. Subsequently, biofilm inhibition was evaluated through crystal violet assays, and the disruption of biofilm structure was visualized under a light microscope. The findings indicated that the nano-hydroxyapatite extract lacked antibacterial activity in inhibiting the growth of both S. aureus and S. mutans. However, the extract demonstrated antibiofilm activity against mono-species biofilms, with observed disruption of biofilm formation upon treatment. As a result, nano-hydroxyapatite extracts derived from eggshells may hold potential as agents for inhibiting biofilm formation associated with dental caries.
Exploring the pharmacological potential of Moringa oleifera folium in health applications: A review Kadek Rahayu Darma Yanti; Wirawati, Kadek Tania; Ompusunggu, Gabrios Bonauli; Wardani, Luh
Pharmacy Reports Vol. 4 No. 3 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.93

Abstract

This review synthesizes current knowledge on the therapeutical potential of Moringa oleifera leaf extract in health. M. oleifera has transitioned from traditional medicine to the forefront of scientific investigation due to its exceptional phytochemical diversity and pharmacological versatility. Evidence supporting cardiovascular, metabolic, and renal benefits is assessed, highlighting mechanisms including nitric oxide modulation, anti-adipogenic effects, protein glycation inhibition, and renoprotection in diabetic conditions. The anti-inflammatory properties of M. oleifera are examined across gastrointestinal, neurological, and pulmonary systems, with significant findings in inflammatory bowel disease models, microglial enzyme modulation, and cancer suppression. Recent research on specific bioactive fractions, molecular targets, and signaling pathways provides mechanistic insights into M. oleifera's therapeutic actions. While substantial preclinical evidence supports M. oleifera's potential, it identifies critical research gaps, particularly in clinical validation, standardization, and pharmacokinetics. M. oleifera represents a promising sustainable resource for addressing global health challenges, especially in chronic disease prevention and management.
The neuroprotective effects of Robusta coffee (Coffea canephora) on neurodegenerative diseases Warman, Ressalia Shoumadani; Iqbal, Muhammad; Triyandi, Ramadhan
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.83

Abstract

Neurodegenerative diseases represent a growing global health challenge, particularly in aging populations. This review examines the neuroprotective potential of Robusta coffee (Coffea canephora) and its bioactive compounds in neurodegenerative conditions. Robusta coffee contains a rich profile of bioactive compounds, including caffeine, chlorogenic acids, and other polyphenols, which demonstrate significant antioxidant, anti-inflammatory, and neuroprotective properties. Evidence from preclinical and epidemiological studies suggests that these compounds can modulate multiple pathways involved in neurodegenerative processes, including oxidative stress, neuroinflammation, and protein aggregation. This review synthesizes current findings on the molecular mechanisms underlying the neuroprotective effects of Robusta coffee components in conditions such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. Recent advances in delivery systems, such as nanoparticle formulations, are also discussed as potential approaches to enhance the bioavailability and efficacy of coffee bioactives. By identifying the therapeutic potential of Robusta coffee components and highlighting gaps in current knowledge, this review provides a foundation for developing novel preventive and therapeutic interventions for neurodegenerative diseases based on these naturally occurring compounds.
Recent advances and applications in the antibacterial activity of Piper betle leaf extract Wardani, Luh; Ompusunggu, Gabrios Bonauli; Wirawati, Kadek Tania; Yanti, Kadek Rahayu Darma
Pharmacy Reports Vol. 4 No. 1 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.87

Abstract

Piper betle leaves contain diverse phytochemicals including phenolics, alkaloids, and flavonoids that demonstrate significant inhibitory effects against both Gram-positive and Gram-negative bacteria, particularly Staphylococcus aureus and Escherichia coli. The review analyzes extraction methodologies, mechanistic aspects of antimicrobial action, and efficacy against specific pathogens. Applications across multiple domains are explored, including clinical treatments for ocular and dental infections, advanced wound healing systems, food preservation through biodegradable packaging, and functional materials development. Despite promising results, challenges remain in standardization, active compound identification, and delivery system optimization. By synthesizing research from the past five years, this review provides a foundation for future development of P. betle-based antimicrobial applications that may help address the global challenge of antimicrobial resistance.
Porang (Amorphophallus muelleri Blume) and its potential in diabetes management Jayaningsih, Ni Ketut Frida Murti; Nuratningsih, Ni Wayan; Wirawati, Ni Kadek Tania
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.90

Abstract

Diabetes mellitus remains one of the most pressing global health challenges, driving the search for natural alternatives to conventional therapies. This review explores the potential of porang (Amorphophallus muelleri Blume) as a promising intervention for diabetes management. Porang is rich in glucomannan, a soluble dietary fiber with diverse therapeutic properties. Modern extraction methods can achieve glucomannan purity exceeding 90%, with ongoing advancements improving yield and quality. Mechanistically, porang exerts antidiabetic effects through multiple pathways, including enhanced insulin gene expression, improved insulin signaling, and reduced glucose absorption. Experimental studies in diabetic animal models demonstrate significant glucose-lowering effects, with blood glucose reductions of up to 50% alongside increased pancreatic β-cell counts. Beyond glycemic control, porang mitigates diabetic complications, reducing glomerulosclerosis and preserving reproductive function. It also offers broader metabolic benefits, such as improved lipid profiles, reduced inflammatory markers, and enhanced gut health via increased short-chain fatty acid production. While current evidence is promising, further clinical studies are needed to optimize dosing, formulations, and long-term efficacy in humans. Nevertheless, porang’s multifaceted therapeutic profile positions it as a viable complementary approach within comprehensive diabetes management strategies.
A bibliometric analysis of ginger's anticancer potential: bioactive compounds, cancer types, and mechanisms of action Maharani, Putu Audi Mas; Sarmoko
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.91

Abstract

This study explores the anticancer properties of ginger (Zingiber officinale) through comprehensive bibliometric analysis of literature published from 2015 to 2024. Using PRISMA methodology, 49 relevant articles were identified from PubMed and analyzed through Biblioshiny and VOSviewer software. The International Journal of Molecular Sciences emerged as the leading publication source. Network visualization identified three major research clusters: antioxidant mechanisms, cancer biology, and phytochemical applications. Triple-negative breast cancer and colorectal cancer represent the most extensively studied malignancies. Mechanistically, ginger compounds (particularly gingerols and shogaols) demonstrate anticancer effects through multiple pathways including apoptosis induction, cell cycle arrest, anti-metastatic activity, oxidative stress modulation, and angiogenesis inhibition. While in vitro and preclinical evidence is robust, clinical translation remains limited. This analysis provides a comprehensive overview of ginger's anticancer research landscape, highlighting established mechanisms, identifying knowledge gaps, and suggesting future directions. The findings support ginger's potential as a complementary therapeutic agent and source of lead compounds for anticancer drug development, while emphasizing the need for advanced clinical investigations.
Banana-derived excipients: drug release, performance, and stability Fauzi, Muh Fajar
Pharmacy Reports Vol. 5 No. 1 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.99

Abstract

Banana-derived excipients have garnered increasing attention due to their potential as natural, sustainable alternatives in pharmaceutical formulations. This study systematically reviewed the effectiveness and compatibility of banana-based excipients compared to conventional synthetic and natural counterparts. A comprehensive literature review was conducted following the PICOS framework, covering studies published between 2013 and 2024. Data extraction focused on physicochemical characterization, functional performance, and drug release properties of banana-derived excipients across various dosage forms. The results indicate that banana starch and crude banana powder exhibit promising binding, disintegrant, and mucoadhesive properties. Their performance in pharmaceutical formulations was comparable to widely used excipients such as maize starch, polyvinylpyrrolidone (PVP), and microcrystalline cellulose. Notably, banana-derived excipients demonstrated sustained-release effects and potential bioavailability enhancement. However, a lack of standardization in processing methods and limited stability data highlight the need for further research to ensure reproducibility and regulatory compliance. Despite their advantages, challenges remain in optimizing formulations and understanding long-term interactions with drug compounds. Future studies should focus on in vivo validation and stability assessments to enhance the adoption of banana-based excipients in pharmaceutical applications. This research contributes to the growing field of sustainable pharmaceutical development by advocating for the integration of environmentally friendly excipients into modern drug formulations.
Molecular docking of several compounds in Bauhinia thonningii as alfa estrogen receptor inhibitors in breast cancer Zaqia, Lulu; Alhestha, Salsabila Zahra; Rahmadini, Celina Fadila; Kusumawati, Maiya; Dhiya, Syifa Nasywa; Andriani, Wellen Putri; Azzahra, Zeta Agustri; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 3 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.70

Abstract

Compounds contained in Bauhinia thonningii have been proven in vitro to have anti-breast cancer effects. This research was carried out to validate in silico the compounds contained in Bauhinia thonningii. The molecular docking process begins with the ER target protein alpha (PDB id: 2BJ4) downloaded from the web http://www.rcsb.org/. After that, validation was carried out on natural ligands and target proteins using AutodockTools (Autodock 4.2 and Autogrid). Continued with optimization of the compounds to be tested, namely 6,8-Di-C-methyl kaempferol 3,7-dimethyl ether; 6-C-Methylquercetin-3,4'-dimethylether; Quercetin‑3‑O‑α‑L‑rhamnopyranoside and Tamoxifen as a positive control was downloaded at https://molview.org/ then geometrically optimized using Avogadro then docked with the target protein ER-α. Obtained bond energy results between natural ligands, 3 test compounds and 1 control compound 4-HYDROXYTAMOXIFEN; 6,8-Di-C-methyl kaempferol 3,7-dimethyl ether; 6-C-Methylquercetin-3,4'-dimethylether ;Quercetin-3–O-α-L-rhamnopyranoside and tamoxifen were -11.32,-6.07, -7.26,-8.88, -10.33 kcal/mol. If we look at the smallest bond energy, it is found that the compounds that have the greatest potential when sorted are the natural ligand, positive control, Quercetin‑3‑O‑α‑L‑rhamnopyranoside, 6-C-Methylquercetin-3,4'-dimethyl ether and 6,8-Di-C-methyl kaempferol 3,7-dimethyl ether.
Molecular docking analysis of guaiacin and chalcone from nutmeg (Myristica fragrans) as novel HSP90A inhibitors for skin cancer treatment Arrafi, Muhammad Zhafran; Cahyani, Ayu Sukma; Sitohang, Nada Nikita; Ulya, Salsa Nabila Ahlika; Anggraeni, Inggrid; Amalia, Miranti; Putri, Gladys Ellnora; Rajwa, Raihan M Dhiya; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 3 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.73

Abstract

Skin cancer represents one of the most prevalent malignancies globally, with Indonesia reporting the third highest incidence among cancer types. Despite advances in treatment, there remains a critical need for novel therapeutic agents. Heat Shock Protein 90 Alpha (HSP90A) has emerged as a promising target for cancer therapy due to its critical role in stabilizing oncogenic proteins. This study aimed to evaluate the potential of guaiacin and chalcone from nutmeg (Myristica fragrans) as HSP90A inhibitors for skin cancer treatment through computational analysis. Molecular docking was performed using AutoDock Tools with the HSP90A crystal structure (PDB ID: 2VCJ). The compounds were assessed for binding affinity, molecular interactions, and drug-likeness properties according to Lipinski's Rule of Five. Redocking validation yielded an RMSD of 1.24 Å, confirming protocol reliability. Guaiacin demonstrated promising binding affinity (-7.40 kcal/mol) with key hydrogen bonds to Asp93 and Lys58, while chalcone showed moderate affinity (-5.99 kcal/mol) with a single hydrogen bond to Thr184. Both compounds exhibited favorable drug-like properties with high predicted gastrointestinal absorption. Guaiacin emerges as a promising natural HSP90A inhibitor candidate with binding energy exceeding the stability threshold (-7.00 kcal/mol) and interactions with critical residues in the ATP-binding pocket, providing a foundation for further development of nutmeg-derived compounds as potential anticancer agents.
Molecular docking of capsaicin and its derivatives as acetylcholinesterase (AChE) inhibitors in Alzheimer disease Syah, Vicky Ardian; Geralda, Rifka; Sakti, Nickyta Salsabila Ira; Febriyanti, Kharisma; Bokshow, Rency Violita Vanden; Wulandari, Valentri; Hasanah, Siti Fadhilatul; Fadillah, Muhammad Zakki; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 4 No. 1 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.74

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder predominantly affecting older adults, characterized by pathological processes that include excessive acetylcholinesterase (AChE) activity leading to depleted acetylcholine levels. Although synthetic AChE inhibitors such as donepezil are used therapeutically, their clinical application is often limited by adverse effects and high costs. Capsaicin, a bioactive compound derived from chili peppers, has exhibited neuroprotective properties—including cognitive enhancement and amyloid-β reduction—suggesting its potential as a natural alternative for AD treatment. This study investigated capsaicin and six structural derivatives as potential AChE inhibitors through in silico molecular docking simulations against the human AChE crystal structure (PDB: 4EY7), using donepezil as a reference ligand. The docking protocol was validated with a root-mean-square deviation (RMSD) value of 0.71 Å, confirming reproducibility and reliability. The calculated binding affinities of the evaluated compounds ranged from –6.13 to –11.60 kcal/mol. Among them, 2-Hydroxy-3-(octyloxy)phenyl-5-(acrylamido)methylbenzophenone (Compound 2) exhibited the strongest binding affinity (–11.60 kcal/mol), slightly exceeding that of donepezil (–11.45 kcal/mol). Compound 2 formed four hydrogen bonds within the active site and shared key interactions with residues Phe338 and Trp286, consistent with the binding mode of donepezil. These results suggest that Compound 2 may serve as a potent natural AChE inhibitor and warrant further investigation as a candidate for Alzheimer’s disease therapy.

Page 5 of 7 | Total Record : 70

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