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Slamet Supriadi
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Indonesian Journal of Life Sciences LPPM - Indonesia International Institute for Life Sciences (i3L) Jl. Pulomas Barat Kav. 88, Jakarta Timur, 13210 Indonesia
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INDONESIA
Indonesian Journal of Life Sciences
Published by Indonesia International Institute for Life Sciences
ISSN : -     EISSN : 26560682     DOI : http://doi.org/10.54250/ijls
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology
The Indonesian Journal of Life Sciences (IJLS) is a journal published by Indonesia International Institute for Life Sciences Press (i3L Press). IJLS is a scientific journal contains original research articles, review articles, and short communication covering all aspects in life sciences. This journal provides immediate open access to its content on the principle that making research freely available to the public to support a greater global exchange of knowledge. Readers can view abstracts and download full-text articles (PDF) free at any cost. All manuscripts submitted to the Indonesian Journal of Life Sciences will be screened for plagiarism and blind peer-reviewed to present valuable and authentic findings in life sciences. Authors with original, clearly analyzed, and logically interpreted research result in the scope of food innovation and nutrition, bio-products and services for sustainable society, information technology in life sciences, as well as health and well-being are very welcome to submit their articles. Every article issued to the editorial of the Indonesian Journal of Life Sciences is free of charge including the cost of repairing the article. IJLS is published bianually on March and September. Manuscripts are accepted on a continuous basis and the submisison is opened through the year.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 85 Documents
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In Silico Evaluation of the Inhibition of Pseudomonas aeruginosa Biofilm Production in Burn Wound Infections Using CATH-2 and LL-37 Peptides Adhiwijaya, Priscilla Klaresza; Kaitlyn, Gabriella Zevania; Valenthenardo, Louis; Anjani, Patricia Tiara; Bani, Mario Donald
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.02
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i02.238

Abstract

Patients with burn injuries are at high risk of bacterial infection due to the loss of the skin barrier, often leading to complications that contribute to increasing death tolls from burn injuries. The formation of biofilms in bacteria increases its survival rate, especially in the rise of antibiotic resistance cases, which ineffectively combats biofilm production. This research explores the use of two types of cationic antimicrobial peptides, LL-37 and CATH2, commonly originating from humans and chickens, respectively, as a form of host defense in preventing the formation of biofilms by one of the most common pathogenic bacterial strains in severe burn wounds, Pseudomonas aeruginosa, through inhibition in its LPS region. In silico analyses were performed using AlphaFold, GLYCAM-Web, YASARA, and AutoDock Vina. It was found that the CATH-2 model has the strongest binding affinity towards the three types of LPS—alginate, Pel, and Psl—scoring between -5.5 and -6.0 kcal/mol, as opposed to the score range of -4.1 to -6.0 for LL-37. However, the LL-37 model is considered more precise than the CATH-2 model overall, meaning the in silico results of the former are likely more accurate in real life than the latter. These results suggest the utilization of the two peptides as treatments in severe burn cases. In future developments, the application of genetically engineered plasmid-inserted Staphylococcus epidermidis, a commensal bacterium commonly found on human skin, to produce peptides may be considered.
Exploring Hemophilia: Understanding the Underlying Mechanisms, Diagnostic Strategies, and Therapeutic Advances Danisa, Michelle; Maringka, Stephanie Grace; Augusto, Efrando; Catherine, Aurelia; Christian, Melinda; Febriana, Gabriella Gita; Wong, Maria Maylyn Evangelina; Tjong, Krystle Hadassa
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i1.187

Abstract

Hemophilia is an inherited blood disorder resulting in impaired blood clotting upon vascular damage due to defective or deficient coagulation factors. The three types of hemophilia are hemophilia A, hemophilia B, and hemophilia C, which result from the defect or deficiency of factor VIII, factor IX, and factor XI respectively. Hemophilia affects hundreds of millions of people worldwide, with the highest incidence in Asian countries including India, Bangladesh, and Indonesia. This review encompasses the epidemiology, etiology, pathophysiology, diagnosis, and treatment for hemophilia, and the literature sources were collected from other publications, including journal articles and books.
Importance of WASH Interventions in Tackling Stunting and Wasting Problems in Children Soegijanto, Steffany; Santoso, Jessica Natalie; Eldyjoe, Angelica Gabriel; Halim, Bernadeth Caecilya Anggraini; Sastra, Timothy; Jossevynne, Zenlly Erenn; Valentino, Figo; Astina, Junaida
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i1.201

Abstract

Child malnutrition is a serious health condition caused by insufficient or excessive consumption of calories, carbohydrates, fats, proteins, vitamins, and minerals. Poor sanitation, hygiene, and viral infections directly related to malnutrition, which also correlated with stunting and wasting. UNICEF and WHO work globally to combat malnutrition, especially stunting and wasting, by implementing WASH programs to minimize diarrheal illnesses and improve nutritional status. Despite encouraging results, WASH interventions face several limitations such as resource demand and adaptation to unforeseen circumstances. Some recommendations for future programs include combining WASH with nutritional education, growth tracking, community engagement, and supplements for better results. To alleviate stunting in children, infrastructure, hygiene education, and public cleanliness should be improved. Taking a holistic approach to physical and cognitive development is essential to solving the complicated issue of child malnutrition, especially in Indonesia.
Canna (Canna edulis) Flour's Properties as Indonesian Functional Food to Lower Colorectal Cancer Risk Santoso, Jessica Natalie; Soegijanto, Steffany; Eldyjoe, Angelica Gabriel; Felicia, Helena; Kusuma, Gabriella Jovita; Wiranti, Rini; Astina, Junaida
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i1.206

Abstract

The imbalanced food supply in Indonesia has posed a significant challenge. The utilization of canna (Canna Edulis) starch can act as a potential solution, enabling society to consume a more diverse variety of commodities rather than relying solely on rice. Canna, an underutilized tuber, is rich in resistant starch and bioactive compounds, showing potential in tackling dietary and health issues. Despite its high glycemic index, efforts to modify canna starch into resistant starch aim to enhance its health benefits by improving blood sugar control and gut health. This paper aims to introduce ganyong (Canna edulis) starch as a versatile alternative to rice or wheat for carbohydrates, which also highlights the urgent need to address and prevent the high prevalence of colorectal cancer in society by the role of bioactivity and mechanisms of action of canna starch. The applications of canna starch in the food industry such as ginger bangket biscuits, cendol, and cookies, is discussed to highlight its potential as a substitute for traditional starch sources, along with its sensory attributes. Although limitations are acknowledged, continued research and development in processing techniques are essential to unlock the full potential of canna starch and its application in addressing food security and health challenges.
The Potential of Foxtail Millet as a Carbohydrate-Based Indonesian Local Functional Food Candra, Andrea Natasha; Halim, Bernadeth Caecilya Anggraini; Kartasasmita, Franchel; Christie, Gladys Gracia; Pandyopranoto, Jemima Patricia; Andriani, Koo Felisha; Margaretha, Febrina; Heerlie, Devita Mayanda; Astina, Junaida
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i1.208

Abstract

Foxtail millet (Setaria italica L.) is a round-shaped cereal grain varied in colors and sizes and is part of the Poaceae family alongside sorghum and maize. It is one of the most extensively cultivated crops in Asia and Africa, as well as in several other developing countries. In 2014 alone, Asia and Africa produced 95% of the total global foxtail millet yield. Foxtail Millet itself is a good source of bioactive compounds such as minerals, phenolic compounds, amino acids, dietary fibers, carotenoids, sterols, unsaturated fatty acids, phytic acids, tocols, and anti-nutritive compounds. Due to these reasons, foxtail millet has several health benefits such as antioxidant activity, anti-hyperglycemic effects, anti-cholesterol effects, anti-hypertensive effects, and anthropometric effects. It has been mentioned that fox millet contains antioxidants, metal chelators, and reductants in the soluble and insoluble phenolic extracts which are beneficial as natural antioxidant sources. In animals, foxtail millet has also been proven to be safe and its benefit has been proven, specifically in terms of its gastroprotective effect. However, foxtail millet might cause an allergic reaction in humans due to cross-reactivity among different grains. Hence, the safety and efficacy of foxtail millet should be studied further. However, potentially, foxtail millet could be incorporated into a variety of aspects of the food industry. One of the functions is that it can be used to incorporate the flour in order to increase the nutritional properties, such as the mineral and fiber content of the flour itself.
In-Silico Study of Diphenhydramine and Orphenadrine Binding Affinities to H1 and NMDA Receptors: Implications for Pharmacological Effects Utama, Andrea Dhieta; Widiyanto, Azura Luna; E, Ervin; Elvina, Lia; Cahya, Rachel Josephine; Feliecia, Silvania; Putri, Stevanie
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i1.222

Abstract

Diphenhydramine and orphenadrine are oral drugs designed to possess different functional groups that affect H1 and NMDA receptors, although for different purposes. This study compares their binding affinities with the two receptors to investigate whether it influences the differing pharmacological effects exerted. This could help better understand the mechanisms, benefits, and risks of the drugs. The physicochemical properties were analyzed using Swiss-ADME, while the binding affinities were tested by molecular docking with PyRx. Lastly, visualization and analysis were done using the BIOVIA Drug Discovery Studio. The result suggests that both drugs have the same affinity for H1 receptors, however, orphenadrine has a slightly higher affinity to NMDA than diphenhydramine. This finding suggests that the binding ability and affinity of orphenadrine to NMDA is the factor of its pharmacological effect difference compared to diphenhydramine. Moreover, the difference in the functional group possessed by the two drugs will make a difference in their absorption and distribution.
In-Silico Design of a PIN1/ABCC5-Targeted Multi-Epitope Vaccine for Nasopharyngeal Cancer Ashiila, Putri; Gustiananda, Marsia
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.218

Abstract

Nasopharyngeal Carcinoma (NPC) is a rare malignancy. However, it is the fourth most common cancer affecting both sexes in Indonesia, and research on NPC remains limited. NPC is related to Epstein-Barr Virus (EBV) infection, making it a potential target for immunotherapy strategies. Developing a multi-epitope-based NPC vaccine targeting tumor-overexpressed antigens may evoke an immune response against cancer cells and benefit patients with advanced cancer stages or those resistant to treatment. Four cytotoxic (CTL) and one helper T-cell (HTL) epitopes from PIN1 were identified using NetMHCpan and NetMHCIIpan algorithms, respectively. Whereas from ABCC5, five CTL and four HTL epitopes were identified using the same algorithms. These epitopes were found to have good coverage across the Indonesian population, with population coverage analysis showing 99% coverage for human leukocyte antigen (HLA) Class I and 95% for HLA Class II. Having fulfilled other criteria such as immunogenicity, IFN-γ-inducing ability, and non-homology to human peptides, the epitopes were assembled into a vaccine construct together with E. coli and Bacillus as adjuvants and appropriate linkers. The construct was shown to have good physicochemical characteristics and the ability to induce CTL and HTL responses, which stem from the engagement of the vaccine with toll-like receptor 4 (TLR4) as revealed by docking simulations.
The Physicochemical Properties, Antioxidant Potential, and Skin Penetration of Pterostilbene-Loaded NLCs Louise, Elaine; Yen, Feng-Lin
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.239

Abstract

Pterostilbene is a naturally occurring polyphenolic compound known for its antioxidant activity and potential use in topical skin care formulations. However, its poor water solubility and limited skin penetration reduce its therapeutic effectiveness. In this study, pterostilbene-loaded nanostructured lipid carriers (PT-NLCs) were developed and evaluated as a topical delivery system to enhance its stability and dermal performance. The PT-NLCs showed a mean particle size of 78–99 nm (88.57 ± 10.60 nm), a polydispersity index of 0.284, and an encapsulation efficiency of 99.98%, indicating a stable nanosystem. The NLC formulation increased apparent water solubility by over 5,000-fold and improved skin penetration by approximately 360% compared with raw pterostilbene. PT-NLCs also demonstrated enhanced antioxidant activity, with about a 34% increase in radical scavenging capacity in the DPPH assay and improved protection of skin cells against oxidative stress while maintaining good cytocompatibility. These findings demonstrate that NLC-based encapsulation effectively improves the solubility, dermal penetration, and antioxidant efficacy of pterostilbene, highlighting its potential as a promising ingredient for topical skin treatment applications.
Comparative Analysis For CNN and MLP Models in Breast Cancer Diagnosis Nurtanio, Priscilla Natalie; Nathaniel, Darren; Sugiarto, Temmy; Angelina, Theresa; Tjandra, Raymond; Kurniawan, Yohana Joevanca; Sampe, Maria Zefanya
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.254

Abstract

Breast cancer remains one of the most common and deadly diseases affecting women worldwide, highlighting the importance of early and accurate diagnosis to improve treatment outcomes and survival rates. However, traditional mammography techniques often fall short, failing to detect up to 20% of cases, especially in women with dense breast tissue, which makes detection more difficult. In response to these limitations, this study explores the use of neural networks to enhance diagnostic accuracy in breast cancer detection, focusing on the Convolutional Neural Network (CNN) and Multilayer Perceptron (MLP). Utilizing the Wisconsin Diagnostic Breast Cancer (WDBC) dataset, a baseline CNN model is compared against an optimized CNN refined through hyperparameter tuning using randomized search, as well as two MLP models implemented via Keras and Scikit-learn, along with their optimized versions. Each model is evaluated using key classification metrics, including accuracy, precision, recall, F1-score, and AUC, with an emphasis on minimizing false negatives, as this is critical in medical diagnosis to avoid missed malignancies. The results indicate that the optimized CNN model achieved near-perfect scores across all metrics and demonstrated the best balance between training and testing data. Therefore, it outperforms the baseline CNN and MLP models in significantly reducing false negatives, showcasing the potential of a well-tuned CNN to enhance the automation and reliability of breast cancer diagnostic processes.
Potential Use of WT1 as a Diagnostic and Therapeutic Marker of Acute Myeloid Leukemia: A Review Rindiarti, Almitra; Harsono, Yeremia O'neal
Indonesian Journal of Life Sciences 2026: IJLS Vol 08 No.01
Publisher : Universitas Bio Scientia Internasional Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v8i01.270

Abstract

Acute myeloid leukemia (AML) is a heterogeneous malignancy characterized by uncontrolled proliferation and impaired hematopoietic differentiation of myeloid lineage with rapid disease progression. Among the various biomarkers studied, Wilms’ tumor 1 (WT1) is a widely expressed gene in AML, making it an attractive biomarker candidate for diagnosis and minimal residual disease (MRD) monitoring. This review evaluates the potential of WT1 as an effective diagnostic biomarker and the current detection methods, highlighting the advantages and limitations of the current gold standard, RT-qPCR, and exploring potential alternative approaches, such as ELISA and antibody-based flow cytometry, for its clinical applicability. Using public gene datasets, bioinformatic analysis further supports WT1’s overexpression in AML, though with varying levels across subtypes, suggesting its potential as part of a multimodal diagnostic plan rather than a standalone marker. Beyond diagnostics, WT1 is also a promising therapeutic target, with peptide and dendritic cell vaccines, as well as TCR-engineered T cells, demonstrating encouraging clinical outcomes. Next-generation strategies, including CAR-T cells, bispecific T-cell engagers, and mRNA vaccines, are advancing preclinical and early clinical studies. Together, these findings highlight WT1 as both a biomarker and a therapeutic target, with future integration into precision medicine likely to improve AML detection, risk stratification, and treatment.

Page 8 of 9 | Total Record : 85

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