cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Slamet Supriadi
Contact Email
slamet.supriadi@i3l.ac.id
Phone
+622129567888
Journal Mail Official
ijls@i3l.ac.id
Editorial Address
Indonesian Journal of Life Sciences LPPM - Indonesia International Institute for Life Sciences (i3L) Jl. Pulomas Barat Kav. 88, Jakarta Timur, 13210 Indonesia
Location
Kota adm. jakarta timur,
Dki jakarta
INDONESIA
Indonesian Journal of Life Sciences
Published by Indonesia International Institute for Life Sciences
ISSN : -     EISSN : 26560682     DOI : http://doi.org/10.54250/ijls
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology
The Indonesian Journal of Life Sciences (IJLS) is a journal published by Indonesia International Institute for Life Sciences Press (i3L Press). IJLS is a scientific journal contains original research articles, review articles, and short communication covering all aspects in life sciences. This journal provides immediate open access to its content on the principle that making research freely available to the public to support a greater global exchange of knowledge. Readers can view abstracts and download full-text articles (PDF) free at any cost. All manuscripts submitted to the Indonesian Journal of Life Sciences will be screened for plagiarism and blind peer-reviewed to present valuable and authentic findings in life sciences. Authors with original, clearly analyzed, and logically interpreted research result in the scope of food innovation and nutrition, bio-products and services for sustainable society, information technology in life sciences, as well as health and well-being are very welcome to submit their articles. Every article issued to the editorial of the Indonesian Journal of Life Sciences is free of charge including the cost of repairing the article. IJLS is published bianually on March and September. Manuscripts are accepted on a continuous basis and the submisison is opened through the year.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 71 Documents
 4   5   6   7   8 
In Silico Evaluation of the Inhibition of Pseudomonas aeruginosa Biofilm Production in Burn Wound Infections Using CATH-2 and LL-37 Peptides Adhiwijaya, Priscilla Klaresza; Kaitlyn, Gabriella Zevania; Valenthenardo, Louis; Anjani, Patricia Tiara; Bani, Mario Donald
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i02.238

Abstract

Patients with burn injuries are at high risk of bacterial infection due to the loss of the skin barrier, often leading to complications that contribute to increasing death tolls from burn injuries. The formation of biofilms in bacteria increases its survival rate, especially in the rise of antibiotic resistance cases, which ineffectively combats biofilm production. This research explores the use of two types of cationic antimicrobial peptides, LL-37 and CATH2, commonly originating from humans and chickens, respectively, as a form of host defense in preventing the formation of biofilms by one of the most common pathogenic bacterial strains in severe burn wounds, Pseudomonas aeruginosa, through inhibition in its LPS region. In silico analyses were performed using AlphaFold, GLYCAM-Web, YASARA, and AutoDock Vina. It was found that the CATH-2 model has the strongest binding affinity towards the three types of LPS—alginate, Pel, and Psl—scoring between -5.5 and -6.0 kcal/mol, as opposed to the score range of -4.1 to -6.0 for LL-37. However, the LL-37 model is considered more precise than the CATH-2 model overall, meaning the in silico results of the former are likely more accurate in real life than the latter. These results suggest the utilization of the two peptides as treatments in severe burn cases. In future developments, the application of genetically engineered plasmid-inserted Staphylococcus epidermidis, a commensal bacterium commonly found on human skin, to produce peptides may be considered.

Page 8 of 8 | Total Record : 71

 4   5   6   7   8 

Filter by Year

2019 2025


Reset
Filter By Issues
All Issue 2025: IJLS Vol 07 No.02 2024: IJLS Vol 06 No.02 2024: IJLS Vol 06 No.01 2023: IJLS Vol 05 No .02 2023: IJLS Vol 05 No .01 2022: IJLS Vol 04 No .02 2022: IJLS Vol 04 No .01 2021: IJLS Vol 03 No .02 2021: IJLS Vol 03 No .01 2020: IJLS Vol 02 No .02 2020: IJLS Vol 02 No .01 2019: IJLS Vol 01 No .02 2019: IJLS Vol 01 No .01 More Issue