cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Slamet Supriadi
Contact Email
slamet.supriadi@i3l.ac.id
Phone
+622129567888
Journal Mail Official
ijls@i3l.ac.id
Editorial Address
Indonesian Journal of Life Sciences LPPM - Indonesia International Institute for Life Sciences (i3L) Jl. Pulomas Barat Kav. 88, Jakarta Timur, 13210 Indonesia
Location
Kota adm. jakarta timur,
Dki jakarta
INDONESIA
Indonesian Journal of Life Sciences
Published by Indonesia International Institute for Life Sciences
ISSN : -     EISSN : 26560682     DOI : http://doi.org/10.54250/ijls
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology
The Indonesian Journal of Life Sciences (IJLS) is a journal published by Indonesia International Institute for Life Sciences Press (i3L Press). IJLS is a scientific journal contains original research articles, review articles, and short communication covering all aspects in life sciences. This journal provides immediate open access to its content on the principle that making research freely available to the public to support a greater global exchange of knowledge. Readers can view abstracts and download full-text articles (PDF) free at any cost. All manuscripts submitted to the Indonesian Journal of Life Sciences will be screened for plagiarism and blind peer-reviewed to present valuable and authentic findings in life sciences. Authors with original, clearly analyzed, and logically interpreted research result in the scope of food innovation and nutrition, bio-products and services for sustainable society, information technology in life sciences, as well as health and well-being are very welcome to submit their articles. Every article issued to the editorial of the Indonesian Journal of Life Sciences is free of charge including the cost of repairing the article. IJLS is published bianually on March and September. Manuscripts are accepted on a continuous basis and the submisison is opened through the year.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 71 Documents
 3   4   5   6   7 
The Perception of Undergraduate Students in Jakarta on the Consumption of Cultured Meat Virginia, Jeslin Audrey; Widjojo, Clara Ayu; Inaray, Ivetta Izhora; Ratnasari, Nanda Rizqia Pradana
Indonesian Journal of Life Sciences 2021: IJLS Vol 03 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v3i2.144

Abstract

Cultured meat, which is meat produced by cell culture, is forecasted to be a prominent solution for the growing meat demand. While startups have been established and cultured meat has been marketed in other countries, research about consumer perception is still lacking in Indonesia. The objective of this study is to identify and analyze the customer standpoint, specifically among undergraduate students in Jakarta, regarding cultured meat production and consumption through an online survey. It is hypothesized that there is an effect of being an i3L, and, a biology or food-related major undergraduate student to the cultured meat consumption acceptance. Moreover, it is predicted that there will be a positive change in cultured meat consumption acceptance after watching an educational video included in the survey. Especially, from the group of vegetarians who are motivated to support animal welfare (i.e. No killing of animals) and improve environmental conditions (i.e. Reduce carbon emission). The results showed that study majors and vegetarian status was not significantly correlated with cultured meat acceptance. Nonetheless, previous knowledge about cultured meat positively affects the acceptance. Moreover, the educational video was able to increase the participants’ acceptance. This implies that awareness raising activities, such as advertisements and campaigns, would be effective.
Systematic Review of the Anti-Cancer Activity of Green Tea (Camellia sinensis)-Derived Compounds in Breast Cancer In Vitro Susilo, Felicia Edgina; Surjaputra, Ilsa Valentina; Boentoro, Silvia Apriliani; Ariela, Yovita; Sulistyo, Bobby Prabowo
Indonesian Journal of Life Sciences 2021: IJLS Vol 03 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v3i2.145

Abstract

Breast cancer is the most common type of cancer occurring in women with increasing prevalence in these past few years. Although many targeted therapies have been developed to increase the specificity of the treatment, many patients still suffer from cancer resistance and relapse. Green tea, a common beverage derived from natural plants, has been shown to induce chemopreventive effects and exhibit anti-cancer activity through its catechins and polyphenols content. The main well-known compound that induces these effects is epigallocatechin-3-gallate (EGCG). Green tea also contains other naturally occurring compounds such as catechin (C), epicatechin (EC), epigallocatechin (EGC), epicatechin-3-gallate (ECG), and others. In this study, we assessed and compared the anti-cancer activity of these green tea-derived compounds towards different types of breast cancer cell lines. A total of 15 original research papers from PubMed, Google Scholar, and DOAJ databases were collected and evaluated for the data extraction. The results showed that EGCG was the most potent compound in green tea that was able to reduce cell viability, wound closure, and induce apoptosis even in highly aggressive MDA-MB-231 and lower grade MCF-7 cell lines with ranging concentration. The second potent compound was ECG, followed by EGC and EC that exhibited intermediate effects. Lastly, catechin was shown to have the lowest anti-cancer activity among all other compounds. Flavonols were also shown to exert cytotoxic effects toward breast cancer cells. Moreover, further study is needed to discover the exact mechanism of each compound and determine its relationship toward different types of breast cancer cell lines.
Bioprocessing of mAb (Monoclonal Antibodies) using Chinese Hamster Ovary (CHO) Cells: A Review Josefano, Richelle Bertly; A, Aivyanca; Dungus, Charlivo Mikaichi; Hamid, Jason Jonathan; Katherine, Katherine
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i01.162

Abstract

Monoclonal antibodies (mAb) are known to be able to be produced from Chinese Hamster Ovary (CHO) cells. It has become increasingly important throughout the years due to its efficiency and revolutionary treatment for various diseases such as cancer, autoimmune diseases, and so forth. This review examines several upstream and downstream processes involved in the production of mAb including CHO cell maintenance, cellular engineering of CHO, transfection of plasmids into CHO cells, clonal selection and screening, culture of rCHO cells, cell harvesting, purification, and polishing. Several challenges of the bioprocessing process include a lack of large up scaling for industrial purposes, high capital costs, as well as productivity inefficiencies. However, a solution proposed is for biopharmaceutical companies to research further into the downstream processing for a continuous, efficient, and productive process.
Improving the Biodiesel Production in Saccharomyces Cerevisiae: Metabolic Engineering and Enzyme Engineering Kembaren, Riahna br
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i01.168

Abstract

The yeast Saccharomyces cerevisiae can produce fuels such as biodiesel using the biomass of lignocellulose. S. cerevisiae metabolize monosaccharide of lignocellulosic hydrolysates to supply fuels/energy globally without competition issue with food supply. Ethanol and free fatty acids (FFAs) are the precursors of biodiesel. S. cerevisiae is able to produce these precursors. S. cerevisiae synthesizes biodiesel from ethanol and fatty acyl-coenzyme A thioesters using wax ester acyltransferase (WS). Here, we review some recent strategies applied to metabolic engineering and enzyme engineering of S. cerevisiae for improving the yield of biodiesel. On the metabolic engineering strategy can be done by directing the carbon flux towards the fatty acids biosynthesis pathway through engineering some genes in the central carbon metabolism. By combined overexpression genes of Acetyl-CoA synthetase (ACS), Acetyl-CoA carboxylase (ACC1), and Fatty Acid Synthase (FAS) will improve biodiesel synthesis. In enzyme engineering, we can remove the allosteric inhibition control of Snf1 to Acetyl-CoA carboxylase ((ACC1), an enzyme that convert Acetyl Co-A to malonyl Co-A) by mutation of two phosphorylation site of ACC1 via site-directed mutagenesis which mutates serine1157,659 to alanine1157,629. This result in enhanced carbon flux to fatty acid synthesis and contribute to a higher yield of biodiesel.
Improvement on Waste Segregation Knowledge by Verbal and Visual Prompt in Indonesia International Institute for Life Sciences (i3L) Shirleen, Deborah; Kho, Katherine
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i01.171

Abstract

In the face of the detrimental effect from the abundant waste, humans were left with no choice but to cycle them. Waste sorting, an important step to maximize the recyclables resources, is essential to be performed. To reinforce the waste sorting behavior, this study observed the impact of verbal prompt intervention. The experiment was done at a higher education institution, Indonesia International Institute for Life Sciences (i3L), that integrates sustainability education into their curriculum. This study observed convenient sampling of one group, pre- and post- intervention. Volunteers stand by and notify wrong waste generators for one hour in the communal cafeteria for one month, after one week of baseline observation. The observation revealed a sufficient number of knowledge on waste sorting on the pre-intervention baseline (75%). The presence of the prolonged intervention increased the number of correct waste sorting to 89.68% in the fourth week of intervention. Nonetheless, a survey conducted to confirm the cause of change, disclosed that the community’s heightened proper waste behavior is independent of the direct reminder, but rather due to the presence of the notifying volunteer. Therefore the root of waste segregation behavior improvement was more than just from verbal reminder, but from the presence of the rangers that enforces the rules.
Drug-Resistant Pulmonary Tuberculosis Putri, Olivia; Salim, Megan Angelita; Gunawan, Aileen; Devin, Devin; Amaris, Ezrela; Alexander, David; Kevin, Gregorius; Febriana, Gabriella Gita
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i01.172

Abstract

Tuberculosis (TB) caused by the pathogenic bacteria Mycobacterium tuberculosis (MTb) still remains a highly prevalent disease, particularly in low and middle-income countries. Due to the bacteria’s atypical cell wall structure, ability to form granuloma, and capacity to switch between replicating and non-replicating states in the host lung parenchyma, the fundamental treatment of patients diagnosed with TB involves a 6-month long daily drug administration. With Indonesia ranking among the nations with the highest TB burden worldwide, there has been an alarming increase of drug-resistant MTb (DR-MTb) strains all over the country in recent years. However, there are currently limited studies available that highlight MTb resistance profiles across different regions within Indonesia. The major risk factors contributing to the emergence and spread of TB in Indonesia include health conditions, environmental conditions, and socioeconomic status. Furthermore, natural compounds and drug repurposing can be employed to combat the further spread of DR-MTb strains across the country, especially in rural regions.
Artificial Intelligence Based Brain Tumor Localization Using YOLOv5 Sadrawi, Muammar; Fugaha, Daniel Ryan; Heerlie, Devita Mayanda; Lorell, Juan; Gautama, Nicolaas Raditya Putra; Aminuddin, Mohamad Zafran
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i01.176

Abstract

Brain tumor is a mutation in the brain cells in which the cells keep dividing. The earlier the tumor detected, the higher survival rate for the patient. This study develops the brain tumor detection system by utilizing the you only look once (YOLO). The model is based on YOLOv5 architect. The open dataset of tumorous images is utilized. From this dataset, the corresponding masks are given alongside the images. Our study tries to compare several YOLOv5 models to localize the brain tumor. The results show YOLOv5m, YOLOv5l, and YOLOv5x models have higher precision and recall values. The inference time from those models is relatively small for recent computational resources. In conclusion, the YOLOv5 models have produced superior result in localizing the brain tumor
The Potential Use of Algae as Biosorbents for Mercury Removal in the Indonesian Water Bodies Josefano, Richelle Bertly; Belva, Felicia Lael; Yoel, Abigail; Rahardja, Richelle Tirta; Dharmawan, Nethania Angeline; Tjandra, Noah William; Bani, Mario Donald
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i02.164

Abstract

Contamination of mercury in the water body in Indonesia has become a big concern for many people due to the harmful effects of this heavy metal when it enters the body. Mercury contamination may cause neurological disorders that lead to loss of senses, and damage the brain, the central nervous system, the kidney, and can lead to birth defects. Human activities, such as Coal-Fired Power Plants (CFFPs) and Artisanal and Small-Scale Gold Mining (ASGM) as well as other mining activities, are among the biggest contributors of mercury emissions in Indonesia’s water body. Biosorbents such as fungi, bacteria and algae can be utilized to alleviate this problem, with algae being the most reliable biosorbent due to its abundance in Indonesia, low cost manufacturing, and high metal ion binding capacity. There are three varieties of algae that can be used as a mercury biosorbent: green algae (Chlorophyta), red algae (Rhodophyta), and brown algae (Phaeophyta). Different studies have shown that the most compatible mercury biosorbent is green algae due to its highest mercury absorption capacity. However, there are limited studies about the use of algae in Indonesia as mercury biosorbent.
Molecular Biomarkers and Pathophysiology Specific to Bipolar Disorder Salim, Megan Angelita; Abriana, Felicia Michelle; Tirta, Matthew Aurelius; Sanny, Sanny; Kristiani, Lidya
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i02.173

Abstract

Bipolar disorder (BD) is an episodic neuropsychiatric disorder with fluctuations between manic and depressive phases according to their types (BDI/BDII/cyclothymic), contributing to the decreased quality of life due to the impairment of cognitive abilities. Early detection is needed for proper treatment, however, the gold standard Structured Clinical Interview for DSM-IV results in misdiagnosis due to its inability to distinguish BD from other neuropsychiatric disorders. Therefore, diagnosis through molecular biomarkers can be performed to accurately distinguish BD from other neuropsychiatric disorders. This review aims to elaborate the evidence of molecular biomarkers in BD patients from recent studies, which may be fundamental in clinical practices for accurate diagnosis. Proteomic studies provide evidence for the differentially expressed proteins, namely brain-derived neurotrophic factors, which can differentiate BD from major depressive disorder and schizophrenia. Moreover, genetic alterations from genomic and transcriptomic studies found that CACNA1C, ANK3, FADS2, and other genes may predispose an individual to BD. Some of these genes are closely related to BD pathophysiology occurrence, including impaired oxidative phosphorylation, imbalance in calcium homeostasis, and neuroinflammation, all of which arise due to mitochondrial dysfunction. These pathophysiology can be alleviated by proper administration of mood stabilizers, antipsychotics, and anticonvulsants, but novel treatments targeting specific pathophysiology and biomarkers of BD are required for better treatment effectiveness. Keywords: Bipolar disorder; mania/depression; molecular biomarker; mitochondrial dysfunction; pharmacotherapies
Identification, Extraction, Phytochemical Screening and Study of Antimicrobial Activities of Native Papuan Tree Bark Extract: Dysoxylum Alliaceum and Aglaia sp. Hadrian, Edwin; Raharja, Gabriella Lysette; Anvolia, Kelly; Insani, Rayyane Mazaya Syifa
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i02.174

Abstract

Indonesia has one of the most diverse groups of ethnicities and high levels of biodiversity. Accordingly, this leads to a great wealth of ethnobotanical knowledge, where different ethnic groups develop their own methods for utilizing local plants. In Sorong, West Papua, locals often used tree barks for medication, two of which are known locally as Kayu Bawang (KB) and Kayu Teh (KT). KB and KT were morphologically identified in this study and their tree barks were extracted. Crude extracts of the tree barks were obtained via maceration using different solvents (hexane, chloroform, ethyl acetate, acetone, and methanol) with a ratio of 1:15 (w/v). Later, the extract was screened for phytochemicals (alkaloids, tannins, phlobatannins, saponins, terpenoids, flavonoids, and cardiac glycosides) followed by an assessment of antimicrobial properties. KB and KT were identified as Dysoxylum alliaceum and Aglaia sp. using the leaves, tree barks, and roots. The extraction yields of KT were highest in methanol (11.4%), while KB showed the highest yield in chloroform (1.83%). KT extracts were shown to contain all seven phytochemicals, while KB extracts lacked in tannins and flavonoids. Antimicrobial activity against E. coli and S. aureus was exhibited by 5% of KB ethyl acetate extract. These findings confirm the potential for KB and KT tree bark applications as functional food in the food industry.

Page 5 of 8 | Total Record : 71

 3   4   5   6   7 

Filter by Year

2019 2025


Reset
Filter By Issues
All Issue 2025: IJLS Vol 07 No.02 2024: IJLS Vol 06 No.02 2024: IJLS Vol 06 No.01 2023: IJLS Vol 05 No .02 2023: IJLS Vol 05 No .01 2022: IJLS Vol 04 No .02 2022: IJLS Vol 04 No .01 2021: IJLS Vol 03 No .02 2021: IJLS Vol 03 No .01 2020: IJLS Vol 02 No .02 2020: IJLS Vol 02 No .01 2019: IJLS Vol 01 No .02 2019: IJLS Vol 01 No .01 More Issue