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Slamet Supriadi
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Indonesian Journal of Life Sciences LPPM - Indonesia International Institute for Life Sciences (i3L) Jl. Pulomas Barat Kav. 88, Jakarta Timur, 13210 Indonesia
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INDONESIA
Indonesian Journal of Life Sciences
Published by Indonesia International Institute for Life Sciences
ISSN : -     EISSN : 26560682     DOI : http://doi.org/10.54250/ijls
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology
The Indonesian Journal of Life Sciences (IJLS) is a journal published by Indonesia International Institute for Life Sciences Press (i3L Press). IJLS is a scientific journal contains original research articles, review articles, and short communication covering all aspects in life sciences. This journal provides immediate open access to its content on the principle that making research freely available to the public to support a greater global exchange of knowledge. Readers can view abstracts and download full-text articles (PDF) free at any cost. All manuscripts submitted to the Indonesian Journal of Life Sciences will be screened for plagiarism and blind peer-reviewed to present valuable and authentic findings in life sciences. Authors with original, clearly analyzed, and logically interpreted research result in the scope of food innovation and nutrition, bio-products and services for sustainable society, information technology in life sciences, as well as health and well-being are very welcome to submit their articles. Every article issued to the editorial of the Indonesian Journal of Life Sciences is free of charge including the cost of repairing the article. IJLS is published bianually on March and September. Manuscripts are accepted on a continuous basis and the submisison is opened through the year.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 71 Documents
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Comprehensive utilisation of sorghum (Sorghum bicolor) in the food industry and its nutritional properties: A review Tan, Daphne; Alfonsus, Angelica Putri; Tinardi, Cicilia; Nathania, Angeline; Vienna, Shane; Astina, Junaida; Fugaha, Daniel Ryan
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i01.190

Abstract

Sorghum is one of the potential local carbohydrate sources in Indonesia. It is rich in nutrients. However, the utilisation of sorghum as staple food in Indonesia is lacking due to limited information on the cultivation, processing, and nutritional properties of sorghum. Hence, it is crucial to encourage the consumption and utilisation of sorghum to promote food diversification and sustainability. Sorghum has a distinct classification depending on its variety and each component has its own discrete functionality, with red sorghum being the most utilised varieties in Indonesia. Sorghum is high in fibre and protein (6.7 g/100 g and 1.6 g/100 g, respectively) and, therefore, contributes to the low glycemic index of sorghum. Several health benefits are possessed by sorghum, including anti-diabetic and antihypertensive properties. Moreover, the gluten-free nature of sorghum makes it suitable for people suffering from celiac disease. Utilisation of sorghum and its processing were also discussed comprehensively in this review, including utilisation of sorghum as the rice substitute, gluten-free flour, syrup, sweet soy sauce, and sorghum as plant-based milk. As such, the implementation of sorghum in Indonesia should be further optimised and promoted due to their beneficial properties as well as diverse utilisation.
CRISPR-Cas9 Mediated Gene Therapy: Current Advancements and Applications Towards Tay-Sachs and Sandhoff Disease Josefano, Richelle Bertly; Yoel, Abigail; Japri, Beatrice Miranda; Belva, Felicia Lael; Widjojo, Clara Ayu; Hermantara, Rio
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i2.195

Abstract

Tay-Sachs disease and Sandhoff disease are neurodegenerative diseases that are classified as autosomal recessive lysosomal storage disorders. They are commonly caused by a mutation that occurs in the HEXA and HEXB genes, which are responsible for encoding beta-hexosaminidase-A (Hex A) and beta-hexosaminidase-B (Hex B). Furthermore, Sandhoff's disease symptoms include spinocerebellar ataxia, motor degeneration, sensorimotor neuropathy, tremor, dystonia, and psychosis, which are comparable to Tay-Sachs disease symptoms. The current treatment of Tay-sachs include enzyme replacement therapy, bone marrow transplantation, and administration of genetically modified stem cells with HexA which do not impede neurological dysfunction and were not effective in the long run. On the other hand, there is no standard treatment for Sandhoff but it utilizes bone marrow transplantation which is ineffective. So far, there is only one available gene editing treatment. Therefore, it might be necessary to consider gene editing as a prospective treatment for both diseases, with CRISPR being a primary method. By utilizing Adeno-associated viruses (AAV) as the delivery method for the CRISPR-Cas9 system, it can replace the defective HEXA or HEXB gene with a modified gene termed HEXM, which was found to be the gene codes for the Hex subunit of the same enzyme that is missing in Tay-Sachs and Sandhoff disease. Several challenges of implementing CRISPR-Cas9 technology to treat Tay-Sachs and Sandhoff disease include off-target mutations, unintentional cleavage of the non-targeted sites, and bioethical challenges. Further studies can be explored using various CRISPR-Cas9 systems to improve its efficiency.
The Ability of Aquatic Carnivorous Plants Utricularia vulgaris L. as Heavy Metal Bioremediators Su'udi, Mukhamad; Sururin, Fahma Wardah; Ardiyanti, Kurnia Dwi
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i2.196

Abstract

Utricularia vulgaris is one of the aquatic carnivorous plants that is able to grow in low-nutrient environmental conditions. This unique plant is also a macrophytic plant whose entire body except for the flowers is submerged in water. Utricularia vulgaris also has no roots so it grows to float in water. The plant was found growing in an environment polluted by heavy metals. Several studies have shown that U. vulgaris is able to absorb several types of heavy metals effectively, such as Cu, Mn, Zn, and Fe. These heavy metals are needed in small amounts by organisms, but in high amounts they can inhibit the growth of aquatic organisms. Utricularia vulgaris, a carnivorous plant, has shown the potential to absorb heavy metals, making it a subject of interest for phytoremediation.
CRISPR-Cas9: A Story of Discovery, Innovation, and Revolution in Genome Editing Hermantara, Rio
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i01.197

Abstract

CRISPR-Cas9 is a powerful and flexible genome editing technology that has transformed the field of life sciences. It enables the creation and modification of genomic sequences of various organisms, with wide-ranging implications for biotechnology, agriculture, and medical research. The origin of CRISPR as an adaptive immune system in bacteria, the elucidation of CRISPR-Cas9 biological and molecular mechanisms, and the subsequent engineering and optimization of it as a programmable genome editing tool are remarkable achievements in science. In this review, we will summarize this fascinating history and also explore the recent innovations of the CRISPR-Cas9 system, which extend the genomic tool box to improve the accuracy and efficiency of genome editing.
Assessing The Role of Psyllium Husk for Sensory Impact on Taste, Aroma and Texture of Rice Krispy Cereal Bar Snack Angrainy, Hanny; Chandra, Thalia; Tjahjono, Novita; Kurniawan, Maycella Sheren
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i01.204

Abstract

The cereal bars market has experienced significant growth due to the rise of the "snackification" trend,where snacks replace meals. Time constraints during meal occasions have led consumers to seek satisfyingsnacks like cereal bars, offering tailored nutrition solutions. Ingredients are not only affecting the nutritionalvalue of cereal bars, but also contributing to their sensory attributes, such as taste, aroma, and texture. Oneof the important ingredients in cereal bars is xanthan gum, which serves as a binding agent. Psyllium husk isa potential substitute for xanthan gum, enhancing cereal bar texture and acting as dietary fiber to enhancefeelings of fullness and facilitate healthy digestion. The objective of this study was to formulate cereal barswith functional properties, utilizing psyllium husk as an essential ingredient and understand its impact onsensorial properties on taste, aroma, and texture, comparing it to xanthan gum. Four types of samples wereexamined using 9-scale hedonic tests among 50 panelists to evaluate the degree of acceptance on thesensory attributes of cereal bars. Results of this study showed that formulations with psyllium husksurpassed those with xanthan gum in terms of aroma and taste, followed by hardness and chewiness,making them preferred choices for cereal bars.
Downstream Critical Process Parameters for COVID-19 mRNA LNP Vaccine Production Aliyansah, Pradip Iramdhan; Kalyubi, Adelia Talita Oriana Athoulloh; Widiyanto, Azura Luna; E, Ervin; Loavenia, Michelle; Putri, Stevanie; Yuan, Tissa; Hartrianti, Pietradewi
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i01.205

Abstract

The COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has led to global efforts to mitigate its effects, with mRNA vaccines playing a crucial role. These vaccines use the virus's genetic sequence to prompt an immune response without introducing the live pathogen, showcasing substantial efficacy in protective immunity. The production of mRNA vaccines involves complex stages, including critical downstream processes of purification and formulation, vital for ensuring the vaccine's purity, potency, and safety. The structural components of mRNA vaccines, such as the Open Reading Frame (ORF), untranslated regions (UTRs), cap structure, and poly(A) tail, along with the delivery system using lipid nanoparticles (LNPs), are essential for their functionality and efficacy. Optimization of these elements is crucial for enhancing vaccine performance. Conventional, self-amplifying, and trans-amplifying mRNA vaccines represent the different strategies employed to target COVID-19 effectively. Each type utilizes structural and delivery innovations to stimulate a robust immune response. The review underscores the significance of precise control in the manufacturing process, highlighting its role in global health security and the advancement of vaccine technology. By understanding and optimizing critical process parameters (CPPs) in the downstream manufacturing process, the pharmaceutical industry can achieve the highest standards in vaccine production, significantly contributing to the fight against the pandemic and future vaccine development, ensuring a swift, effective response to global health crises. This review paper focuses on the downstream stages of mRNA vaccine production, comparing studies on CPP to emphasize the importance of stringent control measures for vaccine quality, safety, and efficiency.
Chub mackerel as potential lipid-based functional food Sode Muda, Eleonora Valentia; Rahma, Adinda Aulia; Jonathan, Brian; Chandra, Jefferson Nathanael; Liony, Jessica Michelle; Kuntadi, Muhammad Fajar; Astina, Junaida
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i02.207

Abstract

Functional foods have gained a lot of attention as people become more aware of the importance of human nutrition. Chub mackerel is classified as one of the functional foods due to being rich in omega-3 fatty acids, which include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that are associated with various health benefits, including anti-inflammatory properties, cardiovascular health support, and cognitive function enhancement. Additionally, chub mackerel also contains high protein, vitamin, and mineral content that contribute to muscle growth, immune system support, and cognitive function improvement. Research has indicated the safety and efficacy of consuming omega-3 from chub mackerel, particularly among vulnerable populations like pregnant women and children. Various processing techniques have been applied to chub mackerel to enhance its quality as a functional food, including roasting and frying. However, non-thermal processing may better preserve the nutritional compositions, mitigating nutrient losses during processing. The future outlook for chub mackerel as a functional food includes further research into alternative cooking methods to preserve omega-3 content and the implementation of regulatory measures and industry collaborations to promote its utilization as a functional food, particularly in regions like Indonesia where it is abundant and affordable. Overall, chub mackerel shows promise as a lipid-based functional food with significant potential for improving public health and addressing the rising prevalence of non-communicable diseases.
The Effect of Alpha-Amylase Types and Time of Enzyme Activation Towards the Sensory and Physicochemical Properties of Oat Milk Pek, Maria Priska Angelina; Dewi, Desak Putu Ariska Pradnya
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i02.231

Abstract

Plant-based or non-dairy milk substitutes are becoming favored in the growing field of functional beverages driven by factors such as health benefits, allergies, lactose intolerance, and the rise in vegan diets. However, there are challenges to producing oat milk, such as achieving the desirable texture and taste. This study is aimed to have 4 treatments utilizing 2 different kinds of amylase (Amylase 1 and Amylase 2) along with 2 different times of enzymatic activation (20 minutes and 30 minutes) to modify physicochemical properties and sensory qualities. This process includes the utilization of 2 amylase enzyme brands, guar gum, canola oil, and oat flour which improves the overall quality of this alternative to dairy milk. Oat milk making involves combining water, oat flour, and oil. The mixture was then processed until smooth before filtration and amylase was added for an enzymatic reaction. The mixture was then pasteurized, and finally, guar gum solution was stirred in before serving. This research investigates the physicochemical characteristics and sensory qualities of enzymatic oat milk, encompassing pH, brix, stability, viscosity, 5-point hedonic test, and rank test. Moreover, it was found that there are significant differences in all of the attributes including pH, brix, viscosity, and stability with the p-value of less than 0.001. It was also found that the time of enzymatic activation had no impact towards the physicochemical and sensorial properties of oat milk. Lastly, sensorial properties of the oat milk prepared with amylase enzymes scored higher in all attributes compared to the negative control. Keywords: Oat milk, amylase, activation time, sensory, physicochemical
Comparative Dissolution Profiles of Branded versus Generic Clopidogrel Bisulfate: Assessing In Vitro Bioequivalence Raisinghani, Prettish Kishore; Kristyawan, Fitri; Sholeh, Aries Badrus; Aliyansah, Pradip Iramdhan
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i02.233

Abstract

Clopidogrel, an antiplatelet agent widely prescribed for thromboembolic disorders, holds a substantial market presence in Indonesia, with a valuation of IDR 4.52 trillion. While plavix (branded form) remains as one of the leading treatments for such conditions, its high cost makes it unaffordable for a significant portion of Indonesia’s population. This underscores the necessity for generic alternatives that mimic the properties of the branded product to ensure broader accessibility and affordability for patients. To achieve this, generic clopidogrel bisulfate tablets must undergo the same crucial biopharmaceutical stages such as disintegration, drug release, aqueous dissolution, and systemic absorption to achieve therapeutic efficacy similar to the branded version. Despite being the most expensive tablet, the branded form serves as a standard reference to evaluate the dissolution profile, quality, and efficacy of locally manufactured generic formulations. This study investigates the dissolution profile and physical properties of generic clopidogrel bisulfate tablets produced by PT Phapros TBK, compared to a branded clopidogrel bisulfate product licensed by Sanofi in France. Quality attributes including weight and size uniformity, hardness, and disintegration time were assessed as per the Indonesian Pharmacopoeia (5th edition) standards. Dissolution tests were conducted at pH levels of 1.2, 4.5, and 6.8, with 12 sample replications at each interval, to determine bioequivalence between the two formulations. Through this research, the aim is to illuminate the bioequivalence of generic and branded clopidogrel products in Indonesia, offering insights into their interchangeability and potential clinical impact in a high-demand market.
The Role of Marula Oil in Alleviating Photoaging: Insights into its Bioactive Components Raisinghani, Prettish Kishore; Lestari, Novita Dwi; Suyanto, Kimberly Alexandra; Utama, Andrea Dhieta
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i02.237

Abstract

Photoaging, caused by prolonged UV exposure, accelerates skin aging through oxidative stress, collagen degradation, and inflammation. With growing consumer demand for natural and sustainable anti-aging solutions, marula oil has gained attention for its potential in mitigating photoaging. Derived from Sclerocarya birrea, marula oil is rich in fatty acids (oleic and palmitic acids) and antioxidants like vitamin C and E. This review investigates marula oil’s bioactive components and their mechanisms of action in alleviating photoaging, focusing on its moisturizing, antioxidant, and photoprotective properties. Moreover, clinical studies examine its ability to improve skin hydration, enhance barrier function, and inhibit enzymes associated with collagen degradation. Despite its promise as a cosmeceutical, long-term studies are necessary to explore its sustained efficacy, molecular pathways, and potential synergy with other natural ingredients.

Page 7 of 8 | Total Record : 71

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