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Indonesian Journal of Life Sciences LPPM - Indonesia International Institute for Life Sciences (i3L) Jl. Pulomas Barat Kav. 88, Jakarta Timur, 13210 Indonesia
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INDONESIA
Indonesian Journal of Life Sciences
Published by Indonesia International Institute for Life Sciences
ISSN : -     EISSN : 26560682     DOI : http://doi.org/10.54250/ijls
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology
The Indonesian Journal of Life Sciences (IJLS) is a journal published by Indonesia International Institute for Life Sciences Press (i3L Press). IJLS is a scientific journal contains original research articles, review articles, and short communication covering all aspects in life sciences. This journal provides immediate open access to its content on the principle that making research freely available to the public to support a greater global exchange of knowledge. Readers can view abstracts and download full-text articles (PDF) free at any cost. All manuscripts submitted to the Indonesian Journal of Life Sciences will be screened for plagiarism and blind peer-reviewed to present valuable and authentic findings in life sciences. Authors with original, clearly analyzed, and logically interpreted research result in the scope of food innovation and nutrition, bio-products and services for sustainable society, information technology in life sciences, as well as health and well-being are very welcome to submit their articles. Every article issued to the editorial of the Indonesian Journal of Life Sciences is free of charge including the cost of repairing the article. IJLS is published bianually on March and September. Manuscripts are accepted on a continuous basis and the submisison is opened through the year.
Arjuna Subject : Imunologi dan Mikrobiologi (semua kategori) - Mikrobiologi dan Bioteknologi Terapan
Articles 76 Documents
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Food Innovation: Fungi and Vegetables Potential as A Healthy and Sustainable Meat Substitute Muliani, Debby; Nathania, Evelyn Adela; J, Jeslin; Jayanti, Yasmin Nadira; Hadrian, Edwin
Indonesian Journal of Life Sciences 2021: IJLS Vol 03 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (460.218 KB) | DOI: 10.54250/ijls.v3i2.127

Abstract

One of the factor-driven global environmental concerns and health issues is excessive meat production and consumption. The popularity of meat substitutes for the benefit of sustainability and well-being has been increasing. This review highlights the health benefits, sustainability, and sensorial properties of plant-based materials as meat substitutes. Each of the materials has its advantages and disadvantages. Mushrooms, mycoprotein, soy, TVP, and seitan have a high potential to become a healthier and more sustainable meat alternative. However, there are some challenges, such as mushrooms' wide variety, mycoprotein production cost, beany and grainy nodes of soy-based products, increased seitan production that negatively impacts the environment, and low protein content of jackfruit. Nuts, cauliflower, potato, and eggplant require significant sensory improvement to mimic meat characteristics despite their environmental advantages. Moreover, their protein content and quality are low. On the other hand, Cottonseed proteins contain toxic gossypol, and research on their sustainability and nutritional value is limited. For legumes and lentils, their processing reduces some nutritional components and their taste and texture from meat. Overall, these fungi and vegetables possess great potential as meat substitutes due to their high nutritive value, workable sensorial properties, and good sustainability compared to conventional meat despite having their challenges to become potential plant-based meat products.
Neem Gum (Azadirachta Indica) Solution Potential for Improving Viability of Bifidobacterium Longum and Lactobacillus acidohilus Bacteria Hamzah, Zahreni; Sulistyani, Erna; Hafizh, Cinantya; Handayani, Ari T.W.
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (528.537 KB) | DOI: 10.54250/ijls.v4i1.128

Abstract

Neem gum is a liquid that comes out of the stems of neem plants (Azadirachta indica) that have hardened and become crystals. Soluble polysaccharides compounds contained in this gum are composed of several types of monosaccharides such as arabinose, fucose, galactose, glucuronic acid, glucose, mannose, and xylose. The content of neem gum has prebiotic potential so it can be used as a source of nutrients for lactic acid bacteria. Bifidobacterium longum and Lactobacillus acidophilus are lactic acid bacteria classified as beneficial bacteria in the gastrointestinal tract. The content of soluble polysaccharides in neem gum can be selectively digested by these bacteria. This study aims to determine the potential of neem gum solution (Azadirachta indica) to the viability value of B. longum and L. acidophilus bacteria. The viability of B. longum and L. acidophilus bacteria was calculated using the MTT assay method. The results showed the viability value of both bacteria exposed to neem gum solution at concentrations of 5% (b/v), 10% (b/v), and 20% (b/v) increased compared to negative controls that were not given exposure to neem gum solution. Based on the results of the study, it concluded that neem gum is effective in increasing the growth of bacteria B. longum and L. acidophilus
Comparison of Weight Reduction and Water Loss for Convective and Osmo-convective Dehydrated Breadfruit (Artocarpus altilis (Parkinson) Fosberg) Mas, Muhammad Abdurrahman; Larasati, Laurensia Citra
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.975 KB) | DOI: 10.54250/ijls.v4i1.130

Abstract

Breadfruit (Artocarpus altilis (Parkinson) Fosberg), a tropical fruit commonly found in Indonesia, contains a well balanced nutritional content. However, breadfruit has a rapid respiration rate which causes the fruit to be underutilized, leading to breadfruit becoming food waste. Convective dehydration is an effective method in slowing down the respiration rate, however, heat exposure can reduce the nutritional content of the breadfruit. The combination of osmotic pre-treatment and convective dehydration act as an alternative to achieve a similar outcome with a shorter amount of thermal exposure. This study aims to perform a study in determining the effectiveness of an osmotic treatment with 50° Brix sugar solution compared to convective dehydration on breadfruit. The results indicate that as expected, the weight reduction (WR) of the osmo-convective samples is lower where the WR is 80.680% for convective dehydrated samples and 57.190% osmo-convective dehydrated samples. The water loss (WL) is statistically similar where WL of osmo-convective dehydrated samples was 18.315% compared to WL of the convective dehydrated samples 19.836%. The higher WR in the osmo-convective treatments show that there is sugar uptake into the fruit, while the similar water loss indicates the same reduction in moisture content between treatments. These results show the potential benefit of applying osmo-convective treatments to breadfruit. However, the research is still in the early stages of development. There are additional parts of the research and parameters that need to be optimized and explored in the future.
Inulin-producing Genes in Gembili (Dioscorea esculenta) and Future Applications for Food Industries in Indonesia Pramanda, Ihsan Tria; Anjani, Dellamartha; Heriawan, Gili
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (965.162 KB) | DOI: 10.54250/ijls.v4i1.133

Abstract

Inulin can be found in abundance in nature, this form of carbohydrate (fructans) is utilized by plants as an energy storage and possibly for other uses. Human use inulin as a dietary fiber and prebiotics to improve the health of their digestive system or to improve the physicochemical and sensory properties of foods. Gembili (Dioscorea esculenta) is a type of yam that grows well in Indonesia and contains inulin up to 14.77% of its dry weight. The current state of inulin production utilizes conventional extraction from tubers; thus, the demands of the market cannot be satisfied, and the price skyrocketed. Biotechnological approaches such as incorporating genes that encodes the enzymes involved in inulin biosynthesis into bacteria or yeasts can be exploited to improve the yield and sustainability. The biosynthesis of inulin involves three main genes 1-SST, 6-SFT and 1-FFT. Genetic information of the gene responsible for the biosynthesis of inulin in Gembili needs to be elucidated.
Effect of Subtitution of Texturized Vegetable Protein Using Tempeh Towards Nutrional and Textural Quality Of Plant-Based Nuggets Indriani, Widya; Crespo, Ivan; Dewi, Desak Putu Ariska Pradnya; Insani, Rayyane Mazaya Syifa
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.86 KB) | DOI: 10.54250/ijls.v4i1.134

Abstract

The development of Plant-based Meat Alternatives (PBMAs) has been focused on mimicking the textural, taste, appearance, aroma, and nutritional properties of real meat products. Texturized Vegetable Protein (TVP) has been widely used in food applications to construct plant-based meat products. However, the high energy cost to produce TVP leaves the price of TVP quite expensive. Therefore, this experiment aims to see the effect of tempeh as an alternative to TVP on the nutritional and textural properties of plant-based nuggets (PBNs). In total, five PBN treatments were analyzed and compared to chicken nuggets for their nutritional and textural properties. The treatments were 1) C1: control (hung + ground TVP), 2) Hung TVP and tempeh (HT), 3) Ground TVP and tempeh (GT), 4) Tempeh only (TT), and 5) Hung TVP, ground TVP, and tempeh (HGT). From the results, all plant-based nugget treatments had significantly higher (p<0.05) protein and moisture content and lower fat content than commercial chicken nuggets. Whereas for textural properties, except C1 and HGT, all other PBN treatments had poorer hardness than commercial chicken nuggets. Overall, the addition or substitution of tempeh on hung and ground TVP treated PBN did not affect the protein, fat, and moisture content of PBNs, but significantly produced better nutritional properties than chicken nugget. In terms of textural properties, combination of Hung TVP, ground TVP, and tempeh provide the desirable textural properties as it can be comparable to chicken nuggets.
A Review on Bioethanol Production through the Valorization of Food Waste in Indonesia Trisna, Tifara Elaine; Jai, Jyotsna; Shirleen, Deborah; Matthew, Ryan; K, Katherine
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v4i2.139

Abstract

Biofuels are one of the numerous alternatives that are currently being considered to replace fossil fuels as it is more environmentally friendly. Specifically, bioethanol is often thought as a better alternative to gasoline fuel as it is considered cleaner, more renewable, and greener as it is synthesized from renewable feedstock which contributes to the reduction of greenhouse gas emissions to the environment. As bioethanol is produced from carbohydrate and starch rich food crops, food waste (FW) poses a potential source for bioethanol production as it is especially rich in carbohydrates and lipids. Bioethanol production itself consists of several steps which includes food waste selection, pretreatment, saccharification and fermentation, and recovery. Cafeteria FW was reviewed to be the best type of FW for bioethanol production as it has the highest carbohydrate and starch content. Subsequently, acid pretreatment was considered to be the best method due to low cost, high yielding, and time efficient method. Moreover, the non-isothermal simultaneous saccharification and fermentation (NSSF) produces 1.42 g ethanol/L.h with a time of 38 hours. Lastly, the enzyme-assisted extraction technique is most preferred to recover the bioactive compounds as it led to the highest yield of product (94%) compared to other methods.
The Influence of Macronutrient Intake towards Intestinal Mucus Production Rimba, Phoebe Anadita; Lumbantobing, Erika; Carol, Lioni; Rahardja, Ritchie
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v4i2.141

Abstract

Intestinal mucus layer plays a crucial role in protecting the epithelium layer and acts as a barrier to separate the epithelium layer from pathogenic microorganisms. The mucus is synthesized by the goblet cells located in the epithelium layer. The production of mucus inside the goblet cells is regulated by the expression of mucin gene family, such as MUC2 for the mucus production in jejunum, ileum, and colon. Recent studies had suggested the influence of macronutrient intake, such as carbohydrate and fat, in mucus production. High fiber diet and resistant starch consumption were found to positively affect mucus production through upregulating mucin gene expression. Meanwhile, high saturated fat diet was found to negatively affect mucus production by promoting ER stress and downregulating epithelial differentiation transcription factor (KLF4). Nonetheless, a low saturated fat diet was found to upregulate mucin expression. Unsaturated fat diet (oleic acid, linoleic acid, EPA, and DHA), on the other hand, decreased mucin expression by disrupting epithelial differentiation transcription factors (HATH1 and TLR4). Studies on the effect of dietary intake on mucus production are still limited, especially in the underlying molecular pathway. Therefore, further research on the molecular pathway on the effect of dietary intake on mucus production needs to be performed.
A Review on Pharmacological Activity of Monarda fistulosa L. Wahyudi, Berthalia Marshella; Chung, Cecilia Ashley; Chelovna, Celine; Soetanto, Fenny; Anggasta, Giovanni; Zafira, Qastalia; Maulida, Nurul Fajry; Crystalia, Audrey Amira
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v4i2.142

Abstract

Monarda fistulosa is a plant often used in traditional medication with numerous benefits. This review paper aims to elaborate on the phytochemicals of Monarda fistulosa that contribute to its pharmacological activity. Numerous studies have found the bioactive compounds of Monarda fistulosa including carvacrol, thymol, thymoquinone, flavonoid, ????-pinene, caryophyllene oxide, limonene, and geraniol. Researchers have found several pharmacological activities in relation to these compounds including antimicrobial, antidiabetic, anticancer, anti-inflammatory, antioxidants, and immunomodulatory properties. Evidence shows that Monarda fistulosa has potential for applications in many areas. Nevertheless, further clinical studies still have to be conducted to assess the effects of this plant.
The aspartate metabolism pathway Jonathan, Michael; Sulistyo, Bobby Prabowo
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v4i2.143

Abstract

Recent research has been conducted to find potential new avenues of drug discovery for treating tuberculosis infection. This endless “arms race” is due to the ability of the bacteria to develop resistance towards the already established antibiotic regimen. Various pathways within Mycobacterium tuberculosis are being studied extensively to open new possibilities in drug development. One of which is the aspartate metabolism pathway. This amino acid pathway is proven to be pivotal for the survival of M. tuberculosis both in vitro and in vivo. Furthermore, this pathway also is absent in humans, making it a very promising candidate for further research and development in drug discovery. However, inhibitors against this pathway are not yet available as most suggested inhibitors against the various enzymes within this pathway only made it until the in-silico stage while few studies managed to synthesize their suggested inhibitors and had tested its anti-tuberculosis activity. This review will discuss said attempts in suggesting inhibitors against the critical enzymes that work within this pathway. The inhibitors that are reviewed in this paper are both synthetic and derived from natural products. The multitude of inhibitors proposed and the various enzymes that they are able to inhibit proved that this pathway has potential that is yet to be explored further.
In silico investigation of bioactive compounds from Ginkgo biloba as alternatives to non-steroidal anti-inflammatory drugs Jai, Jyotsna; Yosiano, Stephanie Angela; Trisna, Tifara Elaine; Rosaceae, Agnes Maria; Kurniawan, Laurentius Hardy; Nurdiansyah, Rizky
Indonesian Journal of Life Sciences 2022: IJLS Vol 04 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v4i2.147

Abstract

Non-steroidal Anti-inflammatory Drugs (NSAIDs) are common over-the-counter drugs that are used for numerous inflammation-associated ailments. Despite their widespread consumption, these synthetic drugs are not without side effects. Adversities caused by NSAIDs range from simple nausea and vomiting to fatal conditions such as hypertension, gastrointestinal bleeding and diminished renal function. There is thus a need to develop novel alternatives to these drugs which possess comparable efficacies. Phytocompounds are attractive alternatives for a plethora of medicines used for various disorders and diseases as they are readily available in nature and have negligible side effects. In an attempt to identify safe alternatives to NSAIDs, we tested six bioactive compounds from Ginkgo biloba (Ginkgolide A, Amentoflavone, Bilobetin, Ginkgetin, Quercetin, and Bilobalide) for their abilities to inhibit Cyclooxygenase-1, Cyclooxygenase-2 and 5-Lipoxygenase which are inflammation-causing enzymes. Molecular docking experiments using Autodock Vina resulted in binding energy values between -6.6 and -11.9 kcal/mol, comparable to that of control drugs, which indicated that the tested phytocompounds were able to bind strongly to the active sites of the three proteins. Analyses of receptor-ligand interactions using Discovery Studio Visualizer revealed that all the tested compounds formed numerous non-covalent interactions with the surrounding amino acid residues, which confirmed their binding stabilities. Finally, evaluation of their drug likeness based on Lipinski’s rule of five showed that the tested G. biloba compounds possess the potential to be taken as oral drugs to replace conventional NSAIDs.

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