cover
Contact Name
Slamet Supriadi
Contact Email
slamet.supriadi@i3l.ac.id
Phone
+622129567888
Journal Mail Official
ijls@i3l.ac.id
Editorial Address
Indonesian Journal of Life Sciences LPPM - Indonesia International Institute for Life Sciences (i3L) Jl. Pulomas Barat Kav. 88, Jakarta Timur, 13210 Indonesia
Location
Kota adm. jakarta timur,
Dki jakarta
INDONESIA
Indonesian Journal of Life Sciences
ISSN : -     EISSN : 26560682     DOI : http://doi.org/10.54250/ijls
The Indonesian Journal of Life Sciences (IJLS) is a journal published by Indonesia International Institute for Life Sciences Press (i3L Press). IJLS is a scientific journal contains original research articles, review articles, and short communication covering all aspects in life sciences. This journal provides immediate open access to its content on the principle that making research freely available to the public to support a greater global exchange of knowledge. Readers can view abstracts and download full-text articles (PDF) free at any cost. All manuscripts submitted to the Indonesian Journal of Life Sciences will be screened for plagiarism and blind peer-reviewed to present valuable and authentic findings in life sciences. Authors with original, clearly analyzed, and logically interpreted research result in the scope of food innovation and nutrition, bio-products and services for sustainable society, information technology in life sciences, as well as health and well-being are very welcome to submit their articles. Every article issued to the editorial of the Indonesian Journal of Life Sciences is free of charge including the cost of repairing the article. IJLS is published bianually on March and September. Manuscripts are accepted on a continuous basis and the submisison is opened through the year.
Articles 71 Documents
Development of Long QT Syndrome Detection Using SciPy Himawan, Moses; Sadrawi, Muammar
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i02.178

Abstract

Long QT syndrome (LQTS) is a type of arrhythmia that manifests itself as the elongation of the QT interval. LQTS is caused due to different disorders in the sodium and potassium channels which results in reduced activity of the cardiac muscle. To diagnose LQTS, an algorithm is used to detect the elongated QT interval through detection of the peaks using Python. The current build of the algorithm is able to detect different ECG graphs for their QT interval with relative accuracy however is not capable of detecting the different components if the graph has too much noise or if they have irregular wavelengths due to other cardiovascular disease (CVD).
Effects of SARS CoV-2 mRNA Vaccines on Graves' Disease Febriana, Gabriella Gita
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i02.180

Abstract

The development of SARS CoV-2 mRNA vaccines has been claimed as a breakthrough in the medical research field. Moreover, these vaccines have been proven to reduce SARS CoV-2 transmission. However, the administration of these vaccines also found to interfere with thyroid functions in some individuals, which include newly onset Graves’ disease in immunocompromised people and worsening condition in Graves’ disease patients. This article reviews cases on Graves’ disease following the administration of first and second dose of SARS CoV-2 mRNA vaccines between the year 2021 and 2022. Furthermore, the possible mechanisms of Graves’ disease development following mRNA vaccines administration are being discussed in this review article.
Comparative Study of K-Mean, K-Medoid and Hierarchical Clustering using Data of Tuberculosis Indicators in Indonesia Pradana Ratnasari, Nanda Rizqia
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i02.181

Abstract

Cluster analysis is an important topic and analysis in which the ultimate goal is to classify data into several groups based on similar basic. The most applied cluster methods or algorithms are k-means, k-medoids and hierarchical clustering methods. Therefore, this study aimed to compare methods in cluster analysis employing healthcare data on attributes related to TB. The best method will be assigned based on the level of accuracy for each algorithm and the number of clusters. There were four main steps in the clustering analysis used in this study, which were feature selection, clustering algorithm, cluster validation and interpretation. The clustering algorithm used are k-means, k-medoids and hierarchical clustering, with cluster sizes of 2, 3 and 4. The result showed that k-medoids have a higher accuracy than other clustering algorithms or methods. This study explained that compared to k-means and hierarchical clustering, k-medoid had the highest accuracy for both training and testing data. K-medoid was better than the other two algorithms as it was more robust to noise and outliers which were found in the datasets. This outcome was consistent with the training and testing datasets. In terms of the number of clusters, the two-cluster model was better than the three-cluster or the four-cluster model as this model could classify the groups vividly. The results were consistent in k-mean, k-medoid and hierarchical clustering methods, with the smallest sum of squares value of 24.7% for the k-mean. The smallest diameters and the average dissimilarities of k-medoid models were found in group 1. This result explained that group 1, in all algorithms, was more compact and more similar than other groups.
Process Modeling and Techno-Economic Analysis of Xylitol Production from Oil Palm Empty Fruit Bunch (OPEFB) using SuperPro Designer® Salam, Wildan Qoharisma; Pramanda, Ihsan Tria; Harjanto, Fariz Hutama Putra; Rukmana, Jaka
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i02.183

Abstract

The utilization of OPEFB as a biomass waste from the crude palm oil industry offers a potential avenue for producing xylitol through biotechnological processes. The production of xylitol involves a series of steps, including hydrolysis, fermentation, and purification. Xylitol, a sugar alcohol used as a food sweetener, is obtained in crystalline form. However, the fermentation process generates impurities that need to be separated to achieve a high purity level of xylitol. To address this, a combined approach of membrane distillation and cooling batch crystallization was employed in this study. The feasibility of establishing a xylitol production plant was assessed through simulation and techno-economic analysis using SuperPro Designer software version 12. The plant was designed to produce 3.00 MT/batch of xylitol as the primary product, requiring 20 MT/batch of OPEFB. Each batch operation lasted for seven days, with a batch cycle occurring every three days. The simulation was evaluated based on the annual operating cost (AOC). The project incurred a total investment of $2.00 MM, with an annual operating cost of $3.78 MM, and generated yearly revenues of $6.84 MM. The economic analysis revealed that the plant was economically viable, with a payback period of 11 months, a gross margin of 44.71%, and an internal rate of return (IRR) of 62.26%.
Assessing the Influence of Butter-Substitution with Margarine in Sorbitol and Sucrose Cereal Bar Base: Taste, Texture, and Aroma Evaluation by Consumer Preference Angrainy, Hanny; Chandra, Thalia; Anjali, Cailin; Utama, Nicholas Kevin
Indonesian Journal of Life Sciences 2023: IJLS Vol 05 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v5i02.188

Abstract

A B S T R A C T Taste, texture, and aroma are fundamental sensory properties in influencing consumer liking of cereal bars. The majority of consumers ranked ‘taste’ as the most important characteristic influencing their purchase intent, followed by textural and aroma features which define the product quality and acceptability. Butter is a major component in cereal bars, and plays an important role in its sensorial properties, however butter is expensive and not vegan friendly. Margarine is often used to substitute butter due to the cost and increasing trend of plant-based. This research aimed to study the effect of butter substitution with margarine in sorbitol and sucrose cereal bar towards consumer preference on taste, texture, and aroma. Four types of samples: sucrose-butter, sucrose-margarine, sorbitol-butter, and sorbitol-margarine were examined using triangle and 9-scale hedonic tests among 50 panelists. Results of this study showed that the substitution of butter with margarine in sucrose cereal bars were found to have a significant difference on various attributes, including firmness, chewiness, taste, and aroma. Furthermore, for the ranking test, the most preferred samples were butter-sorbitol and margarine-sucrose cereal bar base with similar proportion, which is 38% of participants. While the least favorite sample was butter-sucrose with 64% of panelists choosing the samples. This indicates that different combination ingredients can provide high consumer product acceptance for a cereal bar and can be used to develop a butter substitute cereal bar product desirable for the consumer market.
Benefits of Chia Seeds as a Functional Food for Cardiovascular Diseases Prevention: A Review Kim, Jung Yeu; Ningtyas, Alexandra Amanda; W, Reynaldi Budiman; Clarabelin, Clarabelin; Setiawan, Willy; Wu, Aurelia Faustine; Arya, Anganjani Samaraswasdee; Astina, Junaida
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i2.179

Abstract

In order to increase the overall health while keeping the lifestyle, the interest of consuming lipid-based food or lipid-modifying foods are growing. Chia seed is an annual herbaceous plant that is rich in lipids (30–33%), carbohydrates (2–41%), dietary fiber (18–30%), and protein (15–25%). Chia seeds also contain high amounts of bioactive compounds, such as omega-3 fatty acids, antioxidants, and polyphenols to prevent some chronic diseases. Its rate of consumption has grown over the years due to its health benefits for chronic conditions such as obesity, cardiovascular disease, diabetes, and cancer. Some studies have been done to prove the benefits of consuming chia seeds. The aim of this paper is to review the morphology, composition, and benefits of chia seeds towards the prevention of cardiovascular diseases.
Analyzing the Effects of Kefir on the Gut Microbiota Strains in Alzheimer’s Patients Ellivia, Vanessa; Hariyanto, Belinda; Kwan, Erika Marceline; Angelyna, Angelyna; Tjahjadi, Celestine Jovanka; Wiguna, Andrea Benita; Wen, Chelsy Angelline; Astina, Junaida
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i2.182

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that progresses over time and slowly deprives patients of their memory, cognitive abilities, and eventually, capability to carry out even the simplest activities, and even affects the gut microbiota. Studies suggest changes in gut microbial diversity and abnormalities in the gut-brain axis are associated with AD. Probiotics, known for their numerous health benefits, are well recognized as one of the most effective prophylactic strategies against cognitive deterioration in AD. In order to grow, the gut microbiota needs nutrients including Lactobacilli and Bifidobacteria which are frequently linked to the therapeutic potential of kefir. It is proven to modulate the immune system and maintain gut health by modifying the gut microbiota, lowering the prevalence of inflammation as well as oxidative stress, which slows down the progression of AD. Thus, this review summarizes the possible benefits of probiotics, specifically, kefir, on the gut microbiota strains in Alzheimer’s patients. A literature search was conducted on scientific platforms using Google Scholar and PubMed. Given the inclusion criteria and the limitation on the publication year, 53 scientific articles were selected for further analysis. Keyword searches were limited to the following. (1) Alzheimer’s disease and/or (2) gut microbiota and/or (3) probiotics and/or (4) kefir. The findings of this study clarify the association between probiotics and AD in altering the gut microbiota by improving the proliferation of Lactobacillus and Bifidobacterium and subsequently slowing the progression of AD. Keywords: Alzheimer’s disease (AD); gut microbiota; probiotics; nutrients; bioactive compounds; kefir
The Effects and Treatments for Usher Syndrome: A Review Heerlie, Devita Mayanda; Margaretha, Febrina; Fugaha, Daniel Ryan; Parikesit, Arli Aditya
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i01.184

Abstract

Usher syndrome is defined as the rare genetic disorder that affects both vision and auditory. Although the prevalence is really low, only about 4 to 17 per 100,000 people, it is noted to cover at least 50% of deaf-blindness cases. After reviewing the molecular genetics from several papers, there are several causative genes found with the most prevalent being MYO7A, and USH2A that cause USH type 1 and 2 respectively. Furthermore, other literature has found promising treatments that may help to slow down or prevent further degeneration of the syndrome.
Physicochemical Properties of Bread with the Addition of Green Peas (Pisum sativum) Alfonsus, Angelica Putri; Kwa, Audrey Laurelia; Hartono, Hudson; Widjaja, Kristophe Graciante; Josephine, Sheren Tania; Ariska, Desak Putu
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i01.185

Abstract

The objective of this study is to investigate the physicochemical characteristics of bread with the addition of green peas (Pisum sativum). In this study, three different treatments were done including 0% (control), 12.5% and 25% of green peas puree were added to the bread dough mixture and afterwards baked to analyze its physicochemical properties. Texture-wise, the addition of green peas did not show any significant effect (p>0.05) on the springiness of the bread yet it was otherwise for hardness, cohesiveness and chewiness. Moreover, the color of bread in different treatments have their own distinguishable details. Green peas had allowed the bread to become darker in color but the different amount of green peas puree added did not cause a change in the hues of the color. Furthermore, the moisture content of the bread added with the highest amount of green peas was shown to have the highest moisture content and the difference between the moisture content of each treatment was rendered to be significant (p≤0.05). Green peas seem to have caused a decrease in loaf volume and height due to the high amount of fiber contained in it. Nevertheless, the addition of green peas did not give any significant effect on the baking loss, loaf width and loaf length of the bread (p>0.05).
The Antioxidant Activity of Ambon Banana Peel (Musa paradisiaca AAA) against Breast Cancer: A Review Irwantoho, Graciella Virginia; Immanuel, Joya Angelica; Claire, Ashella Loral Lydia; Sugarda, Aqeela Syakira; Refflyn, Valeska; Lee, Ju Won; Astina, Junaida
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i2.189

Abstract

Breast cancer is one of the most prevalent types of cancer in women around the globe, especially those coming from a low-income population like Indonesia. As a preventive measure, consuming balanced diets containing high antioxidant sources are therefore recommended to reduce the risk of breast cancer. Banana peels, for instance, are an undervalued source of antioxidants which also possess high economic and nutritional values. This review aims to provide systematic information about the bioactive composition of ambon banana peels (Musa paradisiaca L. var. sapientum), their antioxidant mechanism on breast cancer, as well as their potential incorporation into food products such as flour, cookies, and chips. The review was conducted by examining literature from the past 10 years (2013-2023) that fit the inclusion criteria. Based on the collected studies, ambon banana peel contains high amounts of bioactive compounds, primarily polyphenols, flavonoids, carotenoids, tannins, saponins, and ferulic acid. Even after the peels are converted into processed food products, the antioxidant activity remains high with proper thermal processing conditions. These antioxidant properties of ambon banana peels provide a promising potential in the treatment of breast cancer through various modes of action, however, clinical studies involving humans are still lacking to further emphasize its therapeutic effects.