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Fathiyyatul Khaira
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fathiyyatul.khaira@gmail.com
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+6285161910033
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jikesi.editorial@gmail.com
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Fakultas Kedokteran Universitas Andalas. Jln. Limau Manis, Pauh – Padang – Sumatera Barat. 25163.
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INDONESIA
Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Published by Universitas Andalas
ISSN : -     EISSN : 27224848     DOI : https://doi.org/10.25077/jikesi.v1i3
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Ilmu Kesehatan Indonesia is a peer-reviewed and open-access journal that focuses on promoting health sciences to integrate research in all aspects of human health. This journal publishes original articles, reviews, and case reports. Subjects suitable for publication include but are not limited to the following fields: Anesthesiology Cardiovascular Cell and molecular biology Child health Dermato-venereology Histopathology Internal medicine Neuro-psychiatric medicine Nutrition Obstetrics and Gynecology Ophthalmology Otorhinolaryngology Pharmacology Pulmonology Radiology Surgery
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 342 Documents
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Pengaruh Mesenchymal Stem Cell (MSC) pada Penyakit Jantung Bawaan dengan Hipertensi Pulmonal Benny Afriansyah; Kino
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1866

Abstract

Background: Congenital heart disease (CHD) with pulmonary hypertension is a progressive condition characterized by vascular remodeling and pulmonary endothelial dysfunction, which leads to increased pulmonary vascular resistance and right ventricular failure. Mesenchymal stem cells (MSCs) represent a potential therapeutic approach for regenerating pulmonary endothelial and vascular cells in patients with pulmonary hypertension. MSCs have the capacity to differentiate into various cell types and secrete paracrine factors that promote tissue Repair. Objective: This study aims to critically review the available scientific evidence on the impact of Mesenchymal Stem Cell (MSC) therapy on pulmonary hypertension associated with congenital heart disease, focusing on therapeutic efficacy, underlying mechanisms of action, and safety profile as a potential clinical intervention. Methods: A narrative review of the literature published between 2007 and 2025 was performed. Relevant studies were identified through systematic searches of PubMed, Scopus, ScienceDirect, and Google Scholar using the following keywords: “congenital heart disease,” “pulmonary hypertension,” and “Mesenchymal Stem Cell.” Results: Studies have demonstrated that MSC therapy can improve right ventricular hemodynamics through adaptive anti-inflammatory and regenerative mechanisms. However, further research is necessary to establish the long-term safety, optimal dosage, and molecular mechanisms underlying the widespread application of MSC therapy, particularly in patients with CHD and pulmonary hypertension. Conclusion: Mesenchymal Stem Cells (MSCs) demonstrate promising therapeutic potential in pulmonary hypertension associated with congenital heart disease through mechanisms including homing capacity, anti-inflammatory effects, and vascular–cardiac regeneration. Therefore, MSCs may emerge as an effective adjuvant or alternative therapeutic option in the future, although further clinical validation is still required.
Suplementasi Asam Lemak Omega-3 dan Vitamin D pada Anak dengan Sistemik Lupus Eritematosus Fika Linatunnafisah; Trismiyanti; Diana Sunardi
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1869

Abstract

Systemic lupus erythematosus is an autoimmune disease characterized by systemic inflammation involving multiple organs. Omega-3 fatty acid and vitamin D have an immunomodulatory effect and considered to decrease the inflammation. However, the effectivity of omega-3 fatty acid and vitamin D supplementation in pediatric SLE is still inconclusive. A 9-year-6-month-underweight girl with neuropsychiatric, hematology, mucocutaneous, and joint involvement SLE is hospitalized for 15 days. Medical nutrition therapy encompasses the provision of energy tailored to the patient’s requirement according to the RDA, macronutrient administration involving a balanced composition of protein, fat and carbohydrates, as well as the delivery of specific nutrients and micronutrients as recommended. Protein was administered at 10% - 17% of total energy, fat is provided at 30% of total energy, micronutrient supplementation included vitamin A, B, and C according to the RDI. The patient was also provided with daily supplementation of 1000 mg of omega-3 fatty acid and 2000 IU of vitamin D3. During the hospitalization, the patient got improvement of the nutritional intake and reduction of VAS score, without any sign of toxicity. Omega-3 fatty acid and vitamin D supplementation is associated to the improvement of clinical condition in pediatric SLE. Keyword: SLE, omega-3, vitamin D

Page 35 of 35 | Total Record : 342

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