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INDONESIA
Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Published by Universitas Andalas
ISSN : -     EISSN : 27224848     DOI : https://doi.org/10.25077/jikesi.v1i3
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Ilmu Kesehatan Indonesia is a peer-reviewed and open-access journal that focuses on promoting health sciences to integrate research in all aspects of human health. This journal publishes original articles, reviews, and case reports. Subjects suitable for publication include but are not limited to the following fields: Anesthesiology Cardiovascular Cell and molecular biology Child health Dermato-venereology Histopathology Internal medicine Neuro-psychiatric medicine Nutrition Obstetrics and Gynecology Ophthalmology Otorhinolaryngology Pharmacology Pulmonology Radiology Surgery
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 352 Documents
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Pengaruh Mesenchymal Stem Cell (MSC) pada Penyakit Jantung Bawaan dengan Hipertensi Pulmonal Benny Afriansyah; Kino
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1866

Abstract

Background: Congenital heart disease (CHD) with pulmonary hypertension is a progressive condition characterized by vascular remodeling and pulmonary endothelial dysfunction, which leads to increased pulmonary vascular resistance and right ventricular failure. Mesenchymal stem cells (MSCs) represent a potential therapeutic approach for regenerating pulmonary endothelial and vascular cells in patients with pulmonary hypertension. MSCs have the capacity to differentiate into various cell types and secrete paracrine factors that promote tissue Repair. Objective: This study aims to critically review the available scientific evidence on the impact of Mesenchymal Stem Cell (MSC) therapy on pulmonary hypertension associated with congenital heart disease, focusing on therapeutic efficacy, underlying mechanisms of action, and safety profile as a potential clinical intervention. Methods: A narrative review of the literature published between 2007 and 2025 was performed. Relevant studies were identified through systematic searches of PubMed, Scopus, ScienceDirect, and Google Scholar using the following keywords: “congenital heart disease,” “pulmonary hypertension,” and “Mesenchymal Stem Cell.” Results: Studies have demonstrated that MSC therapy can improve right ventricular hemodynamics through adaptive anti-inflammatory and regenerative mechanisms. However, further research is necessary to establish the long-term safety, optimal dosage, and molecular mechanisms underlying the widespread application of MSC therapy, particularly in patients with CHD and pulmonary hypertension. Conclusion: Mesenchymal Stem Cells (MSCs) demonstrate promising therapeutic potential in pulmonary hypertension associated with congenital heart disease through mechanisms including homing capacity, anti-inflammatory effects, and vascular–cardiac regeneration. Therefore, MSCs may emerge as an effective adjuvant or alternative therapeutic option in the future, although further clinical validation is still required.
Suplementasi Asam Lemak Omega-3 dan Vitamin D pada Anak dengan Sistemik Lupus Eritematosus Fika Linatunnafisah; Trismiyanti; Diana Sunardi
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1869

Abstract

Systemic lupus erythematosus is an autoimmune disease characterized by systemic inflammation involving multiple organs. Omega-3 fatty acid and vitamin D have an immunomodulatory effect and considered to decrease the inflammation. However, the effectivity of omega-3 fatty acid and vitamin D supplementation in pediatric SLE is still inconclusive. A 9-year-6-month-underweight girl with neuropsychiatric, hematology, mucocutaneous, and joint involvement SLE is hospitalized for 15 days. Medical nutrition therapy encompasses the provision of energy tailored to the patient’s requirement according to the RDA, macronutrient administration involving a balanced composition of protein, fat and carbohydrates, as well as the delivery of specific nutrients and micronutrients as recommended. Protein was administered at 10% - 17% of total energy, fat is provided at 30% of total energy, micronutrient supplementation included vitamin A, B, and C according to the RDI. The patient was also provided with daily supplementation of 1000 mg of omega-3 fatty acid and 2000 IU of vitamin D3. During the hospitalization, the patient got improvement of the nutritional intake and reduction of VAS score, without any sign of toxicity. Omega-3 fatty acid and vitamin D supplementation is associated to the improvement of clinical condition in pediatric SLE. Keyword: SLE, omega-3, vitamin D
Gambaran Infeksi yang Disebabkan Oleh Bakteri Penghasil Extended Spectrum Beta Lactamase di RSUP. DR. M. Djamil Padang Tahun 2022-2023 Larasati; Roslaili Rasyid; Yustini Alioes
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 3 (2026): September 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i3.1429

Abstract

Latar Belakang: Meningkatnya kejadian resistensi antimikroba terutama dari bakteri penghasil ESBL masih menjadi masalah global yang signifikan karena menyebabkan kegagalan terapi yang mengarah pada meningkatnya mortalitas dan morbiditas.Objektif. Penelitian bertujuan untuk mengetahui gambaran distribusi frekuensi dan pola sensitivitas bakteri penghasil ESBL di RSUP. Dr. M. Djamil Padang tahun 2022-2023Metode: Penelitian ini merupakan penelitian deskriptif dengan pendekatan retrospektif melalui pengambilan data sekunder hasil uji sensitivitas bakteri penghasil ESBL terhadap beberapa antimikroba dengan menggunakan alat VITEK-2 yang diidentifikasi dari spesimen pasien di Laboratorium Mikrobiologi RSUP Dr. M. Djamil Padang. Teknik pengambilan sampel adalah total samplingHasil: Penelitian ini menemukan 1.997 bakteri penghasil enzim ESBL dengan jumlah terbanyak adalah Klebsiella pneumoniae (52.83%) diikuti Escherichia coli (46.97%). Spesimen dengan kasus infeksi akibat bakteri penghasil ESBL paling banyak ditemukan pada sputum dengan 955 isolat, urin 470 isolat, dan pus 273 isolat. Kasus infeksi akibat bakteri penghasil ESBL terbanyak ditemukan pada ruang rawatan penyakit dalam sebesar 47.82%. Setiap spesies memiliki gambaran sensitivitas yang berbeda terhadap beberapa antibiotik. Klebsiella pneumoniae masih sensitif terhadap antibiotik meropenem, amikasin, ertapenem, dan sefoxitin. Escherichia coli masih sensitif terhadap antibiotik amikasin, meropenem, sefaperason-sulbaktam, ertapenem, nitrofurantonin, dan tigesiklin.Kesimpulan: Infeksi yang disebabkan oleh bakteri penghasil ESBL perlu menjadi perhatian karena frekuensinya terus meningkat, penelitian secara berkala perlu dilakukan untuk mengetahui pola sensitivitas bakteri ESBL dalam rangka mengurangi kejadian resistensi.
Perbedaan Carrier MRSA pada Rongga Hidung Perawat Berdasarkan Lama Bertugas di HCU Interne RSUP DR. M. Djamil Padang Fadila Khairunnisa
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 3 (2026): September 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i3.1469

Abstract

Abstrak Latar Belakang: Methicillin-resistant Staphylococcus aureus (MRSA) resisten terhadap antibiotik golongan betalaktam sehingga dapat meningkatkan angka morbiditas dan mortalitas di rumah sakit. Lama bertugas di ruang perawatan intensif seperti High Care Unit (HCU) menjadi salah satu faktor risiko terjadinya kolonisasi MRSA pada perawat. Perawat yang memiliki kolonisasi MRSA meskipun tidak bergejala (carrier) tetap berisiko tinggi untuk terinfeksi MRSA dan juga berisiko menyebabkan kolonisasi dan infeksi MRSA pada pasien dan tenaga medis yang lain. Objektif: Penelitian ini bertujuan untuk mengetahui perbedaan carrier MRSA pada rongga hidung perawat berdasarkan lama bertugas di HCU Interne RSUP Dr. M. Djamil Padang tahun 2024. Metode: Jenis penelitian adalah analitik observasional dengan desain cross sectional dengan total 20 sampel nasal swab perawat yang bertugas di HCU Interne melalui teknik total sampling. Setelah itu dilakukan pemeriksaan Gram, uji katalase, dan uji alat Vitek-2 kemudian dianalisis menggunakan uji Fisher exact. Hasil: Hasil penelitian didapatkan prevalensi kolonisasi MRSA sebesar (20%) dengan distribusi kolonisasi MRSA tertinggi pada kelompok lama bertugas (≤3 tahun) sebesar (21,4%) dibandingkan dengan lama bertugas (>3 tahun) sebesar (16,7%). Namun secara statistik menunjukkan tidak terdapat perbedaan signifikan antara kolonisasi bakteri MRSA berdasarkan lama bertugas di ruang HCU Interne (p = 1,0). Kesimpulan: Sebagian besar kolonisasi MRSA ditemukan pada perawat dengan lama bertugas di HCU Interne (≤3 tahun) meskipun secara statistik tidak terdapat perbedaan secara signifikan. Peningkatkan upaya pengendalian infeksi diperlukan untuk memutus penyebaran MRSA di rumah sakit. Kata kunci: MRSA, perawat, lama bertugas, HCU Interne, Vitek-2 Abstract Background: Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to beta-lactam antibiotics, which can increase morbidity and mortality rates in hospital. Length of service in intensive care units such as the High Care Unit (HCU) is one of the risk factors for MRSA colonization in nurses. Nurses who have MRSA colonization even though they are asymptomatic (carriers) remain at high risk of MRSA infection and are also at risk of causing MRSA colonization and infection in patients and other health workers. Objective: This study aims to determine the description of MRSA colonization in the nasal cavity of nurses based on length of service in the HCU Interne. Methods: This study is an observational analytical study with a cross-sectional design with a total of 20 nasal swab samples of nurses working at the HCU Interne through a total sampling technique. After that, Gram examination, catalase test, and Vitek-2 tool test were carried out and then analyzed using the Fisher exact test. Results: The results of the study showed that the prevalence of MRSA colonization was (20%) with the highest distribution of MRSA colonization in the group with long service (≤3 years) amounting to (21.4%) compared to those with long service (>3 years) amounting to (16.7%). However, statistically it shows that there is no significant difference between MRSA bacterial colonization based on length of service in the Internal HCU room (p = 1.0). Conclusion: Most of the MRSA colonization was found in nurses who had served in the HCU Interne for a long time (≤3 years) although there was no statistically significant difference. Increased infection control efforts are needed to stop the spread of MRSA in hospitals. Keyword: MRSA, Nurses, Length of Service, HCU Interne, Vitek-2
Pengaruh Infeksi Blastocystis sp. Terhadap Kadar Interleukin-10 Pada Tikus Jantan Galur Wistar Samora Nainggolan
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 3 (2026): September 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i3.1559

Abstract

Background: Blastocystis sp. is one of the most commonly found protozoa in the human intestine and has an almost even global distribution worldwide. The pathogenic status of Blastocystis sp. remains widely debated in previous studies. Blastocystis sp. can be found in both symptomatic and asymptomatic patients. Interleukin-10 is a crucial cytokine in suppressing inflammatory responses. A deficiency of IL-10 and its receptor (IL-10R) has been associated with ulcerative colitis, Crohn's disease, and celiac disease. Objective: This study aimed to determine whether there was a relationship between Blastocystis sp. infection and interleukin-10 levels. Methods: This study was conducted as an experimental research using a post-test only control group design, with male Wistar rats (Rattus norvegicus) as test subjects. The study was carried out at the animal house and the Biomedical Laboratory of the Faculty of Medicine, Andalas University. Blastocystis sp. infection in rats was assessed through microscopic fecal examination and culture. This study utilized 18 rat serum samples, divided into control and treatment groups. Interleukin-10 levels were measured using the ELISA method. Data analysis was performed using a One-Way ANOVA test. Results: The mean IL-10 levels in both treatment groups increased compared to the control group, although the increase was not statistically significant. Conclusion: The conclusion of this study is that the administration of Blastocystis sp. in male Wistar rats did not significantly affect interleukin-10 levels. Keyword: Blastocystis sp, Interleukin-10 Levels, Rattus novergicus
Profil Kasus Keracunan Di RSUP Dr. M. Djamil Padang Tahun 2019 - 2023 Abubakar Rahmatullah
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 3 (2026): September 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i3.1560

Abstract

Poisoning is a serious medical condition that can be caused by various harmful substances and often not well detected, especially in sudden death. This study aim to determine the profile of poisoning cases at RSUP Dr. M. Djamil Padang during 2019 to 2023. This is a descriptive cross-sectional study with a retrospective approach. It used secondary data from medical records of poisoning patients from 2019 to 2023, with total sampling technique. During this period, 55 patients met the inclusion criteria. Based on the research findings, most cases occurred in the adult age group (74.5%), with the majority being male (63.6%). Agricultural or plantation chemicals were the most common type of poison (56.4%), with most cases involving oral ingestion (76.4%). The majority of cases were caused by accidental exposure (67.3%). Nausea and vomiting were the most frequently reported clinical symptoms (25.4%). Most poisoning cases resulted in patient recovery (70.9%), and the majority were not referred to forensic examination (76.4%). The case profile of poisoning at RSUP Dr. M. Djamil Padang showed the need for caution in the use of toxins in agriculture or plantations, especially pesticides, considering that Indonesia was an agrarian country. Furthermore, an evaluation of the Standard Operating Procedure (SOP) in handling poisoning cases at RSUP Dr. M. Djamil Padang was required.
the CLINICOPATHOLOGICAL FEATURES OF LUNG CARCINOMA PATIENTS AT DR. M. DJAMIL HOSPITAL PADANG FROM 2023-2024: GAMBARAN KLINIKOPATOLOGIS PASIEN KARSINOMA PARU DI RUMAH SAKIT DR. M. DJAMIL PADANG TAHUN 2023-2024 Rahman Wila Azani Azani
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 3 (2026): September 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i3.1626

Abstract

Lung carcinoma is the leading cause of cancer-related deaths in both Indonesia and globally. The incidence of lung carcinoma continues to increase over time. Globally, cancer cases are projected to double by 2050, with lung carcinoma being the most significant contributor. According to the latest GLOBOCAN data from 2022, new lung carcinoma cases reached 2,480,675 worldwide. This study aimed to analyze the clinicopathological profile of lung carcinoma patients at Dr. M. Djamil General Hospital Padang during the period of 2023–2024. This research is a descriptive study using secondary data from medical records with a retrospective approach. The study used a total sampling method, resulting in a total of 287 samples. The findings are presented in the form of frequency distribution tables. The study results showed that 94.4% of patients were over 40 years old, with the majority being male (81.2%) and most of them being smokers (51.9%). The most common pulmonary comorbidity among patients was tuberculosis (15%), and 95.8% of patients presented with mixed symptoms, with 99% experiencing cough. The most frequently found cell type was adenocarcinoma (48.4%), and 84.3% of patients were diagnosed at stage IV. The results of this study showed that most lung carcinoma patients were over 40 years old, male, and either current or former smokers, with tuberculosis being the most common pulmonary comorbidity. Additionally, nearly all patients presented with mixed symptoms, with adenocarcinoma being the most common cell type. Most patients were diagnosed at stage IV, and adenocarcinoma was also the most prevalent histological type across different age groups, sexes, smoking statuses, pulmonary disease histories, clinical symptoms, and cancer stages. Keywords: lung carcinoma, clinicopathology, cell type, characteristics
Efektivitas Kursi Ergonomi Terhadap Keluhan Muskuloskeletal Disorder Pada Pekerja Batik Tulis Rachmawati Prihantina Fauzi; Pambayun Khairul Rijal Muzakki; Rizqy Kartika Sari
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 3 (2026): September 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i3.1724

Abstract

Background: Musculoskeletal disorders (MSD) are a common complaint among informal sector workers, including those in the batik industry, due to static and unergonomic working positions. This study aims to determine the effectiveness of the POSE (Posture Optimized for Sustainable Efficiency) ergonomic chair in reducing MSD complaints among batik workers at the UMKM Dewi Ratih Sragen. Method: This study was a quasi-experimental study with a pretest-posttest control group design. The sample consisted of 44 batik workers, divided into two groups (control and experimental). The experimental group was given the POSE chair intervention for five workdays. The measurement instrument used was the Nordic Body Map (NBM). Result: Data analysis was performed using Paired T-Test and Independent T-Test. The results showed that the experimental group experienced a significant decrease in MSDs scores from 86.50 to 55.05 (p<0.001), while the control group experienced an increase from 86.73 to 87.36 (p=0.175). Cohen's d value of 4.616 indicates a large intervention effect. Conclusion: This study concluded that the POSE chair is effective as an ergonomic intervention to reduce MSD complaints.
Hubungan Status Gizi dengan Respon Klinis Radioterapi pada Pasien Kanker Serviks Stadium Lanjut di Rumah Sakit Universitas Andalas Puteri Khairah Tanisa
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 3 (2026): September 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i3.1752

Abstract

Cervical cancer is the fourth most common cancer globally. Every year there is an increase in new cases and death rates due to cervical cancer, which occurs mainly in developing countries. Radiotherapy is the primary treatment modality for cervical cancer, especially in advanced stages. Cancer patients are susceptible to malnutrition and cachexia, which can affect the clinical response to radiotherapy. This study aims to examine the relationship between nutritional status and the clinical response to radiotherapy in patients with advanced cervical cancer.
Profil Pasien Trombus Intrakardiak di RSUP Dr. M. Djamil Padang Periode 2023–2024: Sebuah Studi Deskriptif Retrospektif Daelita Berliana H -
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 3 (2026): September 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i3.1779

Abstract

Abstract Background: Intracardiac thrombus is a blood clot formed within the heart chambers and can increase the risk of systemic embolism, morbidity, and mortality. Data regarding the profile of intracardiac thrombus patients in Indonesia remain limited. Objective: This study aimed to describe the profile of intracardiac thrombus patients at Dr. M. Djamil Central General Hospital Padang during 2023–2024. Methods: This was a retrospective descriptive study using medical records and echocardiography results of patients diagnosed with intracardiac thrombus. Samples were obtained using a total sampling technique. The variables analyzed included demographic characteristics, precipitating factors, comorbidities, cardiovascular risk factors, thrombus location, complications, and management. Results: A total of 96 patients with intracardiac thrombus were identified, increasing from 41 cases in 2023 to 55 cases in 2024. The mean age was 56.2 ± 12.1 years, with a predominance of males (82.3%). The most common precipitating factors were chronic heart failure (89.6%), valvular heart disease (86.5%), and coronary heart disease (68.8%). The most frequent comorbidity was renal impairment (10.4%). A history of smoking was found in 72.9% of patients, while obesity was present in 27.1%. The most common thrombus location was the left ventricle (79%), followed by the left atrium (17%). Embolic complications occurred in 4.2% of patients. Anticoagulant therapy was the main treatment (93.8%). Conclusion: Intracardiac thrombus is most frequently found in middle-aged to elderly male patients, with chronic heart failure, valvular disease, and coronary heart disease as the main precipitating factors. The left ventricle was the most common site, with embolic complications being rare, and anticoagulants serving as the primary therapy. Keyword: retrospective descriptive, echocardiography, heart failure

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