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Paulus Sugianto
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Departemen Neurologi, Fakultas Kedokteran, Universitas Airlangga-RSUD Dr. Soetomo Surabaya, Jln. Mayjen Prof.Dr. Moestopo No 6-8, Airlangga, Gubeng, Surbaya
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AKSONA
Published by Universitas Airlangga
ISSN : -     EISSN : 28077970     DOI : https://doi.org/10.20473/aksona.v2i1.170
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience
AKSONA is a scientific journal published by the Department of Neurology, Faculty of Medicine, Universitas Airlangga; Dr. Soetomo General Academic Hospital. AKSONA focuses on original research, case reports, and review articles on all aspects of neuroscience: Neurosurgery, Neuropsychology, Movement Disorder, Sleep Disorder, Pain and pain intervention, Neuro infection, etc. This journal is a peer-reviewed journal established to improve understanding of all things in neurology and neurosciences.
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 92 Documents
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Trends in Brain Cancer-Associated Mortality Among South African Men and Women Moodley, Yoshan; Mashele, Samson
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.72696

Abstract

Highlight: Mortality from brain cancer is generally much higher in South Africa when compared with other countries. Brain cancer mortality has declined among South African men and increased among South African women.   ABSTRACT Introduction: South Africa has seen a general increase in cancer burden. Mortality from brain cancer has yet to be studied, which is significant given the poor prognosis associated with this condition. Objective: The objective of this study was to report on the trends in mortality for brain cancer among South African men and women. Methods: This was a descriptive trends analysis of South African national mortality data for the period 2007-2016. The mortality dataset contains information on all reported deaths in South Africa, including deaths associated with brain cancer, and is based on the International Classification of Diseases Coding,10th Revision (ICD-10). A descriptive analysis was conducted to calculate the annual age-specific and age-standardized rates of brain cancer-associated mortality, which were then plotted separately for each gender. Results: There were 4,110 brain cancer-associated deaths included in this study. Mortality fluctuated across the study period but was mostly higher in the older age groups. Age-standardized mortality rates in men ranged from 4.26-4.63 per 100,000 population and declined at the end of the study period. Age-standardized mortality rates in women ranged from 2.34-2.62 per 100,000 population and increased at the end of the study period. Conclusion: The elderly and men had the highest rates of brain cancer-associated mortality, although a declining trend was noted in the latter. Brain cancer-associated mortality is increasing among women. There is an urgent need for improved brain cancer control in South Africa.
Determinants of Executive Dysfunction: Serum NRF2 and Sociodemographic Profiles in Lombok Island’s Coastal Population Wulandari, Inayah; Nurhidayati, Nurhidayati; Hunaifi, Ilsa; Rivarti, Arina Windri; Harahap, Herpan Syafii; Saputri, Legis Octaviana; Suryani, Dini; Zubaidi, Fitriannisa Faradina; Rosyidi, Rohadi Muhammad
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.74449

Abstract

Highlight: Coastal communities show high prevalence of cognitive decline. There is no correlation between NRF2 levels and executive function. Gender and education level were significantly associated with executive dysfunction.   ABSTRACT Introduction: Elderly people frequently suffer from neurodegenerative conditions that affect cognitive function. Redox homeostasis dysregulation plays a significant role in neurodegenerative diseases. Oxidative stress activates the transcription factor called nuclear factor erythroid 2-related factor 2 (NRF2), which is essential for regulating the expression of genes involved in cellular defense mechanisms. Objective: This study aimed to determine the relationship between serum NRF2 levels and executive function, as well as to identify other variables that may influence executive function among residents of coastal villages on Lombok Island. Methods: The study used a cross-sectional design with consecutive sampling. Data on sociodemographic characteristics, hypertension, diabetes mellitus, smoking status, and physical activity were collected. Statistical analyses employed Spearman's rank correlation test, Fisher's exact test, and logistic regression test. Results: A total of 39 participants were included, with an average age of 53.38 years. Most participants were female, had a low educational level, did not have hypertension or diabetes mellitus, had high physical activity levels, and were non-smokers. The average NRF2 level was 0.54 ng/mL. The correlation test showed no significant relationship between serum NRF2 levels and executive function. Fisher's exact test showed a significant relationship between gender and education with executive function. Furthermore, logistic regression analysis identified education level as a predictor of executive dysfunction. Conclusion: Serum NRF2 levels were not correlated with executive dysfunction. Educational level was identified as a predictive factor for executive dysfunction.

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