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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Kedokteran MNJ (Malang Neurology Journal) JOSSAE (Journal of Sport Science and Education) Jurnal Abdi Insani Acta Neurologica Indonesia Jurnal Kesehatan Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rivarti, Arina Windri
Departemen Fisiologi, Fakultas Kedokteran Universitas Mataram, Mataram, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Public Health Other

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EXERCISE PREVENTS AGE-RELATED MEMORY DECLINE: THE ROLE OF NEUROTROPHIC FACTORS Rivarti, Arina Windri; Herawati, Lilik; Hidayati, Hanik Badriyah
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Increasing aging population causes an increased prevalence of neurodegenerative diseases such as dementia that is associated with memory decline. Developing strategies for the prevention and therapy of age-related dementia is important to reduce the burden of treatment costs. Physical exercise is known to prevent cognitive decline and improve cognitive abilities. Physical exercise with moderate intensity for at least 150 minutes/week or 30 minutes/day for 5 days can reduce the incidence of degenerative diseases in the elderly. Thus, physical exercise appears as a simple, inexpensive, and affordable non-pharmacological therapy for most people. The processes of neurogenesis and neuronal survival involve the role of neurotrophic factors including BDNF, IGF-1 and VEGF, which are the three main neurotrophic factors that are known to increase after exercise. Many publications discuss about these neurotrophic factors, but their mechanism of signals and changes related to aging and exercise have not been completely studied. The purpose of this review is to discuss the mechanism of signals and changes of neurotrophic factors (focuses on BDNF, IGF-1, and VEGF) related to aging and exercise.
Latihan Fisik Meningkatkan Kadar Insulin-Like Growth Factor-1 (IGF-1) Wibawa, Junian Cahyanto; Mus, Rosdiana; Gama, Noviyanty Indjar; Rivarti, Arina Windri
Journal of Sport Science and Education Vol 6, No 1 (2021)
Publisher : Fakultas Ilmu Olahraga, Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jossae.v6n1.p46-56

Abstract

This article aims to determine the effect of physical activity in increasing insulin-like growth factor 1 (IGF-1 levels. The method used is a systematic literature review with public databases, direct science, national and international journals with vulnerabilities in 2015-2020. The results showed that physical activity could increase IGF-1 levels. IGF-1 levels are closely related to muscle building, muscle mass, and muscle strength. IGF 1 levels that occur during physical activity can reduce sarcopenia, muscle weakness, and obesity. Given theimportant role physical activity plays in increasing IGF-1 levels, this article looks at how physical activity affects the increase in IGF-1 levels. It can be concluded that physical activity can increase IGF-1 levels as one of the factors associated with increased muscle mass.
POTENSI OMEGA-3 BULU BABI (SEA URCHIN) DALAM KONTROL PROGRESIVITAS DEMENSIA ALZHEIMER Arina Windri Rivarti
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.838

Abstract

With the increasing prevalence of Alzheimer's dementia and the lack of effectiveness of existing drugs in inhibiting the progression of the disease, the investigation of new drug candidates will continue. Omega-3 fatty acids, especially docosahexaenoic acid (DHA), are compounds that can be used as drug candidates for this purpose. Recent scientific evidence, both from epidemiological studies and preclinical trials in experimental animals, shows the potential of these compounds in maintaining cognitive function and inhibiting the progression of Alzheimer's dementia through various mechanisms, including anti-inflammatory, anti-amyloidogenic, and brain neuroplasticity. These compounds are contained in various marine organisms, including sea urchins. Given the wide availability of marine life on the coast and its ability to biosynthesis of omega-3 fatty acids, this marine biota can be considered as the main source of omega-3 in the development of omega-3 as a drug for the protection of cognitive function in Alzheimer's disease dementia.
SKRINING DEMENSIA DAN EDUKASI POTENSI SUMBER DAYA LAUT UNTUK MENCEGAH PENYAKIT NEURODEGENERATIF PADA MASYARAKAT PESISIR DI KABUPATEN LOMBOK UTARA (KLU) Arina Windri Rivarti; Fitriannisa Faradina Zubaedi; Herpan Syafii Harahap; Nurhidayati Nurhidayati; Legis Ocktaviana Saputri
Jurnal Abdi Insani Vol 9 No 4 (2022): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v9i4.827

Abstract

Improving the quality of health services has resulted in a high elderly population. The elderly are more susceptible to various degenerative diseases, including dementia. The high prevalence of dementia is a major health issue that has an impact on global socioeconomic problems. Indonesia is one of the world's largest archipelagic countries. As an archipelago-based region, West Nusa Tenggara (NTB) has numerous marine resources that could be utilized as potential dementia therapies. This program aims to conduct health screenings for dementia and educate about the potential of marine resources for dementia treatment. This program consists of two phases. The first phase consists of a health screening to assess the risk of dementia. This phase includes measuring blood pressure, measuring blood sugar, and evaluating cognitive performance. The second phase consists of health education regarding the potential of marine resources. Based on dementia screening revealed that 96% of participants need additional evaluation. About 47.3% of the patients were diagnosed with hypertension, 61.1% required further confirmation for diabetes mellitus, and 5.6% were diagnosed with diabetes mellitus. Health education explains the importance of marine resources in preventing degenerative diseases, the nutritional value of marine resources, and the proper treatment of marine resources as food and medication. The community's enthusiasm for health education is high. The high interest of the people was evidenced by a large number of attendees and queries asked. The community participates actively, and the programs run as intended.
SOSIALISASI PRAKTIK CUCI TANGAN PAKAI SABUN (CTPS) SERTA PEMANFAATAN LIMBAH UNTUK SARANA CUCI TANGAN SEBAGAI UPAYA MENJAGA KESEHATAN DIRI DAN LINGKUNGAN Legis Ocktaviana Saputri; Arina Windri Rivarti; Mahacita Andanalusia; Lalu Auliya Akraboe Littaqwa; M. Said Ramdlan
Jurnal Abdi Insani Vol 10 No 2 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i2.954

Abstract

Maintaining personal and environmental health can be implemented through Clean and Healthy Behavior (PHBS). One form of application is washing hands with soap (CTPS). CTPS has proven to be effective in preventing disease transmission from one individual to another. CTPS practice is an absolute necessity, while the availability of CTPS facilities is still inadequate. This activity aims to increase the knowledge of elementary and junior high school students and teachers at Pondok Pesantren Nurul Ijtihad Al-Ma'arif NU Central Lombok about CTPS as a strategy to minimize the spread of disease (Covid-19) in the school environment. This activity is carried out in the form of socialization. CTPS Practice Education refers to the procedure for washing hands properly and correctly according to the World Health Organization (WHO). Participants were also introduced to the use of solid waste as an ideal CTPS facility and how to manage the remaining CTPS liquid waste. Pre-test and post-test were given to test the success of the activities carried out. This activity was attended by 75 participants consisting of students, teachers and regular recitation participants at the Nurul Ijtihad Al-Ma'arif NU Islamic Boarding School in Central Lombok. Participants were given education by 3 (three) experts regarding good and correct CTPS practices, the use of solid waste for making CTPS facilities, and the management of liquid waste left over from CTPS practices so as not to have a negative impact on the environment. This activity ran smoothly and proved successful in increasing participants' understanding as indicated by the pre-test and post-test scores which increased from 50.5% to 61.97%. The ideal CTPS practice needs to be constantly reminded in order to prevent disease transmission. Utilization and management of waste in the practice of CTPS is a strategy to prevent environmental pollution.
DISEMINASI INFORMASI DAN DETEKSI DINI GANGGUAN KOGNITIF TERKAIT HIPERTENSI PADA PENDUDUK DI DESA PULAU MARINGKIK, KABUPATEN LOMBOK TIMUR Herpan Syafii Harahap; Yanna Indrayana; Yusra Pintaningrum; Bambang Priyanto; Arina Windri Rivarti; Dini Suryani; Nurhidayati Nurhidayati; Legis Ocktaviana Saputri; Fitriannisa Faradina Zubaidi; Muhammad Hilman Rizaldi; Anang Hermansyah; Restia Restia
Jurnal Abdi Insani Vol 10 No 3 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i3.1010

Abstract

Hypertension-related cognitive impairment has a wide spectrum, ranging from mild cognitive impairment to severe cognitive impairment in hypertensive individuals. Hypertension is currently also known as a risk factor for Alzheimer's dementia and vascular dementia. In its severe form, cognitively impaired individuals will have a high dependence on family members to carry out their daily activities. This community service event aims to increase the understanding of the residents of Maringkik Island Village regarding ​​the importance of prevention and early detection of hypertension-related cognitive impairment. This event was carried out in Pulau Maringkik Village, East Lombok Regency, which is a representative of a coastal area whose population generally has a high level of consumption of sodium salt. This community service activity is carried out in 3 forms of activities, including health education, screening of hypertension, and early detection of cognitive impairment in hypertensive participants. This health education event was attended by 53 participants. Of these, 29 participants (54.7%) were hypertensive. In early detection of cognitive dysfunction, of the 29 hypertensive participants, 19 of them (65.5%) were categorized as having impaired cognitive function. Thus, in this community service events, health education activity, screening of hypertension, and early detection of hypertension-related cognitive impairment are successfully done. The frequency of residents of Maringkik Island Village with hypertension and hypertension-related cognitive impairment is quite high. Promotive efforts to change high-sodium salt consumption habits need to be carried out on an ongoing basis with an educational strategy that is adjusted to the education level of the participants.
Prospecting Marine Natural Products as the Disease-Modifying Treatment of Alzheimer’s Diseases Saputri, Legis Ocktaviana; Harahap, Herpan Syafii; Rivarti, Arina Windri; Zubaidi, Fitriannisa Faradina
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.433-441

Abstract

Alzheimer's disease (AD) is a severe and high costs health problem all over the world. To date, there is no therapy capable of curing AD, making drug discovery a challenging and intriguing field to explore. Targeting marine natural products (MNPs) as a source of drug leads is a suitable choice considering the content of bioactive compounds and promising pharmacological benefits. This article aims to look at MNPs with prospects in several prime targets in AD pathology to cure AD. Marine vertebrates (fishes), marine invertebrates (sponges, tunicates, ascidian, clams, scallops, sand dollars, crabs, cockle, sea cucumber, shrimp, bryozoa, marine worm), algae/seaweed, and marine microorganisms (marine fungi, bacterium, dinoflagellata, microalgae) can be potentially used as disease-modifying treatments (DMTs) for AD. By targeting multiple aspects of AD pathology, these MNPs offer a multifaceted approach to treating and potentially modifying the disease course. This result is an intriguing gap for researchers in the discovery and development of new drugs that can improve AD pathology.
Cognitive Decline Among the Middle-aged Living in the Coastal Area in Lombok Island Suryani, Dini; Harahap, Herpan Syafii; Rivarti, Arina Windri; Nurhidayati; Zubaidi, Fitriannisa Faradina; Saputri, Legis Ocktaviana
Acta Neurologica Indonesia Vol. 3 No. 01 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i01.50

Abstract

INTRODUCTION: Dementia is a leading cause of disability, dependency and poor quality of life. Its prevalence has increased consistently in recent years. Coastal communities who have limited access to health services have a higher risk of developing degenerative diseases including dementia. METHOD: A total of 154 middle-age peoples from four coastal area were recruited in this study. Participants were interviewed to obtain data on sociodemographic characteristics, lifestyle and medical history, then completed neuropsychological tests. Cognitive function was assesed by Mini-cog instruments. RESULT: The number of participants with cognitive decline was 87 people (56%) out of a total of 154 participants. 66% of all participants with cognitive decline were female. History of hypertension (67%), DM (16%), 40% with a BMI ≥22.5, 23% with a history of smoking, and 45% of participants with a low activity level. Multiple linear regression shows that Age and history of Hypertension is associated with cognitive decline (Sig.0.005 and 0.037). DM, BMI, smoking history and activity level is not associated significantly. CONCLUSION: More than half of middle age people on the coast of Lombok Island have cognitive decline. Age and history of hypertension are influencing factors.
THE THE POTENTIAL ROLE OF NRF2 AS A TARGET SITE FOR THERAPEUTIC INTERVENTIONS IN ALZHEIMER'S DISEASE Rivarti, Arina Windri; Harahap, Herpan Syafii; Saputri, Legis Ocktaviana; Suryani, Dini; Rianawati, Sri Budhi
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.10

Abstract

Alzheimer's Disease (AD) is the most common form of dementia, characterized by progressive neurodegeneration leading to cognitive decline and memory impairment, affecting various cognitive functions. AD pathology involves the accumulation of neurotoxic substances such as amyloid beta (Aβ) and tau proteins, mitochondrial dysfunction, oxidative stress, and chronic neuroinflammation, resulting in synaptic loss and neuronal apoptosis. The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has emerged as a pivotal regulator of cellular defense mechanisms, including antioxidant response, autophagy, and inflammation. NRF2 not only inhibits Aβ synthesis and enhances tau protein clearance via autophagy but also reduces neuroinflammation by modulating microglial activation and cytokine production. Additionally, NRF2 activation preserves mitochondrial function by attenuating reactive oxygen species (ROS) production and sustaining mitochondrial biogenesis. Recent studies highlight the therapeutic potential of NRF2 activators, such as sulforaphane and echinacoside, in preclinical AD models, demonstrating reductions in Aβ and tau pathologies and improved cognitive outcomes. These findings underscore the multifaceted role of NRF2 in mitigating AD progression and its promise as a target for developing novel therapeutic interventions. By integrating NRF2-based strategies, future treatments may offer more effective approaches to combat the complex pathophysiology of AD.
Serum Clusterin Level Associated with Post-ischemic Stroke Cognitive Dysfunction Harahap, Herpan Syafii; Indriyana, Yanna; Rianawati, Sri Budhi; Arisetijono, Eko; Rivarti, Arina Windri
Jurnal Kesehatan Masyarakat Vol. 20 No. 3 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i3.4401

Abstract

The exploration of potential blood-based biomarkers that could be useful in the early detection of cognitive impairment associated with ischemic stroke is still being studied. The objective of this study was to examine the correlation between serum clusterin levels and the prevalence of cognitive impairment in individuals with ischemic stroke. A total of 86 outpatients with mild ischemic stroke within the first three months of its onset were recruited from three primary hospitals in Mataram, Indonesia. ELISA was used to measure the serum clusterin level. Patients’ sociodemographic and clinical data were also collected as covariates. The Montreal Cognitive Assessment-Indonesian version (MoCA-INA) instrument was used to evaluate cognitive status. The study used multivariate logistic regression analysis to investigate the effect of clusterin on the occurrence of cognitive impairment associated with ischemic stroke while controlling for other variables. Results: The multivariate logistic regression analysis revealed a significant correlation between elevated serum clusterin levels and a higher prevalence of cognitive impairment in ischemic stroke patients (odds ratio [OR] 3.56, 95% confidence interval [CI] 1.04-12.16, p = 0.043). Conclusion: Elevated serum clusterin levels have been associated with a higher occurrence of cognitive impairment in ischemic stroke patients.
Co-Authors Anang Hermansyah Andhera, Athalita Azizaturrahmah, Gina Aulia Balqis, Ananda Amirah Bambang Priyanto Dini Suryani Dini Suryani, Dini Eko Arisetijono Fitriannisa Faradina Zubaedi Fitriannisa Faradina Zubaidi Gama, Noviyanty Indjar Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Haq, Abiyyu Didar HERAWATI, LILIK Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Hilam, Muhammad Indrayana, Yanna Indriyana, Yanna Lalu Auliya Akraboe Littaqwa M Said Ramdlan Mahacita Andanalusia Muhammad Hilman Rizaldi Mus, Rosdiana Muttaqin, Syihabul Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Ocktaviana Saputri, Legis Prawiro, Aurellia Wongso Restia Restia Ristia, Ovia Intan Sri Budhi Rianawati, Sri Budhi Stephen, Mishael Enoch Wibawa, Junian Cahyanto Wulandari, Inayah Yanna Indrayana Yusra Pintaningrum Zubaidi, Fitriannisa Faradina