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Zahratul Aini
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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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The effects of ethanolic extract of green algae (ulva lactuca l.) on blood cholesterol levels in male rats induced by a high fat diet Wahyu Widyaningsih; Nina Salamah; Fella Qulsum Maulida
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 5, (2016)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss5.art3

Abstract

Background : Nowadays, cardiovascular disease is increasing in number each year. It is triggered by high cholesterol diet consumed by urban people. Green algae (Ulva lactuca L.) contains phytomelatonin levels that can ease cholesterol. Objective : To know about the effect of giving green algae ethanolic extract in male strain Wistar mice's cholesterol level. Methods : This research involved 36 male strain Wistar mice divided to six groups. Negative control injected with 2 ml/200 gBW lard, positive control injected with 0,18 mg/200 gBW simvastatin and lard, group III, V, V each given lard and injected with ethanolic extract of green algae at a dose of 50 mg/kgBW, 100 mg/kgBW and 200 mg/kgBW respectively, and normal control given AD 2 dietary treatment. Each group was given the same treatment peroral in 56 days and the blood was taken every 14 days through sinus orbitalis. The blood cholesterol level was analyzed by using enzymatic CHOD-PAP method. Data obtained were statistically examined using Two way ANOVA , Kolmogorov Smirnov, Levene's method and LSD with confidence level at 95%. Results : The blood cholesterol level were not significanly different between the negative and normal control. The result of cholesterol level for 14, 28, and 42 days for all group did not increase compared to negative control, but cholesterol level in group with 200 mg/kgBW dose extract indicated significant difference with negative control for 56 day. Conclusion : Giving ethanolic extract of green algae for 56 days decreased blood cholesterol level in male rats.
Analysis of capecitabine plus oxaliplatin (xelox) combination in the management of metastatic colorectal cancer compare with fluorouracil and oxaliplatin combination (folfox) Isnatin Miladiyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 5, (2016)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss5.art4

Abstract

Background : Combinations of Fluorouracil (FU) and biomodulator Leucovorin (LV) established as a standard regimen for therapy of colorectal cancer with metastases. To give better antitumor activity in colorectal cancer therapy, oxaliplatin is combined with FU/LV and give significant improvement. Fluorouracil can only be given by intravenous administration. This limitation raised effort to find alternative drugs that can be given orally, such as capecitabine. Capecitabine is an oral FU prodrug, with high oral bioavailability, highly accumulated in neoplastic tissue to be converted in FU, and well tolerated. Some clinical studies revealed effectivity of capecitabine plus oxaliplatin (XELOX) compared to FU/LV plus oxaliplatin (FOLFOX). Objective : This article is aimed to compare non inferiority of XELOX to FOLFOX in colorectal cancer with metastases, viewed form primary outcomes and secondary outcomes. Results : XELOX was comparable to FOLFOX with some benefitsover FOLFOX. Conclusion : XELOX could be considered as FOLFOX replacement as a standard therapyfor colorectal cancer with metastases.
Kefir: A new role as nutraceuticals Hanny Setyowati; Wahyuning setyani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 5, (2016)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss5.art5

Abstract

Nutraceutical is the fusion of nutrition and pharmaceutical. This products, in broad, are food or part of food that provides medical or health benefits including the prevention and or treatment of a disease. Kefir is renowned nutraceutical dairy products produced through fermentation of bacteria and yeasts and naturally present in grains of kefir. The nutritional attributes are due to presence of vital nutrients such as carbohydrates, amino acids, proteins, minerals, phosphorus, vitamin, calcium, and certain biogenic compounds. Intestinal immunity, antimicrobial, anticarcinogenic, hypocholesterolemic effect, antibiabetic, effect on blood pressure level, antioxidant, wound healing, and lactose intoleran can be achieved using this products. The purpose of this review is to gather information about composition, methods of production, and therapeutic properties of kefir products to provide justification for its consumption. This review confirms that kefir can be a new role of nutraceutical products.
Blood, bone and brain nocardiosis infection in an HIV-infected man Muhammad Yazli Yuhana
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 5, (2016)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss5.art6

Abstract

Disseminated nocardiosis is a rare and complicated opportunistic bacterial infection with propensity of delay in establishing the correct diagnosis and high frequency for misdiagnosis and due to the non-specific clinical presentation and the inherent difficulty in cultivating the organism. The infection is caused by gram-positive aerobic actinomycetes in the genus Nocardia. A definitive diagnosis requires the isolation and identification by Gram stain and modified acid-fast stain from a clinical specimen. Treatment heavily relies on species and susceptibility testing. There is a real paucity of prospective studies in nocardiosis infection, resulted in severely limited understanding of its diagnosis and treatment among the medical community. We report a clinical case of a 42-year old HIV-infected Burmese man with culture proven Nocardia infection.
The association between breastfeeding technique and knowledge with exclusive breastfeeding Lina Handayani; Yunengsih Yunengsih; Solikhah Solikhah; Azidanti Saufi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 5, (2016)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss5.art7

Abstract

Background : Breastmilk is the ideal food for babies. There are various inhibiting factors for the formation of awareness of parents in providing exclusive breastfeeding for example ignorance from the mother about the importance of breastfeeding, how to breastfeed properly, and aggressive marketing launched by infant formula manufacturers. Objective : TThis study aimed to determine the association between knowledge and techniques of breastfeeding with exclusive breastfeeding in the area of Puskesmas Pengasih II, Kulonprogo. Methods : This research employed cross-sectional design. The population was all mothers with babies six to 12 months with total sample 142 mothers. The data was analyze using Chi-square test with alpha significance=5%. Results : This study found more subjects with a low level of knowledge (57%), the same goes with breastfeeding technique (52,1%). There was statistically significant association between knowledge with exclusive breastfeeding (p=0,006). There was a statistically significant association between breastfeeding technique with exclusive breastfeeding (p=0,002). Conclusion : There were relationships between knowledge (p = 0.006) and feeding techniques (p = 0.002) with exclusive breastfeeding.
Comparison of reduction sugar analysis method in cilembu sweet potato (Ipomoea batatas l.) using luff schoorl and anthrone method Irfan Imam Taufik; Any Guntarti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 5, (2016)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss5.art8

Abstract

Background: Cilembu Village - Sumedang, West Java is the producer of sweet potato that tastes sweet. The sweet taste was obtained from potato that has been through the process of incubation for 3 weeks, with a result of the change of starch by amylase enzyme into reducer sugars in the sweet potato Cilembu. Objective: The aim of the study is to verify the levels of reducer sugar of sweet potato Cilembu the analysis of reducer sugar itself is required and the comparison of the methods used. Methods: Among many calorimetry methods that used to analyze reducer sugar, the most widely used is Anthrone. The analysis of total carbohydrates, especially reducer sugar is quite simple and sensitive. but the analysis method for reducer sugar is quite simple SNI 3457.1:2008 using Luff Schoorl method that based on titrimetric, it is consuming time, difficult to do for untrained analyser and the reduction reaction is not stoikiometric. the candidate method that using Anthrone method is recommended in order to replace Luff Schoorl method of reducing sugar in SNI 3457.1:2008. Results: The average levels of reducer sugar in sweet potato Cilembu that used Luff Schoorl as a method was 14.88 ± 0.44 (%) whereas Anthrone method was 21,60 1,31 (%). The average levels of reducer sugars in sweet potato Cilembu from Luff Schoorl method completed the Indonesia Pharmacopoeia conditions, that is has a recovery value a 92,49 % % and but has 3,25% CV value. The average levels of reducer sugar in sweet potato Cilembu with Anthrone method did not complete the Pharmacopoeia Indonesia conditions, which has a recovery value a 67,58 % and has CV 6,56 % value. Conclusion: Anthrone method not recommended for analyze the reducer sugars in sweet potato Cilembu.
The effectivity of ethanolic extract of binahong leaves (anredera cordifolia (tenore) steen) gel in the management of diabetic wound healing in aloxan-induced rat models Kintoko Kintoko; Astri Desmayanti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 5, (2016)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss5.art9

Abstract

Background : Diabetes Mellitus (DM) is a disease that can be known by increasing a blood glucose level and caused many kinds of complications if it don't properly treatment, one of those complications is a diabetic ulcer. There are many types of treatments created to overcome the diabetic ulcer, but there are not effective yet. Therefore, ethanolic extract gel of binahong (Anredera cordifolia (Tenore) Steen) leaves is used to make a new innovation of diabetic ulcer treatment Objective : The objective of this research wasto know the concentration of antibacterial and anti-infection activity from ethanolic extract of binahong leaves as wound healing on diabetic ulcer and also to know the changeover of wound diameter. Methods : Binahong leaves were extracted with 96% ethanol by maceration. Then the extract was formulated to be gel product with the concentration of 10% and 30%. The gel product was administrated to diabetic rats which had been made ulcer wound by excision. The result of wound diameter and the percentage of wound healing were analyzed by One Way Anova and then continue analyzed by LSD (Least Significant Different) with significant level of 95%. Results : The result showed that binahong gel with concentration variation of 10% and 30% only affected the organoleptic and doesn't affect the homogeneity, pH, irritation, spreadability and consistency. The result of the effectiveness test of binahong leaves gel is 10% more effective to changeover of wound diameter but there is not significantlydifferent if compared with 30% gel of binahong leaves. Therefore, gel of binahong leavesof 10% is able to provide slightly effective than chloramphenicol™. Conclusion : The concentration of 10% and 30% of binahong gel were effectively usage for wound healing diabetic ulcer in rats.
Mental health stakeholders' perception toward mental illness in West Java Kartika Farahdilla Fitri; Shelly Iskandar; Achadiyani Achadiyani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 3, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss3.art2

Abstract

Background: Mental illness is predicted to rise and will have been as second rank in Global Burden Disease by year of 2020. Two thirds sufferer do not seek and receive a care. Stigma, discrimination, and ignorance about mental health are true obstacles still happening in Indonesia. Mental health stakeholders have essential role for making and applying policy in order to improve sufferer's quality of life. Their perception influence the intervention of mental health. The purpose of this study is to describe mental health stakeholders' perception toward mental illness in West Java.Methods: This was cross-sectional descriptive study which was conducted using questionnaire as secondary data. Sampling method was taken by using total sampling. Subject of this study were 75 representatives of stakeholder working at health department, local general hospital, social service department, and local government regency/city of West Java.Results: Result of this study showed good perception of mental health stakeholders. Respondents had a good perception toward cause and treatment of mental illness.Conclusions: Respondents' perception showed a good understanding toward mental illness. Stakeholders were expected to implement the policy and intervention program in order to handle mental health problem in West Java.
Effectiveness of asmaul husna dhikr therapy to enhance the self control of alcohol abuser Fuad Nashori; Ina Noor Khiyar Nafisa; Rumiani Rumiani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 3, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss3.art3

Abstract

Abstract This research was conducted aiming to find out whether Asmaul Husna dhikr could be using a treatment to enhance self-control among alcohol abusers. There were 18 alcohol abusers age between 18 to 40 years old as subject divided into two groups. The research used quasi-experimental method with nonrandomized pretest-posttest-control group design, comparing the conditions before and after treatment between two groups. Self-control was measured by The Brief Self Control Scale (BSCS) adapted from Tangney, Baumister, and Boone (2004) scale, which self-discipline, deliberate, healthy habits, work ethic and reliability as self-control aspects. The experimental group participated in asmaul husna dhikr activities for about 2 weeks. The result showed significant differences in self-control score between experimental group and control group, by its significant level showing p = 0.001 (p < 0.05). Thus, asmaul husna dhikr could be an effective treatment for enhancing self-control among alcohol abusers.
The effect of co-chemotherapy of ethyl acetate fraction of Long jack roots (Eurycoma longifolia jack) on interleukin-6 expression of 7,12- dimethylbenz anthrasen breast carcinoma model Siti Salma Yusuf; Laela Hayu Nurani; Sitarina Widyarini
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 2, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss2.art7

Abstract

Background: Carcinogenic compound can cause cancer, one of which is 7,12- Dimethylbenz anthrasen (DMBA). Therapy used is chemotherapy using doxorubicin. However, doxorubicin can cause side effects and not specific enough, so it can also impair normal cells and cause resistance, so Long jack roots are needed as co- chemotherapy agent.Objective: To assess the effect of giving co-chemotherapy ethyl acetate fraction of Long jack roots and doxorubicin on the development of breast cancer through inhibition interleukin-6 expression.Methods: A total of 35 female rats SD strain were divided into 5 intervention group, each group contained 7 rats, namely Group 1 (baseline given feed and water), Group 2 (DMBA 20 mg / kg given 2x a week for 5 weeks), Group 3 (DMBA 20mg / kg + Long jack roots Ethyl acetate fraction 100 mg / kg), Group 4 (DMBA 20 mg / kg + Doxorubicin 1,17mg / kg), Group 5 (DMBA 20 mg / kg + Long jack roots ethyl acetate fraction 100 mg / kg + Doxorubicin 1,17mg / kg), then on the 16th week, surgery was done to remove animal’s mammae and organs and to conduct immunohistochemistry test with anti interleukin-6. Results: Interleukin-6 expression test result% with the average value of group I, II, III, IV and V respectively, 6.56 ± 3.50%; 47.21 ± 9.48%; 20.83 ± 10.40%; 49.39 ± 9.87% and 58.37 ± 17.32%.Conclusion: The administration of co-chemotherapy ethyl acetate fraction of longjack roots (Eurycoma longifolia Jack) and doxorubicin is effective inlowering aromatase expression, however not effective in reducing IL-6 expression compared to single regiment doxorubicin in DMBA-induced rat models.

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