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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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Genetic Counseling in Indonesia as a Mandatory Service Lantip Rujito
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 1, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss1.art1

Abstract

No Abstract
The roles of prayers in Islam for treatment (healing); potencies and problems Syaefudin Ali Akhmad
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art1

Abstract

No Abstract
Bacterial isolates and antimicrobial susceptibility in children with acute diarrhea at Ibn Sina Medical College, Bangladesh Sonia Akter; Reena Saad Ferdousi; Mahmuda Siddiqua
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art2

Abstract

Backround: Infectious diarrhea is one of common cause of children diarrhea causing mortality and morbidity worldwide. This study was performed to identify the common bacteria and their antimicrobial susceptibility in children with diarrhea. Methods: A retrospective study was conducted from April 2014 to March 2016 at IBN SINA Medical College Hospital, Bangladesh. Stool samples were cultured on MacConkey agar and blood agar. A standard biochemical procedure was used for full identification of bacterial isolates. Antimicrobial susceptibility tests were done on Mueller-Hinton agar by using disc diffusion method. Data were entered and analyzed by using SPSS version 20 and a p-value of < 0.05 was considered statistically significant. Results: A total of 186 stool samples were tested for bacterial isolation and 55 (29.57%) cases were found to have bacterial isolates. From the total bacterial isolates, the predominant isolate was E. coli 39 (70.91%) followed by Salmonella 9 (16.36%) and Shigella Spp.7 (12.73%). As much as 84.62% E. coli were resistant to co-trimoxazole and cefuroxime while 92.31% E. coli were sensitive to amikacin and 71.79% were sensitive to cefepime and gentamicin. Salmonella were 100% sensitive to cefepime, ceftriaxone, cefixime, ceftazidime, and ciprofloxacin. Shigella were 85.71% sensitive to amikacin and cefepime. Conclusion: The results show that E. coli were the most frequently isolated pathogen in children. The majority of the bacterial isolates were resistant to multiple antibiotics. Hence, antibiotics susceptibility test is mandatory before prescribing any antibiotics.
The effect of fasting to the quality of spermatozoa in adult male rattus norvegicus Nur Azizah Hafaz
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art3

Abstract

Backround: Oxidative stress contributes in male infertility as a causative idiopathic factor. Fasting is one kind of physical stress that can also cause oxidative stress. Furthermore, oxidative stress would increase ROS concentration. The increase of ROS contributes to infertility and decrease of testis weight. A lot of studies had been conducted on more than 24 hours fasting which leads to reducing sperms quantity, volume, and motility. In the other hand, studies on fasting for less than 24 hours are still limited; therefore study to evaluate the effect of stress caused by fasting for less than 24 hours to the quality of spermatozoa in adult male mice is needed. Objective: To determine the effect of 10 hours and 12 hours fasting to the quality of spermatozoa which included its motility, viability, and morphology in adult male mice. Methods: This study is an experimental research. Three months old male Wistar mice were divided into 3 groups, in which each group contained 10 mice. Group 1 was the control group, group 2 was treated with 10 hours fasting for 14 days, and group 3 was treated with 12 hours fasting for 14 days. After the intervention, their sperm motility, viability, and morphology were observed. Motility and morphology data were analyzed using One-Way ANOVA test, whereas the viability data was analyzed using Kruskal. Results: The sperm’s motility, viability, and morphology of the control group were different from the two intervention groups (p < 0,05). Control group had significant difference compared to the group of 10 hours fasting and group of 12 hours fasting (p < 0,05). There was no significant difference between treatment groups (p > 0,05). Conclusion: 10 hours and 12 hours fasting affect the quality of sperm in adult male mice.
The prevalence of dermatological infection in outpatient dermatology clinic of RSUD Wonosari in January-September 2016 Trijanto Agoeng Noegroho; Rosmelia .; Lamya Muthia Nabila
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art4

Abstract

Background: The Skin is a complex organ that protects humans from their surrounding environment, like an infectious pathogenic agent, sunlight exposure, temperature, or other exposures. Skin infections can be divided into bacterial, viral, or fungal infections where infestations of bugs or worms are included. In Indonesia, the exact number of skin infection incidents has not been established. And until now, there are no research reports about the case pattern of skin infections in the area of Kabupaten Gunung Kidul in 2016. Objective: This research aimed to describe the overview of skin infection cases in Outpatient Dermatology Clinic of RSUD Wonosari, Gunung Kidul fromJanuary 2016 until September 2016. Methods: This research was conducted retrospectively based on medical records of all cases of skin infections in Outpatient Dermatology Clinic of RSUD Wonosari during the period of January 2016 - September 2016. Results: All new cases of skin infections in outpatient dermatology clinic of RSUD Wonosari within the period of January 2016 - September 2016 amounted to 303 cases. The cases consisted of 127 cases of fungal infection (42%) with a variety of cases of dermatophytosis, PVC, and candidiasis; 55 cases of bacterial infections (18%) with a variety of cases of impetigo, folliculitis, leprosy, ektima, erysipelas, furuncles, and abscesses; 40 cases of viral infections (13%) with variaty of cases of HFMD cases, Moluscum contagiosum, zooster, warts, varicella; and 81 cases of parasitic infections (27%) with a variety of cases of scabies, creeping eruption, and pediculosis capitis. Conclusion: Skin diseases caused by infections was still a dominant skin disease in the outpatient Dermatology clinic of RSUD Wonosari, with the number of cases 18.35% of all cases of skin and venereal diseases. The most common cause is infection by fungi (7.69%), followed by parasitic infections, scabies (4.91%), bacterial infections (3.33%), and viral infections (2.42%).
New oral anticoagulants for atrial fibrillation Yuliana Yakobus
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art5

Abstract

Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world. Four new oral anticoagulants have become available as alternatives for warfarin in patients with AF. Although the newer aspects have higher acquisition cost, the benefits of cost savings may be derived from potential for decreasing the bleeding incidence and reducing the need for anticoagulation monitoring.
Gel formulation of ethanol extract of mangosteen peel (Garcinia mangostana L.) as a medication for burns in wistar rats Nining Sugihartini; Rinanda Yeshi Wiradhika
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art6

Abstract

Background: Mangosteen peel (Garcinia mangostana L.) has been shown to stimulate the regeneration of damaged body cells and have an antimicrobial activity that can be beneficial in healing burns. Therefore, it is necessary to make it into a gel dosage form that has the advantages of being easily washed with water, high adhesion, cooling of the skin, and good drug release. Objective: To determine the effect of varying concentrations of ethanol extract of mangosteen peel in a gel formulation on wound healing in burns and the physical properties of the gel. Methods: Mangosteen peel extract was obtained by maceration method using ethanol 70%. This extract was formulated in a gel dosage form with variations of extract concentration, namely F I (5%), F II (10%), and F III (15%). The gels were then tested for their physical properties (organoleptic, homogeneity, pH, spreadability, adhesiveness, and physical stability) and their activity against burns experimentally using mice as test animals. Burns were made by using a hot plate with an area of 2 cm x 2 cm. Results: The increase of extract concentration could increase spreadability (p>0.05), adhesiveness (p>0,05), and percentage of healing activity against burns as shown by a significant difference between FI and FIII. On the other hand, the difference in the concentration of the extract did not affect pH (all formulations have pH of 3.5); all formulas also remained homogenous and stable after centrifugation. Conclusion: The best physical properties and wound healing activity for burns was shown by the gel with the ethanol extract of mangosteen peel at a concentration of 15%.
Characteristics of children with secondhand smoking Septian Emma Dwi Jatmika; Muchsin Maulana
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art7

Abstract

Background: Passive smoking has been known to be associated with the risks of several diseases. Children are a group vulnerable to becoming passive smokers through adjacent adult smokers. Objective: To describe the characteristics of children with secondhand smoking. Methods: This research is a descriptive study involving 39 subjects of grade 4, 5, and 6 elementary school students. Inclusion criteria are having no subjective complaints of respiratory disturbances in the last 1 month, not smoking, living with parents/guardians/other family members that smoke inside the house, and willing to become respondents. Meanwhile, exclusion criterion was not returning the questionnaire. Samples were collected using purposive sampling technique. This study was conducted at Banguntapan Public Elementary School, Bantul in Agustus-September 2015. Instruments used in this study included questionnaires and spirometer. Data were analyzed univariately using frequency distribution. Results: More than half of the respondents were ≥ 11 years of age, female in gender, had parents that were ≥ 40 years of age, had parents that worked as labors, lived with one smoking family member, had parents that had started smoking at the age of < 24 years old, had parents that smoked ≥ 9 cigarettes per day, had parents that smoke outside the house, had parents that are mild smokers, and were not exposed to cigarette smoke. The highest level of education of the respondents’ parents was mostly (43.6%) senior high school. Subjective complaints of respiratory disturbances were reported by 74.4% of the respondents. Conclusion: Although no significant signs and symptoms of secondhand smoking were found, children that lived with smoking family members still need to be kept on watch. This is because more than half of the respondents of this study were reporting complaints of respiratory disturbances. Therefore, it is necessary to control the cigarette consumption of parents/ guardians, especially of those who still smoke inside the house.
Potency of xanthone derivatives as antibacterial agent against Methicillin-Resistant Staphylococcus Aureus (MRSA) Isnatin Miladiyah; Farida Juliantina Rachmawaty
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art8

Abstract

Antibiotic resistance is increasing worldwide and becoming a serious problem for the treatment of patients and also affecting their economy. One instance of bacteria that is resistant to the antibiotic is Methicillin- Resistant Staphylococcus aureus (MRSA). MRSA infections are fatal and even deadly. Some MRSA strain has shown resistance towards currently available antibacterial agents. To overcome this, we need new compound alternatives. One of the compounds currently being developed is xanthone derivatives. Xanthones can be found in many kinds of plants, including Garcinia mangostana , in which the active compounds are mangostanin and ±-mangostin. Xanthones is effective against several types of Grampositive and Gram-negative bacterias, including Staphylococcus species. Some studies have shown that xanthone derivatives are effective against Staphylococcus aureus, including MRSA. One of the proposed mechanisms of xanthone's antibacterial activity is the involvement of the bacteria's cytoplasmic membrane. Xanthone amphiphilic compounds are capable of disrupting bacterial membrane through a mechanism called interfacial activity models. Xanthone can also act as the antioxidant and by inducing the release of lipoteichoic acid (LTA) from the cell wall of MRSA. LTA is the main constituent of the cell wall of Gram-positive bacteria, which are covalently bonded to the outside of peptidoglycan. This structure is important for cell division and bacterial osmotic protection. Thus, it is believed that the mechanism of action of xanthones involved damaging bacterial cell membrane.
Effect of regional variation on the total flavonoid level of ethanol extract of mangosteen (Garcinia mangostana) peels Any Guntarti; Juniati Annisa; Mulki Mughniy; Fitria Rizqi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art9

Abstract

Background : Currently, traditional medicines have been widely used by the public. One of them is mangosteen peel. Extract of mangosteen peel contains alkaloids, glycosides, steroids, flavonoids, polyphenols, and tannins. In order to ensure the quality of the extract so that its chemical content can be guaranteed, it is necessary to standardize the quality of the extract that consists of specific parameters. Objective : This study aims to determine the specific parameters using Thin-Layer Chromatography (TLC) and total flavonoid level of the ethanol extract of mangosteen peel from Kalimantan, Java, and Sumatra. Methods : This research was an explorative study. Extraction technique used was maceration with 70% ethanol solvent. The tested specific parameters, namely the identity of the extract with TLC and total flavonoid level, were determined afterward using visible spectrophotometry with the AlCl3 reagent. Results: The result of the qualitative test with TLC showed that the extract of mangosteen peel contains flavonoids, terpenoids, and anthraquinones. Total flavonoid level of ethanol extract of mangonsteen peel from Kalimantan, Java, and Sumatra were (0.301 ± 0.009); (0.398 ± 0.015); (0,747 ± 0,010) mg QE/g extract, respectively. Conclusion : Extract of mangosteen peel contains flavonoids, terpenoids, and anthraquinones. Total flavonoid level of ethanol extract of mangonsteen peel from Kalimantan, Java, and Sumatra were (0.301 ± 0.009); (0.398 ± 0.015); (0,747 ± 0,010) mg QE/g of extract, respectively.

Page 13 of 47 | Total Record : 468

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