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Bayu Brahma
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INDONESIA
Indonesian Journal of Cancer
Published by National Cancer Center-Dharmais Cancer Hospital
ISSN : 19783744     EISSN : 23556811     DOI : https://www.doi.org/ 10.33371
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Indonesian Journal of Cancer is a peer-reviewed and open-access journal. This journal is published quarterly (in March, June, September, and December) by Dharmais Cancer Hospital - National Cancer Center. Submissions are reviewed under a broad scope of topics relevant to experimental and clinical cancer research. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted acceptance for publication. The journal publishes original research articles, case reports, and review articles under the following categories: cancer management, cancer prevention, cancer etiology, epidemiology, molecular oncology, cancer diagnosis and therapy, tumor pathology, surgical oncology, medical oncology, radiation oncology, interventional radiology, as well as early detection.
Arjuna Subject : Kedokteran - Onkologi
Articles 585 Documents
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Fibrovascular Polyps of the Hypopharynx: A Case Report Herdini, Camelia; Wirata, I Komang Praba Edi; Indrasari, Sagung Rai; Yudistira, Danu; Alamanda, Monik
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1352

Abstract

Introduction: Fibrovascular polyps are very rare, non-cancerous growths in the hypopharynx, though they can occur anywhere in the pharynx. Surgical excision is the definitive treatment to alleviate the patient's symptoms with an excellent outcome. This case report aims to share knowledge about the clinical presentation and treatment of this rare condition. Case Presentation: A 45-year-old man complained primarily of recurrent sore throat and frequent choking episodes, particularly during sleep. He also felt a mass in his deep throat, which he felt in his mouth just before swallowing, particularly when he vomited. A pedunculated mass originating from the lateral hypopharyngeal wall is detected during physical examination. After the mass was completely resected, he received proton pump inhibitors (PPI) and postoperative antibiotics.Conclusion: For fibrovascular polyps, definitive surgical excision is the preferred treatment. It is recognized that with total resection, malignant transformation and disease recurrence are relatively rare.
Future Prospects and Challenges of Hyperthermic Intraperitoneal Chemotherapy in Indonesia Pratama, Muhamad Airel; Ihsan, Syarifaha; Linangkung, Arum
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1321

Abstract

Background: Peritoneal carcinomatosis (PC) is a condition characterized by the spread of cancer to the peritoneum, often indicating advanced disease and poor prognosis. Traditionally viewed as a terminal illness, PC typically shows limited response to systemic chemotherapy, prompting a shift towards local-regional management through cytoreductive surgery (CRS) followed by heated intraperitoneal chemotherapy (HIPEC). This study aims to evaluate the potential of introducing HIPEC as a treatment for PC in Indonesia.Methods: A Literature search was conducted in June 2024 by using PubMed as the main electronic database. General terms related to the search, such as “hyperthermic intraperitoneal chemotherapy OR HIPEC”, “peritoneal carcinomatosis OR PC”, “cancer”, and “Indonesia” were used in screening. We included clinical trials that focused on HIPEC for the treatment of PC, comprehensive review articles that discuss HIPEC and its application, as well as studies that provided cost analysis of implementing HIPEC. Two reviewers (MA and SI) were involved in screening and full-text reviews. A meeting was held daily to standardize the reviewers’ understanding. Discussion with one reviewer (AL) was done to analyze results and come up with a suitable discussion.Results: Numerous trials demonstrate the significant benefits of CRS and HIPEC for patients with PC of various origins. Several guidelines outline specific criteria for HIPEC eligibility to ensure optimal outcomes, while others consider the procedure as experimental. Despite its effectiveness, its high costs act as its main challenge, particularly regarding reimbursement policies. CRS-HIPEC, however, remains cost-effective when considering life-years gained compared to standard chemotherapy. Conclusions: While international studies have demonstrated the effectiveness of CRS-HIPEC in treating peritoneal carcinomatosis, the application of this treatment in Indonesia remains largely untested. This study highlights the need for further research on the feasibility, clinical outcomes, and infrastructure requirements for implementing HIPEC in Indonesia. To effectively implement HIPEC in Indonesia, it is essential to consider a few factors, including but not limited to reimbursement policies, adoption of eligibility guidelines, and establishing multidisciplinary standards.
Adrenocortical Carcinoma with Infiltrated and Ruptured Inferior Vena Cava in Adult Woman Maligan, Deden Jinar Wahyudi; Maulana, Akhada; Danurdoro, Aria; Santosa, Hilda; Kumaladewi, Baiq Ratna
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1355

Abstract

Introduction: Adrenocortical carcinoma (ACC) is a malignant tumor that develops in the adrenal cortex. This case involves a rare, aggressive disease that demands specialized knowledge and optimal treatment for a favorable prognosis. This study aims to present the case of a woman with a right-sided ACC extending into the inferior vena cava (IVC), managed through radical resection and IVC repair.Case Presentation: A 50-year-old female presented with a complaint of a lump in the upper right abdomen, which she noticed three months ago. Abdominal computed tomography (CT) scan with contrast revealed a solid, inhomogeneous mass in the right suprarenal region measuring 12 cm x 11 cm. However, three days before the scheduled operation, the patient was brought to the emergency department with complaints of weakness and muscle weakness throughout the body. During the surgery, an adrenalectomy on the right side revealed a tumor infiltrating the IVC, causing venous rupture. The histological examination of the right adrenal tissue revealed ACC, infiltration of tumor cells beyond the capsule, lymphovascular infiltration, and no evidence of tumor cell infiltration into the kidney tissue. The treatment approach for this ACC case involved a complete surgical resection with open adrenalectomy and vena reconstruction. Postoperative results indicated improved patient condition, including symptom relief and favorable biochemical evaluation after surgery.Conclusion: Our patient had a right-sided ACC with local vascular infiltration into the IVC.
Comparison of USG and CT Scan Findings in Late Stage Ovarian Cancer in Dr. Cipto Mangunkusomo National Referral Hospital Sugianto, Sugianto; Purwoto, Gatot; Nuranna, Laila; Putra, Andi Darma; Nuryanto, Kartiwa Hadi; Shelly, Vannesa
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1369

Abstract

Background: Ovarian cancer remains a leading cause of gynecological cancer mortality due to its typically late-stage diagnosis. Current diagnostic methods include ultrasonography (USG) and computed tomography (CT), with CT generally favored for its higher sensitivity and specificity. However, CT's limited availability in resource-poor settings raises the need to assess USG’s diagnostic viability in detecting advanced ovarian malignancies. This study aims to compare the diagnostic accuracy of USG and CT in detecting adnexal masses, ascites, lymph node involvement, omental cake, and distant metastasis in advanced-stage ovarian cancer.Method: A cross-sectional comparative study was conducted at Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, from January 2021 to December 2023. The study included 70 patients with histologically confirmed advanced ovarian cancer (FIGO stages III and IV) who underwent both USG and CT before surgical intervention. Diagnostic performance measures, including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), were calculated for each modality, using surgical findings as the gold standard. Statistical analysis was performed using SPSS software, with significance set at p 0.05.Results: Both imaging methods demonstrated high specificity (100%) and PPV for adnexal mass detection, indicating reliability in confirming positive cases. However, CT showed superior sensitivity and accuracy across most parameters, particularly for ascites (sensitivity: 93.94%), lymph node involvement (56%), and distant metastases (36.67%). In comparison, USG had lower sensitivity, especially for distant metastases (6.67%), but maintained high specificity. These findings suggest that while USG is effective for initial assessment, CT is preferred for detailed staging.Conclusion: This study confirms CT’s superiority over USG in comprehensive ovarian cancer staging, particularly for detecting metastatic indicators. However, USG’s accessibility and affordability support its role as an initial diagnostic tool, especially in resource-limited settings. A multimodal approach, integrating USG for preliminary screening with CT for confirmation, may optimize diagnostic outcomes. Further research should focus on enhancing USG’s sensitivity to bridge the diagnostic gap in underserved regions.
Differences in Tissue Factor Positive Microparticle (Tf+Mps) Levels in Breast Cancer Patients Before and After Chemotherapy Adnyana, I Wayan Losen; Rahayu Srikandi, Ni Made Putri
Indonesian Journal of Cancer Vol 19, No 4 (2025): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i4.1392

Abstract

Background: Cancer-associated thrombosis is a well-known phenomenon that leads to significant patient morbidity and mortality. Malignancy increases the risk of thrombosis, and chemotherapy further elevates this risk. The pathophysiological mechanisms underlying this process are still poorly understood. High levels of tissue factor positive microparticle (TF+MPs) are a risk factor for thrombosis, with levels increasing in patients with cancer. This study aims to find the impact of chemotherapy on TF+MPs levels in breast cancer patients before and after chemotherapy. Method: This longitudinal observational analytic study involved breast cancer patients undergoing chemotherapy at Prof. Dr. I.G.N.G. Ngoerah General Hospital (RSUP), Denpasar, from March to August 2024, in patients above 18 years of age. TF+MPs levels were measured using the Enzyme-linked Immunosorbent Assay (ELISA) method. A paired T-test analyzed the differences in TF+MPs levels in breast cancer before and after chemotherapy.Results: A total of 31 breast cancer cases undergoing chemotherapy were studied. The average age of breast cancer patients was 51.16 ± 6.93 years. No Special Type breast cancer (61.3%) was the dominant type found. Stage III was predominantly observed in breast cancer patients (38.8%), and poorly differentiated grading had a high percentage in breast cancer cases (51.8%). The median body mass index (BMI) of breast cancer patients was 24.3 (18.0-39.7) kg/m². The levels of TF+MPs showed a significant difference in breast cancer patients before chemotherapy, measured at 0.42 ± 0.17 pg/mL, and after undergoing chemotherapy, measured at 0.66 ± 0.28 pg/mL. This represents an increase in TF+MPs levels of 0.24±0.28 pg/mL as observed in a paired t-test (p 0.001).Conclusion: This study demonstrates that chemotherapy significantly increases the levels of TF+MPs in breast cancer patients. Further study is warranted to investigate the clinical implications of monitoring TF+MPs for thromboprophylaxis strategies

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