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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
Core Subject :
Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
Arjuna Subject : -
Articles 355 Documents
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Peranan Bioteknologi Dan Mikroba Endofit Dalam Pengembangan Obat Herbal Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Plants have been the chief source of compounds of medicine for thousand of years. Plants are also the source of many medicines for the majority of the worldÂ’s population. The role of biotechnology is very important for multiplying, conserving the spesies, and enhancing the production of secondary metabolites. Endophytes are microbes that inhabit plants are currently considered to be a wellspring of novel secondary metabolites offering the potensial for medical and industrial exploitation. Natural products from various endophytic microbes have been investigated. Some examples of natural products observed from endophytic microbes are antibiotics, antiviral compounds, anticancers, antimalarial compounds, antioxidants, antidiabetics, and immunosuppressive compounds.
Identifikasi Senyawa Antioksidan Dalam Spons Callyspongia SP Dari Kepulauan Seribu Hanani, Endang
Majalah Ilmu Kefarmasian Vol. 2, No. 3
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Abstract

Antioxidant activity and identification of antioxidative compounds of Callyspongia sponge from Seribu Island (Kepulauan Seribu) were investigated. The sponge was extracted with acetone and the extract was concentrated using rotary vacuum evaporator. DPPH and tiocyanate methods were used to examine the antioxidant activity of the extract. The extract exhibited strong antioxidant activity in DPPH method with IC50 of 41.21 µg/ml. Chemical analysis indicated that the antioxidative compound in the sponge was alkaloid group.
Pengobatan Sendiri Sakit Kepala, Demam, Batuk Dan Pilek Pada Masyarakat Di Desa Ciwalen, Kecamatan Warungkondang, Kabupaten Cianjur, Jawa Barat Supardi, Sudibyo; Notosiswoyo, Mulyono
Majalah Ilmu Kefarmasian Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

The self-medication is an effort conducted by the community to cure theirselves using medicine, traditional medicine or others without health proffesional advice. The aims of this study are to know healthy – illness concept, to know local language, symptoms, cause, prevention and curation of headache, fever, cough and common cold, and the self- medication practice on the village community. This study using qualitative design and data was collected by depth interviewing from 12 key informans at Ciwalen village, Warungkondang sub-district, Cianjur district, West Java, in 1998. Key informans are the chief of RT, the chief of RW, the teachers of elementary school, the health cadres, and the housewives. Data were analyzed using triangulation methode and confirmating the interview result to the key informans. The conclussion of this study are The healthy-illness concept does not only physical aspect, but also social culture aspect. The light illness - heavy illness concept depends on the physical condition of patient, the daily activity and the medication. The community use generally local language nyeri sirah for the headache, muriang for the fever, gohgoy for the cought and salesma for the common cold. The cause of illness is commonly their physical environment, include bacteria for the cought. The prevention of illness is generally conducted by avoiding its cause. The self-medication practice generally use the medicine that were bought from the retail at their village, some of them use the traditional medicine. Reason of self-medication practice are light illness, inexpensive, time eficiency, and as a first aid before going to the health proffesional or health center. The self-medication practice is improperly done, because the community mostly bought a small amount of medicine, so that the brochure of the medicine can not be read.
Perbandingan Pelepasan Propranolol Hidroklorida Dari Matriks Kitosan, Etil Selulosa (EC) Dan Hidroksi Propil Metil Selulosa (HPMC) Sutriyo, Sutriyo; Djajadisastra, Joshita; Indah, Rosari
Majalah Ilmu Kefarmasian Vol. 2, No. 3
Publisher : UI Scholars Hub

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Abstract

Chitosan is a polycatonic biopolymer that can form gel in acidic environment so that can be used as a hydrophilic matrix in controlled release drug delivery system. In this research, propranolol hydrochloride controlled release granule was made in chitosan matrix. Granules were made by wet granulation method with variety of matrices, i.e. chitosan, hydroxypropyl methylcellulose (HPMC) and ethyl cellulose (EC). HPMC and EC were used as a comparing matrix. The release rates of propranolol HCl from matrix were determined by using dissolution apparatus type I with 50 rpm stirring rotation in acidic media of pH 1,2 and base media of pH 7,5 for 8 hours. Sample was taken at certain time and the samples were analyzed by spectrophotometer. The result showed that the release of propranolol hydrochloride from chitosan matrix was the slowest compared to the other matrices.
Optimasi Penetapan Kadar Akrilamida Yang Ditambahkan Ke Dalam Keripik Kentang Simulasi Secara Kromatografi Cair Kinerja Tinggi Harahap, Yahdiana; Harmita, Harmita; Simanjuntak, Binsar
Majalah Ilmu Kefarmasian Vol. 2, No. 3
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Abstract

A method by high performance liquid chromatography for the analysis of acrylamide in potato chips, is reported. The retention time for the elution of acrylamide from the C18RP column ranged from 3 to 3,2 minutes, and the eluate was analyzed by UV-VIS detector. A linear response was found for the acrylamide standard tested within the concentration range of 0,8 – 10µg/ml and the corelation coefficient (r) greater than 0,999, with detection limit 0,06 ppm and quantitative limit 0,19 ppm. Sample preparation was performed by means of solvent extraction using dichlormethane and subsequent re-extraction of the organic solvent with water. This aqueous sample solution was found to be free of any interferences and gave acrylamide and recorveries higher than 90%.
Evaluasi Pelaksanaan Prosedur Pelayanan Obat Pelengkap Oral Di Ruang Rawat IRNA B Perjan RS Dr. Cipto Mangunkusumo Jakarta Harianto, Harianto; Lestari, Itet; B, Laswety
Majalah Ilmu Kefarmasian Vol. 2, No. 3
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Abstract

A research had been performed in order to get general description of the service of an oral complementary drug in the nursing ward of IRNA B of Perjan RS Dr. Cipto Mangunkusumo and it evaluated the operation of the oral complementary drug service was, and also found out the correlation of the orderly medication instruction writing of the oral complementary drug, the orderly operation of the process of the oral complementary drug procurement, drug preservation, drug preparation, the hand-over the oral complementary drug to a patient, and Communication, Information and Education (CIE) in the nursing ward of IRNA B relation to the orderly operation of oral complementary drug service procedure. The research used the cross sectional method of survey which was descriptive and analytic in its nature. The research showed that 74,81% of the patients medication instruction writing in prescription did not fit the requirements in administration writing and medication information completely. 67,94% of the patients bought the prescription (76%-100%) form the drug store in RSCM, 42,75% of patients kept the 76%-100% of their drug in the pharmacy depot, 42,75% of patients prepared the 76%-100% of patient prepared the 76%-100% of their drug in unites of doses by the pharmacy depot. 64,12% of the patients were given their drug by nurses directly, and finished to swallow the drug according to its use direction, and there was none of the patients who got CIE service from a pharmacist. The operation of the oral complementary drug service in the nursing ward of IRNA B was evaluated as less appropriate to the procedure. It could be concluded that there is significant correlation between medication instruction writing, the orderly operation of the process of the oral complementary drug preservation, the drug preparation, the hand-over the oral complementary drug to a patient in the nursing ward of IRNA B with the orderly operation of oral complementary drug service procedure; and there is no correlation between the procurement of the oral complementary drug, the orderly operation of CIE in the nursing ward of IRNA B with the orderly operation of oral complementary drug service procedure.
Pemanfaatan Obat Tradisional Dengan Pertimbangan Manfaat Dan Keamanannya Kumala Sari, Lusia Oktora Ruma
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

Herbal medicines in general are safer than modern drug. This matter is caused by the less side effect of herbal medicines than modern drug. Side effects of herbal medicines can be reduced with the used of right materials, accurat dose, accurat usage time, accurat way of usage, accurat analyze information, and without abusing of herbal medicines itself. Accuracy of materials determine the effect of herbal medicines. Dose measuring in set of gram can lessen possibility the happening of effect which do not be expected. Information which is not supported by adequate basic knowledges and enough study can make traditional drug return to endangering.
Amankah Pengawet Makanan Bagi Manusia ? Harmita, Harmita
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

Uji Stabilitas Sediaan Mikroemulsi Menggunakan Hidrolisat Pati (DE 35–40) Sebagai Stabilizer Jufri, Mahdi; Anwar, Effionora; Utami, Putri Margaining
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

Various solubilization techniques have been developed to enhance the bioavailability of hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion. Microemulsion is a potential carrier in drug delivery system because it has many advantageous characteristics. In this research, hydrophobic drug was made in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model and investigated the influence of adding starch hydrolisates with dextrose equivalent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to the stability of this microemulsion system. This microemulsion consisted of isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35–40 as stabilizer, and water as external phase. The evaluation was stability test both phisically and chemically. The result showed that the stability of microemulsion system increased significantly by adding starch hydrolisates DE 35-40 at 2,5%.
Analisis Glimepirida Dalam Plasma Tikus Harahap, Yahdiana; Mansur, Umar; Sinandang, Theresia
Majalah Ilmu Kefarmasian Vol. 3, No. 1
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Abstract

The aim of this research is to find the method for analyze glimepiride and itÂ’s metabolite. Glimepiride is the second generation of antidiabetic oral from the sulphonyl urea that works by stimulating the insulin secretion from beta cells of pancreas. Glimepiride is isolated from plasma the using chloroform. Using the high performance liquid chromatography method which include C18 reversed phase column, using mixture of methanol:water (50:50, v/v) as a mobile phase, flow rate 1.0 ml/minutes, detection at wavelenght 228 nm with photo diode array detector gives retention times of glimepiride in 17 minutes without any interference from endogen component of plasma and from itÂ’s metabolite. Linearity with added internal standard gliclazide was established for the range concentration 100-1000 ng/ml with coefficient of correlation (r) is 0.9977 and give the limit of quantitation of glimepiride in 50 ng/ml. The results of validation method fulfilled for the given criterias.

Page 2 of 36 | Total Record : 355

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