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Prof. Diah Ayu Maharani, DDS, PhD
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Makara Journal of Health Research
Published by Universitas Indonesia
ISSN : 23563664     EISSN : 23563656     DOI : https://doi.org/10.7454/msk
Core Subject :
Makara Journal of Health Research (MJHR) is a peer-reviewed and scientific journal published by Universitas Indonesia. Starting from 2019 onwards, MJHR is redirecting its scope, focusing on publishing research articles relevant to non-communicable diseases (NCDs) addressing issues of surveillance, disease management and health policy in the Asia Pacific and Mediterranean countries. Relevant academic articles regarding NCDs analyzed from an integrated perspective including individual and population level, experimental and clinical approaches, epidemiology, public health, disease prevention and health promotion, diagnosis, treatment, prognosis and palliative care are welcome.
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Articles 10 Documents
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Search results for , issue "Vol. 24, No. 2" : 10 Documents clear
Serum immune profiling of patients with polycystic ovary syndrome Mobeen, Hifsa; Kashif, Muhammad; Nadeem, Ahmed; Shahzad, Faheem; Tahir, Romeeza; Abbas, Afia; Afzal, Nadeem
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Polycystic ovary syndrome (PCOS), the most prevalent hormonal disorder in females, is characterized by low levels of progesterone, which causes increased estrogen levels leading to production of various anti and auto-antibodies. This study aimed to estimate and compare levels of anti-nuclear antibodies (ANA), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG), and anti-islet cell antibodies (anti-ICAb) in patients with PCOS and healthy controls. Methods: The present comparative study included 82 subjects divided into two groups with 41 individuals in each group. Group I included healthy subjects, while Group II included patients diagnosed with PCOS. Blood samples were collected to determine serum levels of ANA, anti-TPO, anti-TG, and anti-ICAb using commercially available ELISA kits. Data were analyzed by using SPSS 20.0. Results: Two (4.8%) subjects in Group II had ANA, but none of the other healthy individuals had these auto-antibodies. Levels of anti-TPO were higher in Group II (6.01 IU/ml) than in Group I (5.98 IU/ml). Levels of anti-TG and anti-ICAb were higher in Group I (19.86 and 32.49 IU/ml, respectively) than in Group II (19.78 and 26.07 IU/ml, respectively). Conclusion: Levels of ANA and anti-TPO were higher in patients with PCOS than in controls. By contrast, levels of anti-TG and anti-ICAb were higher in controls than in patients with PCOS.
Effects of L-fucose supplementation on the viability of cancer cell lines Mazlan, Muhammad Alif; Yusof, Afzan Mat; Md Isa, Muhammad Lokman
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Fucose is a deoxyhexose sugar. While the biological roles of L-fucose remain unclear, the sugar is known to accelerate the malignant potential of cancer cells. Therefore, this study aimed to evaluate the viability pattern of human cancer and normal cell lines treated with fucose. Methods: The human gingival fibroblast (HGF-1), colorectal adenocarcinoma (HT-29) and skin malignant melanoma (A375) cell lines were cultured and treated with fucose at three concentrations of 1, 5, and 10 mg/ml. Cell viability was then measured using (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay. The data were analyzed using Statistical Package for the Social Sciences software. Results: The percentage of HGF-1 cell viability showed a rapid decline after day 1 of treatment. HT-29 and A375 were capable of surviving treatment with high fucose concentrations. The data were highly significant at p < 0.001. Conclusion: Whereas a high concentration of fucose is toxic to the HGF-1 cell line, the HT-29 and A375 cell lines could potentially adapt to this condition. Down- or upregulation of certain molecules that could induce or inhibit cell death may explain such adaptation. Further testing of up- and downregulated molecules should be conducted in future work.
Pterygium recurrence and corneal stabilization point after pterygium excision using the controlled partial avulsion fibrin glue technique Hilmi, Mohd Radzi; Kamal, Khairidzan Mohd; Azemin, Mohd Zulfaezal Che
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: This study aimed to evaluate the pterygium recurrence rate and corneal stabilization point after pterygium excision via the controlled partial avulsion fibrin glue technique using multiple corneal parameters. Methods: One hundred eyes of 100 patients who had undergone primary pterygium excision surgery via the controlled partial avulsion fibrin glue technique were retrospectively reviewed. Corneal stabilization points were determined over four follow-up sessions (i.e., the 1st, 3rd, 6th, and 12th months after surgery) based on changes in Simulated-K, corneal irregularity measurement, shape factor, and toric mean keratometry. Post-operative courses were followed for 12 months after surgery. Recurrence was defined as the regrowth of fibrovascular tissue 1 mm past the corneoscleral limbus. Results: No sign of pterygium recurrence and the corneal stabilization point were observed at the third month post-operation. Significance improvements in all corneal parameters were noted between the 1st and 3rd months (both p < 0.001); however, insignificant changes were noted at the following 6th- and 12th-month visits (both p > 0.05). Conclusion: The controlled partial avulsion fibrin glue technique may improve surgical outcomes with long-term recurrence rates equal to or lower than those previously reported. Corneal surface recovery is completed after the third month of the excision procedure.
CD34+ UCB stem cells attenuate TGF-β signaling and inhibit liver fibrosis: A new avenue for liver cirrhosis-carcinogenesis prevention Septiana, Wahyunia Likhayati; Antarianto, Radiana Dhewayani; Louisa, Melva; Jusuf, Ahmad Aulia; Barasila, Atikah Chalida; Pawitan, Jeanne Adiwinata; Fasha, Iqbal
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: The liver microenvironment plays a key role in liver fibrosis and carcinogenesis. This study aimed to fill the gap in knowledge on the interaction between hepatic stellate cells and endothelial progenitor cells with biomarkers of liver fibrosis and/or carcinogenesis, including Col1A1, TGF-β, and tenascin-C. Methods: CD34+ stem cells were isolated from umbilical-cord-blood mononuclear cells. 2D and 3D co-culture of CD34+ UCB SCs and LX2 was performed. The cells were incubated in a CO2 incubator for three days. Morphological observation, qRT-PCR of TGF-β1 and COL1A1, and immunocytochemistry of tenascin-C were performed. Results: CD34+ UCB SCs were viable in the 2D and 3D co-culture for 24 h. 3D co-culture of CD34+ UCB SCs and LX2 inhibited in vitro liver fibrosis by lowering Col 1A1 expression as compared to control. We observed lower TGF-β expression in 3D co-culture on days 1 and 2 followed by higher expression of TGF-β on day 3. 2D co-culture of CD34+ UCB SCs and LX2 showed a different level of COL1A1 and TGF- β expression compared with 3D co-culture. Spheroids from 2D co-culture of CD34+ UCB SCs and LX-2 showed immunoreactivity against tenascin-C. Conclusion: Interaction between LX-2 and CD34+ UCB SCs in 3D co-culture inhibits in vitro liver fibrosis. The viability of CD34+ UCB SCs is essential for attenuation of TGF-β signaling in LX-2.
Health-related quality of life and work ability of smallholder rice farm workers in San Jose, Occidental Mindoro, Philippines Gonzales, Artemio Morado, Jr; Ambong, Ryan Mark Aloro; Bais, Leoniel Salibio; Macaspac, Lendon Perez
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Health is an integral form of human capital that can positively influence agricultural worker productivity in the physical, mental, and social domains. Poor health usually represents a burden to farm workers because a failure to meet scheduled tasks on the farm can later affect the dependents who rely on it for food nourishment and sustained livelihood. This study aims to determine the association between health and the work capabilities of smallholder rice farm workers in San Jose, Occidental Mindoro, Philippines. Methods: A cross sectional study was conducted among 100 farm workers. The SF-36 (HRQoL) and Work Ability Index (WAI) questionnaires were used to determine health status and work abilities of the respondents. The association of every health domain was investigated using one-way analysis of variance (ANOVA). Results: The results show that work ability was more associated with physical functioning and vitality scales compared to physical role limitations, bodily pain, general health perceptions, social functioning, emotional role limitations, and mental health in the health dimensions. Conclusion: Given the influence of health-related quality of life, any intervention program for the safeguarding and promotion of work ability among farmers should be based on balancing and optimizing the physical and psychosocial work environments.
Organizational empowerment among Nursing Faculty in the Northwestern Region of Saudi Arabia Alsaqri, Salman Hamdan; Pasay-an, Eddieson; Villacorte, Liza; Madjid, Fredezwinda; Pacis, Carmencita; Al-Sadi, Ahmad Khalil Ahmad
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Background: This study aimed to determine the differences in the workplace empowerment of nursing faculty as it relates to their demographic information. Methods: A comparative cross-sectional study was conducted among 65 nurse educators at the College of Nursing, University of Hail, Saudi Arabia. The data were collected through a survey questionnaire between January and March 2019. Results: Significant differences were found regarding gender and opportunity (p < 0.017), support (p < 0.020), resources (p < 0.022), job activities scale (JAS; p < 0.005), organizational relationship scale (ORS; p < 0.011), and marital status on resources (p < 0.031). In comparison, gender to information and all of the other demographic variables such as marital status (except resources), years of experience, age, nationality, educational qualifications, and specialization were found insignificant to opportunity, support, resources, information, JAS, and ORS, where all of their p-values were more than 0.05. Conclusion: Male nursing faculty were found to be more empowered in terms of opportunity, support, resources, JAS, and ORS but not to information. Married nursing faculty were found more empowered only to resources. This study supports that gender and information, marital status (except resources), years of experience, age, nationality, educational qualifications, and specialization are not determinants for job empowerment.
Indonesian health professions students’ perceptions toward an interprofessional education program: Findings after five years of implementation Sari, Santi Purna; Soemantri, Diantha; Ayubi, Dian; Martha, Evi; Handiyani, Hanny; Findyartini, Ardi
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Background: The Interprofessional Education (IPE) program is important for preparing health professions students to provide future interprofessional collaborative practice. The Universitas Indonesia Health Sciences Cluster has been implementing the IPE program since 2013. A comprehensive evaluation is required following the implementation of the IPE program. The aim of the study was to evaluate the IPE course based on perceptions of undergraduate students at the Universitas Indonesia from 2013 to 2017. Methods: A mixed-methods study utilizing a semi-structured questionnaire was conducted with first year students following the completion of the first stage of the IPE course. A total of 2355 students (56.35%) from the 2013–2017 academic years completed the questionnaire. Results: The results showed that students’ perceptions of the IPE course improved each year on the domains of clear and relevant learning objectives, student-centered teaching methods, staff support, and supporting infrastructures. However, some room for improvement was identified, such as the need for tutors to have a more neutral attitude toward every student despite their background differences. Conclusion: The IPE course has been well perceived by students because of its comprehensive instructional design and principles of IPE that are implemented in the curriculum. The continuous cycles of improvement to maintain the quality of the IPE program will remain a challenge.
Effect of the SIMS program on oral hygiene levels of 5–6-year-old children in the Kampar District, Malaysia: A cluster-randomized controlled trial Anwar, Nurul Hayati; Nor, Nor Azlida Mohd; Yusof, Zamros Yuzadi Mohd
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: This study evaluated the effect of the “Senyuman Indah Milik Semua” program (SIMSP) versus the existing preschool oral healthcare program (POHP) on children’s oral health and parents’ oral health literacy (OHL) in Kampar district, Malaysia. Methods: This was a cluster-randomized, matched pair, examiner-blind, controlled trial. Using computer-generated random tables, 14 preschools were allocated to the SIMSP intervention over 6 months and another 14 were allocated to the POHP, which was concealed at the cluster level. Healthy 5–6-year-old children and parents who understood the Malay language were recruited. The SIMSP was comprised of preschool visits by dental therapists (DTs) who provided oral health education for children and parents. The POHP received visits from DTs only. The primary outcome was the dental plaque score. The secondary outcomes were children’s oral health behaviors and the parents’ OHL. Data were collected during February and October 2019 and analyzed using SPSS software. Results: Overall, 653 children were recruited (intervention: 344 vs. control: 309). At 6-months, 83.4% and 76.4% completed the study, respectively. The mean decrease in the plaque score was higher in the SIMSP than the POHP [p = 0.027, effect size (ES) = +0.51]. Significantly more SIMSP children consumed carbonated drinks ≤ 1–3 times/week (p = 0.033). Parents in the SIMSP had more knowledge (p = 0.024) with higher OHL scores (ES = +0.97) than parents in the POHP. Conclusion: The SIMSP was effective for reducing children’s plaque scores, soft drink intake, and improving parents’ OHL than POHP.
Association between sociodemographic factors and estrogen receptor-positive, progesterone receptor-positive breast cancer subtypes: A cross-sectional study Mugada, Vinodkumar; Kolakota, Raj Kiran; Mahato, Varsha
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Background: The presence of risk factors have a high risk of developing breast cancer. Our study aimed to find an association between sociodemographic factors and the risk of estrogen receptor (ER)-positive, progesterone receptor (PR)-positive breast cancer among women. Methods: A cross-sectional study was conducted on 200 women with breast cancer. Association between sociodemographic factors and hormone receptor subtypes of breast cancer was found using the Chi-square test. Multiple logistic regression analysis was used to know the strong predictors of hormone receptor subtypes. Results: The mean age was 50.08 (10.67) years. Comorbidities had a statistically significant association with ER-positive subtype (p = 0.007). Body mass index had a statistically significant association with PR-positive subtype (p = 0.042). Comorbidities was found to be the strong independent predictor for ER-positive (OR 2.28; 95% CI: 1.28–4.05, p = 0.003) and PR-positive subtypes (OR 1.78; 95% CI: 1.01–3.13, p = 0.03). Conclusion: We conclude that in our study, body mass index was associated with PR-positive subtype, and comorbidities were associated with ER-positive subtype of breast cancer among the women. Comorbidities remained to be a strong independent predictor of ER-positive and PR-positive subtypes of breast cancer.
Perceived need and utilization of dental health care services in Indonesia: A secondary analysis using the national socioeconomic data Malik, Normaliza Ab; Rosalien, Robbykha; Khalissya, Nadine; Badruddin, Iwany Amalliah; Maharani, Diah Ayu
Makara Journal of Health Research Vol. 24, No. 2
Publisher : UI Scholars Hub

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Background: Perceived needs and utilization of oral health services are important to ensure improvements in oral health outcomes and to allocate resources for the continuous provision of the services. This study aimed to determine the factors influencing the perceived needs and utilization of oral health services in Indonesia. Methods: Secondary data from the 2013 Indonesian National Socioeconomic Survey (n = 260,925) was used. Descriptive analysis and logistic regression were employed to describe the relationship between perceived needs and utilization of oral health services. Results: The proportions of Indonesians who had a perceived need for oral health services and utilized the services in 2013 were 1.64% and 2.30%, respectively. A higher probability of perceived need and utilization of dental health care services was observed in the respondents who wereold, females, unmarried, and living in rural areas and in those who had a higher level of education and health insurance. Conclusion: The proportions of individuals who presented with perceived needs and utilization of dental health care services were low and were associated with age, gender, marital status, geographic location, level of education, and insurance status. Appropriate strategies and policies are warranted to improve oral health in Indonesia.

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