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MASALIQ: Jurnal Pendidikan dan Sains
Published by Lembaga Yasin Alsys
ISSN : 28091051     EISSN : 28088115     DOI : -
Core Subject : Religion, Education, Social,
Religion Education Social Sciences
MASALIQ: Jurnal Pendidikan dan Sains was published by Lembaga Yasin alSys which was published six times a year, January, March, May, July, September and November with a minimum of 5 articles. The journal aims to provide a forum for scholarly understanding of the field of education and plays an important role in promoting the process that accumulated knowledge, values, and skills.
Arjuna Subject : Ilmu Sosial - Pendidikan
Articles 708 Documents
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Studi In Silico Senyawa Aktif Gambir (Uncaria gambir) sebagai Inhibitor KRAS G12D pada Kanker Pankreas Vioni Yulianti; Okta Suryani
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9742

Abstract

Although pancreatic cancer, particularly PDAC with the KRAS G12D mutation, has been the focus of various studies, research specifically evaluating the potential of active compounds from Uncaria gambir as KRAS G12D inhibitors through an in silico approach remains limited. This study aimed to analyze the binding affinity, drug-likeness profile, and ADMET parameters of active compounds from Uncaria gambir against the KRAS G12D protein. This study used a computational approach through molecular docking and virtual screening designs involving seven test compounds with the KRAS G12D protein structure (PDB ID: 7RPZ), using MRTX1133 as a positive control. The data were analyzed based on binding affinity, RMSD, Lipinski’s Rule of Five, Veber parameters, and ADMET evaluation. The results showed that roxburghine had the highest affinity (−6.7780 kcal/mol), but did not meet Lipinski’s criteria and was indicated to be hepatotoxic. Gambirine and isogambirine were detected as mutagenic and hepatotoxic, whereas quercetin was considered the most prospective because it had a binding affinity of −5.1256 kcal/mol, an RMSD of 1.0570 Å, and interactions with GLU63, HIS95, and GLN99 residues through H-acceptor bonds, accompanied by a superior pharmacokinetic and safety profile. The conclusion of this study confirms that active compounds from Uncaria gambir, particularly quercetin, have the potential to be further explored as candidate KRAS G12D inhibitors in pancreatic cancer, while also providing an initial contribution to the development of natural compounds based on computational approaches in anticancer research.
Studi In Silico Senyawa Turunan Kumarin sebagai Inhibitor Janus Kinase 1 (JAK1) pada Penyakit Rheumatoid Arthritis Nur Aini Tsuraya; Okta Suryani
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9743

Abstract

Rheumatoid arthritis is a chronic autoimmune disease involving activation of the Janus kinase 1 (JAK1) pathway, making JAK1 a potential target in drug development. This study aims to evaluate the potential of coumarin derivative compounds as JAK1 inhibitors in silico. This study used a computational approach through the molecular docking method to predict ligand–protein interactions, evaluation of physicochemical properties based on Lipinski’s Rule of Five, and ADMET analysis to assess pharmacokinetic and toxicity profiles. The results show that all compounds had negative binding affinity values, ranging from -6.5379 to -6.9271 kcal/mol, indicating stable ligand–protein interactions, although these values were still lower than the positive control Tofacitinib, with a value of -7.3968 kcal/mol. All compounds met the criteria of Lipinski’s Rule of Five, but ADMET analysis showed variations in pharmacokinetic and toxicity profiles. Compound 3 showed the best balance between activity, stability, and safety, whereas compounds 1 and 2 showed potential mutagenicity. The conclusion of this study emphasizes that compound 3 has the potential to be further developed as a JAK1 inhibitor candidate. The implications of this study indicate the importance of structural optimization and further experimental validation to improve the effectiveness and safety of coumarin derivative compounds as therapeutic candidates for rheumatoid arthritis.
Studi In Silico Turunan Kumarin dari Daphne mezereum sebagai Inhibitor EGFR pada Kanker Paru-Paru Roja Seppurnama Sari; Okta suryani
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9744

Abstract

Lung cancer is one of the leading causes of cancer-related death worldwide and is often associated with overexpression of the Epidermal Growth Factor Receptor (EGFR), making the development of EGFR inhibitors an important therapeutic strategy. This study aims to evaluate the potential of coumarin derivatives from Daphne mezereum as EGFR inhibitor candidates in lung cancer therapy using an in silico approach. This study used computational methods, including molecular docking to analyze binding affinity and ligand–protein interactions, drug-likeness evaluation based on Lipinski’s rule, and ADMET analysis to predict pharmacokinetic properties and toxicity. The results show that all compounds had RMSD values ≤ 2 Å, with a re-docking value of 1.1614 Å, indicating the validity of the method. Compound 2 showed the highest binding affinity and optimal interaction with the Met769 residue in EGFR, which plays a role in lung cancer cell proliferation, but it did not meet Lipinski’s criteria and had a less optimal ADMET profile. Conversely, compound 3 (umbelliferone) showed a balance between affinity, drug-likeness, and a good ADMET profile, including high absorption and non-toxic properties. The conclusion of this study emphasizes that compound 3 is more prospective as a lung cancer drug candidate, while compound 2 (7-hydroxycoumarin-5,8-di-β-D-glucopyranoside) has potential as a lead compound for further optimization. These findings contribute to the development of EGFR-targeted therapy based on coumarin derivatives and emphasize the importance of computational approaches in efficient and rational drug design.
Evaluasi Implementasi Sistem Manajemen Keselamatan Konstruksi (SMKK) pada Pembangunan Gedung Kuliah FT (B, C, dan D) Universitas XYZ Zika Dwi Zahara; Ari Syaiful Rahman Arifin
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9827

Abstract

The implementation of the Construction Safety Management System (SMKK) in construction projects is an important aspect for ensuring worker safety, environmental protection, and work continuity. This study aimed to analyze the level of SMKK implementation, evaluate its compliance with Minister of Public Works and Housing Regulation No. 10 of 2021, and identify supporting and inhibiting factors in its implementation in the construction project of the Faculty of Engineering Lecture Buildings (B, C, and D) at XYZ University. This study used a mixed-methods approach with an evaluative descriptive design, involving 22 respondents selected through purposive sampling and total sampling techniques. Data were collected through questionnaires, interviews, observation, and documentation, and were then analyzed using descriptive statistics, data triangulation, member checking, and gap analysis. The results showed that the level of SMKK implementation was in the appropriate category, with an average score of 89.68%. The compliance evaluation showed that all main elements of SMKK had met regulatory provisions and did not show any significant gap with actual conditions in the field. Supporting factors in SMKK implementation included leadership commitment, availability of resources, workforce competence, and structured safety documentation, whereas inhibiting factors included consistency in procedure implementation and discipline in the use of personal protective equipment. The conclusion of this study confirms that the implementation of SMKK in construction projects requires continuous supervision, safety training, and strengthening of safety culture to support the sustainability of an occupational safety system that complies with regulatory provisions.
Verifikasi Metode Uji Nitrit (NO2-N) pada Air Sungai Sesuai SNI 06.6989.9-2004 Angle Cendriani; Ali Amran
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9855

Abstract

Although water quality monitoring has been widely conducted, studies that specifically examine the verification of nitrite (NO₂-N) test methods in environmental laboratories remain limited. This study aimed to verify the nitrite test method in river water based on SNI 06.6989.9-2004 using a UV-Vis spectrophotometer at the Water Quality Laboratory of BSPJI Padang. This study used an experimental quantitative approach through laboratory testing, which included the preparation of standard solutions, construction of a calibration curve, and absorbance measurement at a wavelength of 543 nm. Data were analyzed using linear regression to evaluate method performance parameters, including linearity, precision, and limit of detection. The results showed a strong linear relationship between concentration and absorbance, with a slope value of 3.4324 and an intercept value of 0.0039, indicating good method linearity. This method also demonstrated precision and sensitivity that met the criteria for nitrite analysis in river water. These findings confirm that the SNI 06.6989.9-2004 method can be reliably applied at the Water Quality Laboratory of BSPJI Padang. This study contributes to strengthening the verification of analytical methods in environmental monitoring and supports the implementation of standard procedures in water quality analysis.
Deskripsi Model Mental Peserta Didik pada Materi Struktur Atom Fase E SMAN 1 Kubung Putri Wulandari; Dwi Finna Syolendra
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9869

Abstract

The low achievement in the 2025 senior high school Chemistry Academic Ability Test (TKA) indicates that students’ understanding of chemistry concepts remains suboptimal, particularly in abstract material such as atomic structure, which has the potential to form mental models that are not fully aligned with scientific concepts. This study aimed to describe students’ mental models on atomic structure material in Phase E at SMAN 1 Kubung. This study used a descriptive qualitative approach with 30 tenth-grade students as research subjects. Data were collected through essay tests and interviews. The test instrument was declared valid, with an Aiken’s V coefficient of 0.910. The results showed that students’ mental models were still dominated by the initial model and synthetic model categories, whereas the scientific model category remained relatively low. The interview results showed that students’ mental model patterns were generally consistent between written answers and oral explanations. These findings confirm that students’ mental models on atomic structure material are still at the initial stage to the transition stage toward scientific understanding. The implications of this study indicate the need for chemistry learning strategies that can help students build mental models that are more aligned with the scientific model, particularly in abstract atomic structure material.
Efektivitas Penggunaan E-LKPD Materi Reaksi Redoks Berbasis Problem Based Learning terhadap Hasil Belajar Peserta Didik Fase E SMTI Padang Sampaikan Sabda Zebua; Syamsi Aini
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9899

Abstract

Although the integration of digital learning media has received attention in various previous studies, research that specifically discusses the effectiveness of Problem-Based Learning (PBL)-based E-LKPD in improving learning outcomes on redox reaction material remains limited. This study aims to evaluate the effectiveness of using PBL-based E-LKPD on redox reaction material on the learning outcomes of Phase E students at SMK SMTI Padang. This study used a quantitative approach with a pre-experimental design in the form of a one-group pretest-posttest design, involving 35 students selected using purposive sampling. Data were collected using a multiple-choice test instrument administered in the form of a pretest and posttest, then analyzed using the N-Gain test. The results showed a significant improvement in learning outcomes, with the average score increasing from 29.64 in the pretest to 88.39 in the posttest, and an N-Gain score of 0.83 in the high category. These findings contribute to the development of constructivism-based learning and expand understanding of the integration of digital media with problem-based learning. The conclusion of this study confirms that PBL-based E-LKPD is effective in improving students’ conceptual understanding and learning outcomes on redox reaction material. The implications of this study include theoretical contributions to digital learning innovation and practical implications for educators in improving the quality of chemistry learning through the use of PBL-based E-LKPD.
Pengaruh Kecepatan Pengadukan pada Biosorpsi Direct Blue 86 oleh Kulit Kelengkeng Termodifikasi Anastasya Tri Yolanda; Desy Kurniawati
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9912

Abstract

Direct Blue 86 (DB-86) is an anionic azo dye that is widely used in the textile industry and has relatively persistent properties in aquatic environments, making low-cost adsorbents necessary for the treatment of colored liquid waste. This study aims to evaluate the effect of stirring speed on the biosorption of DB-86 using longan peel modified with duck egg white in batch mode. The biosorbent was prepared from acid-activated longan peel and duck egg white with a KL:PTI mass ratio of 1:1. Biosorption experiments were conducted using 0.2 g of biosorbent and 25 mL of 450 mg/L DB-86 solution at pH 2, a particle size of 63 µm, and a contact time of 30 minutes. Variations in stirring speed were set at 100, 150, 200, 250, 300, and 350 rpm. The dye concentration after biosorption was measured using a UV-Vis spectrophotometer at a wavelength of 627 nm and converted based on the standard curve equation. The results showed that the adsorption capacity increased from 46.734 mg/g at 100 rpm to a maximum of 51.894 mg/g at 200 rpm, with the highest removal efficiency of 95.25%. However, increasing the stirring speed to 250–350 rpm gradually reduced biosorption performance. The optimum condition at 200 rpm indicates that adequate stirring can improve solution homogeneity and external mass transfer, whereas excessive stirring may disrupt the interaction between the dye and the biosorbent. These findings emphasize the importance of optimizing stirring speed in the biosorption process and demonstrate the potential of longan peel modified with duck egg white as a low-cost biosorbent for removing anionic dyes from liquid waste.
Deskripsi Model Mental Peserta Didik pada Materi Termokimia Kelas XI SMAN 2 Padang Farah Nalsha Laila Putri; Dwi Finna Syolendra
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9964

Abstract

The low achievement in the 2025 Senior High School Chemistry Academic Competency Test (TKA) indicates that students’ understanding of chemistry concepts remains suboptimal, particularly in abstract topics such as thermochemistry, which may lead to the formation of mental models that are inconsistent with scientific concepts. This study aimed to describe students’ mental models in thermochemistry as a basis for evaluation in improving the quality of Grade XI chemistry learning at SMAN 2 Padang. This study used a qualitative approach with a descriptive design, involving 30 students selected through random sampling. Data were collected using an essay test instrument that had been validated by experts with an Aiken’s V coefficient of 0.903, and were then analyzed descriptively and qualitatively based on the alignment of students’ answers with scientific concepts. The results showed that students’ mental models were still dominated by the Initial Model and Synthesis Model categories, while the Scientific Model category remained relatively low. Students still experienced misconceptions, particularly in distinguishing between system and surroundings, understanding the direction of heat transfer, and connecting macroscopic, submicroscopic, and symbolic representations. These findings indicate that students’ understanding remains at an initial stage to a transitional stage toward scientific understanding. Thus, this study contributes to mapping the profile of students’ mental models in thermochemistry and serves as a basis for developing more effective chemistry learning strategies through a multiple-representation approach and the use of visual media to help students develop mental models toward the Scientific Model category.
Analisis Semi-Kuantitatif Kandungan Logam Berat pada Air Minum Isi Ulang di Kecamatan Sail, Kota Pekanbaru Menggunakan Metode Test Kit Reggyna Putri Januari; Alizar Ulianas
MASALIQ Vol 6 No 3 (2026): MEI
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9972

Abstract

Refill drinking water is widely consumed by the public because it is considered practical and economical, but its quality needs to be monitored, particularly regarding the possibility of heavy metal contamination that may affect health. This study aimed to analyze the heavy metal content of refill drinking water in Sail Subdistrict, Pekanbaru City, using a semi-quantitative method based on a test kit. The research samples were taken from five refill drinking water depots with the codes A1, A2, A3, A4, and A5. Testing was conducted using a heavy metal test kit that works based on color changes as an indicator of the presence of contaminants. The test results showed that all samples were still below the threshold, with the metal concentrations detected in each sample indicating no significant contamination. These findings indicate that refill drinking water in Sail Subdistrict, Pekanbaru City, is relatively safe for consumption in terms of heavy metal content. Thus, the test kit method can be used as a rapid and practical initial screening tool in monitoring the quality of refill drinking water, particularly for detecting the potential for heavy metal contamination in a simple manner before more in-depth laboratory testing is conducted.

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