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Hafiz Muchti Kurniawan
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Program Studi Farmasi UNAJA Jl. Sersan Muslim RT.24 Kelurahan Thehok Kecamatan jambi Selatan 081334089241 (Septa Pratama) Kota Jambi, Jambi , Indonesia lppm@unaja.ac.id 081334089241 (Septa Pratama)
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PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Published by Universitas Adiwangsa Jambi
ISSN : -     EISSN : 28306090     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Pharmanaja : Pharmaceutical Journal of Unaja merupakan jurnal elektronik yang dikelola Program Studi Farmasi Universitas Adiwangsa Jambi. jurnal ini merupakan media publikasi hasil penelitian dan review artikel pada semua aspek ilmu Farmasi yang bersifat inovatif, kreatif, Original, dan didasarkan pada scientific dalam bidang kajian farmasi klinis komunitas, farmasi bahan alam, kimia farmasi, teknologi farmasi, farmakologi, toksikologi, managemen farmasi, farmasi umum, mikrobiologi farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 6 Documents
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Search results for , issue "Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA" : 6 Documents clear
Pengaruh Ekstrak Daun Teh terhadap Kualitas Motilitas Spermatozoa Mencit Jantan yang Diberi Paparan Asap Rokok Meki Karolina; Edwin Lewis; Evelyn Angie; Sondang, Silitonga
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

Background: Cigarette smoke exposure is a major contributor to male infertility due to its oxidative stress effects on spermatozoa. Tea leaf extract is known to contain high levels of antioxidants that may counteract these effects. Objective: To determine the effect of tea leaf extract on sperm motility quality in male mice exposed to cigarette smoke. Method: This experimental study used 24 male mice divided into four groups: negative control, cigarette smoke exposure, and two treatment groups receiving cigarette smoke exposure along with 200 mg/kg BW and 400 mg/kg BW of tea leaf extract. Sperm motility was assessed using microscopic examination after 14 days of treatment. Results: The group exposed to cigarette smoke alone showed significantly decreased sperm motility. Administration of tea leaf extract at both doses improved sperm motility, with the 400 mg/kg BW group showing a motility value close to the negative control. Conclusion: Tea leaf extract significantly improves sperm motility in mice exposed to cigarette smoke, likely due to its antioxidant content.
Uji Efektifitas Daun Kemangi (Ocium basilicum L.) Terhadap Pertumbuhan Bakteri Staphylococcus aureus Antonius Fransiskus Putra Meliala
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

The present study investigates the antibacterial efficacy of basil leaves (Ocimum basilicum L.) against the growth of Staphylococcus aureus, a Gram-positive bacterium responsible for various human infections. The increasing resistance of S. aureus to conventional antibiotics has necessitated the exploration of plant-based alternatives with potential antimicrobial activity. Basil leaves are known to contain active phytochemical constituents such as flavonoids, tannins, saponins, and essential oils that may contribute to antibacterial properties. An experimental laboratory study was conducted using a completely randomized design, employing various concentrations of basil leaf extract (10%, 20%, 40%, 80%) tested against S. aureus through the disc diffusion method. Chloramphenicol was used as the positive control, and sterile distilled water as the negative control. The results demonstrated a concentration-dependent antibacterial activity, with the 80% extract exhibiting the largest inhibition zone, though still lower than the zone produced by chloramphenicol. The data were analyzed using one-way ANOVA followed by post hoc Tukey test, indicating significant differences (p < 0.05) among the treatment groups. The findings confirm that basil leaf extract possesses antibacterial activity against Staphylococcus aureus, supporting its potential as a natural antimicrobial agent. These results offer preliminary evidence for the development of phytotherapeutic alternatives in combating bacterial infections, particularly in light of rising antibiotic resistance.
Aktivitas Anti Helmintik Infusa Biji Pepaya (Carica papaya L.) terhadap Cacing Ascaris Suum (Studi in Vitro) Edwin Lewis; Hafiz Muchti Kurniawan; Dhanny Jovindho; Andre Budi
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

Ascaris suum infection remains a significant problem in both veterinary and human health, particularly in areas with poor sanitation. The use of synthetic anthelmintics faces challenges such as resistance and adverse side effects, prompting the search for alternative treatments from natural sources. This study aimed to evaluate the anthelmintic activity of papaya (Carica papaya L.) seed infusion against Ascaris suum through an in vitro approach. Papaya seeds were dried, ground, and extracted using hot water infusion at 90°C. The assay involved immersing A. suum worms in various infusion concentrations (10%, 20%, 30%, and 40%) and observing them at 1, 3, and 6-hour intervals to determine paralysis and mortality times. The results showed that papaya seed infusion exhibited significant concentration- and time-dependent anthelmintic activity. The 40% concentration produced the strongest effect, causing paralysis within 1 hour and mortality within 3 hours. This activity is likely due to the presence of alkaloids, carpaine, flavonoids, and tannins in papaya seeds, which are toxic to the neuromuscular system of the worms. It can be concluded that Carica papaya seed infusion has potential as a natural anthelmintic agent against Ascaris suum.
Uji Aktivitas Anti Helmentik Infusa Daun Papaya (Carica papaya L.) terhadap Cacing Ascaris suum (Studi Invitro) Dhanny Jovindho
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

Penelitian ini bertujuan untuk mengevaluasi aktivitas antihelmintik infusa daun pepaya (Carica papaya L.) terhadap cacing Ascaris suum secara in vitro. Ascaris suum merupakan salah satu parasit nematoda gastrointestinal yang umum menginfeksi hewan ternak dan memiliki kemiripan fisiologis dengan Ascaris lumbricoides pada manusia. Penggunaan obat sintetik sebagai antihelmintik telah banyak dilaporkan menimbulkan resistensi serta efek samping, sehingga diperlukan alternatif dari bahan alam yang lebih aman dan efektif. Daun pepaya diketahui mengandung senyawa aktif seperti papain, flavonoid, tanin, dan alkaloid yang memiliki potensi sebagai agen antihelmintik. Metode yang digunakan dalam penelitian ini meliputi pembuatan infusa daun pepaya dalam berbagai konsentrasi (10%, 20%, 40%, dan 80%), kemudian dilakukan pengamatan terhadap mortalitas cacing A. suum pada waktu pengamatan 1, 3, 6, dan 12 jam. Hasil penelitian menunjukkan bahwa infusa daun pepaya memiliki aktivitas antihelmintik yang signifikan secara konsentrasi dan waktu paparan, dengan konsentrasi 80% menunjukkan efektivitas tertinggi yang setara dengan kontrol positif (piperazin sitrat). Uji statistik menunjukkan perbedaan bermakna (p<0,05) antara kelompok perlakuan dan kontrol negatif. Penelitian ini membuktikan bahwa daun pepaya berpotensi dikembangkan sebagai kandidat bahan alam untuk terapi antihelmintik.
Pengaruh Penggunaan BB Cream terhadap Kejadian Acne Vulgaris pada Mahasiswa Ari Denggan Syahputra
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

Background: The use of cosmetics such as BB Cream has become increasingly common among university students, particularly females, due to its ability to provide even skin tone and a radiant appearance. However, the active ingredients and occlusive agents in BB Cream are suspected to trigger or exacerbate acne vulgaris, especially in individuals with oily or sensitive skin types. Objective: This study aimed to analyze the effect of BB Cream usage on the incidence of acne vulgaris among university students. Methods: This was an analytical observational study employing a cross-sectional design. The sample consisted of 120 female university students aged 18–24 years, selected using purposive sampling. Data were collected through structured questionnaires addressing frequency and duration of BB Cream usage, as well as dermatological clinical examinations to assess the severity of acne vulgaris. Data analysis was conducted using chi-square tests and logistic regression. Results: The findings revealed a significant association between frequent BB Cream usage (≥5 times per week) and an increased incidence of acne vulgaris (p < 0.05; OR: 2.34; 95% CI: 1.21–4.51). Moreover, usage duration longer than three months was positively correlated with acne severity. Conclusion: Frequent and prolonged use of BB Cream significantly contributes to the increased occurrence of acne vulgaris in university students. These findings highlight the need for education on appropriate cosmetic use tailored to individual skin types to prevent adverse skin health outcomes.
Pengaruh Ekstrak Daun Teh terhadap Morfologi Spermatozoa Mencit Jantan Galur Wistar yang diberi paparan asap rokok Ezra John Pieter Limbong
PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA Vol. 2 No. 2 (2023): PHARMANAJA : PHARMACEUTICAL JOURNAL OF UNAJA
Publisher : Program Studi Farmasi UNAJA

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Abstract

Penelitian ini bertujuan untuk mengevaluasi pengaruh ekstrak daun teh (Camellia sinensis) terhadap morfologi spermatozoa mencit jantan (Mus musculus) galur Wistar yang terpapar asap rokok. Sebanyak 25 ekor mencit dibagi menjadi lima kelompok perlakuan: kontrol negatif (tanpa perlakuan), paparan asap rokok saja, serta tiga kelompok perlakuan kombinasi asap rokok dengan ekstrak daun teh masing-masing pada dosis 100, 200, dan 400 mg/kgBB. Paparan asap rokok dilakukan selama 30 menit setiap hari selama 30 hari, bersamaan dengan pemberian ekstrak secara oral. Parameter yang diamati meliputi abnormalitas morfologi spermatozoa, vitalitas spermatozoa, berat testis, dan struktur histologis testis. Hasil menunjukkan bahwa kelompok yang hanya terpapar asap rokok mengalami peningkatan signifikan pada abnormalitas morfologi spermatozoa (29,8%) dibandingkan kelompok kontrol (7,4%). Pemberian ekstrak daun teh secara signifikan menurunkan abnormalitas tersebut secara dosis-respons, dengan dosis 400 mg/kgBB menunjukkan perbaikan paling optimal pada semua parameter yang diamati. Penelitian ini menyimpulkan bahwa ekstrak daun teh memiliki potensi sebagai agen protektif terhadap kerusakan morfologi spermatozoa dan jaringan testis akibat paparan asap rokok. Temuan ini memberikan dasar ilmiah untuk pengembangan terapi berbasis antioksidan alami dalam menjaga kesehatan reproduksi pria.

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