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Puma Arfah
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Journal of Food and Pharmaceutical Science
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.581
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
FOCUS AND SCOPE Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research Food Chemistry Integrated Food Science Health, Nutrition, and Food Food Engineering, Materials Science, and Nanotechnology Toxicology and Chemical Food Safety Food Microbiology and Safety Drug Discovery Computational Chemistry and Molecular Modeling Pharmaceutical Biotechnology and Protein-Peptide Chemistry Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology Pharmaceutical Nanotechnology Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism Analytical and Bioanalytical Chemistry Pharmaceutical Chemistry Natural Medicine and Nutraceutical Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 307 Documents
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Modulation of IL-6 and VEGF by Oral and Topical Curcuma longa Extract in an Excisional Wound Model of Diabetic Wistar Rats Andi Iryanti Mattoreang Caca; Chodidjah Chodidjah; Titiek Sumarwati
Journal of Food and Pharmaceutical Sciences Vol 14, No 5 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28410

Abstract

Diabetic wound healing is characterized by persistent inflammation and impaired angiogenesis. Curcuma longa contains curcuminoids, including curcumin, but the comparative effects of oral, topical, and combined administration remain incompletely defined. This post-test-only experimental study included 30 male Wistar rats allocated by block randomization into six groups (n=5): a healthy, non-diabetic, non-wounded physiological baseline group; a diabetic excisional wound plus hydrogel-base control; a povidone-iodine control; oral crude ethanolic Curcuma longa extract (100 mg/kg body weight); topical 10% extract hydrogel (200 mg/day); and combined oral-topical treatment. Groups G2-G6 underwent streptozotocin induction and excisional wounding. Treatments were administered once daily for six days. Serum IL-6 and skin-tissue VEGF were measured by ELISA on day 7. Serum IL-6 did not differ significantly among groups (Kruskal-Wallis, p=0.117). Skin-tissue VEGF differed significantly (one-way ANOVA, p=0.032), and the combined group had higher VEGF than the diabetic hydrogel-base control (Tukey, p=0.013); all other pairwise comparisons were non-significant. Combined oral and topical Curcuma longa extract administration was associated with higher wound-tissue VEGF, whereas serum IL-6 did not differ significantly. The findings suggest a possible pro-angiogenic effect, but require confirmation using quantitative wound-closure analysis, histology, local inflammatory markers, dose-response assessment, and longer follow-up.
α-Glucosidase Inhibition-Guided Fractionation of Kalincung (Uncaria gambir Roxb. By-Product) using Diaion HP-20 Resin Silvy Arundita; Febry Kurniawan
Journal of Food and Pharmaceutical Sciences Vol 14, No 5 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28478

Abstract

Kalincung is a semi-solid by-product generated during the traditional processing of Uncaria gambir Roxb. and may undergo spontaneous fermentation during post-processing storage. However, it remains underexplored despite its potential as a polyphenol-rich resource. This study compared methanolic extracts of kalincung and dried gambir leaves and evaluated α-glucosidase inhibition-guided fractionation using Diaion HP-20 resin. An assessment of phytochemical constituents was carried out, including the determination of total phenolic (TPC), total flavonoid content (TFC), and vanillin–HCl–reactive flavan-3-ol equivalent profile (VAE; expressed as catechin equivalents, CAE), followed by antioxidant assessment using the DPPH assay (IC₅₀) and α-glucosidase inhibition (IC₅₀). Kalincung exhibited higher TPC (40.10 ± 0.07% GAE) and TFC (35.92 ± 1.12% RAE) than leaves (30.94 ± 0.71% GAE and 21.30 ± 0.71% RAE; p < 0.05), while leaves showed higher VAE values (27.46 ± 0.06% CAE) than kalincung (9.84 ± 0.36% CAE; p < 0.05), reflecting differences in vanillin-reactive flavan-3-ol units rather than absolute proanthocyanidin content. Kalincung demonstrated strong DPPH scavenging activity (IC₅₀ = 9.13 ± 0.05 µg/mL) and α-glucosidase inhibition (IC₅₀ = 32.32 ± 1.20 µg/mL), comparable to leaves. Solvent fractionation enriched bioactivity, with the butanol fraction showing improved α-glucosidase inhibition. Diaion HP-20 fractionation yielded a selected active fraction with increased VAE compared with the crude kalincung extract (48.33 ± 0.39% CAE), accompanied by enhanced functional potency (DPPH IC₅₀ = 8.03 ± 0.07 µg/mL; α-glucosidase IC₅₀ = 17.07 ± 0.42 µg/mL), showing activity within the same order of magnitude as (+)-catechin and showing lower IC₅₀ than acarbose under the present in vitro assay conditions. Taken together, these findings position kalincung as a largely overlooked yet functionally relevant source of polar polyphenolic constituents. Its α-glucosidase inhibitory effect, supported by antioxidant performance, suggests meaningful prospects for early-stage functional evaluation.
Global Research Landscape on Lactobacillus-Based Interventions for Hypercholesterolemia: A Bibliometric and Systematic Review of Scientific Evidence and Therapeutic Efficacy Sang Ayu Made Arenawati; I Nyoman Dwika Dharmanta; I Made Agus Gelgel Wirasuta; Made Ary Sarasmita; Putu Prayascittadevi Empuadji
Journal of Food and Pharmaceutical Sciences Vol 14, No 5 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28615

Abstract

The rising prevalence of hypercholesterolemia has increased interest in Lactobacillus-based probiotic interventions as complementary approaches for lipid management. This study synthesizes clinical evidence and research trends to evaluate the efficacy of Lactobacillus supplementation in improving cholesterol profiles. A systematic review was performed following PRISMA 2020 guidelines and registered in OSF with methodological quality assessed using the Critical Appraisal Skills Programme (CASP) Checklist for RCTs, including randomized controlled trials published between 2015 and 2025. Concurrently, a bibliometric analysis of Scopus and PubMed metadata, conducted using Biblioshiny and VOSviewer, characterized global publication trends, leading authors, and thematic structures. The bibliometric analysis demonstrated rapid scientific growth, notable regional clustering in East and Southeast Asia, and evolving research themes related to gut microbiota and metabolic regulation. Seven randomized controlled trials involving 357 adults with dyslipidemia consistently reported reductions in low-density lipoprotein cholesterol (LDL-C) and total cholesterol for several Lactobacillus strains, particularly L. paracasei and L. plantarum. No significant effects were identified for high-density lipoprotein cholesterol (HDL-C) or triglycerides. Mechanistic evidence indicates the involvement of bile salt hydrolase activity, modulation of apolipoproteins, and anti-inflammatory pathways.  In summary, this integrated analysis demonstrates that Lactobacillus supplementation is associated with LDL-C reduction ranging from approximately 2.16 to 28.2 mg/dL, with a favorable safety profile, and represents a promising adjunctive strategy for hypercholesterolemia. The results also highlight significant opportunities to strengthen global research collaboration.
Hypoxia-Conditioned MSC-Derived Exosomes Mitigate Imiquimod-Induced Psoriasiform Dermatitis by Enhancing FOXP3 Expression and Normalizing Keratin-10 Expression Siti Lia Nurhasanah; Sri Priyantini; Eko Setiawan
Journal of Food and Pharmaceutical Sciences Vol 14, No 5 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28643

Abstract

This study evaluated whether hypoxia-conditioned mesenchymal stem cell–derived exosomes (EH-MSC) mitigate imiquimod (IMQ)-induced psoriasiform dermatitis by enhancing immune regulation and restoring epidermal differentiation. Male Wistar rats (n=32) were used: 30 rats were randomized into five experimental groups (n=6 per group)—healthy control (G1), IMQ + saline (G2), IMQ + methotrexate (G3), IMQ + EH-MSC 100 µL (G4), and IMQ + EH-MSC 200 µL (G5)—and two additional rats were used for model validation. Psoriasiform dermatitis was induced using topical IMQ 5% for 7 days, followed by intradermal treatments (EH-MSC on days 1 and 3 post-validation). EH-MSC exosomes were generated from hypoxia-primed MSC cultures and confirmed by CD63/CD9 markers. Cutaneous FOXP3 and keratin-10 (K10) were quantified by qRT-PCR at the terminal time point. IMQ produced typical psoriasiform plaques and histologic changes. FOXP3 differed significantly among groups (ANOVA p<0.001) and increased dose-dependently with EH-MSC, peaking in G5 (1.84±0.29 pg/mL) versus G2 (0.65±0.33 pg/mL). K10 also differed significantly (p<0.001) and shifted toward healthy levels with EH-MSC, most closely in G5 (1.35±0.71 pg/mL) versus G2 (3.86±0.67 pg/mL). These findings show that EH-MSC treatment was associated with increased FOXP3 expression, suggesting enhanced Treg-associated immunoregulatory activity, and normalization of K10 expression toward healthy control levels.
Optimization and Characterization of Serum of Red Onion Skin Extract and Antioxidant Activity Dina Permata Wijaya; Fakhira Nabila; Shaum Shiyan; Herlina Herlina; Viva Starlista
Journal of Food and Pharmaceutical Sciences Vol 14, No 5 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28645

Abstract

Red onion (Allium cepa L.) skin is enriched with flavonoids, steroids, and phenolic compounds, which possess the potential to promote hair growth. The present investigation sought to optimize gelling agent concentrations within hair serum formulations incorporating red onion peel extract (Allium cepa L.) for its antioxidant properties. Formula optimization was executed employing the Regular Two-Level Factorial Design methodology utilizing Design Expert® 13 software. Two independent variables were examined: carbomer 940 concentration ranging from 0.1–0.3% and sodium alginate concentration ranging from 0.5–1%. Through factorial analysis of physical properties, formula 2 emerged as optimal, containing carbomer 940 at 0.3% and sodium alginate at 1%. The resultant formulation demonstrated the following physicochemical characteristics: pH of 6.14±0.01, viscosity of 854.35±12.87 cP, spreadability of 7.26±0.70 cm, adhesiveness of 8.02±0.19 cm, and additional adhesion metrics of 8.69±0.27 cm, 4.17±0.23 s, and 3.35±0.26 s. Accelerated stability assessment via cycling protocols revealed preservation of organoleptic integrity, absence of phase separation or syneresis, and constancy in pH and viscosity parameters. The optimal red onion peel extract serum formulation demonstrated an IC50 value of 84.00 ppm, reflecting substantial antioxidant capacity and considerable promise for further pharmaceutical development as an antioxidant agent.
The Effect of Total Flavonoid Content of Butterfly Pea Flower Kombucha on Reducing Serum Total Cholesterol Levels in vitro and in vivo in Rats Agus Suprijono; Aries Koes Sundoro; Ariani Hesti Wulan S
Journal of Food and Pharmaceutical Sciences Vol 14, No 5 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28878

Abstract

High-cholesterol foods cause metabolic disorders characterized by high cholesterol levels. Butterfly Pea Flower Kombucha, which contains anthocyanins (flavonoids), was obtained by fermenting a mixture of fresh butterfly pea flowers with a SCOBY (Symbiotic culture of bacteria and yeast). This study aimed to determine the effect of butterfly pea flower kombucha in reducing total cholesterol. The study began with the production of butterfly pea flower kombucha from 30%, 40%, and 50% fresh butterfly pea flowers fermented with a SCOBY. Total flavonoid levels were determined using visible spectrophotometry with a wavelength of 439.00 nm. Cholesterol levels were determined in vivo by feeding fermented tea to groups of white rats (C-, C+, S1, S2, and S3) for 10 days, after which they were fed lard for 14 days. The results showed that butterfly pea flower kombucha of 30%, 40%, and 50% had a total flavonoid content of 55.75 + 0.656, 84.59 + 1.912, and 154.38 + 0.476 mgQE/100mL. The sample and control could reduce cholesterol by an average of 11.83 + 0.94%, 21.14 + 1.58%, 31.36 + 0.98%, and 32.85 + 1.17%. Statistical tests showed the effect of butterfly pea flower kombucha which can lower cholesterol. This study shows that consuming butterfly pea flower kombucha can reduce cholesterol.
Assessment of the Antibacterial, Antioxidant, and Short-Term Physicochemical Stability of Soul Wedang (Sodang) Ni Luh Dian Saptari Amelia Putri; I Dewa Made Siwananda; Sagung Chandra Yowani; Ni Putu Ariantari
Journal of Food and Pharmaceutical Sciences Vol 14, No 5 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.29539

Abstract

Sodang is an Indonesian herbal drink composed of lemongrass, ginger, turmeric, lime, palm sugar, and salt. Each constituent is known for its antibacterial and antioxidant properties. However, no studies had previously evaluated the combined activity of these ingredients. This study aimed to determine the antibacterial and antioxidant activities of Sodang, as well as its physicochemical stability during storage. The research consisted of several stages, including concentration of the Sodang extract, moisture content analysis, phytochemical screening, antibacterial testing using the microdilution method, antioxidant testing via the ABTS method, and stability evaluation over a 7-day period. Concentration of 2 Liters of Sodang produced 155 g of thick extract, with a moisture content of 3.98 ± 0.0036%. Phytochemical screening revealed the presence of flavonoids, terpenoids, triterpenoids, and polyphenols. The extract did not exhibit antibacterial activity against B. cereus and E. coli (MIC > 128 mg/mL). The antioxidant activity of Sodang, indicated by an IC₅₀ value of 7,976.67 ± 95.70  ppm, was classified as very weak compared to vitamin C (IC₅₀ = 27.42 ± 0.47 ppm). The physicochemical properties of Sodang remained stable through day 7, as evidenced by consistent organoleptic characteristics, pH, viscosity, and TLC profile for flavonoids and triterpenoids.

Page 31 of 31 | Total Record : 307

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