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Journal of Food and Pharmaceutical Science
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.581
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
FOCUS AND SCOPE Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research Food Chemistry Integrated Food Science Health, Nutrition, and Food Food Engineering, Materials Science, and Nanotechnology Toxicology and Chemical Food Safety Food Microbiology and Safety Drug Discovery Computational Chemistry and Molecular Modeling Pharmaceutical Biotechnology and Protein-Peptide Chemistry Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology Pharmaceutical Nanotechnology Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism Analytical and Bioanalytical Chemistry Pharmaceutical Chemistry Natural Medicine and Nutraceutical Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 274 Documents
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A Simple LC-MS/MS Method for Determination of Gentamicin in Human Plasma and Uncertainty Evaluation Prihati, Dita Amalia; Nurrokhimah, Miftah; Fatimah, Nurul; Harjono, Sigit Sulistya; Nafiisah, Nur Hasna; Yuliani, Hanifah Ratna; Palgunadi, Tama Jahtra
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25028

Abstract

Gentamicin is an antibiotic with a narrow therapeutic index that necessitates therapeutic drug monitoring (TDM) to enhance efficacy and reduce toxicity. The goal of this study was to a simple, sensitive, and reliable LC-MS/MS method for measuring gentamicin in human plasma with a key novelty being the comprehensive assessment and documentation of measurement uncertainty integrated into the method validation process. The method used a Sciex QQQ 4500 LC-MS/MS system equipped with a C18 column, 5 x 20 mm, 4 µm Fusion-RP 80 Å, and operated in multiple reaction monitoring (MRM) mode, employing amikacin as the internal standard. Method validation was conducted following ICH M10 (2022) guidelines, encompassing parameters of selectivity, linearity, accuracy, precision, stability, dilution integrity, and carry-over. The calibration curve showed good linearity (r² = 0.990–0.996) over the range of 100–5000 ng/mL, with a lower limit of quantification (LLOQ) of 100 ng/mL. Across all concentration levels, accuracy (within ±15%; ±20% at LLOQ) and precision (≤15% CV; ≤20% at LLOQ) met the acceptance criteria. Short term stability experiments indicated that the samples maintained enough rigidity for various handling and storage method. We used EURACHEM and JCGM GUM guidelines to figure out the measurement uncertainty. The standard error of the slope (SEm) was the biggest factor. The total uncertainty was found to be 0.27 ng/mL, which means that the expanded uncertainty is ±0.55 ng/mL with 95% confidence. The validated method is strong and dependable, which makes it good for use in clinical settings for gentamicin TDM.
Effect of Avocado Leaf Ethanol Extract Gel (Persea americana Mill) on Healing Diabetic Wounds Widyaningsih, Wahyu; Yuliani, Sapto; Anasyua, Fairuz Khairunnisa; Bahagia, Tasya; Yuliawanti, Risma
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25562

Abstract

Diabetic wounds are a major clinical challenge due to delayed healing and increased complication risks. Ethanol extract of avocado leaves (Persea americana Mill.) has previously shown promise in enhancing tissue regeneration in diabetic wounds, but its potential in gel form remains untested. This study aimed to develop an avocado leaf ethanol extract-based gel and evaluate its woundhealing potential in diabetic mice. Avocado leaves were extracted using 70% ethanol and formulated into a gel, which was evaluated for physical properties and topical suitability. Diabetic mice were divided into five groups: normal control, negative control (gel base), positive control (bioplacenton), and two treatment groups (5% and 10% gel). Diabetes was induced using alloxan (150 mg/kg BW), followed by wound induction and treatment. Wound healing was assessed through visual assessment, wound diameter reduction, and healing duration. Statistical analysis was performed using one-way ANOVA with a 95% confidence level. Results showed the gel meets physical properties (pH test, organoleptic test, homogeneity test, spreadability test) and significantly improved wound healing in diabetic mice. The 5% gel demonstrated wound-healing activity due to bioactive compounds such as saponins, tannins, alkaloids, and flavonoids. Further analysis is needed to identify the specific components responsible for the healing effects, highlighting the gel’s potential for diabetic wound treatment.
Acute Toxicity Test of Healthy Drink of Anthocyanin Pigmented Polyphenols from Black Rice and Sprouts Soybean Kintoko, Kintoko; Salamah, Nina; Witasari, Hardi Astuti; Maulizah, Rizlah
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25784

Abstract

Black rice and sprouted soybean (BRiSS) can be formulated into a healthy drink BRiSS. The safety of this novel combination must be rigorously tested. Therefore, this study was designed to conduct a comprehensive acute toxicity test of the healthy drink flavylium anthocyanins from black rice (Oryza sativa L. indica) pigmented polyphenols from soybean sprouts (Glycine max L.). The black rice was extracted with a 96% ethanol solution in 3% citric acid. The pigmentation process was achieved by adding hydroxyl groups from soybean polyphenols. The active material was mixed with 20% maltodextrin, shaken, poured into a pan, and dried with a cabinet dryer (60° C). The mixture was stirred with 0.3% sodium, 0.1% citric acid, 50% active ingredients, 5% sucrose as a sweetener, 0.05% sodium benzoate, and water, 100 ml. The five groups of male Wistar rats were acclimatized. Group 1 was a control, and groups 2, 3, 4, and 5 were sequentially treated with a healthy drink containing extract doses of 5, 50, 300, and 2000 mg/kg BW. The acute toxicity test results at 30 minutes, 3 to 24 hours, day 3, and day 14 were written on the acute toxicity test clinical symptom observation sheet. All test animals, including both the control and test groups with various dosage variations, did not exhibit changes in skin, fur, eyes, behavior, respiratory systems, and did not experience weight loss, seizures, tremors, lethargy, or diarrhea. The limitation was that the macropathology examination of internal organs (kidneys, liver, heart, brain, stomach, intestines, pancreas) was not performed. Not all animals have mortality in a 5-3000 (mg/kg BW) extract dose.
Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Anggraini, Deni; Agistia, Nesa; Fernando, Armon; Yulia, Amanda; Repuja, Dira
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
Investigation of Column Temperature and Validation of an HPLC-PDA Method for Hydrogen Peroxide Analysis in Hair Cosmetics under Tropical Environments Dinalia, Dinalia; Sosidi, Husain; Ridhay, Ahmad; Hannan, Hannan; Khairuddin, Khairuddin; Satrimafitrah, Pasjan; Syamsuddin, Syamsuddin
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26426

Abstract

Hydrogen peroxide (H₂O₂) is widely used as an oxidizing agent in hair cosmetic products, requiring reliable and validated analytical methods to ensure product safety and regulatory compliance. This study investigated the effect of column temperature and validated a high-performance liquid chromatography–photodiode array (HPLC–PDA) method for H₂O₂ determination in hair cosmetic formulations using triphenylphosphine (TPP) derivatization under tropical laboratory conditions. The triphenylphosphine oxide (TPPO) derivative exhibited a stable maximum absorbance at 222 nm within the concentration range of 20–120 ppm, which was selected as the detection wavelength. System suitability was evaluated at ambient temperature, 35, 40, 45, and 50 °C. Column temperatures between 40 and 50 °C fulfilled all system suitability and validation criteria, demonstrating acceptable efficiency, peak symmetry, retention time stability, and reproducibility. Among these conditions, 40 °C was selected as the optimum column temperature based on overall analytical performance and practical considerations. Method validation showed excellent linearity (correlation coefficient r ≥ 0.995; residual variance Vxo ≤ 5%), acceptable precision (%RSD ≤ 2%), and adequate sensitivity, expressed as limits of detection (LOD) and limits of quantification (LOQ). Accuracy evaluation using matrix-spiked samples yielded recoveries within the AOAC acceptance range (90–107%). Overall, the validated HPLC–PDA method at 40 °C with detection at 222 nm is robust and suitable for routine determination of H₂O₂ in hair cosmetic products under tropical conditions.
Ethnomedicinal Study and Thin Layer Chromatography Confirmation of Medicinal Plants to Treat Digestive Disorders in Medong Village, Pandeglang, Banten Rindita Rindita; Supandi Supandi; Nuriza Rahmadini; Daffa Nur Fadhlurrohman; Syilbi Ayu Riani
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23223

Abstract

Medicinal plants with anti-ulcer and anti-diarrheal properties are often used by the community to treat digestive disorders in Medong Village, Pandeglang, Banten, but have not been well recorded. The purpose of this study was to document the types of plants used as traditional medicine to treat ulcers and diarrhea, and to identify secondary metabolite compounds using thin-layer chromatography (TLC). Sampling was conducted using purposive and snowball sampling methods with 70 informants. Quantitative data analysis was carried out by calculating the use value (UV). The results of data collection from 70 informants identified 15 plant species used as anti-ulcer and antidiarrheal agents. Based on the highest UV value, guava leaves and turmeric had the highest UV as antidiarrheal, and red leaf had the lowest. For treating ulcers, turmeric and nangka walanda leaves have the highest UV, and mamangkokan (Polyscias scutellaria) has the lowest. The parts of the plant that are often used as medicine are leaves, rhizomes, and herbs. Phytochemical screening showed that almost all samples contained secondary metabolite compounds that have antidiarrheal and antiulcer activity, namely flavonoids and tannins, and their presence was confirmed using TLC, with Rf values within the standard value range.
Formulation and Evaluation of Herbal Shampoo containing Red Dragon Fruit Peel Extract (Hylocereus polyrhizus (Hook.) Britton & Rose): toward A Potential Anti-Dandruff Application Desti Kameliani; Sukmawati Sukmawati; Herliningsih Herliningsih; Cucu Suhartini
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23330

Abstract

Dandruff is a common scalp condition influenced by factors such as an oily scalp, hormones, and fungal infections. Red dragon fruit peel (Hylocereus polyrhizus) contains flavonoids with natural antimicrobial activity, making it a promising natural ingredient for scalp care. This study aimed to develop and evaluate herbal shampoo containing red dragon fruit peel extract. Four formulations were prepared with different concentrations of extract: F0 (base), F1 (6.25%), F2 (12.5%), and F3 (25%). Each was assessed for organoleptic properties, homogeneity, pH, viscosity, foam height, and foam stability. The stability test was evaluated using a cycling test. Data analysis with One-way ANOVA revealed that extract concentration significantly influenced pH and viscosity stability (p < 0.05). F1 showed optimal physical properties and complied with SNI 06-2692-1992 standards. These findings support the potential use of red dragon fruit peel extract in herbal shampoo formulations for future anti-dandruff applications.
Detection of Adulterants in the Essential Oil by Curcuma aeruginosa Roxb. FTIR Spectroscopy and Multivariate Analysis Bekti Nugraheni; Ratna Asmah Susidarti; Purwanto Purwanto; Abdul Rohman
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25651

Abstract

Authentication of Curcuma aeruginosa Roxb. essential oils (EOs-CA) is critical to prevent adulteration and to ensure the quality and safety of derived products. This study aimed to evaluate the effectiveness of Fourier Transform Infrared (FTIR) spectroscopy in combination with chemometric methods for the authentication of EOs-CA, particularly in the presence of adulterants such as Virgin Coconut Oil (VCO). VCO was selected as an adulterant model due to its spectral similarity with EOs-CA. Discriminant Analysis (DA) and multivariate calibration techniques—Partial Least Squares (PLS) and Principal Component Regression (PCR)—were employed for the classification and quantification of adulterated EOs-CA samples, including those mixed with Curcuma xanthorrhiza essential oil (EOs-CX). A total of 26 samples were prepared, comprising binary mixtures of EOs-CA/EOs-CX and ternary mixtures of EOs-CA/EOs-CX/VCO, with adulterant concentration levels ranging from 0% to 100%. FTIR spectral data were collected in the wavenumber range of 4000–650 cm⁻¹ using an Agilent Cary 630 FTIR-ATR spectrophotometer (USA). Chemometric analyses were conducted using DA, PLS, and PCR methods through TQ Analyst software version 9 (Thermo Fisher Scientific, Inc.). The DA method successfully classified authentic and adulterated samples with accuracy rates of 99.99% and 99.96% for the binary and ternary systems, respectively. Quantitative determination of EOs-CA in binary mixtures with EOs-CX was achieved using the second derivative of FTIR spectra in the 1770–728 cm⁻¹ region, yielding coefficients of determination (R²) of 0.9992 and 0.9994 for the calibration and validation models, respectively. The Root Mean Square Error of Calibration (RMSEC) and Prediction (RMSEP) were 1.19% and 1.16%, respectively. These findings demonstrate that FTIR spectroscopy combined with chemometric techniques provides a reliable and accurate method for detecting adulteration and authenticating EOs-CA against potential adulterants such as EOs-CX and VCO.
Prediction of the Potential Active Compounds in Cucumber (Cucumis sativus L) against Hypertension using Pharmacological Network (Cytoscape) Camelia Maktur; Febrial Hikmah
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26201

Abstract

Hypertension is the leading cause of heart disease, kidney failure and stroke in Indonesia. Antihypertensive drugs have proven effective in managing blood pressure levels. However, long-term use of these medications may lead to side effects, reduce patient compliance and increased healthcare costs. Various studies have reported the cucumber (Cucumis sativus L) effect in controlling blood pressure. The purpose of this study is to investigate the molecular basis of these effects and identify the specific pathways involved. This research is a systematic review in silico network pharmacology analysis to forecast the antihypertensive potential of cucumber derived active compounds. By employing computational methods to explore plant-based therapeutic effects, the study identified bioactive components and their targets through the ChEMBL database, followed by protein validation using the Open Targets Platform. The findings contribute to the growing evidence that cucumber plants may play a role in hypertension management through multi-target mechanism.
Optimization, Characterization, and Antioxidant Activity of Sunflower Oil-Based SNEDDS using Response Surface Method Rodhia Ulfa; Gressy Novita; Sella Asharianti
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26418

Abstract

This study aims to optimize, characterize, and evaluate the antioxidant activity of sunflower seed oil-based SNEDDS using Tween 80 and PEG 400. The study utilizes Simplex Lattice design and Response Surface Methodology to obtain a formula with the best physical characteristics and efficacy. Sunflower seed oil was selected due to its high content of essential fatty acids and antioxidants. The optimization method involved determining the ratio of surfactant, cosurfactant, and oil, as well as characterization tests of particle size, polydispersity index, zeta potential, emulsification time, and antioxidant activity. The results showed an optimal formula with a nano particle size of 13 nm ± 0.346, low polydispersity index (0.161 ± 0.067), and zeta potential of -21.8 mV ± 0.577, ensuring physical stability. The antioxidant activity of SNEDDS remained high with an IC50 of 18.06 μg/mL. Formulation verification through statistical analysis confirmed the consistency of experimental results with optimization software predictions. In conclusion, the optimized sunflower seed oil SNEDDS offers an innovative oral formulation that is efficient, stable, and safe, with the potential to improve bioavailability, pharmacological activity, and the utilization of local vegetable oils in modern pharmacy.

Page 27 of 28 | Total Record : 274

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