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Journal of Food and Pharmaceutical Science
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.581
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
FOCUS AND SCOPE Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research Food Chemistry Integrated Food Science Health, Nutrition, and Food Food Engineering, Materials Science, and Nanotechnology Toxicology and Chemical Food Safety Food Microbiology and Safety Drug Discovery Computational Chemistry and Molecular Modeling Pharmaceutical Biotechnology and Protein-Peptide Chemistry Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology Pharmaceutical Nanotechnology Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism Analytical and Bioanalytical Chemistry Pharmaceutical Chemistry Natural Medicine and Nutraceutical Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 224 Documents
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The Characteristic of Lada Powder wrapping with various of packaging (biodegradable film of composite film from Sodium CarboxymethylCellulose which syntesized from Pineapple crown, Biodegradable film of Commercial Sodium CarboxymethylCellulose, and Plastics) during storages Susana, Susana; Mangunsong, Lamria; Iskandar, Dodi; Purwandani, Ledy
Journal of Food and Pharmaceutical Sciences Vol 6, No 3 (2018): J. Food Pharm. Sci (Sept-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (401.048 KB) | DOI: 10.14499/jfps

Abstract

ABSTRACTThis study aimed to evaluate the use of the composite film Sodium Carboxymethyl Cellulose on the crown of the pineapple to volatile substances of Lada powder, include piperin content (HPLC), Steps being taken in this research is the manufacture of composite films NaCMC and application in Lada powder. The stages in this research are cellulose extraction step and cellulose modification into CMC, making and characterizing composite film as spice packing and its application as spice packer. Cellulose extraction from pineapple crown with 12% NaOH and carboxymethylation with sodium monocloroacetate. Films of sodium carboxymethylcellulose, polyethylene glycol 400 as plasticizer and emulsifier and coconut oil as hydrophobic component to obtain composite film as a spice packing with mechanical properties such as seal strength, thickness, WVTR and solubility in hot water suitable for application as spice packing with thickness 0.085mm) and 350ºC sealing temperature variations. The result of the study of carboxymethyl group of pineapple crown CMC synthesis with HPLC showed that plastic packaging is best compared to using CMC comercial and pineapple crown to lada powder wrapping.
Chemical Characterisation, Organic Acids by HPLC, Fatty Acids by GC-GCMS and Antioxidant Activity of Commonly Consumed Leafy Vegetables in India Pamidighantam, Prabhakara Rao
Journal of Food and Pharmaceutical Sciences Vol 6, No 3 (2018): J. Food Pharm. Sci (Sept-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (408.576 KB) | DOI: 10.14499/jfps

Abstract

Chemical, organic acids, fatty acid composition and antioxidant activity of commonly consumed leafy vegetables such as Hibiscus cannabinus, Rumex vesicarius, Basella rubra and Alternanthera sessilis were investigated. High performance liquid chromatography (HPLC) was used to quantify organic acids in leaf powders. Protein and fibre contents of Alternanthera sessilis leaf powder were the highest (31.2, 12.5% respectively) and lowest in Hibiscus cannabinus leaf powder (20.86 and 3.94%) among the leaf powders analysed. Oxalic acid was found to be the dominant acid in all the leafy vegetable powders and it was maximum in Alternanthera sesilis (10733 mg/100g) and Basella rubra (23331 mg/100g) powders. Gas and mass chromatography (GC-MS) analysis of leaf powder lipids were rich in palmitic (14.6 – 24.2%), linolenic (25.6 -56.9%), linoleic  (15.4-21.1%) and oleic (2.6 -  13.7%) acids. Hibiscus leaf powder exhibited maximum inhibition of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical with 95% inhibition at 2.8 mg/ml concentration and assay 92%  of ABTS (2, 2-Azinobis-3-ethyl Benzothiazoline-6-Sulfonic acid) diammonium salt) at 0.6mg/ml concentration.
Analytical method development of pitavastatin-loaded SNEDDS formulation: Multivariate analysis regarding ultraviolet spectrophotometry analysis Rohman., Abdul
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (559.273 KB) | DOI: 10.14499/jfps

Abstract

Herein, this work aimed to develop and assess feasibility of multivariate model of partial least square analysis for specific quantification of pitavastatin (PVT)-loaded self-nano emulsion (SNE) formulation using UV-Vis spectrophotometry.    PVT loaded into self-nano emulsion formulation comprising of Capryol-90, Tween 80, and Transcutol P under different loading levels i.e. 10-90 mg/mL. All samples scanned using UV-Vis spectrophotometer from 300-200 nm. PVT and SNE were prepared separately for estimation of interference. Multivariate model was constructed using partial least square (PLS) regression analysis as well as principal component analysis for qualitative pattern recognition. Cross-validation using a leave one out technique and goodness of fit parameters were applied for model evaluation.    The results revealed that maximum sensitivity of PVT was obtained at 244 nm. SNE formulation had different interference value and decreased exponentially as increasing the PVT loading in the SNEDDS formulation. The highest drug loading had an interference value of 7.11%. Therefore, the SNEDDS formulation interfered the PVT quantification and mainly depended on the drug loading. Finally, multivariate analysis, PLS could be applied to eliminate the placebo/formulation interference for PVT quantification independently towards drug loading level.
THE EFFECT OF ADDITION OF PIRDOT LEAF EXTRACT AND JUICE OF RED WATERMELON ALBEDO ON CARBONATED COCONUT DRINK OF BLOOD GLUCOSE LEVELS OF MICE Utami Barus, Cindy Puteri
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.152 KB) | DOI: 10.14499/jfps

Abstract

In this study, the effect of addition of pirdot leaf extract and juice of red watermelon albedo on carbonated coconut drink of blood glucose levels was done by giving samples orally to mice. This study used 30 white male wistar mice, which were divided into 6 treatment groups that containing 5 mice in each group i.e: normal untreated mice given with aquades (negative control), diabetic untreated mice given with aquades (positive control), normal mice treated with 0.6 mL per 27 g bw per day of carbonated coconut drink, diabetic mice treated with 0.6 ml per 27 g bw per day of carbonated coconut drink, normal mice treated with 0.6 mL per 27 g bw per day of commercial soda, and diabetes mice treated with 0.6 mL per 27 g bw per day of commercial soda. The treatment was carried out for 14 days and observations made on blood glucose levels and body weight of mice. The results showed that giving of carbonated coconut drink by adding pirdot leaf extract and juice of red watermelon albedo had a highly significant effect on blood glucose levels of mice. The effect was hypoglycemic effect, which can reduce blood glucose levels on the diabetes group about 6,536%, while on the non-diabetic group about 3,316%. However, the giving of commercial soda provides a hyperglycemic effect that increased blood glucose levels about 19,787% on the diabetic group, while on the non-diabetic group about 12,750%. In addition, giving of carbonated coconut drink by adding pirdot leaf extract and juice of red watermelon albedo had a highly significant effect on the body weight of mice. The effect was weight gain on the diabetes group about 4,171%, while on non-diabetics about 2,564%. However, giving commercial soda had a weight loss effect about 33,750% on the diabetic group, while on the non-diabetic group about 6,884%.
KNOWLEDGE, ATTITUDE AND PERCEPTION ON HALAL DIETARY SUPPLEMENTS AMONG SPORT STUDENTS IN UNIVERSITIES OF MALAYSIA SANTA, KHAIRIAH BINTI
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/jfps

Abstract

This is a cross-sectional study. It was disbursed between April 2019 and May 2019, using module and self-administered questionnaires to evaluate the Knowledge, Attitude and Perception (KAP) regarding halal supplement among sport students in public universities of Malaysia (UITM, UM and UPSI). Aim for this study is to find out the awareness level of halal dietary supplement among sport students’ in three public universities.  The study was conducted on a sample of n=167. Inclusion criteria was a full time students of sport school of public university in Malaysia. Data was collected through module presentation and pre-post questionnaires. Results discovered that student have a good knowledge and positive attitude and perception regarding halal supplement after intervention. Mean knowledge score out of maximum possible 8 was 0.96±0.101, mean attitude score out of maximum possible score of 50 was 4.50±0.623, while mean perception score out of maximum possible score of 75 was 4.69±0.551. Mean overall KAP score out of maximum possible score of 167 was 3.38±0.365. There was a significant, positive and fair correlation between knowledge and attitude, knowledge and perception and attitude and perception which is all p=0.000. Result shows that the better knowledge the students have on halal supplement, the better their perception and attitude is towards halal supplement. P value of 0.05 or less was taken as statistically significant.
OBTAIN CUCURBITACIN FROM Ecballium elaterium and Cucurbita pepo and CONVERTING INTO A PHARMACEUTICAL FORM Duran, Derya
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (40.275 KB) | DOI: 10.14499/jfps

Abstract

The squirting cucumber plant is widely used in the treatment of sinusitis, rheumatism, and hepatitis. It is reported that the liquid obtained from fruits is widely used in the treatment of sinusitis among people, especially in Turkey. The active components of Nigella sativa seeds are shown to be effective in inflammatory diseases caused by histamine. In this study, it was aimed to create a spray form by extracting Ecballium elaterium and Cucurbita pepo plants, which are easily found in almost every region of Turkey, mixing them with black cumin oil which is used widely and traditionally, and using inactive ingredients. Firstly, the amounts of cucurbitacin D, I, B, E from Ecballium elaterium were determined by HPLC and validation of cucurbitacin active substance analytical method was performed. Physicochemical properties of the nasal spray including pH, osmolality, specific gravity, and viscosity values were determined. Skin irritation, sensitization, and cytotoxicity tests were performed on the final product. The total amount of cucurbitacin D, I, B, E in squirting cucumber was found to be about 4% of the fruit juice. The proportion of these substances was also examined in squash juice and was found to be 0.033% for the respective amount. Skin irritation, sensitization, and cytotoxicity tests were performed in the obtained product and no adverse effects were observed. In addition, physicochemical parameters of the spray, such as pH, osmolality, specific gravity, and viscosity were measured. Results were found as 6.179, 630 mOsmol/L, 55.4 Mpa/s and 1,080 g/cm3 at ph 25 ºC, respectively.
Formulation of Anti-Acne Gel of Moringa oleifera, L. Ethanolic Extract and Antibacterial Test on Staphylococcus epidermidis Ermawati, Dian Eka; Ramadhani, Cahyarani Intan
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/jfps

Abstract

Moringa oleifera L. leaves contain flavonoid, alkaloid, and phenolic compounds which have antibacterial activity. Staphylococcus epidermidis is one of the bacteria that causes acne. The purpose of this study is to compare bacteriostatic ability of the extracts and gel for S. epidermidis bacteria and to get gel formula that can fulfills the physical properties of a good gel.Moringa leaves were extracted with maceration method using ethanol 70% in three days. HPMC 4000 was used as the polymer. Extract was added with variation concentrations of 5, 10, and 15%. Physical evaluation of gel was organoleptic, homogeneity, pH, viscosity, adhesion, and spread tests for 4 weeks. In vitro bacteriostatic activity test with 1% clindamycin gel as positive control and polymer gel as negative control.The result showed that variations concentrations of ethanolic extract of Moringa leaves affected the physical properties of gel including viscosity, pH, adhesion and spreadability. Bacteriostatic activity test of ethanolic extract of Moringa leaf was classified as strong activity, while 15% Moringa leaf ethanol extract gel was classified as moderate activity with average diameter was 9.14 mm
Phytochemical composition, mineral content and antioxidant activities of the methanol extract of Curcuma longa and Viscum album Nwozo, Sarah Onyenibe; Effiong, Magdalene Eno
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/jfps

Abstract

The medicinal value of plants have assumed a more important dimension in the past few decades owing largely to the discovery that extracts from plants contain not only minerals and primary metabolites but also a diverse array of secondary metabolites with antioxidant potentials. However, there is dearth of knowledge on the medicinal uses and nutritional benefits of Curcuma longa and Viscum album. This study was designed to focus on the phytochemical and mineral composition in addition to the antioxidant activities of the methanol extracts of C. longa and V. album. Results indicated that the micro and macro mineral analysis exhibited significant presence of Fe, Zn, Mn, Ca and Mg while Cd, Pb, Ni and Cr were present in minute quantities. Phytochemical screening unravelled the presence of alkaloids, cardiac glycosides, steroids, phenols, tannins, saponins and flavonoids that were also proved by the quantitative analysis. There was a high correlation between the flavonoid content and antioxidant activities of the plant extracts. The antioxidant activities of the extracts were found to be concentration dependent. The results suggest that both plant extracts have good medicinal potentials and can serves as good sources of macro minerals.
The Biochemistry, Toxicology, and Uses of the pharmacologically active phytochemicals: Alkaloids, Terpenes, Polyphenols, and Glycosides Awuchi, Chinaza Godswill
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/jfps

Abstract

The research focused on the biochemistry and the medicinal uses of alkaloids, terpenes, polyphenols, and glycosides. Several parts of plants such as bark, root, leaf, stem, etc. are being used to revert abnormalities back to normal, prevent illnesses, or allay symptoms. These plant parts contain bioactive compounds such as terpenes, glycosides, polyphenols, and alkaloids. Alkaloids have a range of pharmacological activities such as antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine), antimalarial (e.g. quinine). Other alkaloids possess stimulant (e.g. cocaine, caffeine, theobromine, nicotine) and psychotropic activities (e.g. psilocin), and have been widely used as recreational drugs or in entheogenic rituals. Alkaloids can be toxic too (e.g. tubocurarine, atropine). Although alkaloids act on diverse metabolic systems in humans and animals, they almost uniformly induce a bitter taste. The characteristics and number of the structures of phenol in polyphenols underlie the unique chemical, physical, and biological (metabolic, therapeutic, toxic, etc.) properties of specific members of the class; e.g. ellagitannin and tannic acid. Generally, foods often contain complex mixtures of polyphenols. Several polyphenolic extracts, such as from grape seeds, olive pulp, maritime pine bark, or grape skin, are sold as ingredients for functional foods, cosmetics, and dietary supplements. Terpenoids and terpenes are the primary components of the essential oils of most types of flowers plants. Essential oils are used widely as scents and fragrances in perfumery and also in traditional medicine, such as aromatherapy. Similarly, many plant glycosides are used as medicines Amygdalin and laetrile (a synthetic derivative) were investigated as potential drugs for cancer treatment and were promoted as alternative medicine; nevertheless, they are ineffective and dangerous. Pharmacologically active phytochemicals can have useful applications, as well as safety concerns.
Radical Scavenging Activity and Quercetin Content of Muntingia calabura,L Leave extracted by Various Ethanol Concentration Pertiwi, Ratih Dyah
Journal of Food and Pharmaceutical Sciences Vol 7, No 1-3 (2019): J. Food Pharm. Sci (January-December) In Press
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/jfps

Abstract

ABSTRACT Muntingia calaburais broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract of Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colourimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated thatMuntingia calaburaleaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solvent Keywords: DPPH, Muntingia calabura, phenolic total, antiradical activity, TLC densitometry 

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