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INDONESIA
Journal of Food and Pharmaceutical Science
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.581
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
FOCUS AND SCOPE Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research Food Chemistry Integrated Food Science Health, Nutrition, and Food Food Engineering, Materials Science, and Nanotechnology Toxicology and Chemical Food Safety Food Microbiology and Safety Drug Discovery Computational Chemistry and Molecular Modeling Pharmaceutical Biotechnology and Protein-Peptide Chemistry Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology Pharmaceutical Nanotechnology Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism Analytical and Bioanalytical Chemistry Pharmaceutical Chemistry Natural Medicine and Nutraceutical Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 224 Documents
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Radical Scavenging Activity and Quercetin Content of Muntingia calabura L. Leaves Extracted by Various Ethanol Concentration Ratih Dyah Pertiwi; Suwaldi; Ronny Martien; Erna Prawita Setyowati
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.581

Abstract

Muntingia calabura is broadly cultivated and has become a common roadside tree in Indonesia that is known as "Kersen," or cherry. The current study aimed to determine the activities of the phytochemical constituent (i.e., phenolic and flavonoid total contents) with various concentrations of ethanolic extract of M. calabura leaves (EEMC) to determine the best one and the in vitro antioxidant activities and quercetin content using TLC Densitometry. The extraction was carried out by maceration with various concentrations of ethanol (96% v/v; 70% v/v and 50% v/v) to obtain the ethanolic extract of Muntingia calabura, L leaves. The determination of Quercetin was conducted by Thin Layer Chromatography (TLC) densitometry, and the total phenolic was analyzed with reagent Folin-Ciocalteu while the flavonoid content we identified by applying the colorimetric method. The antioxidant capacity was measured using the radical scavenging assay of 1,2-diphenyl-2-picrylhydrazyl (DPPH). The phytochemical study showed that phenolics, saponins, tannins, and flavonoids were present in all EEMC. The extract obtained by 96% ethanol showed the highest total antioxidant activity, reducing power and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity. The same extract also exhibited the highest flavonoid content. However, the extract obtained by 70% ethanol showed the phenolic content, and the highest quercetin content was obtained by using 50% ethanol. The result from the EEMC analysis indicated that Muntingia calabura leaf extract contains essential bioactive compounds and shows potential as a source of antioxidants in M. calabura which uses 96% ethanol solvent and has the highest quercetin content in M calabura using 50% ethanol solvent.
Optimization of Liquid Soap Containing Bentonite and Combination of Corn Oil and Virgin Coconut Oil For Cleansing Najs Mughalladzah Chairunnisa Mahdi Pratama; Astri Desmayanti; Marchaban; Abdul Rohman
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.640

Abstract

This research was intended to formulate liquid bentonite soap using combination of corn oil andvirgin coconut oil used for cleansing najs mughalladzah (extreme najs). five formula of soap designated with I-Vapplying bentonite and combination of VCO and CO with different concentrations. The assessment of sopquality was based on organoleptic evaluation, foam stability, density, pH-value, and total of active component.Evaluation results were analyzed using simplex lattice design (SLD) to obtain optimum formula. Verificationof optimum formula was analyzed using one sample t-test with level of significance of 0.05. The resultsshowed that optimum concentration of bentonite was 6.5% with percentages of corn oil 85.43% and virgincoconut oil of 14.57%. Based on one sample t-test, there is no significant difference (pH > 0.05) from pH-valueresponse and foam stability between the predicted optimum formula as analyzed using SLD and actualformula. Bentonite liquid soap which is formulated using combination of corn oil and virgin coconut oilaccording to National Standardization Body SNI 2588:2017 so that the soap formula could be applied forcleansing najs mughalladzah.
The Profile of Anticancer Activities of Sambiloto Extract (Andrographis paniculata Nees) from Several Locations in East Java Roihatul Mutiah; Fina Luthfiana; Arief Suryadinata; Wirda Anggraini; Anik Listiyana
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.647

Abstract

Sambiloto (Andrographis paniculata Nees) contains andrographolid compound which has potentialas an anticancer. The difference of growth location has affected the distinction of metabolite content. Thisstudy aims to determine the profile of anticancer activities of A. paniculata extract from several locations inEast Java. The extracts from several locations were tested for activity on T47D cancer cell using MTT assaymethod. Thus, the result of this study describes that A. paniculata extract from several different locations doesnot provide significantly different anticancer activities with the amount of (p>0.05). The extracts which havemoderate anticancer activity were A. paniculata extracts from Selopuro Subdistrict Blitar Regency, SingosariSubdistrict Malang Regency, Lowokwaru Subdistrict Malang City, Klojen Subdistrict Malang City,Purwodadi Subdistrict Pasuruan Regency, Purwosari Subdistrict Pasuruan Regency, and PandaanSubdistrict Pasuruan Regency
Total Flavonoid Content and Antioxidant Activity of Temu Mangga (Curcuma mangga Val. & Zijp) and its Classification with Chemometrics Yuniar Intan Hartono; Indah Widyastuti; Hanna Zaidah Luthfah; Rosy Islamadina; Adelin Theresia Can; Abdul Rohman
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.650

Abstract

Indonesia is a rich country in terms of its biodiversity. Herbs that are widely used tomaintain a healthy body comes from the Zingiberaceae family, including temu mangga. Temu mangga(Curcuma mangga Val. & Zijp) is effective for relieving gastric pain, diarrhea, menstrual pain, acneand ulcers, and increasing appetite. Besides, temu mangga is considered to have antioxidant activitydue to the presence of the phenolic and flavonoid compounds. This study aims to determine thecorrelation and classification of temu mangga from various places based on total flavonoid contentand antioxidant activities. The samples were extracted with methanol, then tested for totalflavonoid content by AlCl3 method and antioxidant activity by DPPH free radical capture method.Analysis was performed using correlation coefficient value and chemometrics PCA (PrincipalComponent Analysis) and CA (Cluster Analysis) to see the relationship between total flavonoidcontent with their antioxidant activity and to see their classification. Total flavonoid content ofmethanolic extract of temu mangga gives a moderate correlation to its antioxidant activity with r =-0.6085 and clustering samples successfully determined by PCA and CA which resulted in 4 groups.Keywords: Curcuma mangga Val. & Zijp, Methanolic Extract, Flavonoid, Antioxidant, PCA, CA
Chemical Profile and Observing Honey Adulteration Using Fourier Transform Infrared (FTIR) Spectroscopy and Multivariate Calibration Sulistyo Prabowo; Yudha Agus Prayitno; Yuliani
Journal of Food and Pharmaceutical Sciences Vol 8, No 1 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.653

Abstract

Honey is a complex mixture that contains nutrients and bioactive composition and chemical compositionthat is needed by the human body. Honey is also rich in antioxidants because it is prone to falsification given its manyproperties. This study discusses the chemical and nutritional profiles and the observation of counterfeiting in honey usingthe infrared septicroscopy method. The honey used is obtained from providers of native honey from Kalimantan forestswith 3 kinds of honey brands, namely Mahuka A (MHA), Mahuka B (MHB) and Mahuka C (MHC). Tests of chemicaland nutritional profiles included Water content, ash content, protein content, fat content and calcium levels followed byhoney counterfeiting observation using the Fourier Transform Infrared (FTIR) method with a combination of Partial leastsquare (PLS) calibration model and Principle Component Regression (PCR). The results of all honey samples havevarying values in the water content between 26.75 - 31.00%. Ash content of 0.10 -0.16%. Protein content 0.24 - 0.88%fat content 0.08 -0.44% carbohydrate content. Observation of FTIR honey counterfeiting is used to replace the authenticity of Honey (MH). FTIR combined with Partial Least Square (PLS) was optimized in the subsequent testing ofa mixture of sucrose (MCS) with native honey (MH). Calibration models were taken in a combination of regions 1423 -1825 cm-1. A high coefficient of determination (R2) of 0.9960 with a calibration value (RMSEC) of the root error of thesquare root low of 0.0898% v / v was successfully understood in the MHA on the PLS model. high R2 values and lowRMSEC and RMSEP values on calibration and validation assessments with both accuracy and precision models used.
Chemometrics Application for Grouping and Determinating Volatile Compound which related to Antioxidant Activity of Turmeric Essential Oil (Curcuma longa L) Rosy Islamadina; Adelin Can; Abdul Rohman
Journal of Food and Pharmaceutical Sciences Vol 8, No 2 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.658

Abstract

Turmeric essential oil is known to have antioxidant activity. Various in vitro antioxidantactivity assays has been carried out. Related to this research, it tries to examine the antioxidantpotential of turmeric essential oil and see the composition that is responsible for antioxidant activitycombine with chemometrics. The research method used was a narrative review of 60 articlesobtained from several databases. The review conducted on profiling essential oil compounds thatidentified using GC-MS and evaluation of the antioxidant activity of turmeric essential oil with themost commonly used method including scavenging radical 2,2 diphenyl-1-picrylhydrazyl (DPPH)and 2,2-azinobis (3-ethylbenzothiazoline-6 sulfonic acid (ABTS). Analysis methods used forgrouping various multivariate data subjects and determaining the relationship between thevariables were Principal Component Analysis (PCA) and Cluster Analysis (CA). According to thereview, turmeric essential oils are proven to have potential antioxidant activity and have variationsin chemical contents. PCA was success for grouping subjects with various correlated variables,determining variables wich the most influential and correlation between variables. CA method canbe used to group samples without requiring mutually correlated variables.
The Effect of Metanolic Extract and Ethyl Acetate Fraction of Kepel Fruits to Lipid Peroxide Concentration in Liver of CCl4-induced Rat Mitsalina Fildzah Arifah; Sudibyo Martono; Sugeng Riyanto; Claude Mona Airin
Journal of Food and Pharmaceutical Sciences Vol 7, No 3 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.661

Abstract

Accumulation lipid peroxidation can lead to the formation of malondialdehyde to generatefree radicals. Antioxidant will minimize free radical related health problems, such as naturalantioxidant from meat of kepel (Stelechocarpus burahol) (Blume) Hook. F. & Thompson) fruits.Antioxidant activities of methanol extracts and acetate ethyl fractions meat of kepel fruits calculatedprofile of malondialdehyde concentration (ng/mL) in CCl4 induced acute liver toxicity in femaleSprague Dawley rats using ELISA competitively method. All of groups induced CCl4 i.p. at 0 h, exceptuntreated and solvent control group, then vitamin C , methanol extracts and acetate ethyl fractionsp.o. once daily for 72 h. Identification of secondary metabolite was using phytochemical screeningand Thin Layer Chromatography (TLC). Liver weighed and calculated relative organ weight (ROW)of liver, then all of data analyzed using statistic tests, One Way ANOVA and Kruskall Wallis. Thisstudy showed methanol extracts can decrease MDA concentration, ALT and AST were more potent(significantly p<0.05) than acetate ethyl fractions and vitamin C. The TLC analysis identified methanolextracts have same polarity with quercetin (Rf = 0,26) and acetate ethyl fractions showed otherflavonoid class, except rutin and quercetin. ROW of acute liver toxicity in rats increased significantlyin CCl4 and vitamin C groups.
The Biochemistry, Toxicology, and Uses of the Pharmacologically Active Phytochemicals: Alkaloids, Terpenes, Polyphenols, and Glycosides Chinaza Godswill Awuchi
Journal of Food and Pharmaceutical Sciences Vol 7, No 3 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.666

Abstract

The research focused on the biochemistry and the medicinal uses of alkaloids, terpenes,polyphenols, and glycosides. Several parts of plants such as bark, root, leaf, stem, etc. are being used torevert abnormalities back to normal, prevent illnesses, or allay symptoms. These plant parts containbioactive compounds such as terpenes, glycosides, polyphenols, and alkaloids. Alkaloids have a rangeof pharmacological activities such as antiasthma (e.g. ephedrine), anticancer (e.g. homoharringtonine),antimalarial (e.g. quinine). Other alkaloids possess stimulant (e.g. cocaine, caffeine, theobromine, nicotine)and psychotropic activities (e.g. psilocin), and have been widely used as recreational drugs orin entheogenic rituals. Alkaloids can be toxic too (e.g. tubocurarine, atropine). Although alkaloids act ondiverse metabolic systems in humans and animals, they almost uniformly induce a bitter taste. Thecharacteristics and number of the structures of phenol in polyphenols underlie the unique chemical,physical, and biological (metabolic, therapeutic, toxic, etc.) properties of specific members of the class;e.g. ellagitannin and tannic acid. Generally, foods often contain complex mixtures of polyphenols. Severalpolyphenolic extracts, such as from grape seeds, olive pulp, maritime pine bark, or grape skin, are sold asingredients for functional foods, cosmetics, and dietary supplements. Terpenoids and terpenes are theprimary components of the essential oils of most types of flowers plants. Essential oils are used widely asscents and fragrances in perfumery and also in traditional medicine, such as aromatherapy. Similarly,many plant glycosides are used as medicines. Amygdalin and laetrile (a synthetic derivative) wereinvestigated as potential drugs for cancer treatment and were promoted as alternative medicine;nevertheless, they are ineffective and dangerous. Pharmacologically active phytochemicals can haveuseful applications, as well as safety concerns.
Comparison of Anti-oxidant Activity of Five Elected Wild Commercial Mushrooms in Four Different Solvents as an Alternative Oxidative Stress Reliever Shahnaz Salamat; Muhammad Shahid
Journal of Food and Pharmaceutical Sciences Vol 7, No 3 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.667

Abstract

Mushroom also known as a lit source of nutritional and therapeutical component so in order toevaluate the usefulness of the Pakistani wild mushroom strains as the possible nutracueticals, adetailedstudy entailing several tests for the determination of anti-oxidant potential was carried out on the electedmushrooms in four different solvents. Strains of Lentinus edodes, Pleurotus ostreatus, Volvariella volvacea,Pleurotus eryngii and Ganoderma lucidum were extracted for this particular purpose in the water, n- butanol,n-hexane and choloroform solvents. Test models including Total Phenolic Content assay, Total FlavonoidContent assay, 2,2-diphenyl-1,1-picrylhydrazyl (DPPH) Scavenging Activity assay and Reducing Powerassay were utilized for carrying out the comparative analysis among the selected mushrooms. The acquiredresults indicated that the extract of Volvariella volvacea and Pleurotus eryngii possess copacetic anti-oxidantpotential and can be utilized as oxidative stress reliever in humans. Furthermore, extraction studies alsoindicated that water is the most suitable solvent for anti-oxidants extraction for these mushrooms. Finding ofthe anti-oxidant potential for elected wild mushrooms contra indicate that these mushrooms can be safelyexploited as a amended natural anti-oxidant in comparison to its synthetic counterpart.
Analysis of Adulterated Pangasius Hypopthalmus Oil by ATR-FTIR Spectroscopy and Chemometric Lisa Andina; Revita Saputri; Aristha Novyra Putri; Endang Lukitaningsih; Abdul Rohman
Journal of Food and Pharmaceutical Sciences Vol 7, No 3 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.668

Abstract

In this recent study, ATR-FTIR spectroscopy and chemometrics have been successfully used for theclassification and quantitative analysis of adulterated Pangasius Hypopthalmus (P. hypopthalmus) oil. The aimof this research was to evaluate the ability of ATR-FTIR spectroscopy and chemometric to perform theclassification and quantitative analysis of adulterated P. hypopthalmus oil in a binary mixture with palm oil(PO) and coconut oil (CO). In the development of FTIR spectroscopy combined with chemometrics for theclassification and quantitative analysis of P. hypopthalmus oil, P. hypopthalmus oil (MP and LFP) mixed withother oils such as coconut oil (CO) and palm oil (PO) at concentrations of 1-99% v/v. Classification of P.hypopthalmus oil, PO and CO were performed by the principal component analysis (PCA) and thequantification analysis was carried out by partial least square (PLS). Based on the optimization process, thebest classification results were obtained using the first derivative spectra at wave numbers of 1400-1100 cm-1.The prediction of percentage adulterated oil by PLS method also showed very good values of R2 greater than0.9999 and low standard error values in the range of 0.0176-0.703. The prediction was also perform at1400-1100 cm-1 wavenumbers using the first derivative spectra.

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