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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 1,092 Documents
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Job Performance and its Correlation with Decision-Making to Teachers of Physical Education in Najaf Governorate Jameel Hamid Kadhim
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

There is no doubt that the professional performance of the teachers of physical education is the basis of their work, which is linked to their scientific specialization, and to the ability of the teacher and the school to perform their official duties and responsibilities, the extent to which they succeed in fulfilling their educational and scientific message to our children, namely the creation of education Psychologically, mentally, physically and socially balanced, the functional performance of a teacher and the school of Physical Education is the cornerstone and basis of the process of education and instilling the values, principles and good qualities of studentsThe Objectives of ResearchPreparation of the functional performance measures to identify the level of physical education teachers in the governorate of Najaf.Preparation of a decision-making scale by teachers of physical education in the Governorate of Najaf.To identify the nature of the relationship between the performance and decision-making of the teachers of physical education in the Governorate of Najaf.The researcher used the descriptive approach in the survey method and in the relational relationships method to see the relationship between variables and predictive studies. The research community is a teacher of male and female physical education in secondary, middle, intermediate and vocational schools in the governorate of Najaf, where there are 363 teachers and schools distributed to (310) schools for the 2016-2017 school year.In the light of the findings of the researcher, he concluded that:Research capabilities (functional and decision-making scale) in the measurement of search variables.Teachers of physical education in Najaf Governorate enjoy a positive level of performance and decision-making.There is a positive correlation between the research variables, the functional performance and the decision-making factors of the teachers of physical education in the Governorate of Najaf.Keywords: Job performance, Decision-making and physical education.
The Effect of Educational Exercises and Added Weights in Some Kinematic Variations of the Performance Angle of the Shudder Effect on the Horizontal Bar of Youngsters Nada Ibrahim Abdulreda
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

The objective of the research was to prepare educational exercises and weights to improve and develop some kinetic variables for the performance angles of the skill of the generator on the young Horizontal bar machine and also to identify the kinetic variables for the performance angles of the skill either hypothesized. The research and training program had a positive effect on some kinetic variables for performance angles of the skill of the catalyst, Statistical significance between the results of the tribes and Posttests of the research sample in some kinetic parameters of the performance angles of the skill of the generator on the brain of young people. The researcher used the experimental method in designing a single group as well as the use of video imaging and determined the research community in a deliberate manner. The pilot experiment was conducted. The experiment was carried out by a group of six players, aged 10-13 years. And then the tests of the Pre group of research and then were applied educational exercises and exercises with weights added two (14) week and the existence of three training units per week and the number of educational units and training (42) training unit and when the program was completed tests dimensionality and processing the results statistically. The fourth part included presentation, analysis and discussion of the results. The researchers concluded that the educational exercises and the added weights contribute to the improvement of some kinematic variety of the performance angles of the skill of the skeletal system in the brain of young people and recommended the use of educational exercises and exercises in weights added to other skills in the gymnastic and other devices. The trainers should take into account the values of the biochemistry variables that have been achieved when training the performance angles of the skill of the generator on the brain of young people.Keywords: Educational Exercises, Weights Kinematic Variations, Performance Angle, Shudder Effect and the Horizontal bar.
Lipoprotein-Associated Phospholipase A2 Activity increase the Sensitivity of Framingham Score for detecting the incidence of Acute Myocardial Infarction in sub-population of Indonesian Male Patients Andi Wahjono; Saifur Rohman; Miryanti Cahyaningtias; Rina Yudha; Yanna Indrayana; Mifetika lukitasari; Rusdianto Rusdianto; Aditya Kurniawan; Djanggan Sargowo; Sasmojo Widito; Dadang Hendrawan; Jayarani Fatimah Putri; widodo Ph.D
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker of cardiovascular disease. Framingham score is currently a widely used risk stratification tool for detecting the incidence of acute myocardial infarction (AMI), although it is not very sensitive. Adding Lp-PLA2 to the Framingham score can raise the odds ratio (OR) for AMI, but requires further research.Objectives: In this study, we examine the role of Lp-PLA2 in increasing the sensitivity of the Framingham score for detecting the incidence of AMI.Methods: This study was a case-control study of 97 male patients, 60 of whom had AMI and were treated in the intensive care unit as test subjects, and 37 of whom were non-AMI patients with normal treadmill test used as controls.Results:Lp-PLA2 activity was found to be higher in the AMI group than that in the control group (83.97 ± 27.15 nmol/ml/min vs. 55.04 ± 31.99 nmol/ml/min). Eighteen patients (30%) with AMI were included in the high-risk category according to the Framingham score; this number increased to 36 patients after the addition of Lp-PLA2 activity to the Framingham score. Analysis using a receiver operating characteristic (ROC) showed a cut-off value for Lp-PLA2 activity associated with AMI of approximately 74.21 nmol/ml/min with an accuracy of 67%. The OR for detecting AMI incidence increased after the addition of Lp-PLA2 activity from 1:01 (CI 95%, 0.414–2.48) to 4.67 (CI 95%, 1.88-11.61).Conclusions:   The addition of Lp-PLA2 activity may increase the sensitivity of the Framingham score for detecting the incidence of AMI.
ND3 Mitochondrial Polimorphism G-10399-A and C-10401-T Significantly Associated with Elevated Serum 8-OHDG Concentration and Increased Risk of Malignant Behavior in Breast Cancer Wayan Tianing
Journal of Global Pharma Technology .
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Abstract

Introduction: ND3¬ gene polymorphisms had been associated with the risk of breast cancer. However, it association with cancer cell behavior and progression is yet to be evaluated and thus this research evaluate the relationship between ND3 gene polymorphisms with 8-OHdG concentration that represent oxidative DNA damage and with the risk of malignant cancer behavior. Method: A case-control study was conducted in Faculty of Medicine Udayana University and Sanglah General Hospital from January to December 2016. The case group was defined as sample with lymph vascular invasion and histological grade III. The blood samples were obtained to evaluate the polymorphism and serum 8-OHdG concentration. The polymorphisms were detected using PCR and sequencing while serum 8-OHdG concentration was determined using ELISA. Result: 70 subjects were enrolled in this study with 35 samples for each group. Increased serum 8-OHdG were associated with the presence of ND3 polymorphism [375.37±203.56ng/mL in wild type vs 610.65±271.9ng/mL (G-10399-A) and 636.18±287.75ng/mL (C-10401-T); p<0.05] and the number of polymorphism [391.45±210.97ng/mL for no polymorphism vs 487.52±227.18ng/mL in one polymorphism and 861.36±253.27ng/mL for two polymorphism; p<0.05]. Finally, the presence of polymorphism increased the risk of more malignant cancer behavior (OR: 4.792; 95%CI: 1.741 – 13.188). Conclusion: G-10399-A and C-10401-T ND3 polymorphism clearly increased oxidative DNA damage and the risk of malignant cancer behavior in breast cancer patients.Keywords: ND3 gene polymorphism G-10399-A and C-10401-T, 8-OHdG, malignant behavior, breast cancer
The Association between Toll-like Receptor 7 and Hepatitis C Virus in a Sample of Iraqi Rheumatoid Arthritis Patients Dunya Muyad Ahmed
Journal of Global Pharma Technology .
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Abstract

Background: Rheumatoid arthritis (RA) is one of the chronic inflammatory autoimmune diseases that included articular and joints infections. Viral infection and immunity had been suggested to play a role in the pathogenesis of autoimmune diseases. Objectives: The present study designed to estimate the association among RA, Hepatitis C virus (HCV) infections and the role of innate immunity expressed by toll-like receptor-7 (TLR-7) as a possible triggering factor in the sera and blood samples of 47 RA patients.  Results: The findings of the present study demonstrated that 18 of the 47th RA samples were positive for anti-HCV IgM and IgG antibodies, and 13 of the 18th HCV IgG and IgM seropositive samples were positive for HCV-RNA by using RT-PCR technique. Also, the findings revealed a significant association between RA, HCV infections and TLR-7 serum level in the studied groups. There was a significantly increased level of TLR-7 in the RA group (103.0±73.8 ng/ml) compared to controls (72.9±36.8 ng/ml). Conclusion: These findings concluded that hepatitis C virus infection and TLR-7 might have a role in RA pathogenesis.Keywords: Autoimmune disease, Rheumatoid arthritis, Hepatitis C virus, Innate immunity, Toll-like receptor-7.
Investigation of Immunomodulation Effects of Ethanolic Neem Seeds (Azadirachta indica) Extract on Induced Immune Response in BALB/C Mice with Vibrio alginolyticus Whole An Ihsan Dhari Awad
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The Current study  was  studied the immunomoduatory  potentials  of Ethanolic Neem seed    extract in treated mice with Vibrio alginolyticus whole antigen through estimation the phagocytic activity of and lymphocyte proliferations as well as  estimation of  the serum fractions to evaluate the humoral immune response . The study was divided into 4 groups:  Group (I) was included treated mice with normal saline. Group II was included  mice treated with Vibrio alginolyticus  antigen only , Group,(III): included mice were treated with  (200 ug /Kg) of the neem extract combination with  Vibrio alginolyticus  antigen ,finally , Group IV included mice were treated with  (300 ug /Kg) of the neem extract combination with  Vibrio alginolyticus  antigen. The results of NBT index and MTT test were revealed group III and group IV showed highly significant increase (P≤ 0.05) comparison with other Groups .More further results of gel electrophoresis in current study were showed the level of Gamma globulin serum, Alpha-1 level, Alpha-2 level, Alpha-beta level were highly significantly in Group III and Group IV comparison with other groups. In other hands in this study the results were showed there is no significant difference between group III and group IV in NBT index and MTT test as well as Gel electrophoreses. Depending on the results of current study   the Ethanolic Neem extract had a positive immunomodutory effect on the induced immune response.Keywords: Neem Seeds extract, Immunomodulatory Effects, Vibrio alginolyticus whole antigen, Immune response.
Clinical Measures for the Cytokine Levels After and Before Hirudotherapy in Rheumatoid Arthritis Patients Dina A. A. AL-Roubaey
Journal of Global Pharma Technology .
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Abstract

Hirudotherapy is one of the oldest complementary medical methods using in treatment of disease like inflammatory disease, osteoarthritis, and after being surgery. The aim of this study was to identify what areroles of leech bioactive substances on the treating of rheumatoid arthritis disease. The study was carried out in Al-Najaf City/ Center of leech therapy, during the period from October 2016 to October 2017, the study involved (140) RA patients who attended the hospital, the majority of the study were women (64.29%), and the most effected age groups were from 61-70 years old in percentage (42.86%) followed by the age group 71-80 years old (25%), also the results showed a highly significant increased mean serum level of  hs-CRP  (9.35  vs. 1.19 mg/ ml), and cytokines including IL1β (59.87 vs.12.43 pg/ml), IL-6 (70.34vs. 13.33 pg/ml), IL-8 (53.25 vs. 11.61 pg /ml), IL-10(44.58 vs. 10.50 pg/ml), IL-17(77.45 vs. 10.42 pg/ml), and TNF-α(68.30 vs. 11.81 pg/ml) for RA patients as compared to controls group, in addition the study showed that the patients after hirudotherapy have a significant decreased mean serum level of  hs-CRP  and cytokines (IL1β, IL-6, IL-8, IL-10, IL-17, and TNF-α) as compared to the patients before hirudotherapy. It was concluded that leech therapy is a highly effective in treating RA patients by reducing the severity of disease. It was recommended to achieve more investigation for assassement the role of leech therapy and their bioactive substances in the treatment of RA disease.Keywords: Hirudotherapy, Cytokines, Rheumatoid Arthritis patients.
Influence of Blanching, Frying and Storage on the Physicochemical Properties and Shelf Life of Fried Taro (Colocasia Esculenta) Chip Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Taro (Colocasia esculanta) tubers have the great importance of functional foods. Taro tubers are important sources of carbohydrates as an energy source. Taro tubers provide a number of desirable nutritional and health benefits such as anticancer activity, phenolic acid and phytochemicals. Taro deteriorates rapidly as a result of its high moisture. The high perishability of taro during storage remains a major constraint. It is widely cooked by deep frying and consumed in forms of French fries and chips. The major challenge for the food industry is to produce low fat fried product with desirable texture, color and flavor. This research has been focused on different parameters of blanching, drying for minimum oil absorption and sensory palatability while maintaining the most phytochemical components such as total phenolic, total flavonoid and anthocyanin; extending product shelf life during packaging and preservation. Results revealed that blanching 95oC in 30 seconds with ascorbic acid of 0.15 g/100g taro, frying 2.0 cm of taro chip in soybean oil heating at 155oC in 2 minutes was appropriated. Fried taro chip could be preserved for 12 weeks under vaccum at 4oC. Moisture and oil content, as well as colour and texture are important quality attributes of fried taro products. Frying of taro chips is carried out to convert the tubers to value added products. Frying method brings out unique flavor and texture to the products that improve their overall acceptability.Keywords: Taro chip, Blanching, Frying, Shelf life, Anthocyanin, flavonoid.
Implementation of Total Ergonomics Approach through Multidisciplinary Sciences for the Improvement of Workers’ Health Quality: Literature Review Doctoral Dissertation Udayana Bali-Indonesia Wahyu Susihono
Journal of Global Pharma Technology .
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Abstract

Total Ergonomics Approach is application of SHIP (Systemic, Holistic, Interdisciplinary and Participatory) through appropriate technology consideration in conducting design of working condition, work attitude and work system. The Total Ergonomics Approach model has been implemented in various disciplines such as Industrial, Agriculture, Fisheries, and Computer design, Education, Health, Hospitality, Building and Religious. Since 2006 to 2016 (10 years) was found nine scientific sectors that apply the concept of Total Ergonomics Approach. The results of the implementation indicate an incensement in the quality of workers’ health through the reduction of musculoskeletal complaints, fatigue, workload and some other complaints as an impact of ergonomic intervention. The science of ergonomics can be applied to solve various problems in a multidisciplinary range of sciences. Ergonomic improvements take account of human abilities, skills and limitations. Humans become the main factor in every design and improvement work.Keywords: Total Ergonomics, quality of work health, SHIP.
Feasibility of Pickling from Common Bean (Phaseolus vulgaris) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Common bean (Phaseolus vulgaris) is often a main source of protein, dietary fiber and minerals in diet offering benefits for human health. With the purpose of accelerating the commercial value of this vegetable, objective of this study focused on the lactic acid fermentation of the common bean into pickle. Different technical parameters such as blanching time and temperature, calcium chloride concentration in soaking, salt sugar percentage submersion affecting to fermentation were examined. This research was conducted in 2019 in the Labone Scientific laboratory. Results showed that 95oC in 6 seconds were suitable for blanching of common bean. The optimal calcium chloride concentration for soaking was recorded at 0.2% for soaking of common bean. The optimal salt: sugar was noticed at 7.5%:2.5% adequately for pickling in 14 days.  As a result from pickling process, common bean will get a longer shelf life, translucent appearance, firm texture and pickle flavor. Pickled common bean was ideal for promoting the positive health image of probiotics. The findings of this investigation help diversifying the multiuse of common bean in food processing enterprises.Keywords: Common bean, Phaseolus vulgaris, Pickling, Blanching, Soaking, Calcium chloride.

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