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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 10 Documents
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Search results for , issue "Volume 09 Issue 03" : 10 Documents clear
Potential Regulatory Functions of Propolis to Ameliorate Hematopoietic Disorder in Diabetic Mouse Model Muhaimin Rifa’i
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

Diabetes mellitus (DM) in autoimmune case, related to cytotoxic T cells activation as a response to autoantigen. In the recent studies, propolis is known as a potential immunomodulator. The aim of this study is to determine the effect of propolis as a regulator to ameliorate diabetic mouse model. In vivo experiment was done using streptozotocin-induced diabetic mice. There are five experiment groups; that are DM group (diabetic mice model without treatment); propolis ethanolic extract treatment group doses of 50, 100, and 200 mg/kg BW; and normal mice group. Effect of propolis was observed 14 days post treatment by flow cytometric analysis. The number of CD8+CD62L-, CD4+CD25+CD62L+(Treg), B220+,  and NK+ cells was assessed from splenic cells. The result showed that administration of propolis for 14 days could reduce the number of cytotoxic T lymphocytes (CTL) memory significantly (p ≤ 0, 05). Especially the doses of 100 and 200 mg/kg BW could suppress the activation of CTL quite similar to those normal groups. Propolis with the dose of 200 mg/kg BW increase the number of  Treg, B220, and NK cells. The increase of Treg may reduce the activation of CTL and prevent tissue damage by autoreactive cells, and finally hematopoietic imbalance can be overcome. Keywords: B220, diabetes mellitus, immunomodulatory, NK, propolis.
Vaginal Birth After Cesarean Characteristics with Maternal and Perinatal Out Come in Sanglah Hospital, Bali, 1st January 2015 to 31st December 2016 Period:A Descriptive Study I Ketut Surya Negara; Gede Agus Hendra Sujana
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

Cesarean section delivery is a common choice for some women because it is often considered faster and safer. Over the past few decades, the cesarean section continues to be performed more frequently. As a result, there is also an increase in the number of women with a history of cesarean section and become a problem for pregnancy and subsequent types of labor.  Method This is a retrospective descriptive study obtained using medical records in Sanglah Hospital Bali, 1st January 2015 to 31st December 2016 Period. Results Within 2 years since January 1, 2015 - December 31, 2016, the number of births in Single Deposer hospital as many as 2502 cases, consisting of 1753 (70.06%) vaginal delivery and 749 (29.94%) with cesarean section. Of all deliveries, the total number of deliveries with uterine scarring were 247 cases, consisting of 190 (76.92%) of direct cases of cesarean section, and 57 (23.08%) cases were decided by TOLAC. Of 57 TOLAC cases, 49 cases were successful VBAC (85.96%), while 8 cases were unsuccessful VBAC (14.04%).The incidence of VBAC was most frequently found in the age group of 20-35 years old (82.46%), body mass index (BMI) of ≤30 kg/m2 (91.23%), and gestational age of ≤40 weeks (84.2%). Based on the number of previous vaginal deliveries after cesarean, women with a history of vaginal delivery was most common with 29 cases. Based on previous cesarean section indications, fetal distress had the highest number of cases (35.09%). Women with cervix dilatation of ≥4 cm are more likely to have successful VBAC (85.96%). Almost all VBAC was spontaneous vaginal delivery (97.96%), except one. Almost all newborn have a birth weight of less than 4 kg (98.25%). Anemia and hysterectomy are among maternal morbidities found in our study. Based on perinatal morbidity, asphyxia, neonatal dengue, ARDS, and jaundice, were found in our study and only four newborns needed to be treated in the neonatal intensive care unit (NICU). Conclusion The success rate of VBAC in this study was high, the indications of previous cesarean section most due to fetal distress. Moderate asphyxia was the most common perinatal morbidity, followed by ARDS, severe asphyxia, neonatal dengue and jaundice. However, in most cases there is no perinatal morbidity. Keyword: Vbac, Tolac, Maternal Perinatal Outcome.
Morphological Features of Human Cerebellar Cortex in Old Age Irina A Balandina
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

The objective of the study is to establish regularities of age changes in the structural organization of thecerebellar cortex in old age as compared to young age by using necropsy material. Craniometrical,organometric, histological, immunomorphological and morphometric studies of the cerebellar cortex in219 human corpses (108 men and 111 women) aged from 18 to 44 years and from 75 to 90 years.Comparative analysis of the parameters of Purkinje’s cells in these age groups revealed a decrease in theneurons’ height and width. It was found that the distance between the bodies of the neurons of ganglioniclayer increases with age, which is obviously due to the progressing disorganization and apoptotic death ofPurkinje’s cells. An increase in the number of astrocytes immunopositive to glial fibrillary acidic protein,S-100 protein and vimentin in the granular and molecular layers of the cerebellar cortex is observed, aswell as a decrease in the number of Purkinje’s cells immunopositive to neuron-specific enolase andimmunonegative to S-100 protein and vimentin, which can be considered as a manifestation ofneurodegeneration. Immunohistochemical techniques provide a more differentiated approach to themorphological assessment of the cerebellar cortex in old persons and make it possible to get moreobjective and complete information about the postnatal morphogenesis.
RP-HPLC Method Development and Validation for the Estimation of Methylcobalamin in Bulk BS Muddukrishna
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

The subsequent artefact entail of extremely subtle and informal Reversed phase HPLC (RP-HPLC) technique for approximation ofMethylcobalamin in large quantity. Shimadzu LC-20-AD(Kyoto, Japan), with auto sampler and (PDA/UV) detector was used for the separation of Methylcobalamin.C18 Hypersil BDS (5.0 micron,150 x 4.6mm) column was aimed at the separation and mobile phase(MP) comprising of(55:45 v/v) Methanol:o-phosphoric acid 0.02%v/v pH 2.3 was cast-offby keeping the rate offlow1 ml/minalong the effluents supervised on 223nm. linearity is undeviating having line equationf(x) =4.87512e-006*x-0.702284 with correlation coefficient(R2) of 0.997. Theprocessremained precise with 0.5% RSD(intra-day precision)&(Inter-day precision) is 0.43%. The LOD & LOQ was0.1499μg/ml and 0.4542μg/ml respectively.The establishedprocess wasvalidated forlinearity,system suitability,precision, and robustness; henceforthverifies in order that this one is exceedinglyrelevantto approximate Methylcobalamin in routine analysis.Methods name: Estimation of Methylcobalaminby HPLC.Keywords: Methylcobalamin, Reverse phase hplc (RP-HPLC), Validation and chromatography.
Evaluation of Phenol Removal from Aqueous Solution by Banana Leaf Ash Hamed Biglari
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

Several industries such as crude oil refineries, petrochemical plants, processing of olive oil, pesticide manufacturing, and oil and sewage activities produce significant amounts of phenol and its derivatives that are among the most important toxic compounds present in industrial wastewater. The present study was conducted to evaluate the absorption potential of phenol from aqueous solutions using the banana leaf ash (BLA). In this basic-applied research, the banana leaf ash (0.1- 1 g) was used as an absorbent according to the purposes intended in laboratory scale and in batch system, and then changes of phenol concentration effect, pH, contact time and Freundlich and Langmuir adsorption equations were investigated. The removal efficiency was 88.93% at pH of four, initial concentration of 10 mg/L and the contact time of 75 minutes. The Langmuir and Freundlich adsorption isotherms were studied to assess the adsorption equilibrium reactions, which the results demonstrated better compliance of adsorption equilibrium reactions with the Freundlich adsorption isotherm (R2 0.900) compared to the Langmuir adsorption isotherm (R2 0.758). Based on the findings of the present study, the banana leaf ash is an inexpensive absorbent with high absorption potential and appropriate ability to the removal of phenol from water and wastewater samples. Keywords: Phenol removal, Banana Leaf Ash, Aqueous Solution, Adsorption, Adsorbent 
Regularities of Organometric Characteristics of Cerebellum in Young and old Age Irina A Balandina
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

Background: The interest in morphological studies of cerebellum in different periods of postnatalontogenesis is steadily increasing. The most acute lack of age anatomy data exists for elderly patients.Since the information on structural peculiarities of cerebellum and its cortex at old age is poorlyrepresented in literature, being also contradictory in many ways, the study underlying the current paperwas dedicated to this issue. Aims: The purpose of the study was to find regularities of age-relatedchanges in organometric parameters of cerebellum and structural organization of its cortex at old age ascompared to the young age at old age as using necropsy material. Methods: The paper is based onmorphological study of cerebellums of 219 human corpses (108 male and 111 female) of young and oldages using organometric, histological and morphometric research methods. The study includedcomparative analysis of the mass, linear dimensions, thickness of the cerebellar cortex in young and oldages. Results: The regularities of age variability of organometric characteristics of cerebellum wereidentified, manifested in reduction of its weight and linear dimensions in people of senile age comparedto younger people. It was found that the thickness of molecular and granular layer of cerebellum ischaracterized by age-related decrease in parameters. Conclusions: The results of this morphologicalstudy can serve as a basis for identifying specific regularities of age anatomy of cerebellum and havepractical significance as standard indicators, which will allow using these data for diagnostic andtherapeutic purposes.
Arsenic Removal from Aqueous Solutions by Raw and Incinerated Pine Bark Mojtaba Afsharnia
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

In this research, raw and incinerated pine barks were evaluated as absorbents for the removal of pentavalent arsenic As(V), from aqueous solutions. After preparing artificial wastewater samples containing different concentrations of arsenic, the impact of the parameters including pH, adsorbent dosage, contact time and initial arsenic concentration was assessed on arsenate adsorption level by both of the absorbents. The results showed that the pine bark ash could remove arsenic from aqueous solutions better than the raw pine bark in optimum conditions of contact time of 60 minutes, pH 7, absorbent dosage of 1 g/l and initial arsenic concentration of 1000 µg/l with absorption efficiency of 95.86%. Considering the high efficiency of absorbent at neutral pH as well as the availability and low cost of the pine barks, the use of pine bark ash is suggested as an effective absorbent for removing arsenic from aqueous solutions.Keywords: Pine Bark, Arsenic, Aqueous Solutions
Estimating the Amount of Methane Gas Generated from the Solid Waste using the Land GEM Software, Sistan and Baluchistan Mohammad Reza Narooie
Journal of Global Pharma Technology Volume 09 Issue 03
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The biodegradation of organic compounds in the waste produces different gases such as methane gas. Despite the adverse greenhouse effects of the methane, this gas has many fuel values. Since estimating the amount of methane gas produced from the waste can be an economic and useful way for more accurate control and management of waste disposal in the Sistan and Baluchistan Province, conducting this study is essential. In this research, after collecting required information such as population, growth rate, the results obtained from the physical and chemical analysis of the waste, geographic data and the desired disposal system using LandGEM software, the methane generation potential obtained from the waste disposal in the Sistan and Baluchistan Province was investigated. The results of this study showed that the methane production potential in the Sistan and Baluchistan Province is 147 m3/ton, and if the waste disposal process was started in 2006, the methane generation would be 567 m3/h in 2011 and by considering a 20-years period, this amount will be 3596 m3/h in 2026. Therefore, according to the presence of adequate landfill sites in the Sistan and Baluchistan Province, it can be concluded that the controlled burial along with the gas extraction equipment in this province is a useful way for the waste management.Keywords: Estimating, LandGEM, Methane, Solid Waste, Sistan and Baluchistan
An Overview: The Treatment of Tuberculosis Nitin kumar
Journal of Global Pharma Technology Volume 09 Issue 03
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Abstract

Tuberculosis is an infectious disease which is caused by bacteria. Tuberculosis most commonly affects the lungs, but it can also affect any other organ. The infection doesn`t always result in disease. The human immune defense cells can check and control pathogens, so that progression to disease only occurs in about 10% of adults. However the infection may remain latent and can reactive at any time, also after decades if e.g. the immune system is weakened. If left untreated, tuberculosis is a life-threatening illness. The main burden of tuberculosis is carried by developing countries. The cases of tuberculosis have been declining in Germany for years. But the global increase of tuberculosis affects every region of the world, also developed countries. In the early 1940s and 1950s, tuberculosis (TB) was the number one cause of death. Patients with TB were admitted to the many sanatoria we had in various parts of the country and were often managed by surgical means. TB chemotherapy became available only in the late 1950s. At this time, TB was already a major cause of morbidity and mortality. Realizing its seriousness, the Malaysian government launched its National TB Control Programme (NTP) in 1961. Multi-drug-resistant tuberculosis (MDR-TB) is defined as tuberculosis that is resistant to at least isoniazid and rifampicin: the two most powerful first-line treatment anti-TB drugs. This type of drug resistance, called acquired drug resistance, occurs in TB because a patient’s bacterial population survives for several months during treatment.  Keywords: Drug-resistant, Mycobacterium tuberculosis, Ethambutol.
Prevalence of Pregnant Women with Anemia in Sangkan Gunung Village, Karangasem Regency, Bali-Indonesia Luh Seri Ani; Ketut Suwiyoga
Journal of Global Pharma Technology Volume 09 Issue 03
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Pregnant women are one of the groups with the risk of having anemia. Some factors that are correlated to anemia is an infectious disease, bleeding, and low iron daily intake.These factors were related to the knowledge level of pregnant women and iron supplementation compliance. This is a cross-sectional study with descriptive methods, where 34 pregnant women were chosen by consecutive sampling method. Anemia was then measured by sahli method, and hemoglobin level < 11 g/dl were categories as anemia. The results were analyzed with univariate and bivariate analysis using SPSS 23. Anemia in pregnant women at Sangkan Gunung village, Sidemen sub-district is20,6%.  Most anemia incidents were found in 20-35 years old pregnant women, with low education level, work at the office, zero parity, and in afirst trimester. Anemia was not associated with chronic energy deficiency, knowledge level and iron supplementation compliance level (P>0,05). Anemia prevalence of pregnant women was relatively low, but the preventive effort must be taken to decrease therate of anemia prevalence.Keywords: Knowledge, Compliance, Iron tablets, Pregnant women, Anemia.

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