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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 100 Documents
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Search results for , issue "Volume 11 Issue 09: (2019) September 2019" : 100 Documents clear
Corrosion Protection and Biological Activity Studies for Electrochemical Polymerized Poly (N-benzothiozolyl tetrahydrophthalamic acid) on Stainless Steel Alloy Mayasa I. Ali
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The present work reports the electrochemical synthesis of poly (N-benzothiozolyl tetrahydrophthalamic acid) on stainless steel 316 (S.S) which acts as working electrode by using electrochemical polymerization technique. The formed polymer film was characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and Atomic Force Microscope (AFM). Corrosion protection tests for coated and uncoated S.S with polymer film were studied in 0.2 M of hydrochloric acid (HCl) solution by followed Tafel and potentiodynamic procedures. Kinetic and thermodynamic of activation parameters (Ea, A, ΔH*, ΔS* and ΔG*) were calculated. Also, investigations the effect of the synthesized polymer on some strain of bacteria a gram positive bacterium which is Staphylococcus aureus (Staph.Aure) and negative bacteria which is Escherichia coli (E.Coli). In addition the polymer film was modified with nanomaterials which are (ZnOn (nano) and Graphene).Keywords: Electrochemical polymerization, Conducting polymer, Stainless steel, Anticorrosion, Antimicrobial activity
Sperm DNA Fragmentation and Chromatin Maturation of Prepared Sperm with ALA Supplementation: The Effect of Embryo Development Quality silvia werdhy lestari; aucky hinting; Petrus Supardi; anom Bowolaksono; asmarinah asmarinah
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract: This study was aimed to determine the differences in embryo quality between spermatozoa with good or poor of DNA fragmentation index and chromatin maturation, through spermatozoa preparation with the addition of ALA. This experimental study compared the quality of embryos that fertilized by spermatozoa with DNA fragmentation and chromatin maturation, with and without ALA supplementation. In this study semen samples from 20 patients were collected, which were then prepared and examined for DNA fragmentation index (DF) and chromatin maturation (CM). Then the sample was divided into 4 groups, namely the good DF - good CM, good DF - poor CM, poor DF - good CM and poor CM - poor CM, further divided again with and without treatment (ALA supplementation). After injection of spermatozoa into the oocyte, the development of embryo was observed in each group. In the group without treatment, significant differences in embryo quality were obtained between groups of good DF - good CM with poor DF - good CM, good DF - good CM with poor DF - poor CM, good DF - poor CM with poor DF - good CM and good DF - poor CM with poor DF - poor CM (p <0.05). In the treatment group, there were not significant difference in the quality of the embryo between treatment groups, namely with or without ALA, in the group with good or poor DF, and with good or poor CM (p> 0.05). Embryo fertilized by spermatozoa with good or poor DF and with good or poor CM, with the supplementation of ALA, the quality was not significantly better than without the supplementation of ALA.    Keywords: spermatozoa DNA fragmentation, spermatozoa chromatin maturation, ALA, in vitro fertilization, embryo quality 
Effect of Functionalized Graphene Oxide (FGO) on the Electrical and Dielectrical Properties of PVA Films Sundus H. Merza
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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In the present work, nanocomposite of poly (vinyl alcohol) (PVA) incorporated with functionalized graphene oxide (FGO) were fabricated using casting method. PVA was dispersed by varying content of FGO (0.3, 0.5, 0.8, 1 wt %). The PVA- FGO nanocomposite was characterized by FT‐IR, FE-SEM and XRD. Frequency dependence of real permittivity (ε’), imaginary (ε’’) and a.c conductivity of PVA/FGO and PVA/GO nanocomposite were studied in the frequency range 100 Hz- 1 MHz.  The experimental results showed that the values of real (ε’) and imaginary permittivity (ε’’) increased dramatically by increasing the FGO content in PVA matrix. PVA/ FGO (1 wt %) nanocomposite revealed higher electrical conductivity of 6.4×10-4 Sm-1 compared to 1.4×10-8 Sm-1 for PVA/GOKeywords: Dielectric spectroscopy, Functionalized Graphene oxide, Nanocomposite, PVA, Maxwell-Wagner-Sillars polarization.
Staphylococcus aureus Enterotoxin as a Major Risk Factor for Multiple Sclerosis Severity Suhaib Khalid Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Background: Staphylococcus aureus produce enterotoxins that function as super antigens which activate auto reactive CD4+ T-cells potentially target the basic myelin protein into the CNS. Objective: This study investigates the correlation between the colonization of S. aureus harbouring enterotoxins with multiple sclerosis (MS) exacerbation.  Methods: A total of 200 nasal swabs were collected from three study groups: Healthy controls as a Non-MS Subjects (n=100), relapsing remitting MS or exacerbated (n=50) and newly diagnosed MS. (n=50). S. aureus was isolated from the anterior nares of these groups following standard operating procedures. Antibiotic susceptibility test against 19 antibiotics using disk diffusion method were done. Staphylococcal super Antigen SeA, seB, seC genes were amplified using standard conventional polymerase chain reaction (PCR) technique and resolved by agarose gel electrophoresis. Results: In this study, Out of 100 MS patients and 100 healthy control groups, there were 36% and 46% males and 64% and 54% females respectively.  A total of 81(81%) were colonized with S. aureus includes, 31(38.2%) newly diagnosed MS and 50(61.8%) exacerbated MS while only 12(12%) isolated from control non-MS group. All S. aureus isolates were resistant to Methicillin (100%) and sensitive to Impenem (100%). PCR results showed that,  the frequency of enterotoxins (sea, seb and sec) in MS patients was (42.4%) including (40.8%) were from newly diagnosed and (43.3%) were from relapsing remitting while there is no  enterotoxins was detected in control group. the prevalence of se A was significantly higher (p<0.00) in the MS exacerbation (72%) than in newly diagnosed group (64.5%). Conclusions: The frequency of S.aureus isolates and its enterotoxin seA gene is high in the MS patients and this gene serve as an important marker in the severity of MS disease. Also S.aureus isolates were sensitive to imipenem which is considered as a better choice for nasal decolonization of S.aureus in the MS patients.   Keywords: Multiple sclerosis (MS), Staphylococcus aureus, Super antigens, Enterotoxin A, B, C.   
Study the Effect of Some Heterocyclic Compounds on the Cholinesterase Enzyme in Human Blood Serum Meaaad Nasser
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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This research involve synthesis  of three  type of heterocyclic derivatives (thiadiazole, thiadiazole-shiff base, thiadiazole-azo) by three step, the first step react p-hydroxybenzoic acid with thiosemicarbazide to get compound (1), the second step include react (1) with (p-chloro benzaldehyde, p-hydroxy benzaldehyde) to get thiadiazole-shiff base derivatives (2,3) respectively, in other side the third step involve react (1) with 1-naphthol and salicylaldehyde to get, thiadiazole-azo derivatives (4,5) respectively, all these derivatives were characterize  by FT-IR, 1H-NMR, 13C-NMR  spectra .After that the effect of these compounds was studied  on the activity of the enzyme acetyl cholinesterase in the human serum. Compounds that have the donated  groups in the ring  showed a high inhibition ratio, either the compounds containing the withdrawing groups in the ring showed a low inhibition ratio because  the effect of resonance.Keywords: Thiadiazole, thiadiazole-shiff base, thiadiazole-azo, cholinesterase
Synthesis and Characterization of Azo Dyes Ligands Complexes with Rh (III) and La (III) and Studies Their Industrial and Bacterial Application Amer. J. Jarad
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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1-[4-(2-Hydroxy-4, 6-dimethyl-phenylazo)-phenol]-ethanone (HL1) and 2-(4-methoxy-phenylazo)-3, 5-dimethyl-phenol (HL2) were produced by combination the diazonium salts of amines with 3, 5-dimethylphenol. The geometry of azo compounds was resolved on the basis of (C.H.N) analyses, 1H and 13CNMR, FT-IR and UV-Vis spectroscopic mechanisms. Complexes of La (III) and Rh (III) have been performed and depicted. The formation of complexes has been identified by using elemental analysis, FT-IR and UV-Vis spectroscopic process as well, conductivity molar quantifications. Nature of complexes produced have been studied obeyed mole ratio and continuous alteration ways, Beer's law followed through a concentration scope (1×10-4 - 3×10-4 M). High molar absorbtivity from the compound solutions were noticed. Analytical data showed that all the complexes offered 1:3 metal-ligand ratios. In the radix from physicochemical datum an octahedral structure was described of the complexes. Biological activity of these compounds was assayed. Other than, the dyeing carried out of the produced compounds was practical in cotton fabric. The dyes were checked into light and detergent firmness. Keywords: Complexes, Azo dyes, Biological activity, Acetophenone, Aniline.
Real Time PCR and Urine Cytology for Detection of BK Human Polyoma virus in-patient with Hemorrhagic Cystitis in Iraq Faiz Kamel Al-Salami
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Hemorrhagic cystitis (HC) is considering one of the important complications in lower UT. Hemorrhage, hematuria, and dysuria are most common symptoms. In hemorrhagic cystitis, short-term hematuria can also be seen in bladder infections a result of viral infection. Viral cystitis represents another form of non-bacterial urinary tract infection touching adult and children. Human polyoma virus BK types I and V, Adenovirus types 21 and 11 and CMV viruses also can be cause of hemorrhagic cystitis. For direct detection BK polyoma virus from the aim of the present study work was to find out the relation of polyoma virus BKVS with acute syndrome consists of hematuria. This study was performed on two hundred and thirty bloody urine and blood specimens were collected from patients group comprised 170 male and 60 female age group 6 -65 years  Patient samples (Urine and blood) were collected for detection of Human polyoma virus (BKVS) by using urine cytology, Real time PCR and conventional PCR technique. All bloody urine cultured on ordinary media to differentiate between bacterial and viral infection.  The result of  present  study was found that 154 samples (67%) have positive bacterial culture which excluded and the other 76 samples(33%) give negative bacterial culture were included as suspected  a viral cause of hematuria. All negative culture cases was classified as 4(5.26%) patients with glomerulonephritis, 15 (19.73%) chronic renal failure, 14 (18.42%). urinary tract infection, 27(35.5%) kidney transplantation 16 (21.5%) cystitis. urine cytology for detected decony cell (DC) showed that 13(17.1%) samples were positive for BKVS and 87(82.9%) were negative. All urine patients 76 with 25 urines samples of control were analyzed by RT-PCR for detection BVS. It was found only 5(6.67%) as a positive result. In conclusion this study report the design, development and application of real time PCR and  urine cytology assay for rapid, specific and highly sensitive detection of   BK virus genotype I2b.Keywords: Real Time PCR, Urine cytology, BK virus& Haemorrhagic cystitis.
The Effect of Oral Vitamin D on Patients with Alopecia Areata Ethar Salah Nadhim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Background: Patients who had alopecia areata (AA) presented with markedly lower levels of vitamin D3. Adding to that, vitamin D supplementation could have a protective role in human autoimmune illnesses such as AA, so the aim of the study was to identify the role of systemic vitamin D effect on patients with AA in comparison with the other medications, study the effect of combination of vitamin D and other medications on all symptoms of AA and study the C-reactive protein (CRP) and its relationship with AA. Conclusion: The patients with AA who were treated by combination treatment (steroids and vitamin D) had a better response than the patients who were treated by steroids only, and the response of the group of patients with AA who were treated by vitamin D only was not significant. There was non-significant association between CRP and AA.Keywords: Vitamin D, Alopecia areata, Vitamin D deficiency.
Synthesis and Thermal Characterization of new interpenetrating polymer network (IPN) Silicone- Epoxy Resins Ali M. Abdulla
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Polymers are widely used in industry and in our daily life because of their diverse functionality, light weight, low cost and excellent chemical stability. However, on some applications such as heat exchangers and electronic packaging, the low thermal conductivity of polymers is one of the major technological barriers.   Interpenetrating polymer network (IPN) is a novel type of polymer hybrids, which possess physicochemical properties suitable for high performance coating. Heat resistance IPN have been prepared from immiscible resins , epoxy and silicones using a cross-linking agent and a catalyst. The products were analyzed by, FTIR, TGA, DSC, UV-Vis and SEM studies .It was different from those of the individual resins. Silicone micro domains could be seen uniformly distributed in epoxy   regions.                                         Keywords: Silicone-Epoxy Resins,  Interpenetrating polymer network (IPN), Polymer.
Isolation and Diagnosis of Staphylococcus spp. using VITEK-2 System from Nasal and Ear of Healthy Carriers Sddiq Ghani Al-Muhanna
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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One hundred of nasal and ear swabs were collected from healthy students of Babylon University who not suffering from any upper respiratory tract infection and have not received any antibiotics from the period of two. All they were cultured on suitable media .The positivity of culturing on Mannitol salt agar (selective media for Staphylococci) was 20% distributed as 14% for nasal swabs and 6% for ear swabs. When Biochemical and Serological tests were used for identifying Staphylococcus species, the results showed that 45% of these isolates were Coagulase positive while 55% were Coagulase negative .Staphylococcus species were identified by using VITEK-2: Staphylococcus aureus 45%, S. epidermidis 20%, S.capitis sub.capitis20% and S.cohni. Sub. cohni 10% .Antibiotic sensitivity test for Staphylococcus isolates showed sensitivity for ciprofloxacin to all isolates while appeared resistant to Nalidixic acid, Kanamycin  and Gentamycine, most of Staphylococcus aureus isolates were resisted to Methicillin antibiotic. 

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