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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
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Articles 56 Documents
Search results for , issue "Volume 12 Issue 09 (2020) Sept. 2020" : 56 Documents clear
Social Capital, Family Support, Behavior Use of Personal Protective Equipment (PPE) as the Alternative to Improve the Performance of Employees Exposed to High Intensity Noise Budi Yulianto; Bambang Sunarko; Nurlailis Saadah; Uswatun Khasanah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Introduction: Many previous studies have shown that noise intensity in weaving of the textile industry exceeds TLV (> 85dBA) which is difficult to avoid and impossible to reduce. Employees who are exposed to noise and do not use PPE with a long duration of exposure will get an effect in terms of both physical and psychological health. This results in a decline in their performance. This study aims to examine the social aspects of the workplace (social capital), social aspects of the family (family support), and the attitude of employees towards PPE to the performance of those working in weaving exposed to high intensity noise for a long time through work stress. Methods: This study used an observational analytic design with a cross-sectional approach. The location of this research was the textile industry of PT Dan Liris in Banaran, Grogol, Sukoharjo, Central Java. The population of this study was 343 employees working in the weaving department of PT Dan Liris, who met the criteria. The sample size was 170, taken by proportional simple random sampling technique. Exogenous variables in this study included: social capital, family support, employee attitudes toward PPE, and work stress. Endogenous variables in this study included: employee performance, social capital variables, family support, employee attitude towards PPE, work stress, and performance which were measured using a questionnaire. The data were analyzed using path analysis. Results: There was a positive direct effect between social capital and employee attitudes towards PPE on employee performance, meaning that the social environment of employees who had good social capital could improve their performance by 0.085 points. In addition, good employee attitude towards PPEcould also improve their performance by 0.376 points. Keywords: Social capital, Employee Attitude towards PPE, Performance
Anti-Dandruff Activities of Ethanol Extract and Water, N-Hexan, Ethyl Acetate Fractions of Key Lime (Citrus Aurantifolia) Leaves Against Malassezia Furfur Resmi Mustarichie
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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The objective of this research was to determine the Anti-dandruff characteristic of ethanol extract and its fractions of key-lime leaves (Citrus aurantifolia L) against the fungus Malassezia furfur. C. Aurifolia leaves were collected from villagers' vegetable crops in Kendari, Southeast Sulawesi, Eastern Indonesia. It was macerated with ethanol 96%, rotary evaporated till viscous extract was obtained. The extract was analyzed its phytochemical substances and tested its Minimum Inhibitory Concentration (MIC). The extract was fractionated using ethyl acetate and n-hexane. Both ethanol extract and its fractions were tested their anti-dandruff activity using the fungus Malassezia furfur. DMSO was used as negative control and ketoconazole 1% as a positive control. All data were statistically analyzed. Phytochemical screening found that key-lime leaves contained flavonoids, polyphenols, saponins, steroids & triterpenoids, and tannin. The results showed that key-lime leaf extract was able to inhibit the activity of the Malassezia furfur fungus, the inhibition zones of the extract were 1% (6.0 mm), 4% (7.55mm), 8% (8.44 mm), 16% (9.9 mm), and 29% (16.7) mm) which was slightly greater than 1% ketoconazole as a positive control. The higher the concentration of lime leaf extract, the greater the inhibitory power against the Malassezia furfur fungus. Statistical data shows that the fraction of key-lime leaf had the best antifungal effect shown by the ethyl acetate fraction. The study concluded that either ethanol extract or its fractions of c.aurantifolia leaves has anti-dandruff activity against M. furfur. The ethyl acetate fraction was found to have a better activity compared to n-hexane and water fractions. This finding could be useful to elucidate the compound which is responsible for this action. Keywords: Citrus aurantifolia, Anti-dandruff, MIC, Malassezia furfur, Ethanol extract.
The Accuracy of Brachial Artery Volume Flow as a Predictor of Brachiocephalic Arteriovenous Fistula Maturation Patrianef Darwis
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Objective: This study aims to investigate brachial artery volume flow accuracy in predicting AVF maturity. Methods: This was a cross-sectional study involving 80 patients that underwent AVF creation in Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Parameters recorded include demographic data, ultrasound parameters in six weeks after AVF creation, and complications. Diagnosis tests were performed to determine the area under the curve (AUC), cut-off, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results: Of 80 patients that underwent brachiocephalic AVF, we found that 64 (80%) successfully mature, and 16 (20%) failed to mature. Receiver operating characteristic (ROC) for brachial artery volume flow in predicting brachiocephalic AVF had AUC of 97,6 %. With cut-off brachial artery volume flow of 700 ml/minute, the sensitivity, specificity, PPV, NPV, and accuracy were 98.44 % (95 % CI 91.6-99.7%), 87.5 % (95 % CI 63,9 % - 96.5 %), PPV 96.9 % (95% CI 89.4-99.15%) NPV 84.6 % (95 % CI 66.5 % - 93.8 %) 93.33 % (95 % CI 70.1-98.8%), respectively. Conclusions: Brachial artery volume flow six weeks after AVF creation is an accurate parameter in predicting brachiocephalic AVF maturity. Keywords: brachial artery volume flow, maturity, arteriovenous fistula
Phytosterol Composition in Various Kinds of Red Beans Processing (Vigna angularis) Sugijanto Kartosentono
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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The high level of blood cholesterol can be overcome by consuming phytosterols obtained from plants, especially nuts. One of the leading beancommodity in the society is red beans (Vignaangularis). This study aims to identify the content of phytosterols in red beans and the processing effect of phytosterols. Red beans sample which has been processed, was extracted with n-hexane, acetone, and hydrolyzed. The results of sample extraction were analyzed using the 6890 Series Agilent Gas Chromatography instrument with a Flame Ionization Detector (FID) and HP-5 column (5% Phenyl, 95% Methyl Siloxane). Phytosterol content in the form of campesterol, stigmasterol, and sitosterol was found in red bean samples. The most composition of stigmasterol was found in baked samples and significantly different from boiled samples (p
Antioxidant Activity Assay of Combination of Purified Extract of Banana Peel (Musa Paradisiaca Sapientum) and Andrographis Paniculata Leaves Jastria Pusmarani M.Sc., Apt.
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Antioxidant is a compound that able to postpone, slowdown and prevent free radical reaction which able to postpone degenerative disease. Banana peel (Musa Paradisiaca Sapientum) and Andrographis paniculata contain flavonoid compound which have antioxidant activity. The aim of this study is to measure antioxidant activity of the combination of banana peel extract and Andrographis paniculata to DPPH free radical (2,2-difenil-1-pikrilhidrazil). Extraction process of banana peel using methanol, meanwhile Andrographis paniculata using ethanol 70%. Extract purification conducted using n-hexan and ethyl acetate. This study using combination of the purified extract of banana peel and Andrographis paniculata with the following comparison consecutively (1:10) (1:1) (2:1) (1:2) (0:1) concentration of  20,40, 60, 80 and 100 ppm, measured their antioxidant activity with DPPH method using visible spectrophotometry, thus resulted in IC50value. IC50value for the combination of purified extract of banana peel and Andrographis paniculata (0:1) as many as 256.76 ppm, the combination of purified extract of banana peel and Andrographis paniculata (1:1) as many as 140.33 ppm, the combination of purified extract of banana peel and Andrographis paniculata leaves (1:2) as many as 110.05 ppm, the combination of purified extract of banana peel and Andrographis paniculata (2:1) as many as ppm, the combination of purified extract of banana peel and Andrographis paniculata (1:0) as many as 184.13 ppm. The result can be concluded that combination of purified extract of banana peel and Andrographis paniculata have an antioxidant activity even though in moderate category included purified extract of combination of of banana peel and Andrographis paniculata with comparison (0:1) (1:2), (2:1), (1:1) and (1:0) have medium antioxidant activity.
Development of the Potential of Extrak Lidah Mertua (Sansevieria sp) and Lemongrass (Cymbopogon Nardus) in Lowering the Number of Air Germs of Space through Humidifier Modification AT Diana Nerawati
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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According to Regulation of the Minister of Health No.1077 of 2011, indoor air pollution especially houses are very dangerous to human health, because in general people spend more time doing activities indoors so that the house becomes very important as a micro environment related to the risk of air pollution. Efforts to deal with indoor air pollution caused by germs need to be carried out, especially indoor air pollution the danger level is greater than outdoors. The goal is to test the decrease in germ rate in the air of the room with humidifier modification using sansevieria and lemongrass extrak. The experimental design used in the study is One Group Pretest Posttest Design. As a humidifier modification material to lower the Air Germ Number of the Room. The achievement of this goal was done using pre-experiments with the form of One Group Pre- Post Test Design. The free variables are Sansevieria extraks with concentrations of 30%, 40% and 50% and the bound variables are germ numbers. Analysis of the data used in the form of a paired t test and Anova test. The results showed that the average extrak air germs of Sansevieria and Lemongrass concentrations were 30% before treatment of 15.6 CFU/dm3 and after treatment of 3.4 CFU/dm3, while the concentration of 40% of space air germs before treatment is 19.8 CFU/dm3 and after treatment 5.6 CFU/dm3 and the concentration of 50% of space air germs before treatment is 17.2 CFU/dm3 and after treatment is 6 CFU/dm3. The result of the paired t test showed that p < 0,05, means there is a significant difference in the decrease in the number of germs before and after treatment at all conditions. Extrak Sansevieria and Lemongrass are able to lower the number of air germs of space. at extrak concentrations Sansevieria 30% and lemongrass 0.1 % the average decrease in the germ rate is 78.2%, while for concentrations 40% the average decrease in germ rate is 74.24% and the average 50% concentration decrease in the germ rate is 65.11%. Anova test results obtained that tongue in-laws extract (Sansiviera,sp) concentrations of 30% 40% and 50%, have a p value of > 0.05, which means there is no meaningful or insignificant difference.The results of this study are extrak Sansevieria sp and Cymbopogon Nardus as humidifier fluid modification at concentrations of 30%, 40% and 50% have the same effectiveness in lowering indoor air germs. Recommendations for development and trials modify sansievera and lemongrass extrak solutions with other oceans that can also absorb air pollution. Keywords: Germ numbers, Humidifier, Extrak sansieveira and cymbopogon nardus, air spaces.
Diagnosis and Management of Interventional Endovascular Carotid-cavernous Fistula: a Retrospective Study Luh Putu Lina Kamelia
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Carotid-cavernous fistula (CCF) is a consequence of incremental intracavernous pressure. The direction of drainage is usually multidirectional. Initial DSA (digital subtraction angiography) solves in obtaining its information along with advanced technology nowadays. Aim: The study aims to analyze clinical characteristics, cerebral angiographic features, and management of endovascular embolization of CCF. Methods: The study is a retrospective analysis of each patient diagnosed with CCF. They were treated with endovascular embolization from January 2019 to April 2010 at the Brain Center Dr. Wahidin Sudirohusodo (DWS) General Hospital Makassar. We performed DSA on all patients before the endovascular procedure with catheterized access through the right femoral artery. Result: Angiograms of all patients showed typical CCF lesions, 8 patients then received endovascular management by coiling method, 2 were treated with a detachable balloon, while 1 received an Onyx injection. All patients experienced gradual improvement for orbital symptoms. Conclusion: Endovascular embolization-followed cerebral DSA is a useful diagnostic and therapeutic management to improve patients' clinical symptoms with CCF. Keywords: Carotid-cavernous fistula, Digital subtraction angiography, Embolization, Balloon, Onyx.
Ethnopharmacology of The Tengger Tribe Society: Inventory Study of The Use of Medicinal Plants Hadi Prayitno; . Ari P; Erwin Nur Rif’ah; Dewi Rokhmah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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The Tenggerese community is a community that inhabits the area commonly called "Tengger village". The community trust of the Tengger Tribe towards Mount Bromo and Mount Semeru is very large, so that it has created a close relationship between the people of Tengger Tribe and nature. The ethnobotany study is expected to not only be a documentation of traditional knowledge in the use of plants for subsequent generations, but also as one of the capital in the development and preservation of biological natural resources, especially for the use of traditional medicines in the Tengger tribe. This research is qualitative research. The results of the study indicate the occurrence of the Tengger Tribe Knowledge, Beliefs and Local Wisdom Inventory in Probolinggo Regency, with the decline in Tengger tribe knowledge and belief in the nature and benefits of medicinal plants. This was caused by the success of the health program by the government so that many residents took advantage of modern medicine when they were sick, Tengger Tribe who lived in Lumajang Regency showed the use of plants in every religious or cultural ritual or treatment, based on the teachings of their ancestors which is often done in the community around the informants from generation to generation. The Tengger tribe who lives in Pasuruan Regency shows that the rituals have been carried out from generation to generation and there are no special rituals when using the medicinal plants. The perceptions, attitudes and behavior of the community regarding the Tengger tribe medicinal plants in Probolinggo Regency showed a mediocre attitude because they had rarely used it as well as other forms of behavior, namely informants had not used the medicinal plants anymore, except for a few the older ones in the remote Tengger Mountain.In Lumajang, the type of traditional medicine in the Tengger tribe is actually still perceived and responded to quite positively by informants doing treatment in the traditional way within certain limits. However, they are more open to the patterns of modern medicine, especially among the younger generation. in Pasuruan Regency, residents perceive medicinal plants as plants that can treat a disease that they know from their ancestors before. Inventory of medicinal plants in the Tengger tribe domiciled in Probolinggo Regency there are at least 3 types of plants that are still used for medicinal purposes in the face of health problems such as red ferns, fennel and saffron plants. Whereas in Lumajang Regency uses include sugar cane plants, dlingu plants and banana plants for cases of health problems. The use of medicinal plants in Pasuruan Regency includes: dringu plants, black mustard greens, fennel, besides that there are also castor plants, muscle flour, ciplukan fruit, amethyst plants and ganjan plants. Keywords: Ethnopharmacology, Tengger Tribe, Society , Inventory Study, Medicinal Plants
Effects Mixture Powder of Black Rice, Red Beans and Moringa Leaves on Blood Glucose in Hyperglycemic Rats Lalu Juntra Utama
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Introduction: The increase in blood sugar or hyperglycemia is a metabolic disorder known as diabetes mellitus and is associated with the rise of oxidative stress and complications in the vascular system. Further, it will cause alteration in carbohydrate and fat metabolism leads to a reduction of the antioxidant defense system. Black rice, red beans and moringa leaves contain oleic acid, butyric amino acid, antioxidants, phytic acid and arginine which can improve insulin sensitivity and blood glucose homeostatis. This study aims to identify the effect of mixture powder (black rice, red beans, and moringa leaves) based feeding against the blood glucose level in rats. Methods: The study was an experimental research with pre and post control group design. A total of 20 Sprague Dawley female rats were divided into four groups, namely standard feed (PS), 80% mixture powder feeding (PB8), 50% mixture powder feeding (PB5) and 20% mixture powder feeding (PB2). The mixture powder intervention was executed about 5% of body weight for 28 days. Fasting blood glucose was measured using the GOD-PAP method. The data obtained was conducted the statistical analysis using the Analysis of Variance (ANOVA) at a 95% confidence level. If it showed a significant effect on the response variable, then Duncan's Multiple Range Test would be conducted. Results: There were significant differences in fasting blood glucose among groups after the mixture powder intervention. The results revealed that after 28 days, mixture powder might lower the serum glucose concentration from 122.69 mg/dL to 97.70 mg/dL (20.37%) in the PB8 group and from 123.91 mg/dL to 113.28 mg/dL (8.58%) in the PB5 group, but vice versa, the blood glucose in the PS group, intervened by standard-based feeding increased by 5.73%. According to these results, mixture powder can be considered to reduce blood glucose in people with obesity and metabolic syndrome. Conclusion: The intervention of a mixture of black rice, red beans, and Moringa leaves may significantly influence the fasting blood glucose in rats. Keywords: Black rice, red beans, moringa leaves, fasting blood glucose
Determination of Standard Parameters of Acorn Squash Leaves Oleh S. Shpychak
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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One of the priority tasks of pharmacy is to find new sources of raw materials for the medicinal products. The purpose of this work is to determine a number of indicators of the quality of promising medicinal raw materials that are the leaves of acorn squash Cucurbita pepo (Cucurbitaceae) for the creation of regulatory and technical documentation. For our research one of the most competitive kind - "Ukrainian multi-plant" was chosen. This kind is not sensitive to climatic conditions (drought-resistant). It has been grown in many countries with moderate climate and the most parts of Ukraine (Polissya, forest-steppe, steppe) and other since 1950. In this way, for the first time, 7 series of acorn squash leaves of "Ukrainian multi-plant" were studied. The main diagnostic features of morphological structure, including morphometric indicators, the main diagnostic microscopic features of the powder of acorn squash leaves were determined. The work presents the limit values of the main figures of 7 series of raw materials: weight loss during drying (not more than 8.5 %), total ash content (not more than 3.7 %,), extractive substances content (not less than 20.0%), phenolic compounds content (not less than 2.0 %). According to the results obtained the regulatory and technical documentation “Methods of quality control of” Acorn squash leaves “has been developed. Keywords: Acorn squash, Leaf, Morphological structure, Microscopic diagnostic signs, Plant raw materials.

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