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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis and Characterization of New Schiff bases Derivatives of Acetohydrazide and its Cyclization Reaction Mustafa M. Shihab
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

This work includes synthesis of hydrazide from 5-Amino-1, 3, 4-thiadiazole-2-thiol. Also reaction of hydrazide with different aromatic aldehydes by using glacial acetic acid as catalyst to synthesis of some new Schiff bases derivatives that coupled with thioglycolic acid to synthesis five- member ring heterocyclic compounds derivatives containing thiazolidinone ring. All synthetic compounds were definite by their melting point, FT-IR spectra and 1H-NMR spectra for some of them.Keywords: 5-Amino-1, 3, 4-thiadiazole-2-thiol, thiazolidinone, Schiff bases, Heterocyclic compounds, Thiadiazole.
POLYMORPHISM AND EXPRESSION OF TLR2 GENE IN IRAQI PULMONARY TUBERCULOSIS PATIENTS Lara Ghali A.Ali; Nawal Mohammed Utba; Ahmed Asmer Mankhi
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

AbstractObjective The innate immune system has evolved as the first line of defense against microorganisms, which involves specific pathogen recognition receptors such as toll-like receptors (TLR). The aim of the present study was to investigate whether the TLR2 gene polymorphism could influence the susceptibility to pulmonary tuberculosis (TB) and its expression level as well as its concentration in patients’ sera.Methods A total of 120 subjects, including 80 patients with TB including 40 multiple drug resistance (MDR), 20 recently diagnosed (RD) and 20 old cases (OC) of TB patients, in addition to 40 healthy control, were examined for TLR2 polymorphism over locus -100 microsatellite guanine-thymine repeats, 24969 (T>C) and 5305 (C>T). TLR2 gene expression was assayed using a real time PCR technique; furthermore, sera from 68 TB patients and 20 healthy control were assayed for TLR2 level using ELISA technique.Results We found that the TC genotypes showed a significantly increased frequency in MDR patients than control (35% vs.12.5%, respectively; **P = 0.034), and the associated OR value 3.77 with EF value of 0.25. That may regard TLR-2 rs3804100 TC as TB susceptibility genotype in the investigated Iraqi patients. Whereas the TLR-2 serum levels varied significantly (*p<0.05) between studied groups in regard to TT genotypes. For TLR-2 rs7696323, all TB patients and control groups have CC genotypes (Wild type). In respect to (GT)n microsatellite repeat; GT repeat alleles had insignificant differences (p > 0.05) between MDR and OC than control groups, while RD group was significantly higher [**P = 0.006] than control group in GT(24) repeat allele, with OR value of 5.2 and EF value of 0.33. Furthermore, this GT repeat allele associated with susceptibility to TB. For TLR-2 gene expression, the results revealed a significant decrease (*p< 0.05) in TB patients in comparison to control groups. A novel TLR-2 rs3804100 SNPs were detected in Iraqi Arabs at g.24870 in 15%, g.24864 in 1.25% and g.25212 in 32.5% of patients. Nevertheless, in control the novel SNPs were g.24887 in 2.5%, g.25212 in 7.5% and g. 25216 in 7.5%. On the other hand, a novel TLR-2 rs7696323 SNPs were determined in Iraq Arabs patients and control at g.23934 in 10%, g.23564 in 1.25%, g.23460 in 6.25%, g.23445 in 11.25%, g. 23452 in 10% and g. 23477 in 10% of TB patients. While in control group, g.23957 in 7.5%, g.23438 in 7.5%, g.23445 in 7.5%, g.23452 in 32.5% and g.23443 in 2.5% of control.ConclusionTLR2 genetic polymorphisms influence susceptibility to pulmonary TB. TLR2 variants play a role in the development of TB disease, probably by affecting TLR2 expression level. Moreover, the present study showed that during anti-tuberculosis treatment, which were seems likely responsible for controlling infection and excess inflammation
Molecular Detection of Cytomegalo, CDK2 and P27 in Tissues from Patients with Thyroid Carcinoma Shakir H. Mohammed Al-Alwany
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Background: Thyroid cancers are related to many environmental and genetic predisposing factors. Cytomegalovirus infection may activate the protein kinase pathways, where in papillary thyroid cancer aberrant activation of these pathways is frequently associated with BRAF mutation. The bulk of thyroid cancers has maintained the expression of p27 which is the inhibitor of Cdk2.Objective: The study was designed to examine cellular dysregulation mediated by the concordant protein expressions of CDK2 and P27 tumor suppressor genes with CMV in tissues from thyroid goiter and thyroid cancers.Patients and Methods: A seventy thyroid tissues were examined for HCMV-DNA and CDK2 & P27 genes expression. Those samples belonged to ( 30) patients diagnosed with thyroid cancer and (25) thyroid goiter tissues blocks as well as (15) autopsies from apparently normal thyroid tissues. The detection of HCMV was by in situ hybridization (ISH) whereas CDK2 & P27 genes expression by immunohistochemistry (IHC). Results: HCMV DNA-ISH reaction in thyroid cancers was found in 14 / 30 (46.7%), whereas 32% (8 out of 25cases) HCMV- positivity was detected in thyroid goiter group. None of healthy thyroid tissues revealed ISH reaction. The difference of the HCMV in thyroid cancers and  control was highly significant. Detection of CDK2 in thyroid cancer was found in 13 out of 30 (43.3%) and benign thyroid goiters group was 28 % (7 out of 25). Detection of p27- expressions in thyroid cancers  in 18 out of 30 (60%) was noticed; In thyroid goiter was detected in 36% (9 out of 25) and none of the examined healthy thyroid in the control group revealed such IHC- reactions for both CDK2 &P27 IHC reactions. The difference between the percentages of CDK2- as well as P27 proteins detection in thyroid tissues & control group was statistically significant (<0.05).Conclusions: The significant detection of HCMV along with CDK2 & P27genes expression in thyroid cancer patients could support an etiologic role for that virus along with these genes in thyroid carcinogenesis.Keywords: Thyroid Cancer, HCMV, ISH, IHC, CDK2&P27.
Nursing Supervision Model toward Patient Safety Goals On The Ward Nursalam .
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Clinical supervision of interactive reflective model is a guideline for the implementation of patient safety goals at the hospital.  This supervision supports the one who is supervised to improve self-awareness and professional development in the implementation of patient safety goals. The purpose of this research was to find out the influence of reflective interactive supervision model toward  the implementation of patient safety goals. The method used is quasi-experimental with pretest-posttest with control group design.  There were 24 subjects in interventions and 24 subjects in control  group. Data were taken using a proportional stratified random sample. The data were analyzed by using chi-square, independent sample t-test, paired sample t-test, Pearson correlation, and general linear model repeated measure was used for multivariate analysis. The result shows that there are significant differences after the implementation of interactive reflective supervision (p < 0.000). The average achievement score of the implementation of patient safety goals between groups shows a significant difference. In the intervention group, the achievement score began to show an improvement starting from the second measurement and the maximum score was seen in the fifth measurement. Clinical supervision interactive reflective model is potentially required by the head nurse as a guideline for supervising the implementation of the patient's safety goals in the hospital.Keywords: Supervision, Interactive reflective, Patient safety goal, Hospital.
Investigation of the E-Selectin rs5368 (C468T) Single Nucleotide Polymorphism Role INA Group of Type Two Diabetes Mellitus Iraqi Patients Nadia Fadhil Salman
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

Introduction: E-select in his cell glycoprotein that is expressed on the surface of endothelial cells in response to proinflammatory cytokines and it supports the rolling of leukocytes at the sites of inflammation and tissue injury.  Diabetes mellitus is a global health problem represented by metabolic disorder in which the genetic predisposition and unhealthy lifestyle interact with environmental factors to unmask the disease which might be a result of inflammation reflecting response. Aim: Detection of the E- Selectin rs5368 (C468T) Single Nucleotide Polymorphism role in a group of Type 2 Diabetes Mellitus Iraqi patients.  Material and methods: The E- Selectin rs5368 (C468T) Single Nucleotide Polymorphism was characterized using Restriction Enzyme Fragment Length Polymorphism (RFLP-PCR) technique by designing new set of specific primers, then the PCR product was visualized by agarose gel electrophoresis. Results: There was no significant association found between any of the E-Selectin rs5368 (C468T) genotypes and the incidence of T2DM. Also there was no significant difference for the allele’s distribution between the patients and control groups. Conclusions:  This study showed a success in the primers design and the PCR- RFLP protocol and techniques for the E-Selectin rs5368 (C468T), the sequence of E-Selectin rs5368 (C468T) polymorphism is found to be in concordance with the global registered NCBI sequence. The genotyping results showed that the E-Selectin rs5368 (C468T) polymorphism is not associated with the incidence of T2DM. Also there was no significant difference for the allele’s distribution between the patients and control groups.Key words: Type 2 Diabetes Mellitus, E- Selectin rs5368 (C468T) Single Nucleotide Polymorphism.
Isolation of Moraxella and Streptococcus from New Packed Orthodontic Materials Batool Hassan Al-Ghurabi
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

This study aimed to test the sterility of new unused orthodontic arch wires received from manufacturers. Forty samples of arch wires with two types of wires (nitinol and stainless steel) from four companies were used directly from the manufactures package in this study. Out of (40) arch wires tested, bacteria was isolated from 3 (7.5%) samples, only two genera of bacteria were isolated, namely Moraxella and Streptococcus. Current results appear that bacterial contamination on arch wires give lights on the need of sterilization before clinical use.Keywords: Orthodontic materials, Arch wires, Microbial contamination.
Copper Tetra-Tert-Butyl Phthalocyanine Thin Films for Ammonia Gas Detection Ameer A. Alhusseiny
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Thin films of copper tetra-tert- butyl Phthalocyanine (CuPc) have been prepared from their solution in chloroform using spin coating technique. Films then heated to (100, 200 and 300) oC to study the effect of annealing temperature on the characteristics of the prepared films. UV-visible spectrophotometer was used to investigate the absorption properties of the materials as well as the optical energy gaps. The morphology characteristics have been carried out utilizing atomic force microscopy (AFM). To demonstrate the sensing properties of CuPc films, I-V measurements were carried out using Keithly 2400 instrument to calculate the resistance before and after exposure to ammonia odorant. The prepared samples show a decrease in the resistance values after exposure to the contaminated air. Time dependency was also carried out to investigate the response and recovery time of the prepared device.Keywords: Copper phthalocyanine, Thin films, Gas sensor, Ammonia detection.
The Effect of Using Pain Management Techniques in the Rehabilitation of Chronic Lower Back Injury in Athletes and Non-Athletes Haider Jumaah Asree Ktaiman
Journal of Global Pharma Technology .
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Abstract

In the past few days increased chronic lower back pain, where today is a disease of the era due to the high effort and continuous and disproportionate exercise of the athlete and loads of low back, and the fact that chronic lower back pain is a disease of the modern era and through the experience and work of researchers in medicine Physical therapy and physiotherapy have found that there is little or no use of pain management techniques to treat chronic low back pain and that chronic low back pain is a disease of the modern age. Therefore, researchers considered this study as the first study in Iraq in terms of Techniques in pain management to treat chronic lower back pain. The researchers used the experimental method was the sample included the 12 players injured who suffer from the bottom of the chronic back pain represented by convulsions and muscle cramps, chronic where formed the experimental group of 6 players used pain management techniques within the program consists of 16 weeks either the control group used its traditional 16 week. Search Results showed superiority of the experimental group on the control group in the test Schober to measure the degree of pain where he showed differences (0.021 (in the test side flexibility differences emerged (0.01).Keyword: Pain management techniques, Rehabilitation, Lower back injury.
Maintaining and Developing Ethical Corporate Culture Moslem Soleymanpor
Journal of Global Pharma Technology Volume 08 Issue 05
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Abstract

Of  all  the  issues  boards  of  directors,  executives,  and  managers  face,  one could  argue  that  unethical  corporate  activity  is  one  of  the  most  significant  in  terms  of its  potential  negative  impact  and  also  one  of  the  most  difficult  to  properly  address. This  article  argues  that  three  key  elements  must  exist  if  illegal  or  unethical  activity within  and  on  behalf  of  organizations  is  to  be  minimized  through  developing  and sustaining  an  ethical  corporate  culture.  The  three  elements  include  (1)  the  existence of  a  set  of  core  ethical  values  infused  throughout  the  organization  in  its  policies, processes,  and  practices;  (2)  the  establishment  of  a  formal  ethics  program,  including a  code  of  ethics,  ethics  training,  an  ethics  hotline,  and  an  ethics  officer;  and  (3)  the continuous  presence  of  ethical  leadership-that  is,  an  appropriate  ‘tone  at  the  top’  as reflected  by  the  board  of  directors,  senior  executives,  and  managers.  While  each  of these  three  elements  is  distinct,  they  also  overlap,  relate  to,  and  reinforce  each other.  This  article  discusses  each  of  the  three  key  elements  necessary  to  develop  and maintain  an  ethical  corporate  culture. Keywords: Ethical corporate culture; Ethical values; Ethics programs; Ethical  leadership. 
Effects Cuminum cyminum Extracts in Lipid Profile Levels and Internal Tissues of Infected Balb/c Mice with Hydatid Cysts Maroof Sabti Juma Al-Ammash
Journal of Global Pharma Technology .
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Abstract

Hydatidosis is one of the most cosmopolitan zoonotic disease that may causes death and still very common in the developing world. The present study aimed to detect the effects of Albendazole and C. cyminum extracts on lipid profile, liver and spleen of infected Balb/c mice with hydatidosis. This study showed positive results for tannins, phenolic compounds, flavonoids and glycosides in alcoholic and aqueous extracts of C. cyminum, while negative result for  alkaloids. Significant (p ≤ 0.05) increasing of total cholesterol was detected for the third (273.57 mg/dl) and fourth (281.73 mg/dl) positive control groups.   Triglycerides shows significant increasing in groups 3 (248.65 mg/dl) and 4 (260.30 mg/dl) of positive control groups. About HDL-C, significant decreasing was recorded  in the third and fourth positive control groups (40.87 mg/dl and 33.42 mg/dl, respectively), while significant (p ≤ 0.05) elevation  was occurred for HDL-C in Albendazole treatment group (60.87 mg/dl) as compared with the negative control group, with no significant differences were reported for HDL-C in alcohol and aqueous extract treated groups. For histological study, the present study showed degeneration of hepatocytes, thickening wall of hepatic blood vessels and infiltration of lymphocytes for Albendazole treatment group, while alcoholic and aqueous extract treated groups showed central vein, hepatocytes and sinusoids with normal sizes. Concerning spleen, results in the current study showed normal shape and size for white pulp, red pulp and central artery of all treatment groups, while edema and necrotic materials appeared in some of positive control groups.Keywords: Hydatidosis, Hydatid cyst, Cuminum cyminum extract Histological effects.

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