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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Adding Different Concentrations of the Mint oil Mentha spicata L. to the Ration on Some Blood Traits of Broiler Chicks Ross 308 Nihad Abdul-Lateef Ali
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

This study was conducted at poultry farm of Animal Resources Dept., College of Agriculture, and University of AL-Qasim Green to investigate the effect of adding different concentrations of the Mint oil Menthaspicata L. to the ration on some blood traits of broiler chicks Ross 308. Use the 144 broiler chicks Ross 308 day-old were randomly assigned to four treatments by 3 replicates per treatment (12 chicks per replicate). The treatments were as follows: The first treatment (control) without adding mint oil to the ration. Adding mint oil at a concentration of 600 mg / kg basal feed (second treatment). While third treatment had mint oil at a concentration of 800 mg / kg feed. Adding mint oil at a concentration of 1000 mg / kg feed (fourth treatment). The study included the following characteristics: red blood cell counts, white blood cell counts, hematocrit, hemoglobin concentration and differential leucocyte count. The results indicated that the addition of mint oil at a concentration of 600 ، 800 and 1000 mg / kg feed to broiler ration led to a significant improvement in white blood cell counts of broiler chick’s ، and addition of 1000 mg Mint oil / kg of significantly improved the lymphocytes cell compared to the first treatment (control) and the second treatment. Keywords: Mint oil, Broiler chicks, Blood parameters.
Effect of Frozen Storage on Nutritional Chemical Quality of Shrimp (Exopalaemon Styliferus) from the South of Iraq Mahdi Hassan Hussain
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The aim of this research is to investigate the influence of frozen storage at -20°C for six month on nutritional chemical quality of shrimp Exopalaemon styliferus that include moisture, PH. protein, fat, volatile basic nitrogen (TVB-N), trimethylamine nitrogen (TMAN), Free fatty acid (FFA) Formaldehyde (FA) content, thiobarbituric acid reactive substances (TBARS) and astaxanthin. Results of present study indicated that values of PH, TVB-N, TMAN, FFA, FA and TBARS were increased with increasing time during frozen storage. However, values of moisture, protein, fat and astaxanthin were decreased during storage.Keywords: Frozen storage, Shrimp, Nutritional quality, TVB-N, TMA, Formaldehyde.
Synthesis, Characterization, and Antimicrobial Activity of New Schiff’s and Mannich Bases of Isatin and Isatin Derivatives May Mohammed Jawad Al-Mudhafar
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Objective: Schiff’s and Mannich bases of isatins are an important group of heterocyclic compounds which are of great importance in medicinal chemistry as antimicrobial agents. In the vision of these facts, new bis-Schiff bases and Mannich bases of isatins were synthesized. Methods: Three different bis-Schiff bases (3a-c) have been synthesized by reacting isatin, 5-fluoroisatin and 5-methoxy isatin with thiophene-2-carboxaldehyde using hydrazine hydrate to link between the carbonyl compounds, and then these bis- Schiff bases were condensed with two different secondary amines (piperidine and morpholine) separately, and formaldehyde to form the Mannich bases (4a-c and 5a-f), respectively. Results: The structures of the newly synthesized compounds were confirmed using (Fourier- transform infrared) FTIR, 1H-nuclear magnetic resonance spectroscopy (¹H-NMR) and CHNS elementary analysis. All the synthesized bis-Schiff bases and Mannich bases were screened for their antimicrobial activities. Conclusion: The target compounds showed convincing antibacterial activity, whereas their antifungal activity was more potent, and the most active ones were Mannich bases of 5-methoxy isatin derivatives (4c and 5c) against Candida albicans.Keywords: Antimicrobial activity, Bis-Schiff bases, Isatin derivatives, Mannich bases, Thiophene-2-carboxaldehyde.
Effect of Valsartan on Echo Cardio Graphic Fraction Shortening, Troponin I, Malondialdehyde in Trastuzumab Treated Females with Breast Cancer Maysaa Ali Abdul Khaleq
Journal of Global Pharma Technology .
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Abstract

Background: Trastuzumab therapy is highly effective in HER2 positive breast cancer patients, but it is complicated by cardio toxicity. Objective: To elucidate the possible effects of valsartan medication on echocardiographic fraction shortening, serum troponin I and serum malondialdehyde in trastuzumab treated patients with HER2 positive breast cancer. Patients and Methods: A total of twenty six female patients with HER2 positive breast cancer were enrolled in this study. The patients were randomized into two groups, thirteen patients in each group. Group I included patients who received trastuzumab medication for 8 cycles with 21 days apart. Group II included patients who treated with trastuzumab medication with valsartan 40 mg, orally, once daily dose for 8 cycles. Echocardiography was used to measure fraction shortening at zero time, 4th and 8th cycles in both groups Serum troponin I and malondialdehyde were measured at zero time, 2nd, 4th, 6th and 8th cycles in both groups. Results: Treatment with trastuzumab medication caused a significant reduction in echocardiographic fraction shortening at an only 8th cycle in comparison to baseline level readings (P < 0.05). Combined trastuzumab plus valsartan medications caused a significant increment in echocardiographic fraction shortening in comparison with that of trastuzumab medication group (P < 0.05). Regarding serum troponin I and malondialdehyde, trastuzumab medication caused a significant increment in both these markers compared with those baseline readings (P < 0.05). Combined trastuzumab plus valsartan caused significant reduction in troponin I and malondialdehyde in comparison with that of trastuzumab medication group (P < 0.05). Conclusion: Valsartan causes significant increase in echocardiographic fraction shortening level and cause significant reduction in serum troponin I and malondialdehyde in trastuzumab treated patients.Keywords: Valsartan, Trastuzumab, Cardiotoxicity, Fraction shortening, Troponin I, MDA.
Copper (II) and Silver (I) Complexes with bis Schiff Base Ligand: Synthesis, Spectral Characterization and Thermal Studies Ahmed Razzaq Ibrahim
Journal of Global Pharma Technology .
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Abstract

Metal complexes of the bis Schiff base (BSAA) ligand, synthesized via condensation 4-amino antipyrine with 4-(4-dimethylamino) benzalidene amino) benzaldehyde which has synthesized from condensation p-amino benzaldehyde and p-dimethyl amino benzaldehyde, are synthesized from nitrate salts of Cu(II) and Ag(I) with ligand in ethanol. The metal complexes and ligand are characterized o86n the basis of elemental analyses, melting point, molar conductance, UV –Vissible , FTIR and thermo gravimetric analysis. The molar conductance data revel that the metal chelates of the ligand with Cu (II) and Ag (I) are electrolytes. From the suggest that the concent sites were proven to be through oxygen of the ring and Nitrogen of the azomethine group.Keywords: 4-aminoantipyrine, copper, Silver, TGA
Direct Molecular Detection and Phylogenetic Relationship of Staphylococcus aurous from Mastitis Milk in Sheep and Cows Esraa T.M.
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The present study included the direct detection of Staphylococcus aurous isolated from milk of sheep and cows  infected by mastitis based 16SrRNA gene by PCR technique and study the phylogenetic relationship analysis based on spa gene of using DNA sequence method.  The study includes collected 32 sheep and 45 cow’s mastitis milk samples. These samples were submitted to milk DNA extraction, and then performed PCR technique. The PCR results were showed significant at P value: (< 0.05) in prevalence between sheep and cow Staphylococcus aurous positive isolates at (5/15.5%) and (14/31.1%) respectively.  DNA sequencing of partial sequence of spa gene was showed Staphylococcus aureus sheep isolate was genetic relationship analysis different than cow isolate and related to NCBI-Blast Staphylococcus aureus isolate H13939 (AM407304.1) at  (99%) homology sequence identity and NCBI-Blast Staphylococcus aureus strain AO124 (JX912490.1) at  (94%) homology sequence identity total genetic change (0.005). In conclusion, Staphylococcus aurous isolated from mastitis milk in sheep and cows were not related genetically. Therefore, Spa gene analysis was provides an efficient method for investigating phylogenetic relationships among different clinical isolates and can be useful for monitoring distribution of pathogen related to public health.Keywords: Staphylococcus aureus, Milk, Sheep, Cow, PCR, 16SrRNA, spa gene.
Integrated View of Formaldehyde in Lung Toxicity: Molecular Mechanisms, Cellular Aberrations and Pathological Considerations Soheir E. Kotob
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Formaldehyde (FA) is an indoor and occupational pollutant, with marked carcinogenic impact on the airways. The current investigation was initiated to determine the molecular, immunohistochemical and histopathological alterations in lung tissue of rats subjected to FA inhalation and to provide new reliable biomarkers of the hazardous insults of FA on the lung. Adult female Wistar rats were assigned into five groups; (1): negative control; (2): 10 ppm FA inhalation for 15 days; (3): 20 ppm FA inhalation for 15 days; (4): 10 ppm FA inhalation for 30 days and (5): 20 ppm FA inhalation for 30 days. After the experimental periods; rats were killed and lung tissues were harvested and prepared for molecular genetics, immunohistochemical and histopathological procedures. Molecular genetic results indicated significant overexpression in pulmonary Cyp2c6 gene in the group of rats submitted to FA inhalation (20 ppm) for 30 days. The expression level of pulmonary Bhmt gene showed significant upregulation in the groups of rats inhaled 10 and 20 ppm FA for 30 days. Pulmonary Mapk12, HLA-A and GsTpi gene expression levels revealed significant over expression in the groups of rats subjected to FA inhalation (10 ppm) for 30 days and (20 ppm) for 15 as well as 30 days. Meanwhile, the level of expression of pulmonary gene HLA-A recorded significant downregulation in the group of rats inhaled FA (10 ppm) for 15 days versus the control counterparts. In addition, immunohistochmical findings denoted positive immunoreactive responses for PCNA and cytochrome c in the lung tissue with different degrees according to the dose and duration of FA exposure. Histopathological description of lung tissue sections of rats underwent FA inhalation revealed various levels of histoarchitectural alterations depending on the dose and time interval of FA subjection. According to the before mentioned data, it seems that extreme FA burden on the lung leads to devastating effects on the molecular level (genotoxicity) and on the cellular level (proliferation and apoptosis). Also, morophological deformation depicted by histopathological investigation indicated the induction of conformational and structural alterations of lung tissue as a consequence of FA inhalation.
Synthesis, Spectral Characterization and Biological Activity of Dithiocarbamate-based Ligand and its Metal Complexes Mohamad J. Al-Jeboori
Journal of Global Pharma Technology .
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Abstract

This work is based on the synthesis, structural characterization and biological activity of somedithiocarbamate-based complexes. The free dithiocarbamate ligand was prepared via several synthetic routesincluding the formation of Schiff-base. The reaction of 2,6-diaminopyridine with benzaldehyde resulted in theformation of Schiff-base which reduced to the corresponding diamine by methanolic NaBH 4 . The reaction ofdiamine with CS 2 in a methanolic solution of KOH resulted in the preparation of the free dithiocarbamateligand. Macrocyclic complexes were formed from the reaction of the appropriate metal chloride with the ligandin an ethanolic medium. The suggested geometries around metal centres were determined using a range ofphysicochemical and spectroscopic techniques. The analytical and spectroscopic data revealed the formationof four and six coordinate complexes. Complexes of the general formula [M(L)] 2 (where M= Fe(II), Co(II) andZn(II) indicated metal centres adopt tetrahedral geometries. Complexes with the general formula [M(L)(H 2 O) 2 ] 2(where M= Mn(II), Ni(II), Cu(II) indicated octahedral structures around metal centres. Biological activity of theligand and its complexes against four strains of bacteria (Escherichia coli (E. coli), Pseudomonas aeruginosa,Bacillus cereus and Staphylococcus aureus) and antifungal activity against two types of pathogenic fungi,Aspergillus niger and Aspergillus parasiticus are tested.Keywords: Dithiocarbamate ligand; Transition metal complexes; Spectral characterization; Biological activity.
Presenting a Method for Line Selection on SCTP-CMT Protocol Using Adaptive Neuro-Fuzzy Inference System (ANFIS) Abozar Dolatabadinezhad
Journal of Global Pharma Technology Volume 08 Issue 04
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Abstract

The issue of line selection and the amount of data to be streamed in SCTP_CMT with dissimilar lines is one of the important challenges to increaseSCTP-CMT protocol efficiency. Line selection with lower probability of failing in data streaming from several simultaneous paths is possible by the use of line properties such as bandwidth and line congestion. In this study, a controlling method has been presented using ANFIS for an optimal line selection and the number of data appropriate with each line properties. Using a random data set, the neuro-fuzzy system was evaluated in this study and finally the idleness of data streaming lines was calculated using the proposed neuro-fuzzy system compared to the random selection of data streaming lines. Results of evaluations indicate a reduction of idleness of the data streaming lines in the proposed method compared to the random line selection method in SCTP-CMT. The reduction in idleness of data streaming linesdirectly influences the time of data streaming and can reduce the time required for data streaming.Keywords: Communication protocol, Sctp-Cmt, Fuzzy logic, Neural network, Fuzzy system, Bandwidth, line congestion.
Various Technical Variables in Blanching, Coating, Frying to the Physicochemical Properties Fried Pigmented Potato (solanum tuberosum l.) Crisp Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Pigmented potato (Solanum tuberosum L.) varieties are a rich source of anthocyanins, in particular acylated derivatives. The potato products such as French fries, chips, balls etc. are also fried products which absorb high amount of oil. These products though taste good, pose health problems due to high calorie and cholesterol intake. The consumers prefer to low fat and fatfree fried foods. This research has been focused on different parameters of blanching, coating, frying, kind of frying oil for minimum oil absorption and sensory palatability while maintaining the most phytochemical components such as total phenolic, total flavonoid and anthocyanin during preservation. Results revealed that blanching 95oC in 30 seconds with ascorbic acid of 0.05 g/100g potato, coating with carrageenan 0.20%, frying 4 mm of potato crisp in sunflower oil heating at 155oC in 2 minutes was appropriated. Fried potato crisp could be preserved for 12 weeks at ambient 4oC. Moisture and oil content, as well as colour and texture are important quality attributes of fried potato products which were significantly affected by blanching.  Reducing the oil content of fried potato slices by application of coating is an effective method. Frying of potato crisps is carried out to convert the tubers to value added products. Frying method brings out unique flavor and texture to the products that improve their overall acceptability. Kind of oil used for frying also positively affected to oxidative reaction in fried potato crisps. The present study has examined various technical aspects to minimize the oil uptake in fried foods still retaining the desirable texture and flavor of the final product.Keywords: Potato crisp, Blanching, Coating, Frying, Shelf life, Anthocyanin, Flavonoid, Carrageenan.

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