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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis, Characterization and Antibacterial Study of New 4-Thiazolidinone and Tetrazole Compounds Derived from Thiosemicarbazone and Hydrazones Israa A. Mosa
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

A new 4-thiazolidinone, substitutedbenzylidene-thiazolidinone and tetrazole were synthesized from thiosemicarbazone and hydrazone. The thiosemicarbazone was prepared by the reaction of thiosemicarbazide with aldehyde derivative from L-ascorbic acid in absolute ethanol using glacial acetic acid as a catalyst. 1, 3-thiazolidin-4-ones were synthesized from the condensation of thiosemicarbazones with chloroacetic acid in presence of anhydrous sodium acetate. A 1, 3- thiazolidine-4-one was reaction with several 4-substitutedaldehydes to produce new derivatives with a double bond at the position-5 of the 4-thiazolidinone ring. While the tetrazole compounds were synthesized by 1, 3-cycloaddition reaction of sodium azide and hydrazone compounds in dimethylformamide. The hydrazone compounds were prepared by the reaction of phenylhydrazine or substituted phenylhydrazine with aldehyde derivative from L-ascorbic acid in absolute ethanol using glacial acetic acid as a catalyst. The structures of newly synthesized compounds were established on the basis of spectroscopy data.Keywords: L-Ascorbic acid, 4-Thiazolidinone, Alken, Thiosemicarbazone, Tetrazole, Hydrazone. 
Evaluation of Serum 8-Hydroxy-Deoxyguanosine, Interleukin-6 and Interleukin-7 in Type 2 Diabetic Iraqi Females Shakir F.T. Alaaraji
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Background: Diabetes a devastating disease throughout the world. It is related with numerous mechanisms, the first one is oxidative stress. Oxidative stress shows an main role in the pathogenesis and the complications of disease. Objective: The aim of the current study was to measure five important factors in patients with type 2 diabetic patients (the amount of 8-OHDG, IL-6, IL-7, Blood Pressure, and Pulses). These factors were surveyed in type 2 diabetic patients to compare with healthy controls and study the association among 8-OHDG in diabetic patients with other parameters in the study. Materials & Methods: Population consists of 51 patients diagnosed with T2DM and a control group of 31 healthy people. 8-OHDG, interleukin-6, interleukin-7 and blood pressure levels were assessed in all subjects. Results: Levels of five markers in serum (8-OHDG, IL-6, IL-7, Blood Pressure, and Pulses) were significantly greater inT2DM group compared to control group. The receiver operator curve (ROC) analysis of the forthcoming variations revealed the descending order of serum IL-7 (0.975), IL-6 (0.972), and 8-OHDG (0.899), Conclusion: the study recommends that 8-OHDG level in type 2 diabetic patients may be a useful marker of DNA damage. So we should monitor this variable level in blood continuously to maintain their health.Keywords: ● T2DM ● Interleukin-6 ● Interleukin-7 ●8-OHDG.
Formulation and Characterisation of Nanosuspension of plant extract Cocculus Pendulus Sampath Kumar Ramala
Journal of Global Pharma Technology Volume 11 Issue 07 (2019) July 2019
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ABSTRACT:Nanotechnology is a promising technique to increase the bioavailability of herbal medicines. The present study was  formulated to evaluate nanoparticles using an ethanolic extract of Cocculus pendulus. The sonoprecipitation technique was employed for the preparation of nanosuspensions with poloxamer-407 and PVA with many trails and finally the optimized nanosuspension demonstrated a mean particle size, polydispersity index, and zeta potential of 536 nm, 0.256, and − 17.6 mV, respectively. The results of the characterization studies illustrated that the nanosuspension was in the nanometer size range and spherical in shape had good surface morphology. The present outcomes clearly demonstrated that to obtain an effective therapeutic potential, nanoformulation of medicinal plants is a better alternative than conventional dosage forms. Key words:Nanosuspension, sonoprecipitation, mean particle size, polydispersity index, and zeta potential
Effect of Ethanol Extracts of Mustard Green (Brassica rapa L.) on Streptozotocin Induced Rats Sri Wahjuni
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Objective: This experimental study was conducted to evaluate the effect of the mustard green extract on blood glucose and the pancreas histopathological feature. Methods: Five groups of rats divided into the control group that received standard food (P0) and streptozotocin-induced group (P1, P2, P4, and P4). P1 (positive control group) was given glibenclamide; P2, P3, and P4 (treatment group) were given mustard green ethanol extract at a dose of 0.5; 2.0; and 5.0 mg/kg body weight/day respectively. The separation of ethanol extract of mustard green was carried out by  LC-MS/MS. One way ANOVA and Post hoc test was conducted to evaluate the mean difference of the blood glucose. Results: Post hoc test showed significant result for P0 vs P3 (p<0.001), P0 vs P4 (p=0.001), P1 vs P2 (p=0.048), P2 vs P3 (p=0.001). Comparison between P1 and treatment group was found a similar effect on blood glucose between P1 vs P3 (p=0.048) and P1 vs P4 (p=0.830). Histological studies showed the administration of ethanol extract of mustard green showed a restorative effect. Conclusion: Administration of ethanol extract of mustard green decrease the level of blood glucose and might be a usable treatment for hyperglycemia.Keywords: Mustard green (Brassica rapa L.), Streptozotocin, Hyperglycemic effects.
The Performance of Ross 308 and Arbor Acres Broiler Breeder and their Commercial Broiler in Iraq Khalid Hamid Hassan
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

The broiler industry in Iraq depends on importing or producing hatching eggs by using many commercial broiler breeder, such as Hubbard, Lohmann, Ross 308 and Arbor Acres, to supply hatcheries within the broiler industry in Iraq. The aim of this study is evaluating the performance of the female line of Ross 308  and Arbor Acres broiler breeder, and the performance of its broiler progeny. The chicks of the two genetic groups were reared up from hatch to 35 days of age, and the process was replicated for three hatches. The results showed a significant difference in egg weight between Ross 308 and Arbor Acres female lines (77.68 and 69.62 g. respectively) and a significant difference in albumin weight and shell thickness, while there are no significant differences between the genetic groups in body weight, egg production and number of eggs per hen. There is a significant superiority of Ross 308 compared with Arbor Acres in protein and triglyceride concentrations in blood plasma. There are no significant differences between Ross 308 and Arbor Acres broiler in all growth traits.Keywords: Broiler performance, Hatching eggs, Ross 308, Arbor Acres.
The Effect of Hypoxic Control Mask Exercises on Some Physiological Indicators in Terms of the Sport Technology for Young Players in Volleyball Suhad Qasem Al-Moussawi
Journal of Global Pharma Technology .
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Abstract

The objectives of the study was to prepare exercises using the hypoxic mask in volleyball, to identify the effect of exercises using the hypoxic control mask in some physiological indicators in terms of the sports technology of young players in volleyball, the experimental method was used in experimental design of two experimental groups with tight control in both the tribal and remote tests on a sample of (12) young players from the volleyball industry club in the sports season (2018), were deliberately selected. The sample was randomly divided into two experimental groups of equal number. The dependent variables were determined by physiological indicators (time of the anaerobic threshold, frequency of breathing during the voltage, peak oxygen during the voltage), Adopting the technology of sport by testing the physical effort with a device system (Fitmatepro), these exercises were implemented at the beginning of the main section of the training unit at a rate of (3) training modules for a period of (8) training weeks. This indicates the number of training units (24) training units. The training exercises are similar to the volleyball skill and height control. (2000-3000) meters in increments and not more than (20) minutes from the main section of the training module, so as not to constitute harm or risk to the safety of young players, and the results were processed by the system (SPSS), and concluded the researchers that training with the hypoxic mask helps young players volleyball To develop the threshold And increase the peak oxygen, and the number of times the breath during the effort, which is a training tool that can help trainers to compensate for training in the highlands or training in different circumstances, and the young players in the volleyball who train them outperform others who train without them when developing these indicators.Keywords: Hypoxic mask, Exercises, Physiological indicators and sport technology.
Utilizing Bioidentical Hormone as Efficacious and Safe Hormone Jopy Wikana
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

Background: The relative safety and efficacy of bioidentical hormone compared with synthetic version of hormone replacement therapy (HRT) is still the subject of debate. Some data suggest that bioidentical hormones have opposite physiological effects to synthetic hormones, which associated with lower risk of breast cancer and cardiovascular events. Nevertheless, there is still little evidence to support claims that bioidentical hormones are safer and more effective. Methods: Published papers were identified from PLOS, PubMed/MEDLINE, ProQuest, ScienceDirect, Google Scholar, and Elsevier (SCOPUS) databases, written in English, and fully accessible by reviewers, for studies enrolled postmenopausal women using bioidentical hormones vs. synthetic hormones as HRT. Results: A hundred and eighteen of 341 citations were reviewed. The results of this study found the disparities between bioidentical and synthetic hormones with respect to safety and efficacy. Bioidentical hormones have demonstrated effectiveness in addressing menopausal symptoms. Clinical data has indicated that bioidentical hormone, especially progesterone is associated with a diminished risk for breast cancer and cardiovascular disease, compared with commonly used synthetic versions. Conclusions: The use of bioidentical hormone therapy is well tolerated, provides symptom relief and can address the safer and more efficacious forms of HRT with respect to the lower risk for breast cancer and cardiovascular disease. Thus, bioidentical hormones remain the preferred method of HRT.Keywords: Progesterone, Estradiol, Synthetic progestins, Breast cancer, Cardiovascular disease,
Molecular Detection of New Delhi Metallo Beta Lactamase 1 (NDM-1) - Producing Salmonella Typhi in Patients with Typhoid Fever Qasim S. Al-Mayah
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Background: Antibiotic resistance among different pathogenic bacteria becomes a major therapeutic change and requires prompt solutions. Aims: this study aimed to investigate the prevalence of New Delhi metallo-β-lactamase-1 (blaNDM-1) gene in Salmonella Typhi isolated from patients with typhoid fever. Materials and Methods: This a cross-sectional study including 100 patients with typhoid fevers. A blood sample was collected from each patient, and cultivated on a selective media for Salmonella where the diagnosis was made phenotypically and by API20E system. Disk diffusion test was used to examine the microbial sensitivity to imipenem and meropenem, while the ability of the bacteria to produce the carbapenemase was examined using Modified Hodge’s test. For blaNDM-1gene detection, the plasmid DNA was extracted and a specific set of primers was used to amplify this gene in conventional polymerase chain reaction (PCR). Results: Out of 100 patients, 37 (37%) had a positive blood culture, of which 13 isolates showed some antibiotic resistance: 7 isolates for imipenem, 4 isolates to meropenem, and 2 isolates both antibiotics. Of those 13 isolates, 10 (76.9 %) were positively showing their ability to produce carbapenemases, while 9 isolates (69.2%) showed a successful blaNDM-1 gene amplification. Conclusions: There is a relatively high rate of carbapenemases-producing and as well as NDM-1 producing S. Typhi strains among Iraqi patients with typhoid fever
The Effect of Assertiveness Training Skill on Feelings of Happiness and Mental Health of Students in Iran Bahram Gheitarani
Journal of Global Pharma Technology .
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Background and objective Assertiveness is one skill that it can change interpersonal relations and cause happiness. Hence, the aim of present study is the effect of assertiveness training skill on feelings of happiness and mental health of students. Methods and materials the method in this study is empirical method with control group. Statistical population in this study consists of all male high school students of Radar City by 2016. Among those students identified with low assertiveness by their teachers and those with low scores in Mental Health Questionnaire, 30 students were selected randomly and were placed in two experimental and control groups. The experimental group received sessions of assertiveness training and control group was remained in waiting list. Both groups fulfilled Happiness Questionnaire and General Health Questionnaire (GHQ) before and after intervention. Data analysis was done using analysis of covariance (MANCOVA) using SPSS-22.Results The results showed that there is significant difference statistically between two groups in terms of amount of happiness and mental health after training assertiveness training (p<0.01). Conclusion Training assertiveness skill can enhance happiness and mental health of students.Keywords: Assertiveness methods, Happiness, Mental health.
Study Expression of Fibronectin in the Samples of Oral Squamous Cell Carcinoma Zaidoon Jasim Rmaidh
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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The current study included samples of 30 sample oral squamous cell carcinoma with a ranged age 33-67 years in mean age 47±9 in different sex.  Regarding the size of oral squamous carcinomacase, 10 cases of each size T1, T2 and T3 appeared in the same percentage (33.3%). Concerning grade of oral squamous cell carcinoma case, majority of them (15) cases (50%) had grade I, while (10) cases (33.3%) had grade II (oral squamous carcinoma well differentiated), (3) cases (10.0%) had grade III and (2) cases (7.1%) had grade IV (differentiated poorly oral squamous carcinoma).The results of analysis showed Positive fibrnectin expression using Immuno staining teqnique was found in all oral squamous cell carcinoma cases as brown extracellular matrix, cellular localization expression and cytoplasmic expression, fibrnectin expression using immunohistochemichal staining of the oral squamous carcinoma cases  which reveals that (5) cases (17.3%) showed  protein expression weak positive, (15) cases (50%) showed protein expression moderate positive and (10) cases (33.3%)showed  protein expression strong positive.Keywords: Fibronectin, Squamous carcinoma in oral, Immunohistochemichal teqnique.

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