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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Compensatory and Adaptive Features of the Cerebellum under Stress Alexey Rozhentsev
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

The paper discusses the results of the study of compensatory and adaptive changes in rat cerebellar tissues under stress. As a stress factor, the experiment simulated (hypobaric) hypoxia. Since hypoxia remains one of the central issues in the modern medical science, it is directly or indirectly related to human diseases of various etiologies. To identify the features of compensatory and adaptive changes in the rat cerebellum under the action of hypoxia, we conducted comprehensive histological and histochemical studies. At the early stages of hypoxia, changes in the cerebellar tissue could be found, that were characterized by a significant increase in the volume of intracellular structures. With a prolonged hypoxia, a decrease in the volume of intracellular structures was observed which, in turn, entailed a decrease in total glycosaminoglycans and a change in the ratio of sulfated and non-sulfated glycosaminoglycans. In addition, we noted cerebellar neuron migration into the molecular layer.  The experiment revealed that hypoxia has a significant effect on the intensity of metabolic processes in cells, with the generation of intermediate metabolic products leading to a change in pH.Keywords: Hypoxia, Cerebellum, Rats, Compensatory and adaptive changes, Glycosaminoglycans.
Cytological Diagnosis of Ovarian Tumors Ahmed Al Qteishat
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Ovarian cancer is one of the most common oncology disorders of the female reproductive system. The aim of the study is to estimate the efficiency of cytological methods in identification of specific characteristics of ovarian cancer and other cancers of female reproductive system. The research was conducted in oncology clinics of Moscow (Russian Federation) and Sofia (Bulgaria) within a period between 2012 and 2019. The study involved 373 cancer female patients who were divided into two groups: the study group (242 women, average age 38.5 ± 7.8 years) and the comparison group (131 women, average age 42.1 ± 9.0 years). The study group included patients diagnosed with ovarian, breast, and endometrial cancer, while the comparison group comprised patients with stomach and lung cancer. The methods of light microscopy, immunocytochemistry and cytological methods were applied in this research. Two types of breast cancer (with ductal breast cancer predomination over the lobular one) and three types of ovarian cancer were specified. The final diagnosis of small cell lung cancer was 15% of lung cancer cases. This cytocentrifuge method was applied in 20% of ovarian cancer cases. Immunocytochemistry revealed a significant response to epithelial antibodies and a negative response to mesothelial ones in breast cancer (p ≤ 0.001). Also, there was no response to monoclonal antigens in ovarian cancer (p ≤ 0.001). This enabled the researchers to recognize and diagnose the mentioned cancer types. A one-year mortality of breast and ovarian cancer was established in 45-47% of patients, which indicated that disease was diagnosed at advanced stages. The study showed the cytological methods to be not equally used in different cancer types: mostly used in breast and ovarian cancers of the study group and almost not applied in lung cancer. In the comparison group, such results were obtained only in stomach cancer. Cell vacuolization was detected in 65% of ovarian cancer cases, while in 80% of ductal breast cancer cases there were specified clusters of spherical cells. Cell structures in the form of bands and chains were found in 75% of lobular breast cancer cases. Single signet ring cells were identified in 20% of stomach cancer cases in the comparison group. The results of the study proved the cytological methods to be significantly important in facilitating the diagnosis of adenogenous ovarian and breast cancer in the study group. Keywords: Ovarian cancer, Breast cancer, Endometrium, cytological methods, Monoclonal antigens.
Building Design and Performance Test of Vibration Beds with Whole Body Vibration Desak Ketut Indrasari Utami
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Introduction: Vibration is a mechanical motion that oscillates around a fixed point. Whole Body Vibration (WBV) can be defined as vibrations that pass through the surface, backrest, or the floor, either in standing or reclining position. WBV has been proved to lower the level of awakening, inducing sleepiness by providing sense of comfort, and improving insomnia. This study aims to construct a bed with Whole Body Vibration (WBV) which was expected to provide comfort, lowering sleep onset, as well as inducing sound sleep, thus becoming a non-pharmacological treatment option for sleep disorders. Method: This study was conducted in two stages which began with designing and manufacturing of the vibration bed and followed by a performance test. Assesment was conducted based on subjective interviews. Performance test results were presented descriptively. Result: According to the functionality testing, the vibration bed could produce vibration frequency between 1-4 Hertz and displacement 0.094-0.397 mm on vertically directed vibration. According to performance test, as many as 94.1% of subject’s preferred 1 Hertz frequency compared to other frequencies. Furthermore, 88.23% felt comfortable using the vibration bed, 76.47% experienced improvement in onset of sleep and also more soundly sleep. There were only 23.52% of subjects that experienced no change from previous sleep pattern. No side effects were found during the performance test. Conclusion: Lower frequency Whole Body Vibration (WBV) bed with vertical vibration effectively enhanced the subjects’ sense of comfort and improved sleep quality with no observed side effect.Keywords: Whole Body Vibration, Vibrating bed design, Insomnia, Performance test.
Development and Validation of a Simple UV-Spectroscopic Method for the Estimate Metoprolol Tartrate in Bulk and Tablet Formulation SG Vasantharaju
Journal of Global Pharma Technology Volume 9 Issue 07
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Abstract

Objective: UV-Spectroscopic method was developed and validated for quantitative determination of metoprolol tartrate. Method: The absorption maxima of metoprolol tartrate were found to be 223nm by using methanol as solvent. Results: The linearity range for metoprolol tartrate was 7-22μg/ml with correlation coefficient (r2) value 0.9982. The method was said to be accurate with 100% recovery and precise, robust as the %RSD was below 2. Metolar-50 marketed formulation was considered as test and assay was carried out. Assay was found to be 98.73%. Conclusion: So, a novel, simple and sensitive method was developed for assay of metoprolol tartrate and validated according to ICH Q2R1 guidelines.Keywords: Spectroscopic, Metoprolol tartrate, Absorption maxima, Assay.
Partial Purification of Leucine Aminopeptidase and its Correlation with Some Biochemical Parameters in Sera of Subclinical Hyperthyroidism and Hyperthyroidism Patient Noorhan Khalid Shafeeq
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

The study aimed to purify of Leucine aminopeptidase (LAP) from sera of hyperthyroidism patients and its relation to some thyroid hormones (TSH, T3, T4) of subclinical hyperthyroidism and hyperthyroidism patients with lipid peroxidation levels that may be play a role in this diseases. Specimens were collected during the time from Nov 2017   until Jan 2018 from Endocrine and Diabetes Center, blood samples were   collected from fifty healthy control and one hundred patients, patients were divided into two groups consisted of (50) with hyperthyroidism and (50) with subclinical hyperthyroidism. The aged for all subjects ranged (15-60) years with body mass ranged ((25- 29) kg/m2. The purification is done by addition of ammonium sulfate, dialysis, ion exchange chromatography by using DEAE -Sepharose and gel filtration chromatography by using Sepharose 6B. FT3, FT4, TSH, LAP, peroxynitrite, malondialdehyde were determined. Results showed the precipitate and concentrated protein appeared five peaks after eluted with Tris- HCl (50 mM, pH 7.0 in ion exchange column, LAP located in the first peak (wash fraction) and the second peak (elution fraction eluted with 0.1 M NaCl), also, results showed single peak for both first and second peaks after eluted in gel filtration chromatography following steps by using sodium dodecyl sulfate-polyacrylamide gel. As well as results showed a non- significant elevation in   BM, FT3 and   FT4 in subclinical-hyperthyroidism group when compared to the control group. And a highly significant elevation in LAP, peroxynitrite and MDA levels in the patient group compared to the control group, while a highly significant decrease in TSH   levels was found in the patient group compared to the control group. Results showed a non-significant elevation in BMI in hyperthyroidism group when compared to the control group., also, showed a highly significant elevation in FT3, FT4 LAP, peroxynitrite and MDA levels in the patient group compared to the control group, while a highly significant decrease in TSH levels was found in the patient group compared to the control group. From this study, it is concluded   Leucine aminopeptidase    which partial purification from sera of hyperthyroidism   patients   by ion exchange chromatography and gel filtration   chromatography   have  two  isoenzymes  ,also, concluded a highly significant elevation in LAP, peroxynitrite and MDA levels in the patient group compared to the control group , in addition to their correlation with thyroid hormone in the patient group, compared to the control group indicate that  these parameters have an effect on these diseases.Keywords: Leucine aminopeptidase, Subclinical hyperthyroidism, Hyperthyroidism, Subclinical hypothyroidism, Hyperthyroidism, Lipid peroxidation.
The Relationship between Blood Pressure with P-Selectin in Indonesian Hypertension Patients R. Mustarichie
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objective: The involvement of vascular inflammation is shown in the initiation and development of hypertension. P-selectin plays an important role in the inflammatory response through the initiation of leukocyte adhesion in platelets and endothelial cells. The purpose of this research was to determine the relationship between blood pressure and P-selectin in Indonesian hypertensive patients. Methods: The cross-sectional design study was conducted in 56 patients with hypertension, aged 40 to 60 years, blood pressure and serum P-selectin (sP-selectin) concentration measured. sP-selectin was determined by a colorimetric ELISA sandwich. Interpretation of the relationship between blood pressure components and sP-selectin concentration was carried out by statistical analysis. Results: It was found that sP-selectin level did not correlate significantly with systolic blood pressure (r = 0.078; P = 0.568), diastolic blood pressure (r = -0.014; P = 0.921), mean arterial pressure (r = 0.062; P = 0.648), and pulse pressure (r = 0.062; P = 0.648). Conclusion: Our results concluded that the increase in blood pressure components was not significantly associated with an increase in circulating sP-selectin concentration in hypertensive patients. Thus, there was no significant correlation between blood pressure and P-selectin in hypertensive patients. The tendency of positive results indicated an inflammatory involvement in hypertension.Keywords: Blood pressure, P-selectin, hypertension, Vascular inflammation adhesion, ELISA.
Employing the Physicochemical, Spectroscopy, Antimicrobial and Antifungal Efficacy Studies of P-Hydroxy Acetophenone Based Azo Schiff Base Complexes Wurood Ali Jaafar
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The azo Schiff base [Reaction of 4-aminoanypyrine and P-hydroxy acetophenone] and O-Phenylene diamine have been prepared. One azo  Schiff  base  chelate  of Co(Il), Ni(II), Cu(II) and Zn(II)ion was also  prepared. The chemical frameworks of the azo Schiff base and   like elemental analyses (CHN), determinations of molar conductance, 1 H &13C NMR, IR mass and electronic spectroscopy .The elemental analyses exhibited the combination of [L: M] 1:1 ratio. Established on the values IR spectral, it is showed that the azo Schiff base compound acts as neutral hexadentate ligand bonded with the metal ion from two hydroxyl, two azomethine  and  two azo groups  of the  azo  Schiff  base  compound  in  chelation  was confirmed  by  IR  , 1Hand 13CNMR  spectral outcomes. The UV-Vis spectral values appeared the existence of π→π* (phenyl ring), n→π* (N=N, -OH and HC=N) and an octahedral structure was suggested for the coordinate. The mass spectral outcomes assured the purity of the ligand. Furthermore, the antimicrobial and antifungal efficacy results revealed that the metal complexes were found to be more active than the free ligand.  In general the activity order of the synthesized compounds can be represented as Fe (II) > Cu (II) > Ni (II) > Zn (II) > Co (II) > L.   Keywords: Azo Schiff base, P-hydroxy acetophenone, antifungal efficacy, Spectroscopy.
The Short-Term follow up of Changes in Serum Leptin, Ghrelin, and HBA1c after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) Operation Safauldeen Salim
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Introduction: Morbid obesity is connected with various health related problems, so treating obesity is an essential clinical concern. Swedish subject obesity study with 10 years follow up showed that surgical option is far better than conservative approach. Aim To assess changes in adipose hormones and HbA1c in obese patients after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB). Materials and Methods the study was conducted on 25 subjects (14 females and 11 males), age 32±6, with BMI 52.01 ± 3.5 Kg/m² underwent LRYGB during the period from June 2015 to the end of February 2016. Fasting blood glucose (FBG), HbA1c, serum level of Lept in and Ghrel in were measured before the operation, 2, 4 and 6 months after LRYGB procedure. Results At 6 months point following LRYGB, a significant reduction in body weight and BMI (p< 0.001) was reported. The mean weight of the participants decreased to 82.7 Kg, mean BMI decreased to 31.1 Kg/m2 and mean fat % declined to 35.55%. The mean loss in the EBL percent was 77.3 % and %Excess Weight Loss (EWL) was 39.9%. There was significant reduction in FBG, HbA1c and serum Leptin level (p< 0.001) with significant increase in serum Ghrelin level (p<0.001).Conclusions LRYGB produced a rapid and significant weight loss and improvement in glucose homeostasis within six months after surgery. It had resulted in significant changes in the level of leptin and ghrel in. There were differences between males and females after 6 months of follow-up.Keywords: Obesity, Bariatric surgery, Ghrelin, Leptin, Follow-up. Fasting blood Sugar, Excess weight Loss.
Anaerobic Threshold is Significantly Enhanced by High Intensity Interval Training (HIIT) in Balinese Athletic Students Indira Vidiari Juhanna
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Introduction: Anaerobic threshold is a physiological point when lactate production begins to exceed the lactate spent via oxidation process resulting in increasing amount of lactate in the circulation. It is an important aspect of sports physiology and several methods have been developed to enhance it. However, little study had conducted to evaluate the effectiveness of high intensity interval training (HIIT) in enhancing the anaerobic threshold. Method: A quasi experimental study with pre test and post test group design was conducted at Ngurah Rai Sports Building Square from January to February 2017. The subjects were randomly divided into two groups in which the first group received HIIT and the second one was the Steady State Training group performed for 2 minutes of sprint and 2 minutes of jogging for 6 weeks. Results: 24 male students were enrolled in this study with mean age 13.92±1.165 years for the first group (HIIT) and 14±1.128 years old in the second one (SST). The anaerobic threshold was significantly after the intervention (HIIT [before vs after]: 178.17±2.368 vs 197.83±3.460; SST: 177.17±1.586 vs 185.25±1.288; p: <0.05). The value difference (after-before) comparison between both groups also proved to be significantly different (HIIT vs SST: 19.67± 2.309 vs 8.08 ± 1.311; p<0.05). Conclusion: Both HIIT and SST were proved to significantly enhance the anaerobic threshold in male highschool students. However, HIIT had significantly higher enhancement compared to SST.Keywords: Anaerobic threshold, Steady State Training, lactate, high intensity interval training.
Relationship between HCMV and Diabetic Mellitus Type 2 of Elderly Patients in Al-Najaf Governorate Elham Jawad Kadhum
Journal of Global Pharma Technology Volume 11 Issue 05.
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The sudden rise mellitus (DM2) and related complications go along with increasing evidence of clinically major age and gender differences. The aim of current study was to study the relationship between the virus and diabetes mellitus type2 through detection of human cytomegalovirus (HCMV) infection in DM2 patients in Najaf governorate by detection of human cytomegalovirus DNA in blood samples by using of PCR technique. Blood samples were collected from 93 diabetic patients randomly. Regarding PCR technique, the study showed that among 93 diabetic patients gave positive results in 39 patients(42%); In contrast, in control group PCR positive result was only 4.4% (4 out of 90) with significant differences . This study concluded that the higher prevalence of HCMV DNA in DM2 patients comparing with normal individuals, which means that patients with DM2 were at high risk for HCMV infections.Keywords: HCMV, DM2, PCR.

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