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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Anxiety, Depression and Sexual Dysfunction in the Patients Undergoing Bone Marrow Transplantation Mohammadi Ali
Journal of Global Pharma Technology .
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Abstract

Introduction nowadays, following improvement in bone marrow transplantation (BMT) techniques, and increase in life expectancy in patients whom undergoing this procedure, researchers have paid attention toward improvement in quality of life of these patients. Some of the most important problems of these patients include anxiety, depression and sexual dysfunction. Considering that there are few studies regarding the prevalence of these disorders and its related factors and because of controversy in their results, and lack of any study in this topic in Iran, this study was performed. Material and Method: This study was a cross sectional study and the sampling method was simple sampling method. The studied community was 60 patients who were received BMT and referred to oncology clinic of Taleghani hospital in Tehran. The inclusion criteria were receiving BMT from 3 months to 3 years, and having consent for participation in the study. The exclusion criteria were not having consent for participation in the study, and the age under 18 years. The study tools were three questionnaires: Persian version of hospital anxiety and depression scale (HADS) and Arizona Sexual Experience Scale (ASEX) both were standardized previously; and a questionnaire regarding demographic data of participants and other needed data such as history of anxiety, depression and sexual dysfunction prior to BMT, type of primary disease, and type of performed BMT that were extracted from the patient’s records. After data gathering, the data was analyzed using SPSS software version 22 and using general indexes of descriptive statistics, qui-square and t-test. Results 25 participants were female and 35 men. The rate of anxiety, depression and sexual dysfunction prior to BMT were 21(35%), 10(16.7%) and 16(26.7%) respectively and after BMT were 7(11.7%), 6(10%) and 38(63.3%) respectively. The increase in sexual dysfunction after BMT was statistically significant. (p=0.024) Conclusion the rate of sexual dysfunction may increase after BMT.Keywords: Bone marrow transplantation, Anxiety, Depression, Sexual dysfunction.
Phytochemical Properties and Antioxidant activity of Pollen of Typha domingensis pers. Grow in Marshes of Maysan Governorate Southern of Iraq Ali Nazar Yaseen
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The aim of this study was to evaluate the antioxidant activity of the Typha domingensis Pers, naturally growing pollen in the marshes of Maysan province in southern Iraq, and to link them effectively with the total flavonoids. (75 Ethanol+75 Water) for pollen these grains contain many effective plant compounds such as tannin, glucoside, alkali, saponin, polyphenols, and flavonoids. Flavonoids were extracted from pollen and detected using thin film chromatograph technique. The amount of flavons in the extract was estimated by chromatic method with aluminum chloride and was found to be approximately 71.3 milligrams per 50 grams of pollen powder. In determining antioxidant activity, the DPPH assay was used to show that the pollen extract had a good ability to inhibit DPPH free activity by 36.21% at 250 μg / ml of flavonoids compared to standard ascorbic acid (98.01% inhibition). The research concluded that the pollen extract contains the compounds of tannins, glycosides, alkalis, sapphones, flavonoids and phenolic compounds. Total flavonoids from pollen extract showed significant antioxidant activity.Keywords: Bardy, Typha domingensis Pers., Phytochemical, Phenolics, Flavonoids.
Immunological Changes Associated with Rheumatoid Arthritis Mohammed Abd Jwad
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Rheumatoid factors (RF) are IgM autoantibody directed against the Fc portion of IgG. Rheumatoid factor is a well-established distinguishing and prognostic test in Rheumatoid Arthritis. High titer IgM RF is relatively specific for the RA diagnosis in the context of chronic poly arthritis, and was for decades the sole serologic criterion widely used in diagnosis of RA. Those, whom likely to assume a more prompt destructive form of disease in particular, are subject to early identification, It is vital to because the benefits gained in laying early aggressive mediation with disease modifying agents. A variable disease course is to be followed by patients where outcome measures are to be calculated such as functional status and radiological assessment of joint damage. An increasing risk is manifested for those patients with an established RA diagnosis. Positive testing results, anti-CCP antibodies or both are placed in a category of developing an erosive joint damage and impairment of function. As a result, patients should receive an anti-rheumatic therapy that could suppress the disease early stage activity. Patients, who are RA and anti-CCP diagnosis both be considered. Rheumatic factors are the conspicuous markers for patients with RA. Those markers are useful clinically .Antibody Rheumatic factors and anti-CCP testing is necessary for predicting and diagnosing of functional and radiographic outcomes. Patients with early diagnosed arthritis and who are anti-CCP and RA antibody positive considered being at higher and increasing risk of manifesting development of erosive joint disease. While those patients with neither markers are less likely to be develop the like symptoms, thus, symptomatic treatment (e.g. with non-steroidal anti-inflammatory drugs) may be appropriate for those lacking both anti-CCP and antibodies RF. From June 29th to October 1st (2016) this research was conducted during the mentioned period at Baghdad teaching hospital consultation clinic, which involved (47)patients with RA, they were 13 male and 32 female , this data was then subjected to statistical assessment by the IBM SPSS program 20th version which comprised of the arithmetic mean, Standard deviation, SEM, the study is aiming to identify the factor of rheumatoid in the diagnosis of RA and the value of biologic markers that have been assessed for disease activity assessment and for the prognosis of rheumatoid arthritis, particularly the use of anti-CCP antibodies test in diagnosis and predicting the prognosis of rheumatoid arthritis.Keywords: Predictive and prognostic values of Rheumatoid factor, Rheumatoid factor Titer, anti-CCP antibodies.
Isolating and diagnosing the Campylobacter Bacteria Types from Raw Milk and its Products and its Relation to Children Diarrhea Idriss Saleh Jalil
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The study comprised Isolating and diagnosing the Campylobacter Bacteria Types from Raw Milk and its Products and its Relation to Children Diarrhea. The study is conducted in the Graduate Studies Lab. In the College of Pure Sciences. The researcher compiled (164) samples from various sources comprising of (40) raw milk samples, (40) local white cheese samples, (40) local cream samples compiled from local markets in Baqubah city during the period of time from (1/11/2017 to 15/9/2018), and (44) samples of feces from children with diarrhea (watery, mucoid, bloody) of ages between (3 months to 5 years) in Al-Batoul Hospital for Maternity and Children. Results of the study exposed that (44) samples, with a ratio of (37.0%), showed negative growth to the bacterial plantation, and (90) samples, with a rate of (62.19%) mirrored positive growth to the bacterial plantation. Moreover, it is founded that (65) samples with a ratio of (51.829%) were Campylobacter bacteria as the ratio of isolated bacteria from raw milk reached up to (20) samples with a rate of (50%), (9) samples from local white cheese with a rate of (22.5%) and (8) samples from local cream in a ratio of (20%). It is worth noting that bacteria were diagnosed in terms of ability to live on selective media (Skirrow-Preston) and the second method which is planting on non-selective media (Blood agar, Chocolate agar, Macconkey agar). In addition, the ratios of isolated bacteria from feces samples were, (5) samples of bloody sustenance (11.36%), (19) samples of mucoid sustenance (43.18 %) and (20) watery samples (45.45%). The bacteria were also diagnosed by means of micrography which showed its negativity and positivity towards Gram stein; (92.90%) were negative to Gram stein, while (8.09%) were positive to Gram stain.   Furthermore, micrography exposed their negativity to Gram stein and showed its different shapes; Bacillus, Spiral, S-shape and Bird-wing shape. Results showed an increase of bacteria in milk and milk products which included many sicknesses and sitotoxism causes which lead to diarrhea among children. Biochemical and physiological examinations were executed and isolates were oxidase-positive, catalase, urease test, Hippurate hydrolysis test, and growth test within (37o C -42o C) temperatures as well as their tolerance of salinity with concentrations between (1.5 %-3.5%).Isolates were sensitive to Nalidixic acid and resistant to Cephalothin.     Keywords: Campylobacter (C. jejuni, C. coli, C. hyointestinalis, C. lari), cadF gene, Diarrhea for children.
Spectrophotometric Method for Determination Folic Acid via Diazotization and Coupling with 4-Aminoantipyrine Resala A. Saleh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Uncommon coupling reagent is used for the simple and sensitive spectrophotometric determination of folic acid in pure form and in its pharmaceutical preparations. The method is based on the diazotization of the p-aminobenzoyl glutamic acid formed after reductive cleavage of folic acid, followed by coupling 4-amino antipyrine to give an orange product with λmax of 469nm. The results follow ‘Beer’s law in the concentration range of 2-100 µg.mL-1 with molar absorptive of 3266.36 L.mol-1.cm-1. The limit of detection was found to be 0.1482 µg.mL-1 and the Sandell’s sensitivity value was 0.1351 µg.cm-2. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed methods. The proposed method was successfully applied to the determination of folic acid in pharmaceutical preparations.Keywords: Folic Acid; Spectrophotometry; 4-Aminoantipyrine
Assessment of Interleukin (IL-10) Level in the Serum, Placenta and Amniotic Fluid of Aborted Women Infected with HCMV Siham J. Mohsin
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

This research was conducted on 48 women who suffered from spontaneous abortion for one and multiple fold during the first and second stage of pregnancy and with age averages ranging from 14-43 years. which have been confirmed to be infected with the Human Cytomegalovirus (HCMV) by using the Enzyme Link Fluorescent Assay technique (ELFA) ,However, they did not suffer from chronic diseases such as blood pressure, diabetes and other immune diseases , In order to measure the level of interleukin (IL-10) by the enzyme-linked immunosorbent assay (ELISA) in blood samples, placenta and amniotic fluid that collected from women at the time of abortion and while they were in the Curettage Hall of Al -Zahra Hospital and Al-Hakim Teaching Hospital / Najaf Governorate, For the period from October 2015 to April 2016, comparison was made with 10 women who had no history of previous miscarriage or inflammatory disease and had been as control group. The results showed no significant differences between the level of the inflammatory inhibition factor interleukin (IL-10), that measured in the serum of abortive women and the control group, which reaching the level to (5.905 ± 1.5707) Pg/ml. also noted high Significant decrease P ≤ (0.01) in the interleukin (IL-10) concentration that measured in the placenta and amniotic fluid of abortive women compared to healthy Control group. From the above results, concluded that the decrease level of interleukin (IL-10) in abortive women infected with virus may be plays a major role in cases of spontaneous abortion.Keywords: HCMV, Abortion, interleukin (IL-10), ELISA.
The Impact of Training Program to Develop the Most of Functional and Skill Abilities for the Players in the Volleyball Maysaloun Zuhair Hussein
Journal of Global Pharma Technology .
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Abstract

The preparation stage in the quality of the year and the private is the basis on which the team is built and which depends on access to high levels of sports, both in terms of functional or technical and the requirements of training in volleyball is many and multiple, the training process has become complex, and requires planning based on the sound scientific foundations through which possible to achieve the best possible results in light of the capabilities of the player and its potential, so that training these capabilities is the cornerstone on which the training is based on the type of the game as the player cannot reach the high performance without the availability of such Capacity and sustain training and improve their level, and the importance of this study in building the basic rule of volleyball and the need to develop a training curriculum interested in how to train the early stages of the year, which prompted the researcher to engage in this research attempt to apply the scientific foundations in the training of volleyball with appropriate ages and important in sports training.The research objectives to:Preparation of a training curriculum to develop some of the skills and skills of the players of the volleyball.Knowledge of the impact of the curriculum in developing some of the functional and skill capabilities of the players of the volleyball.The researchers used the experimental method (designing two groups) to suit the problem of research. The research community determined the club members in front of Al-Mutaqin and Al-Husseiniya club in the youth category. The number of players was 32 and a simple random sample of 24 players was selected and divided into two groups (Experimental and control).From the results obtained, the researchers reached the following conclusions:The training curriculum has a positive effect on the development of functional abilities (lactic non-oxygen ability, lactic oxygenation, oxygen capacity), and skill capabilities (Service, defense of service, preparation (passing), spike and block).The evolution of experimental group members was better with the functional and skillful abilities of all tests compared to control group members.The highest significant value of the experimental group in the non-lactic capacity tests for the functional abilities and the overwhelming impact on the skill capacity.Keywords: Training program, Functional and skill abilities.
Teaching Curriculum Using the Effect Competitive Learning Style According To the Training Network Exercises Learn Some Offensive Skills of Basketball Emad Toma Radi
Journal of Global Pharma Technology Volume 11 Issue 6.
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Research objectives of preparing an educational platform for educational units using the teaching and learning style of individual and collective competition according to exercises training network to learn some offensive skills of basketball.The researcher pilot curriculum sample that consisted of the first grade students of faculty of Physical Education in the  Mustansiriyah  University, whose number reaches 57 students divided into three experimental groups used tools and means of information collection and tests the skill and experience of the scientific Choose foundations of exploratory pretest curriculum dimensional tests and statistical means. And then present, analyze and discuss the results of the three aggregates, and then the researcher arrived to conclusions as follow:That the teaching curriculum using competitive learning network, according to the training exercises had a positive impact on learning performance level skilled in the handling of the Invite long over your shoulder shots jumping among students in the sample.Keywords: Teaching curriculum, Competitive learning, Training network exercises and offensive skills.
Assessment of Dietary Intake among Patients with Metabolic Syndrome and Comparison with Healthy Patients in Accordance with the Questionnaire Ayaulym Nurgozhina
Journal of Global Pharma Technology Volume 12 Issue 08
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Abstract

Metabolic syndrome is a cluster of conditions that occur together, increasing the risk of heart disease, stroke, hypertension, and glucose intolerance. Metabolic syndrome has a major impact on the development of diabetes and cardiovascular diseases. Insulin resistance and β-cell function are also related to metabolic syndrome function. It is crucial to manage correct balance of energy requirement of cells and bodily inflammation for insulin sensitivity and control of metabolic syndrome [1].
Study of Prevalence of Toxoplasma Gondii among Heamodialysis Patients in Thi-Qar Province Bassad A. Al-Aboody
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Toxoplasmosis is a widespread zoonotic disease caused by one of opportunistic parasite called Toxoplasma gondii .The current study was conducted in Thi-Qar province to investigate the parasite Toxoplasma gondii among heamodialysis patients using Enzyme Linked Immunosorbent Assay test and study some of the factors that may affect in the prevalence of infection, such as age, sex and a number of heamodialysis. 100 was collected samples of blood  from heamodialysis patients  from Hussein Teaching Hospital for the period from October 2015 to the end of  March 2016 and prepared a questionnaire form for each person to get their information, as well as the collection of 50 blood samples from healthy persons for the purpose of comparison between them with the current study. The results of the current study showed that the prevalence of toxoplasmosis in Thi--Qar province in renal dialysis patients and a comparison group of 28% and 24% respectively. Recorded results of Enzyme Linked Immunosorbent Assay ELISA test results for a positive antibody IgG in heamodialysis patients and a comparison, 25 % 22% respectively. As for the IgM antibody study did not record any positive result in heamodialysis patients group while in comparison group was 2%. The ratios antibodies IgG & IgM together in heamodialysis patients and comparison group 3%, 0.0% respectively. The highest infection rates for heamodialysis patients was in the age group (40-49 years) was 26.67% and the lowest rates of infection in the age group (>60years) 23.08 %  and reported significant differences P <0.05 to infection rates in males highest compared to females where it was 35.18% and 19.56% respectively. For factor number of heamodialysis show high infection rates in patients who have been exposed to more than>6times of heamodialysis 25.53% as for those who were exposed to 1-6 was ratios have 16.67%.Keywords: Toxoplasma gondii, Toxoplasmosis,   Heamodialysis patients, Prevalence, ELISA, risk factors.

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