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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Assessment the Effect of Different Genotypes of Sulfotransferase 1A1 Gene on the Response to Monoxide in Patients with Androgenic Alopecia Moaed E. Al-Gazally
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Objective is to assess the association between a specific genotype and the response to monoxide in patients with androgenic alopecia. Methods and materials: This study was conducted with the participation of thirty five androgenic alopecia patients. The presence of G<A single nucleotide polymorphism in the sulfotransferase 1A1 gene is detected by restricted fragment length polymorphism polymerase chain reaction technique. Result:  In this study, it was found that the levels of response to monoxide  are differ with different genotypes of the sulfotransferase 1A1 gene, and there is significant association between  the allele type and the response to monoxide. The G allele is significantly associated to the response in a p- value of 0.016 and also there is significant association to the GG genotype in a p- value of 0.0011, while it is insignificant to the GA genotype. Conclusion: The results of this study indicate that the monoxide is effective for those patients who are carrying the GG genotype of the sulfotransferase 1A1 gene, and that can be used as a genetic test to predict the response monoxide.
Synthesis and Identification of Some Shiff Base and Chalcone Compounds and Studying the Effectiveness as Flame Retardant of Some Thermosetting Polymers Sabrean Farhan Jawad
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

In this work, seven additives were used, namely: (5-(6-methylbenzothiazol-2-yl)diazenyl)-2-hydroxybenzaldehyde)(AdditiveI),(5-6-methylbenzothiazol-2-yl)diazenyl)-2-hydroxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one) (Additive II), 5,6-(methylbenzothiazol-2-yl)diazenyl)-2-hydroxyphenyl)-1-(4-hydroxyphenyl) prop-2-en-1-one (Additive III), 5-6-methylbenzothiazol-2-yl) diazenyl)-2-hydroxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one (Additive IV), 4-6-methylbenzothiazol-2-yl) diazenyl)-2-2-hydroxy-5-methylphenyl)imino)methyl)phenol(AdditiveV). 4-6-methylbenzothiazol-2-yl) diazenyl)-2-2-hydroxy-5-ethylphenyl)imino)methyl) phenol (AdditiveVI) and(1E)-N-(5-((6-methylbenzo [d] thiazol-2-yl)diazenyl)-2-hydroxybenzylidene)-N'-(4-chlorophenyl)formimidamide(AdditiveVII). The effects of these additives on flammability of some of the thermosetting polymers (unsaturated polyester and epoxy resins), have been studied. Sheets of the specimens (resins with different weight percentages of additives), in dimensions (150X150X3) mm were prepared. Two standard test methods used to measured the flame retardation which are: (ASTM: D-2863) and (ASTM: D-635). Results are obtained from these tests indicated that, additive 6B has high efficiency as flame retardant, self–extinguishing (S.E.) at the percentage (0.1 %) for unsaturated polyester and the epoxy resins. Also self- extinguishing (S.E.) at the percentage (0.1%) for additives 1B, 4B and 5B,  in unsaturated polyester resin and non-burning occurs in 0.15% with Additive 6B and 5B in unsaturated polyester resin but it is occur in 0.2% with additives 6B and 5B in epoxy resin. Additive B shows low effect on flammability in both resins.Keywords: Flame retardant, Flammability, Polyester resin, Unsaturated polyester resin, Epoxy resin, Schiff base, Chalcones, Synthesis of shiff base, Identification of shiff base, Synthesis of chalcone, Identification of chalcone.
Antibacterial Effect of Freshwater Crab Powder against Pathogenic Bacteria Nebrass F. Chachain
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

The objective of this study was to examine the antibacterial effect of crab powder on Klebsiella pneumonia, Pseudomonas fluorescens and Escherichia coli. Four concentration (250,300,400 and 500) mg /ml was used ,all bacteria giving the inhibition zone in all concentrations .Powder of freshwater Crab were  show the highest inhibition zone (18mm) in bacteria in  P. fluorescens at concentration 500 mg/ml and lowest inhibition zone  to same species of bacteria was  (11mm) at 250 mg/ml concentration .Keywords: Pathogenic Bacteria; Freshwater Crab Powder; Antibacterial Effect.
Synthesis, Characterization of Some Novel 1, 4- Benzoxazine- 3- One Derivatives Starting From O-Amino Phenol and Study Their Biological Activity Helen Abd Al Hassan Mahmood
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

In this work: Benzoxazinone derivatives were used as a precursor to synthesize of many heterocyclic systems. The aim of current study was to use the easily available o-amino phenol for the synthesize of 1, 4-benzoxazine-3-one. The benzoxazinone compound of interest was  synthesized by reacting the  o-amino phenol with chloroacetyl chloride, The treatment of  o-chloro acetamidophenol (FH)  and anhydrous potassium carbonate in refluxing DMF afforded the corresponding 1,4-benzoxazine -3-one (1) in excellent yield. The treatment of ethyl chloroacetate with compound (1) gave compound (2), while compound (3) was produced by reacting of hydrazine hydrate with compound (2). Compound (3) was used as precursor to synthesize  (5a-d),(ST),(6),(7a,7b),(8,9)  by its reaction with different chemical reagents,  while on treatment of the compound (1) with 4-nitrobenzaldehyde in acetic anhydride: triethylamine (2:1) as a solvent gave chalcone (10). The structures the synthesized compounds have been confirmed by FT-IR, 1H-NMR, and Mass spectroscopy. The synthesized derivatives have been screened in vitro for antimicrobial properties. The results of this investigation revealed that the newly synthesized compounds are potent antimicrobial agents.Keywords:  2-Aminophenol, Benzoxazinone, Schiff’s base, 1, 2, 4-triazole, Antimicrobial.
Gap Analysis between the Current and Desired states of Talent Management Programs and Determination of Improvement Priorities by using Importance-Performance Analysis (IPA) Abdolali Keshtegar
Journal of Global Pharma Technology Volume 09 Issue 05
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Today, talent management is one of the main areas of human resources management for gaining competitive advantage and it is essential for organizations to examine systematically the status of their talents and take steps in order to enhance the situation. Given the importance of this subject, the present study aims to conduct a gap analysis between the current and desired states of talent management and also determine the improvement priorities using the Importance-Performance analysis (IPA). This study is a descriptive survey and the statistical population consists of all staff of the department of education in the city of Birjand in Iran. A sample size including 86 people was determined. In this study, two researcher-made questionnaires were used in order to achieve the research goals. After the confirmation of validity and reliability, these two questionnaires were distributed among the respondents and finally, 76 questionnaires were collected and studied. The gathered data were analyzed by means of SPSS statistical analysis software and based on the IPA model. The results of this study showed that there was a significant gap between the current and optimal states of talent management, and this gap was present in all four main dimensions of the research and all factors. According to the IPA model, the eight following factors were determined as improvement proprieties: Adjustment of salaries of employees with their activities, planning to prepare right people for filling key roles, harmony between the post and people who are selected for it, the existence of the sense of success and progress in the organization, continuous evaluation of staff performance and identifying their weakness and strengths, modifying undesirable behaviors, actively creating equal development opportunities for employees, coaching and educating prominent and professional people. According to the existing gap and given that the improvement priorities are of all four dimensions of talent management, it is thus recommended to focus on all four aspects for improving the situation and in case of restrictions, it is recommended to put the aforementioned determined improvement priorities at the top of improvement programs in the short term.Key Words: Gap analysis, Talent Management, Determination of Improvement Priorities.
Use of Iranian Medicinal Plants Effective on Male Fertility Indices Mahnaz Yavangi
Journal of Global Pharma Technology Volume 08 Issue 10: (2016) October 2016
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Abstract

This systematic review article was conducted to report medicinal plants that are effective on male fertility indices. To conduct this review, search terms fertility or pregnancy combined with medicinal plants, herb, and phyto were used to retrieve relevant publications indexed in ISI, PubMed, and Iranian scientific databases. Escanbil, Fumaria parviflora L., Apium graveolens L., Achillea millefolium inflorescence, Urtica dioica L., Withania somnifera L., Phaleria macrocarpa, Satureja khuzestanica, Achillea millefolium, Malva sylvestris, Humulus lupulus L., Allium cepa, Petroselinum crispum, Carthamus tinctorius, and Zingiber officinale were reported to be medicinal plants with fertility indices-promoting properties. Medicinal plants that are used in Iran affect hormonal compounds and other effective compounds on hormonal system as well as the proliferation and viability of sex cells due to their antioxidant properties, and therefore enhance fertility in human and animals. Keywords: Physiotherapy, Infertility, Pregnancy, Iran.
Sequencing of Entamoeba Histolytic Cysteine Protease 5 (CP5) Isolated from Diarrheic Cases in Babylon Province Hayam K. Al- MasoudI
Journal of Global Pharma Technology .
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The results of the current study revealed that the amplified DNA for cysteine proteinase (CP5) in 40 cases .The characterization of the cysteine proteinase  which is the most important virulence factors secreted by E. histolytica have led to a better understanding the pathogenic mechanisms of E. histolytica (pathogenic ) are distinct species from the nonpathogenic      or   a harmless commensal.
Biocontrol of Pseudomonas Aeruginosa Biofilm Using Bacteriophages Zahraa J. Jameel
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

inanimate surfaces. Clinically, it is considered essential in the practical therapy. In current study, the inhibition effect of bacteriophages against biofilm of P. aeruginosa detected by ELISA method had been assessed. 50 samples had been collected from wounds infections in General Baqubah Hospital to isolate Pseudomonas aeruginosa and tested for 10 groups of antibiotics.  Befor the treatment, Pseudophage was isolated from sewage water of General Baqubah Hospital through pseudophage enrichment. The biocontrol of biofilm activity of pseudophage was applied by using the ELISA method. For the 50 samples were collected from wounds infections, and 10 isolates only were able to grow on Pseudomonas and Cetrimide agar. P. aeruginosa isolates showed high resistance associated with Cefepime (30 μg), Fusidic acid (10 μg) and Ampicillin (10 μg) 9(90%) while P. aeruginosa isolates showed high resistance associated with Erythromycin 80% then Imipenem and Tetracycline 70%. All 10 P. aeruginosa isolates have the production of biofilm. 4 P. aeruginosa bacteriophages (Pab 1, Pab 2, Pab 3, Pab 4) were isolated from sewage water, the Pab4 had a wide range. P. aeruginosa were sensitive to pseudophage by spotting assay were inhibited the biofilm formation. Active effect of pseudophage to inhibit Pseudomonas aeruginosa' biofilm in vitro.
The Risk Factors That Affecting Carpal Tunnel Syndrome (CTS) Agusni Karma; Tri Riana Lestari; Ujang Abdul Muis; Rizki Rohimah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Introduction: Nowadays, interaction between human and mechine is often happened, it can be with computer or laptop, using computer/laptop with mouse in long period without resting the wrist will lead to symptom of Carpal Tunnel Syndrome (CTS). CTS have a significant correlation with improper posture of the hand and the age. This research is to know the relation between age, improper hand position, and work period towards risk of CTS on staffs who work in front of computer/laptop >4 hours a day. Methods: For the method was give some questionnaires, direct observation and Phallen test to each respondent. Results: From 33 of respondents was found 26 staffs who had risk of CTS. In improper hand position and work period factor was found the p-value of 0.000. But in the age factor was found p-value of 0.277. Analysis: In improper hand position and work period factor it caused by wrong position of the hand and pressure median nerve. In the age factor it caused due to staffs often did wrist gymnastic on work hours which is one of the exercises that preventing CTS. Conclusion: There is correlation between improper hand position and work period with risk of CTS. Keywords: Carpal Tunnel Syndrome, Improper Hand Position, Work Period
Preparation, Characterization and Biological Activity of New Derivatives of 3-Cyclic Oxazepine, 3-Cyclic Lactam and 3-Aminomethyl Imidazo (1, 2-a) Benzthiazol Rana Abid Ali
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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In this work a series of fourteen new compounds were synthesized. Compound [1] was formed from the reaction of 2-aminobenzothiazole and p-bromophenacyl bromide. Aldehyde group [2] was obtained from the reaction of compound [1] with pocl3 in presence of DMF and CHCl3 .After that   shiff bases have been synthesized from the reaction of compound [2] with different aromatic amine to give new shiff bases [3-5]. These new shiff bases have been reduced to their corresponding amine [6-8] by means of sodium borohydride. Then reaction of shiff bases [3-5] with phenyl isocyanate gives 3-cyclic lactam derivatives [9-11].  3-cyclic Oxazepine derivatives [12-14] were obtained by reaction of shiff bases [3-5] with succinic anhydride. These new formed compounds were diagnosed by12 C-NMR, 1H-NMR for some of them and FT-IR spectroscopy. Some of the prepared products have been studied their biological activities toward two kinds of bacteria. These products showed good efficacy to moderate toward bacteria.Keywords: Benzothiazole, Shiff bases, Lactam, Oxazepine, Biological activity.

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