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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Inability of Polysaccharides of Spirulina Platensis to Protect Hepatocyte Cells Line on Toxoplasma Gondii Infection In Vitro Lucia Tri Suwanti
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Toxoplasmosis is one zoonotic disease which caused by an obligate intracellular protrozoan parasite,  Toxoplasma gondii. The parasite infects humans and warm-blooded animals (mammals and birds). The drug of choice against toxoplasmosis is combination between pyrimethamin with sulfadiazine, but both can induce side effects and toxic to host cell, so alternative therapeutic compounds are needed.  Many reseachers have explored microalgae for food and medicine. One of the main components of  Spirulina platensis that plays a role in enhanching immunity is polysaccharides. The present study investigated effect of Spirulina polysaccharides on Toxoplasma gondii infection in Vitro. Polysaccharides of S. platensis were extracted with hot water and alkhaline method. Extraction Rate (ER), sugar and protein levels were compared between the two methods. The Hepatocyte Cells Line (HCL) were infected with T. gondii and treated with polysaccharides of S. platensis. The parameters were Parasite burden and Viability Host Cell. The result shows that Extraction Rate, carbohydrate and protein levels were affected by extraction method. Carbohydrate level in polysaccharides with hot water extraction was higher than alkhaline extraction, on the contrary, ER and protein level were lower. Polysaccharides of S. platensis did not protect HCL infected with T. gondii. More than 5 mg/mL polysaccharides of S. platensis was toxic to host HCL.  Keywords: Alkaline extraction, Hot water extraction, Polysaccharides, Spirulina platensis, Toxoplasma gondii.
AN EFFICIENT MODEL FOR SUGARCANE YIELD PREDICTION sumathi A
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

Sugarcane is one of India's most basic renewable business crops. Yield prediction is one of the important problems in agricultural field. Data mining techniques are better choice to solve this problem. Using different data mining techniques increase the sugarcane yield performance.
Biomedical and Psychosocial Treatments in Pediatrics Khudhair Khalaf Shallal
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Over the past 20 years our talents about evidence-based psychological interventions for pediatric chronic pain has dramatically increased. Overall, the evidence between assist about psychological interventions because pediatric persistent discipline is strong, demonstrating fantastic psychological and behavioral effects because a range over youngsters along a thoroughness over judgment conditions. However, wide range get admission to according to tremendous psychologically-based judgment administration treatments remains a challenge for deep kids anybody go through with pain. Increasing get admission to in accordance with care then lowering chronic biomedical biases to that amount break prosperity over psychological purposes are an interior center of attention over contemporary judgment treatment interventions. Additionally, so the variety regarding evidence-based redress increase, tailoring redress according to a toddler or family’s precise wishes is increasingly more possible. This thesis intention (1) discuss the theoretical frameworks namely nicely as the particular psychological advantage yet techniques so presently preserve story as like effective retailers over change; (2) criticism and shorten tendencies within the development concerning well-researched outpatient interventions above the previous public years; yet (3) discuss after instructions for intervention lookup over pediatric chronic pain.Keywords: Chronic pain, Pediatric, Psychological intervention, Parent, Child, Evidence-based, Empirically supported.
Synthesis, Characterization and Study of the Biological Activity of New Metal Complexes of Ligand[2-(3-benzoylthioureido)-3-(-4-hydroxyphenyl) Propanoic Acid (BHP) Enass Jasim Waheed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

In this paper, series of new complexes of Manganese(II), Cobalt(II), Nickel (II) Cupper(II) Zinc(II), Cadmium(II) and Mercury (II) are prepared from the new ligand  [2-(3-benzoylthioureido)-3-(-4-hydroxyphenyl) propanoic acid (BHP) derived from tyrosine and benzoylisothiocyanate .Chemical structures are obtained from their 1 H, 13CNMR spectra (for BHP), elemental microanalyses, molar conductance, FTIR, UV–Vis, magnetic susceptibility in addition to TGA/DTG and DSC analysis, the suggested geometry for all complexes was tetrahedral. The biological activity of BHP and its complexes has been extensively studied against two bacterial species Staphylococcus aurous (G+) and Escherichia coli (G-) by agar-well diffusion technique, where Mn(II), Co(II), Ni (II)  complexes showed greater biological activity compared to ligand. Keywords: Tyrosine, Metal complexes, Biological activity.
Effect Specific Cooling Times on Motility and Membrane Integrity of Cauda Epididymal Bovine Bull Sperm Asmaa Sh. Aliawy
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Cauda epididymides (CEs) collected post-mortem could be an important source of genetic material from male for conservation and use for assisted reproductive technologies. In this study, we characterize the epididymal sperm (ES) collected post-mortem from CEs of bull cow raised locally. Testicles (n=30) were sliced off from bull cow post-mortem, placed in a box at ambient temperature and transported to the laboratory within 2 hr. The CEs were detached from the testicle and the tail were sliced longitudinally and dropped into a 50-ml conical tube with 15 ml TRIS citric acid. The ES was collected after 10 min, washed through centrifugation and measured. The Live Epididymal Sperm Cooling Sperm 76.40±0.93, 48 hours 68.94±2.38, initial motility, 72 hours 64.23±2.47, 96 hours 60.62±2.40 and 56.62±2.31 per cent, Membrane integrity with initial motility cooling time had the lowest values compared to the gap in initial motility cooling period and 120 hours cooling time .sperm motility whereas through CASA, For CASA (VAP, VSL, VCL, ALH, WOB, LIN), there were no interactions between different cooling times. In addition, different cooling times (P>0.05) affected sperm motion kinematics, i.e. VAP, VSL, VCL, ALH, WOB and LIN, but these parameters are influenced during the cooling process. With epididymal sperm cry presets, both VSL and VAP values were the highest. Cry retained (VSL: 66.25±2.21μm / s, VAP: 81.42±1.46μm / s) compared with 48 hours (VSL: 59.09±1.52μm / s, VAP: 76.67±1.43μm / s), During the cryopreserved cooling period of 5.29±0.14μm (P
Correction of the Tooth Alignment In Case of the Popov-Godon Phenomenon Using A Dental Implant With Immediate Loading (Clinical Case) DilanyanK. Mamikon
Journal of Global Pharma Technology .
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Abstract

This paper describes a clinical example with immediate loading on the dental implant with a temporary (cobalt-chromium alloy crown) that was mounted in the area of the secondary edentulism of tooth 24 with the Popov-Godon phenomenon of its antagonist – tooth 34 – with vertical malalignment and tilt towards the tongue. This pathology is part of the second form and second subgroup thereof. Treatment started with the mounting of a dental implant in the area of the secondary edentulism of tooth 24 with immediate loading on the dental implant, with a view to correcting the impaction of the antagonist tooth 34 into its usual alignment in a continuous dental arch. This work was done in clinical conditions. The patient was examined once every fortnight after the fixation of the temporary pontic. Spot X-ray of the dental implant and tooth 34 was conducted. The work lasted four months. Over the course of the work, all structures were produced once.Keywords: Tooth Alignment, Popov-Godon Phenomenon, Dento-Alveolar Malalignment, Dental Implant, Dental Arches.
MOLECULAR ANALYSIS OF LACTIC ACID BACTERIA ISOLATE SR2 FROM BALI CATTLE RUMEN I Dewa Made Sukrama; Komang Januartha Putra Pinatih; I Wayan Suardana
Journal of Global Pharma Technology Volume 09 Issue 05
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Abstract

Bali cattle with its distinctively genetic characteristics, namely simple life or easy to adapt on unfavorable environmental condition was known as cattle pioneer. These characteristics were due to specific type of lactic acid bacteria (LAB). These facts indicate that the LAB identification with specific advantages was absolutely necessary for further research in order to prevent incorrect interpretation. Generally, molecular approach is the accurate method of identifying microorganism, and in this case, we used the analysis of the 16S rRNA gene. Research activities began with cultivation of SR2 isolates on specific media deMann Rogosa Sharpe (MRS) followed by Gram stain, catalase test, and formation of CO2 gas. Molecular analysis was performed by PCR of the 16S rRNA gene using primers 27F and 1492R. The PCR products were sequenced and nucleotides data were analyzed by Mega 5.2 Software tool. The results showed that phenotypical isolates of SR2 showed characteristics as LAB isolates, and the results of the 16S rRNA gene analysis showed that isolates SR2 included into Lactococcus lactis strain with a bootstrap value of 100.Keywords - Bali cattle, lactic acid bacteria, molecular analysis, rumen, SR2 isolate
Pathological Risk Factors in Retinoblastoma Patients Underwent Enucleation I Wayan Eka Sutyawan
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Objective: Retinoblastoma is a malignancy that originates from primitive retinal cells and is usually found in children under 4-5 years of age. Retinoblastoma is the second largest cause of death among other malignancies in developing countries. The purpose of this study was to determine the characteristics and pathological risk factors of enucleated retinoblastoma Patients and Methods: This is a descriptive study with a cross-sectional study design conducted retrospectively by evaluating data from the patient's medical record. A total of 18 subjects were enrolled in this study. Characteristics observed were sex, age, and laterality.  Data was compiled and calculated by Microsoft Excel 2017 software. All calculations and presentations were conducted in descriptive manner. Results: Unilateral retinoblastoma cases (77.2%) were found more often in this study. Leucochoria was the most often presenting symptoms (61.1%), followed by propotosis, strabismus, and cellulitis. Out of 18 subjects, 72.2% subjects had intraocular retinoblastoma. The most common PRF finding in this study was optic nerve invasion (44.4%), followed by choroid invasion, and scleral invasion. While 11.1 % of the subjects had no PRF findings. Conclusion: Invasion to the optic nerve was the most common pathological risk factors found in enucleated retinoblastoma. Other PRFs include choroid invasion and sclera invasion. PRFs may become a sign that determines the progressivity of retinoblastoma, and it can also determine further decisions regarding the prevention of recurrence and possible adjuvant therapy in retinoblastoma patients.Keywords: Pathological risk factor, Retinoblastoma, Enucleation.
The Use of Methanolic Extract of Annona Muricata Linn Leaves as an Effective Anti-Hyperglycemia on Mice Anak Agung Wiradewi Lestari
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Background: Extracts from various morphological parts of soursop leaf (Annona muricata Linn/Annonaceae) are widely used in many parts of the world for the management, control, and treatment of a human diseases, including diabetes mellitus (DM).  This study investigates possible anti-hyperglycemia effects of methanolic extract of Annona muricata Linn in mice experimental paradigms of DM.Materials and Methods: The mice used were divided into three experimental groups. Group A served as ‘control’ animals and received sodium citrate buffer solution in quantities equivalent to the administered volumes of methanolic extract of Annona muricata Linn. Diabetes mellitus was induced in Groups B and C by intraperitoneal injections of streptozotocin (STZ, 80 mg/kg body weight). Group C were additionally treated with methanolic extract of Annona muricata Linn (100 mg/kg body weight, PO) for two weeks.Results: A statistically significant lower blood glucose level was found in Group C compared to Group B in sixth (215.14±78.37 vs 319.57±135.92 mg/dL) and seventh week (158.57±24.23 vs 238.85±51.35 mg/dL) of observation.Conclusion: Daily dose of 100 mg/kg body weight methanolic extract of Annona muricata Linn administration lowers blood glucose compared to those who did not receive in mice.
Variable Number Tandem Repeats (VNTR) MAOA Gene Promoter Polymorphism Association with Adolescent Delinquency in Bali: A Preliminary Study Anak Ayu Sri Wahyuni
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Background: One of the genes that concern behavioral problems is the MAOA. Animal studies have shown that increased dopaminergic and noradrenergic function is associated with aggressive behavior. It is therefore obvious that any change in the catabolism function possessed by MAOA can lead to aggressive behavior. Individuals with decreased or increased MAOA function in most cases had a 30 bps of VNTR (Variable Number Tandem Repeat) polymorphism on the MAOA gene promoter. Children with 3R or 5R alleles are more likely to develop into violent behavior than those with alleles of 3.5R or 4R. Aim: The study aims to determine the proportion of VNTR polymorphism of MAOA gene promoter with juvenile delinquency in Bali and the relationship between VNTR polymorphism of MAOA gene promoter with juvenile delinquency in Bali. Method: The populations in this study were adolescents (12-18 years old) divided into case and control group matched by age and sex. Participants were asked to provide a blood sample for DNA extraction. The analysis on MAOA data cannot be conducted because the outgoing data is a constant. Result: All samples in the group had a high activity (100%) and only two samples (4.6%) had heterozygous genotyping, as well as the statistical analysis, could not be performed. Conclusion: This study has not been able to answer the hypothesis, because it was unable to be analyzed. The analysis cannot be fixed because all the measurements obtained are homogeneous.Keywords: Variable Number Tandem Repeats (VNTR), MAOA, Delinquency.

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