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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Optical and Morphological Characterizations of Element Oxides Compound (Y2O3 / SeO2) Nano-Composite Structures Synthesized Via Chemistry of Laser Ablation Ayad F. Al-Kaim
Journal of Global Pharma Technology .
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Abstract

The elements Oxides compounds S1(Y2O3) & S2(Y2O3/SeO2) are prepared chemically as an initial stage and affected by Laser Neodymium –YAG ablation  energy (200 mJ), pulses (200 pulse) and  frequency (6Hz) at temperature (65°C) with distilled water as a second stage. (XRD) showed that the oxides compounds were Polycrystalline to the two samples with a difference in the intensity values by increasing crystallization in the first sample and the appearance (Y (OH) 3, PLA) of the) Cubic) , (Monoclinic) forms of the yttrium oxide (S1) and in the second sample (S2) confirmed the formation of SeO2 based (Y2O3) in a quadrilateral and Monoclinic. The Field Emission-Scanning Electron Microscopy(FE-SEM)  images of the two samples (Y2O3) & (Y2O3/ SeO2) showed nanoparticles of Yttrium Oxide & Selenium Oxide as multi-shapes (sheets & rods) with (Y2O3: 82nm) and (Y2O3/ SeO2: 91nm) in grain size  showed long nanotubes distributed on the nanoparticles spread more widely (S1), and the sample (2S) showed the presence of selenium as well as SeO2 in varying proportions and in spherical forms spread over the surfaces of the Y2O3 nanoparticles. This was reinforced by the EDX analysis with the presence of these oxides. The results of the optical properties showed the value of absorbance increased in the S2 than in the S1, energy gap for the indirect electronic transmission were observed. They showed that they were semi-conductive materials with values of (3.5 eV) for the first sample & (3eV) in the second sample.Keywords: Laser ablation, Y2O3/SeO2 nanostructure, Optical & structural properties.
Preparation of a New Acrylonitrile Co-Polymer and Studying the Flammability and Mechanical Properties of Its Composites Mohammad N AL-Baiati
Journal of Global Pharma Technology Volume 09 Issue 05
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Acrylonitrile co-polymer was prepared, by four steps, the first was prepared the hetro-cyclic monomer,the second include prepared linear polymer, the third step includes prepared partially cross-linkedpolymer and the fourth step includes added four different moles (0.5, 1.0, 1.5 and 2.0 mole) ofacrylonitrile monomer. The effect of four types of inorganic phosphors salts in four different weightpercentage (0.2, 0.4, 0.6 and 0.8%), on flammability and mechanical properties (Flexural and Tensile)strength of co- polymer, has been studied. Four standard test methods used to measure the flameretardation and mechanical properties, which are: ASTM: D–2863, ASTM: D–635,ASTM: D – 790 andASTM:D-638.Results obtained from these tests indicated that, the co-polymer which prepared has highvalue of flame retardant and mechanical properties comparing with any thermosetting polymer, on theother hand, additive IV has high efficiency as a flame retardant and high effect on the values ofmechanical properties, but additive I show low effect on retard composition and low effect on the valuesof mechanical properties. This ability to flame retardency increased with the increasing in the number ofmonomers of acrylonitrile.Keywords: Polymer, Modified co-polymer, Acrylonitrile co-polymer, Condensation Polymerization, Fireretardant, Flammability, Additives.
Ruthenium (II) and Platinum (II) Complexes of 4, 5, 6- Triaminopyrimidine; 2-Hydroxy-4, 5, 6-Triaminopyrimidine and uric Acid: Synthesis, Characterization and Physicochemical Studies Suha Y. Nassar
Journal of Global Pharma Technology .
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Six Ru(II) and Pt(II) of uric acid; 4,5,6-triaminopyrimidine and 2-hydroxy-4,5,6-triaminopyrimidine complexes were prepared and identified by elemental analysis, conductivity measurement, melting point records, U.V.-visible, FTIR, 1H-NMR, 13C-NMR and HSQC spectroscopy. Some physicochemical properties of the prepared complexes were studies such as their luminescence characters and nanonature, using XRD and SEM techniques. Four biological activities of these complexes, such as antibacterial, antioxidants and cytotoxic activities have been studied besides their interaction with bacterial DNA.
The Tolerability and Degradation Rate of Amoxicillin Alone and with Clavulanic Acid in the Acidic and Alkaline Medium Abbas Razzaq Abed
Journal of Global Pharma Technology Volume 11 Issue 07
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This study deal with the effects of various pH values (1-14) on the stability of Amoxicillin alone and with Clavulanic acid. The degradation rate of Amoxicillin alone and with Clavulanic acid was determined by using Bacillus thuringiensis as indicator to act of drug used in this study. Amoxicillin alone and with Clavulanic acid was high stability at an acidic pH, while increasing the pH value led to decrease its stability at the statistical level (P value < 0.05). Maximum stability of Amoxicillin alone and with Clavulanic acid was experienced at pH values (4, 5,6,7,8 and 9), While their degeneration rate was significantly higher at acidic medium (pH=1) and alkaline pH medium (pH= 11, 12, 13 and 14) at p-value < 0.05. Therefore, the Amoxicillin alone and with Clavulanic acid is best given to humans and animals in pH value from 4-9.Keywords: Tolerability, Degradation, Amoxicillin, Clavulanic, acid, Alkaline, Medium.
Genetic Polymorphisms in 665bp Fragment of Exon 10 in Aryl Hydrocarbon Receptor Nadhim MH
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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A  cross sectional biochemical and molecular genetics study was achieved from December 2016 to September 2017, enrolled seventy patients (36 males, and 34 females) with somatotrophic pituitary adenoma continuously attended to the National diabetic center in Baghdad. Their ages were between 20 to 70 years. This research aimed to observe the frequency in 665bp fragment of exonic 10 of aryl hydrocarbon receptor (AHR) genes mutations. Polymerase chain reaction (PCR) was used for the detection ofAHRmutations as a cause of acromegaly, by using specific primers for amplification of exon 10 ofAHRgene on chromosome no.7. Sequencing was applied forPCRproducts ofAHRgene, ten different alterations inAHRgene were diagnosed .Four mutations inAHRwere recognized in 20/70 (29%) patients which their codons A474T with substitution adenine by thymine (A/T), 176 and 180 with substitution thymine by adenine (T/A), and codon 411 with substitution of (C/T) for 665bp.We concluded that ten novelties SNP were detected in Iraqi acromegalic cases. Genetic variants potentially inducing functional abnormalities of the aryl hydrocarbon receptor (AHR) pathway are associated with a more severe acromegaly, increased pituitary tumor size, and somatostatin analog resistance in patients living in HR areas.
Relationship between Lipid Profile and Some Physiological Markers in Pre and Post-Menopausal Type II Diabetic Females Noora M. Hameed
Journal of Global Pharma Technology .
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This study aimed to compare lipid profile level rates in pre and post-menopausal type II diabetic females. The hormones including (Estradiol and Insulin) and the physiological parameters (Cholesterol, high density lipoproteins, Triglyceride, Low density lipoproteins, Very low density lipoproteins , Hemoglobin A1c, Fasting Blood Glucose, insulin resistance, insulin sensitivity, systolic and diastolic blood pressure). This case-control study was done in a period of March 2016 to October 2016, where the samples collected from Al-Sadr Teaching Hospital in Najaf Province. The number of samples was (80) patients with type 2 diabetes with an average age (36-65 year), all of them were with type 2 diabetes are divided to premenopausal and post menopause, Also, the study included 40 apparently healthy people with an average age ( 36-65 year) , as control matched with disease group. The results showed that patients with type 2 diabetes , had significantly( p ≤ 0.05 )  higher cholesterol, Triglyceride, Low density lipoprotein, very low density lipoprotein, Hemoglobin A1c, insulin, insulin resistance and Fasting blood glucose levels rate than control group, while the levels rate of insulin sensitivity is decreased significantly (p ≤ 0.05)  in type 2 diabetic patients when compared with control group . The Estradiol levels rate was significantly (p ≤ 0.05) higher in premenopausal females while it decreased in postmenopausal females of both control and type 2 diabetic patients. Systolic and diastolic pressure showed significant difference between patients with type 2 diabetic and control. According to the comparison of premenopausal and postmenopausal women in both diabetic patients and in control group, the results showed significant ( p ≤ 0.05) elevation in Estradiol hormone level rates, Insulin hormone level rates and insulin resistance in both groups. On the other , the comparison of premenopausal patients with diabetic and  premenopausal control groups the statistical analysis showed significant elevation (p ≤ 0.05) in cholesterol levels rate, Low density lipoprotein (LDL), HemoglobinA1c  levels rate (HBA1c), fasting blood glucose (FBG), Estradiol hormone level rates, Insulin hormone level rates, insulin resistance ,insulin sensitivity and diastolic blood pressure. According to the comparison of postmenopausal diabetic patients and postmenopausal control group, there were significant differences (p ≤ 0.05) in cholesterol levels rate, Low density lipoprotein (LDL), HemoglobinA1c levels rate (HBA1c), fasting blood glucose (FBG), Estradiol hormone level rates, Insulin hormone level rates, insulin resistance and insulin sensitivity.Keywords: lipid profile, Diabetes mellitus, Pre and Post-Menopausal, estradiol    
Insights on the Role of Mesenchymal Stromal Cells Infusion in Enhancing the Inhibitory Network and Synaptic Plasticity in Chronic Epileptic Rats Rania S. Salah
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Objective: Temporal lobe epilepsy (TLE) is characterized by progressive synchronization with high frequencies of drug resistance. Mesenchymal stromal cells (MSCs) could open promising avenues for epileptic therapeutic approaches. The rational of the current research was to realize the therapeutic outcome of bone marrow (BMSCs) and adipose (ADMSCs)-drived MSCs against chronic epileptogenic alterations implicated in pilocarpine-induced TLE. Methods: Adult male Wister rats were distributed into five groups: Gp1: non epileptic control group, Gp2: chronic epileptic control group, Gp3: chronic epileptic group treated with BMSCs, Gp4: chronic epileptic group treated with ADMSCs and Gp5: chronic epileptic group treated with carbamazepine (CBZ). Gama-aminobutyric acid (GABA), semaphorin4D (Sema4D) and galanin concentrations were evaluated in brain via ELISA. Gene expression level of hippocampal synapsin-I was estimated using sqRT-PCR. Histological explorations of hippocampus and cerebral cortex were carried out. Results: Significant decline in GABA, galanin and Sema4D contents as well as synapsin-I mRNA level were recorded after pilocarpine injection. BMSCs or ADMSCs transplantation or CBZ administration constructed significant upgrade in GABA, galanin and Sema4D concentrations as well as synapsin-I mRNA level. Micrograph of brain tissue sections of epileptic rats showed nucleus pyknosis and neurodegeneration while, the treated groups demonstrated almost intact histological architecture. Conclusion: Based on the forementioned results, this work established the exact mechanisms underlining epileptogenesis and offered a new hope for treatment of focal epilepsies by employment of MSCs which achieved significant neuroprotective activity through modulating epileptic neuronal circuit, secreating neurotrophic molecules and restoring synaptic plasticity. Keywords: Chronic epilepsy, mesenchymal stromal cells, neuroprotection, GABA, Sema4D, galanin, synapsin-I.
Executive Attention and its Relationship to Precision Throwing the Air Pistol to Female Players in Iraqi Clubs Eman Shalaka Awad Al-Shaher
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Through the experience of the researcher in the field of firing an air air pistol as a player in the national team for women noted the presence of several factors affect the performance of players and lead to failure as a result of throwing during the competition, local or international The most important factors are the psychological factors that have a prominent atmosphere of competition, Increase the psychological burden on shooters. It may be difficult for the trainer to know or measure the psychological phenomena or mental processes of knowledge of the players through the presentation or viewing, and with the development of methods and scientific methods, it is possible to measure these variables easily and with high accuracy and guaranteed results.The study aimed to identify the relationship between the operational attention and accuracy of shooting with the air pistol of the shooting playersThe conclusions were as follows:The results of the study showed that the higher the level of executive attention the higher the accuracy of throwing the players high.There is a significant positive relationship between the attention of the executive and accuracy of shooting with the air pistol of the shooting players.Keywords: Executive attention, Precision throwing and air pistol.
The Association between Plasma Soluble ICAM-1 and Adiponectin with Over Nutrition in Pediatric Patients with Dengue Infection Ni Kadek Elmy Saniathi
Journal of Global Pharma Technology Volume 11 Issue 04.
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Introduction: Dengue Hemorrhagic Fever (DHF) is one of the urgent health problems in tropical countries, including Indonesia. On the other hand, the prevalence of overweight is also increasing among children even in developing countries. Recent studies proved that adiponectin has significant influence toward immune system. Therefore, this study aimed to provide a preliminary data about the relationship between overweight and DHF with sICAM-1 as the biomarker. Method: An analytic observational study with nested case control study design was conducted using 78 subjects. The DHF status was established using 1997 WHO criteria while the sICAM-1 and Adiponectin were assessed using ELISA technique. All of the data were statistically analyzed. Result: The baseline characteristics of the subjects between the groups were considered homogenous. The Odds ratio of overweight toward the risk of dengue shock syndrome (DSS) was found to be quite high at 2.89 (95% CI: 0.81 – 12.25) while the adiponectin level was also significantly different between overweight and normal subjects in DHF group. However, no significant difference was found in sICAM-1 level between the groups. Conclusion: It can be concluded that sICAM-1 and adiponectin level was differ between patient with over-nutrition than normal counterparts with over-nutritional patients tended to have higher sICAM-1 and lower adiponectin level. But the difference was not statistically significant.Keywords: Dengue hemorrhagic fever, Overweight, sICAM-1, Dengue shock syndrome.
Development of Instruments to Measure Disaster Preparedness Hery Sumasto
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Objective: Indonesia is called a disaster supermarket due to any disaster exists. The community preparedness in Indonesia is still low. The university academic community needs to be prepared so that it has enough capacity during disasters. The purpose of this study was to develop an instrument to measure disaster preparedness at a university in Indonesia. Method: Research and Development method was used in this study. The participants were directorate officers, lecturers/staff, and students. The development of the instrument was carried out by literature study, Focus Group Discussions (FGD), and expert consultation. The instrument development steps were instrument assessment, formulating strategic problems, instrument trials, and analysis. Results: The instruments produced in this study had five parameters, including knowledge, attitude, and practice (KAP); the university policy; resource mobilization capacity; early warning system; and emergency response planning. The result of an instrument trial showed that the University had high disaster preparedness (97%). Discussion: The instruments produced in this study can be used to measure disaster preparedness in the University.Keywords: Research and development, Disaster preparedness, Disaster instruments

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