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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Magnetized Water on Reducing the Histological and Physiological Effects of Experimental Infection with Ascaridia galli in Domestic Chicken Sukayna Jabbar Mushattat
Journal of Global Pharma Technology Volume 10 Issue 01: (2018) Jan. 2018
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Abstract

The current study was carried out to determine the effect of magnetized water in reducing the damage of Ascaridia galli parasites. 45 local chickens were divided randomly in to three groups G1 control group, G2 infected group, and G3 infected and treatment with magnetized water. In all groups 15 lacal chickens. Results showed a significant improvement in the blood parameters of RBC, WBC, MDA.SOD, Ca, CL, Na in G3 treated with magnetized water compared with the rest of the groups G1 and G2, where the results showed significant decrease in RBC measurement and significant increase in measurement WBC in G2 compared with the rest of the groups and with a potential P <0.05. The histological study of the intestinal tract showed a significant improvement in the magnetized water treatment group. The histological study of the intestinal tract showed significant improvement in the treated group with magnetized water G3 Where the histological sections showed re-spawning in the vesicles and epithelial layer lining the intestines and the lack of necrosis in the intestinal wall and the lack of lymphocyte infiltration in addition to the number of larval stages of Ascaridia galli in the intestinal epithelium.Keywords: Infiltration, chicken.
Quantum-Chemical Study For Some β-Lactam Drevatives by using Hyper Chem Calculations Zainab Y. Kadhim
Journal of Global Pharma Technology .
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Abstract

In the present research, we studied the properties of   three β-lactam derivatives(C18H12N2OS3 , C25H17FN2O3S and C22H19ClN2O5S2). The study was carried out by using semi-empirical methods (ZINDO/1, ZINDO/S, and PM3), to identify the binding energy ∆Eb, heat effect of ∆Hof formation, and dipole moment for some β-lactam derivatives.   Inaddtion, the electronic transitions and vibration modes were computed for these compounds. HOMO and LUMO energies were calculated to determine the reactive sites of these compounds.Keywords: β-lactam, Semi-empirical methods, Heat the formation.
Evaluation of Some Oxidative Stress Parameters in Iraqi Patients with Inflammatory Bowel Disease Hisham A. Shaker
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Objectives: Inflammatory bowel disease (IBD) refers to chronic inflammations that affect any part of the gastrointestinal tract (GIT). This study aimed to evaluate of some oxidative stress parameters (TOC, TAC, OSI and MDA) in sera of Iraqi patients with IBD. Methods: Three main groups were included in this study; 30 patients (15male &15female) with Crohn’s disease (CD group), 30 patients (15male & 15female) with ulcerative colitis (UC group) and 30 (15female & 15female) apparently healthy controls (HC group) comparable for age and gender without a history of IBD were involved in the current study. Results: TOC in the sera of both patient groups (CD&UC) was a highly significant increase (p<0.001) when compared to the (HC group) while significant decrease (p<0.05) in the TAC of (CD group), as well as highly significant decrease (p<0.001) in the TAC of (UC group) was observed in comparison with their levels in corresponding (HC group). A highly significant increase (p<0.001) in serum (OSI) of two patient groups (CD & UC) in comparison to that of (HC group).Meanwhile, significant increase (p<0.05) in serum MDA concentration of both patient groups (CD & UC) when compared to that of the (HC group) was observed. Conclusion: We found a significant increase in TOC, OSI and MDA while a significant decrease in TAC of patient groups. Therefore, CD and UC subjected to an increased in oxidative stress situation.Keywords: Inflammatory bowel disease, Crohn’s disease, Ulcerative colitis, Oxidative stress.
Characterization of Carotenoid Extract and Bioactivity Membrane of the Seeds of Annato (Bixaorellana) Lia Kusmita
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Bixa Orellana has a typical compound in the form of carotenoids. The types of carotenoids found in these compounds are bixin and norbixin. Both of these compounds have many benefits, one of which is as an antioxidant. Its nature as an antioxidant can also be used as a sunscreen. The purpose of this study was to determine the characteristics of carotenoid pigment in extract of the B.orellana sees membrane. Besides that, it is also to determine its biological activity in the form of antioxidants and sunscreen protectors. The TLC results showed 4 spot of carotenoids in the extract. Spot 1 identified as a bixin compound, because it has the same Rf as the bixin standard. HPLC result showed there were 5 peaks. The peak in tR of 9.046 was identified as norbixin and the peak in tR of 9.819 was identified as bixin. Carotenoid extract on the membrane of the seeds of B. orellana has antioxidant activity 16 times greater than standard bixin. Carotenoid extract at a concentration of 3.10 ppm had an SPF value of 6.27, including the extra protection category, and had a %TE value of 21.71% and Tp of 18.24% in the sunblock category. Keywords: Carotenoid, Antioxidant, Sunscreen, Bixin.
The Patho-Histological Change of Fetus Amniotic Sac as a Result of Bacterial Infection Sura I. A. Jabuk
Journal of Global Pharma Technology .
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Abstract

Amniotic fluid is defined as a transparent liquid that is present in the uterus during pregnancy. In this study obtain 100 sample of vaginal swaps(50from normal birth and 50 from caesarean), 100 samples of amniotic fluid (50 samples from normal birth and 50 samples from caesarean) from pregnant women revision born lounge  in Hilla teaching hospital, and 50 samples of amniotic sac from the caesarean women to made histological section. The result showed the number of positive swaps of bacteria  was 81 (81%) , while positive samples from amniotic fluid was 76 (74%) from the total 100 sample and present relationships between vaginal  infection and the present of bacteria in the amniotic fluid .The  type of  aerobic bacteria isolated was Escherichia coli ,Pseudomonas aeruginosa, Bacillus subtilis, Klebsiella pneumonia, Staphylococcus epider midis, Staphylococcus aureus,  Streptococcus  mutans, Proteus mirabilis and anaerobic bacteria was Peptp streptococcus sp. Neisseria gonorrhoeae, Lactobacillus sp. and Actinomyces sp. were isolated from amniotic fluids and vaginal swabs. then injection the same bacteria isolated in mice and made histological section from mice amniotic sac. Cross section of amniotic tissues in both of women and mice showed infiltration of lymphocyte, hemorrhage and elongation of epithelial cell as a result of bacterial infection.Keywords: Amniotic fluid, Amniotic sac, Caesarean, Vaginal infection. In vitro, In vivo.
Study the Effect of Oxides Emitted from the Smoke of Bakeries on the Density of Bone Reham K.H. Ibrahim
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Objectives: Osteoporosis is bone disorders that excess a person’s dangers of fracture due to low bone mineral density, impaired bone microarchitecture/mineralization, & diminution bone strength. This asymptomatic condition often remains undiagnosed until it manifests as a low-trauma fracture of the hip, spine, proximal   humerus, pelvis, & wrist, which frequently leads to hospitalization. Methods: The present study of 41 bakeries worker’s various places in Baghdad. Serum levels of vitamin D3, PTH hormone, Calcium, magnesium   and phosphorus were measured and analyzed of the bakeries smoke resulting from the combustion of kerosene substance by a device (aeroqual).Results: a significant increase in serum level of parathyroid hormone in bakery workers' group when the compared to a healthy control group (P=0.003). a slightly decrease of vitamin D3 in bakery worker groups as compared with a healthy control group, but it was not significant differences (p=0.068). Calcium, magnesium & phosphorus were determined in sera of healthy control group & bakery workers' group as It is clear that, there is no significant variation in the   calcium   & magnesium concentrations between control group and bakery workers' group (p=0.612), (p=0.748), respectively, while a significant decrease in the phosphorus concentrations, in bakery workers' group as compared to a healthy control group. This result showed that there was an appositive correlation between magnesium and years of work. Conclusion: It is possible to predict the risk of osteoporosis in bakeries bone by measuring levels of vitamin D3, PTH and bone minerals (Ca, Mg, and phosphorus) in their sera, and measuring the toxic oxides concentrations (NO2 and CO) emitted from the smoke of bakeries resulting from combustion of kerosene used as fuel.Keywords: Osteoporosis; Vitamin 25 (OH) D3, PTH hormone, Magnesium.
Investigation of Dried Herbal Tea Production from Gymnema Sylvestre Leaf Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Diabetes mellitus is a major public health problem in the developed and developing countries. The Gymnema sylvestre is one of the important anti-diabetic medicinal plant. Gymnema sylvestre is a slow growing, perennial medicinal woody climber found in North of Vietnam. Gymnema sylvestre is useful in controlling blood sugar to treat type-II diabetes. Gymnemic acid, the active ingredient of this plant, is extracted from leaves. There is a growing demand for G. sylvestre leaves in the pharmaceutical trade. There was not any research mentioned to the production of herbal tea from Gymnema sylvestre. Therefore, objective of this study focused on the effect of blanching temperature and time; heat pump drying temperature and storage condition to Gymnemic acid (%), color (sensory score) of the dried Gymnema sylvestre tea. Results showed that Gymnema sylvestre should be blanched in hot water 95oC at 4 seconds in ascorbic acid 0.5% and then beeing dried by heat pump dryer at 40oC until 6.5% moisture. The final herbal tea could be preserved under vacuum in PET/AL/PE bag at 4oC to maintain antioxidant activity for 12 months. Gymnema sylvestre is most important for plant prospecting.Keywords: Gymnema sylvestre, Herbal tea, Blanching, Drying, Vacuum, Gymnemic acid.
An Epidemiological and Therapeutic Study of the Cryptosporidium parvum Parasite in Some Farm Animals in Anbar Province /Iraq Suad Shallal Shahatha
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

This study was conducted to investigate of Cryptosporidium parvum parasite in some farm animals in Anbar Province by examining 564 feces samples (148 sheep, 144 cows, 132 goats, and 140 chickens). The results showed that the infection rates of the examined animals were 35.8 %, 41.6 %, 34.8 % and 25.7 % respectively. There were no significant differences (p ≥ 0.05) between the sexes in infection. The infection rate in small age’s groups was 46.5% while the large age’s groups 21.4 %. Significant differences were observed (p ≥ 0.05) between infection rates in rural areas and urban areas (44.9 %, 21.1) % respectively. The study also involved an effect of a water extract of the Zygophyllum fapago plant (also locally known as Chicken choking plant (on Cryptosporidium parvum parasite growth. As part of this study, a concentration of between 0.05-5 mg/ml was used. The application of these concentrations led to an inhibitory effect on parasite growth - an application of relatively higher concentrations caused greater effects in times of growth between 1-5 days.Keywords: Epidemiological, Cryptosporidium parvum, Animals, Extract, Anbar.
Molecular Modeling and Prediction of Pharmacokinetics of Some Substituted Benzothiazoles That Block Steroidal Sulphatase Inhibitors for the Treatment of Breast Cancer Srimathi R
Journal of Global Pharma Technology Volume 12 Issue 04 (2020) April 2020
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Abstract

Objective:Breast cancer is the second leading cause of cancer deaths in women worldwide. Around 60 to 80% of breast cancers are hormone dependent (HDBC). Aromatase and steroidal sulfatase (STS) are targets that increase the concentration of estrogens in circulation, thereby causing breast cancer. At the molecular level, 87% of expression of Steroidal sulfatase is observed and therefore STS is targeted. A series of fifteen substituted 2-phenyl 1,3- benzothiazoles were designed to be an inhibitor of STS, the enzyme responsible for conversion of Estrone sulfate (E1) to Estradiol (E2). Estradiol is the active steroid hormone found in circulation that leads to carcinogensis and results in breast cancer.Materials & Methods:Fifteen substituted 2-phenyl 1,3- benzothiazoles were sketched using Chemsketch (ACD LABS) and 2D structures were saved . The 2D structures were converted to 3D structures with Openbabel and energy minimized using Avogadro. The crystal structure of Human estrone sulfate 1P49 was downloaded from protein data bank (RCSB PDB) and prepared using Protein preparation wizard of Autodock 4.2. The grid box was set at 60*60*60 Å and x=72.242 and y=-1.284, z=28.246 centered on C β atom and docked.Results & Discussion:The docked complex was explored for possible interactions to substituted benzthiazole. Herein, we report the interactions of amino acid residue Arg98, Thr99, His290, Lys368, Thr 91as the best possible interactions that plays a role in inhibiting the binding of Ca2+to the active site. Compound 7C and 8C are reported with better binding affinities.Conclusion:Results obtained from insilico evaluation would provide insights in interaction of benzothiazole with STS explaining its favorable interactions.
Preparation of Calcium Carbonate and Magnesium Oxide Nanoparticles by Co-Precipitation Technique Jalil R. Ugal
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

Calcium carbonate and magnesium oxide nano-particles were prepared by the co-precipitation method using their simple salts as starting materials. They were characterized by Atomic Force Microscope (AFM) and X-ray diffraction (XRD). The average diameter was 70 nm for CaCO3 and 84 nm for MgO nanoparticles. Keywords: Nan particles, AFM, X-ray diffraction.

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