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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Self-care Practices of Diabetic Patients toward the Prevention of Osteoporosis in Babylon Governorate, Iraq Wael Sulaiman Sabea
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Background: Diabetic patients with uncontrolled insulin are exposed to a potential risk of osteoporosis because disorder of osteoblast-osteoclast function and confusion in the metabolism of calcium, phosphorus and vitamin "D". Objectives: The aim of the study to determine self-care practices of diabetics about the prevention of osteoporosis. Patients and methods :A cross-sectional design study had conducted in in Babel Governorate/Iraq in Endocrinology and Diabetes Diseases Center from 3rd November 2018 to 10th March 2019.Samples were collected during systematic random technique using a questionnaire form had constructed and developed by a researcher after extensive review of related books and available literature. SPSS was used for statistical analysis in the present study. Results: 420 diabetic patients of type 1 and type 2 had been participated in the study with response rate (96. 99%). Their ages ranged from 15-75 years with a mean and standard deviation of 51.8 ± 13.5 years, 53.4% were female and 46.7% were male. More than half of diabetics were married and the majority (63.3%) were livening urban areas. 26.9% of diabetics were illiterate and type 2 diabetes was accounted for 81.2%; hypertension was calculated for 36.4% while obesity for 35.7% of them. The majority (66.4%) of diabetic patients had illustrated fair score (62-77) towards self-care practices about the prevention of osteoporosis. There was significant correlation (P. value ≤ 0.05) between good self-practices of diabetics toward the prevention of osteoporosis and relating to their adult age group, living in urban areas, employed group, high educational grade, type 1diabetes and insulin intake, family member with diabetes, diabetics with normal body mass index. Conclusions: The current study had concluded that diabetic patients generally had fair grade of self-care practices about the prevention of osteoporosis. Recommendations: The study has been suggested the enforcement of well-organized ceaseless educational courses supported with modern educational technologies for diabetic patients in diabetic centers and conducting studies on large samples of diabetic patients in other governorates in Iraq to determine self-care practices towards the prevention of osteoporosis and as well as to determine the prevalence of osteoporosis among diabetics.Keywords: Diabetic patients, Self-care practices, Prevention, Osteoporosis.
Determination of TNFR1 Level and its Association with ACR and eGFR in Iraqi Patients with Different Stages of Diabetic Nephropathy Sabreen Ali Mezil
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Background: recently, studies have been focused on diabetes complications, such as neuropathy, retinopathy and nephropathy. Attempts were conducted to diagnosis diabetic complication cases to determine the relevant proper markers that can be employed for early detection purposes to prevent the development and progression to final disease stage. The aim of this study is to determine TNFR1 in diabetic nephropathy and its relation with renal function under various stages of this disease.   Materials and Methods: 90 patients (45 male and 45 female) with T2DM, aged (40-60), who attend to Baghdad Teaching Hospital /Medical City, were classified into three groups according to albumin-creatinine ratio (ACR) in urine. The first patients group consists of 30 diabetic patients with ACR less than 30mg/g (normoalbuminuria). Whereas; the second patients group includes 30 diabetic patients with ACR range 30-300 mg/g (microalbuminuria). The third patients group comprises 30 diabetic patients with ACR more than 300 mg/g (macroalbuminuria).In addition to 30 healthy subjects as control group. Fasting blood glucose, serum creatinine and blood urea were assayed by enzymatic methods. Soluble TNFR1 was estimated by ELISA. Modification of diet in renal disease (MDRD) formula was used to calculate of eGFR. Results: There are significant differences between values of TNFR1, ACR and eGFR. A high significant increase of TNFR1 (p˂0.001) was noticed in macroalbuminuria patients group in comparison with normoalbuminuria and control groups. Also, there is a significant increase in ACR level in macroalbuminuria group than other studied groups. In contrast, a significant decrease in eGFR was recorded in macroalbuminuria group in comparison with other patient and control groups. A high significant increase in of both Creatinine and blood urea levels were recorded in macroalbuminuria patients group than other patient and control groups. Conclusion: sTNFR1 associates with renal function in the case of diabetic nephropathy. Consequently, it considers a better predictor of renal function for patients with diabetic nephropathy. Keywords: T2DM, Nephropathy, TNFR1, ACR, EGFR, Microalbuminuria, Macroalbuminuria.
New Metal Complexes Derived from Mannich-Base Ligand; Synthesis, Spectral Characterisation and Biological Activity Safaudeen A. Hussain
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

In this work, the preparation of a new bidentate Mannich-base ligand and its metal complexes are reported. The formation of the ligand (R)-2-((R)-(4-(dimethylamino) phenyl)-(phenyl-amino) methyl) cyclohexan-1-one (HL) was achieved from the reaction of dimethylaminobenzaldehyde, aniline and cyclohexanone in a 3:3:5 mole ratio, respectively. The reaction of the ligand with Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions in a 2:1 (L:M) mole ratio resulted in the isolation of monomeric complexes. The ligand and its metal complexes were characterised using a range of analytical and spectroscopic techniques including; elemental microanalysis, magnetic susceptibility, conductance FT-IR, electronic spectra, electrospray mass spectroscopy and 1H, 13C-NMR spectra. The characterisation data indicated the isolation of six and four coordinate monomeric complexes with the general formula; [M(HL1)2(Cl)2].(H2O)2 (where M= Mn(II), Co(II), Ni(II), Cu(II)) and [M(HL1)]Cl2.(H2O)2 (where M= Zn(II) and Cd(II)). The ligand and its complexes were screened against several bacterial strains and fungi species. The obtained data indicated that the complexes are more active against several kind of organism, under survey, compared with the free ligand.Keywords: Mannich-base ligand; Monomeric metal complexes; Structural study; Biological activity.
Laparoscopic Versus Conventional Surgery for Colotomy Closure; Molecular Evaluation Hameed Abed Kate
Journal of Global Pharma Technology Volume 12 Issue 01
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The goal of this study was to compare between laparoscopic and conventional surgery on the healing of colotomy closure by using cruciate mattress suture pattern. Twelve adult local breed bucks (male goat), were used, it was divided into two equal groups. In group A (Conventional group), the colotomy incision was created and closed by cruciate mattress suture pattern, while in group B (Laparoscopic group), the colotomy closure by same pattern intracorporeally using 3-0 Polygalactin-910.Molecular assessment at zero time, one and three weeks post operation by vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) gene expression to evaluate the colotomy healing process.Molecular evaluations indicate that the highest value of vascular endothelial growth factor was noted in group A whereas the lower value in group B at one-week post operation. The highest value of fibroblast growth factor-2 was noted in group B while the lower value in group A at one-week post operation. In conclusion the study clearly demonstrated that the healing process in cruciate suture laparoscopically superior to that occur in conventional technique.Keywords:Enterotomy, Colotomy, Laparoscopy, Cruciate Mattress Suture Pattern, Molecular, VEGF, FGF-2, Quantitative PCR, Colon, Bucks. Goat.  
Bacteriological and Enzymatical Study on Rheumatoid Arthritis Patients Teeba Fares Hadi
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

The current study included the collection of 175 samples(blood-urea)of patients suffering from rheumatism, collected from Baghdad Teaching Hospital (Educational Laboratory), Al- Kindy Teaching Hospital, Al-Imamian Al-Kadhimya in Medical City in Baghdad at different duration between 2016/10/1 -2017/2/1. The bacterial growth results showed that 80% of urea samples positive for bacterial culture, while the rate of samples did not show any bacterial grow this 20%. The isolation subjugates to morphological, microscopically and biochemical tests, as also diagnosis by Api system. The most frequent bacterial pathogenic is E. coli which appeared highly rate(41.97)% followed by E. cloacae (21.25)%,P. aeruginosa (12.5)%, Salmonella (10)% and the proportion of K. pneumonia(7.5)%, while S. marcescens showed (6.25)%. When the measurement of the concentration of liver enzymes Glutamic Oxalate Transaminase (GOT), Glutamic Pyruvate Transaminase (GPT), Alkaline phosphates’ (ALP), the results showed a significant degreaseP≤0.05 in the level of enzyme GPT in patients serum which reachto16.94±0.84 mg/ml, while its level in the healthy serum was 0.68± 6.78 mg / ml.ALP enzyme results showed non-significant high atP≤0.05 in the level of patients serum with rheumatoid arthritis, as it reached the level in the serum 2.46±134.42 mg/ml, while the level in the healthy serum was 0.50±4.11 mg/ml. The enzyme GOT showed on-significant high at P≤0.05 in the level of patients serum as it reached the level in the serum 0.88±21.51 mg/ml, while the level in the healthy serum was 0.50±4.11 mg/ml.Keywords: Liver enzymes, Rheumatoid arthritis, Bacteria.
Estimation of Anti CMV Antibodies in Iraqi Pregnant Women Infected with Chronic Cytomegalovirus Safa A. Khudhair
Journal of Global Pharma Technology .
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Abstract

Cytomegalovirus (CMV) is a double-stranded DNA virus that belongs to the Herpesviridae (Herpesvirus) family, and it is the largest herpes virus in size. It affects all age groups and spreads worldwide. Human cytomegalovirus (HCMV) can cause fatal diseases to humans, and it is the most common cause of congenital birth and maternal infections. The study was conducted on 122 Iraqi pregnant women who had chronic CMV infection (with positive IgG antibodies), and 10 healthy women (with negative IgG and IgM antibodies) as control group for comparison purposes at Al-Elwiya hospital from May to August 2017. Venous blood samples were collected from the studied women to evaluate the levels of serum anti CMV IgG and IgM antibodies.  The results of the study showed that the highest antibody titers was within the age group (< 25 years) and women without previous abortion showed the highest CMV infection (55%), while no significant difference was shown between the IgG and IgM values within the categories of number of pregnancies.Keywords: CMV IgM & IgG antibodies-Pregnancy.
Synthesis, Antibacterial Evaluation and Docking Study of Some New Fused Pyrido-Pyrimidine and Naphthyridine Cycles Hamid H. Mohammed
Journal of Global Pharma Technology Volume 11 Issue 05.
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New fused pyrido-pyrimidine and naphthyridine cycles were synthesized and characterized using spectral analysis. Initially, 2-cyano-N-(1-phenylethylidene) acetohydrazide (2) was prepared from the reaction of cyanoacetic acid hydrazide (1) with acetophenone then cyclized to 4,6-diamino-2-oxo-1-((1-phenylethylidene)amino)-1,2-dihy-dropyridine-3-carbonitrile (3) by the action of malononitrile and triethyl amine in dioxin. Fused pyridopyrimidine cycles (4-6) were obtained from the reaction of compound 3 with formic acid, glacial acetic acid and propionic acid, respectively in the presence of POCl3 as a catalyst. The novel cycles (7-9) were synthesized from the cyclization reaction of compound 3 with benzoyl chloride, phenylisocyanate and phenylisothiocyanate in presence of pyridine. Naphthyridine cycles (10-13) were obtained by cyclization of compound 3 with some of aliphatic ketones namely; acetone, cyclohexanone, 2-butanone and 4-methyl-2-pentanone, respectively in presence of FeCl3 as catalyst. The antimicrobial activity of the synthesized derivatives was evaluated against several bacterial species as well as candida albicans. Docking study was also achieved to explore the binding affinity of the potent discovered hit (9) inside the binding pocket of glucosamine-6-phosphate synthase, a target enzyme for the antimicrobial agents.Keywords: Naphthyridine Cycles; Fused Pyrido-Pyrimidine; Antibacterial.
Corrosion Protection Enhancement using Electropolymerized Aniline Coating on Carbon Steel Pipelines in Industrial Water Abdulkareem M.A. Al-Sammarrai
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Corrosion of carbon steel in different water system utilities exhibited serious source of financial loses. In this study, electrochemical polymerization of aniline on carbon steel were studied in three types of industrial water (cooling water, waste water and treatment water) as corrosive media. The corrosion parameters; corrosion potential, corrosion current, polarization resistance, corrosion rates, and thermodynamic functions were estimated from Tafel and potentiodynamic procedures at four temperatures; 293,303,313and 323K. Protection enhancements were recorded at all industrial water used in this study and efficiencies of 78-91% were achieved. The results are supported by surface morphology examination before and after coating of carbon steel using atomic force microscope (AFM) and optical light microscopy (OM). Keywords: Electrochemical polymerization, Polyaniline, Nanofibers, carbon steel, Industrial water.
Synthesis and Biological Evaluation of New Boron Compound with Cephalexin and some of Its Transition Metal Complexes Asmaa Mohammed
Journal of Global Pharma Technology .
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Abstract

Synthesis of the ligand [ 7-(2-amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic boric anhydride] by the  reaction of cephalexin monohydrate with boric acid  in a mole ratio (1:1).  The metal complexes of this ligand with Cr(III),Co(II),Ni(II)and Cu(II) have been also synthesized .The ligand and its metal complexes were characterized by UV-Vis, FTIR, 1HNMR, 13CNMR  , atomic absorption spectra, CHNS analysis, melting point ,magnetic susceptibility and molar conductivity measurements  . The antimicrobial activity for the ligand and its metal complexes were evaluated against Pseudomonas auroginosa (G-), Staphylococcus aurus (G+), Klebsiella pneumonis (G+) and Staohylococcus epidermidis (G+) and Asporgillus as fungi.                                                                                   Keywords: Boron compound, Cephalexin.
Comparing the Radiation Adaptation in Rat after Receive Lethal Dose of Toxic Permethrin Feeding Farshid Gheisari
Journal of Global Pharma Technology Volume 08 Issue 02
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Abstract

Human exposure to ionizing radiation has long considered harmful to biological tissue and in sufficient amounts and intensities can be irreversible tissue damage, cancer and even death of an organism cause. On the other hand many researches that have taken place in recent decades show that low doses of ionizing radiation cannot be extrapolated effects (Extrapolation) the results of the effects of high doses predicted. Several cases of the positive effects of low doses of ionizing radiation in the form of bio-cognitive Hormetic or irritant effects have been reported. In this study 60 male Wistar rats with a genetic structure identical all homogenous inbred were randomly divided into 4 groups (3 groups for each of radioisotopes and underlying soil with a high dose control group), divided are. In order to prevent any Bias in the study, Permethrin is fed to all groups with a amount of poison. Mice were coded and only after completion of the test will be Decoding. The highest survival duration pertains to the group that received technetium-99m. Next is Ramsar soil group which is statistically indicative of a significant difference in respect to technetium-99m group. Iodine 131 takes the third rank and it is statistically not indicative of a significant difference with neither of the control and other groups. Low dosages of technetium featuring higher than normal natural radioactivity in Ramsar was selected as challenging dose and orally-fed Permethrin chemical compound was selected as the lethal factor. Data analysis reflects the creation of an adaptive effect subsequent to the prescription of low dosage technetium as well as a synergistic effect exerted by technetium and the regional soil characterized by a high background dosage on test rats’ survival time following to the administration of permethrin lethal dosage. 

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