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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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High Spectrum of PTEN Gene Mutations in Iraqi Breast Cancer Patients Wafaa Sabri Mahood
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Breast cancer conceder the higher tumor rate among Iraqi women.  New potential and prognostic markers are required to identify those women. PTEN gene (phosphatase and tensin homolog deleted from chromosome 10) is tumor suppressor; its mutations in breast cancer are well reported in many populations but not in the Iraqi people. The main purpose of this research was to identify the PTEN mutation spectrum as predictive marker in Iraqi patients with breast cancer and benign lesion. The mutations in the 7th exon of PTEN gene was analyzed on thirty tow Iraqi females with breast disease, twenty women were diagnosed breast cancer and six women with precursor lesions of the breast (benign) in addition to six healthy women served as reference (controls). Results showed several mutations including thirty different mutations in malignant samples, the most five were characterized by high alteration  rates75% (15/20), at position 115833 and 115950  these are T>G and T>A  followed  by  65%(13/20)  and 50 % (10 /20)  at positions 115921 and 115843 respectively  this is G>C, other more mutations frequency 45% (9/ 22)   at position 115912 this is G>T .We also detected an insertion G and T between (115833-115834) in 20%(4/20) and 10 % (2/20) respectively .Comparison of mutations between malignant and benign patients showed the frequency of several mutations in three sits (115833, 115843 and 115912) were appear in both benign and malignant patients may indicating to important role of the three sits in initiation and progression of breast cancer. Other two positions (115832, 115949) also have high mutations rate were found only in malignant patients indicating that these positions may have a role in progression of breast cancer.  In conclusion we believe that PTEN gene is a promising biomarker that could be useful in detection of breast cancer patients and predicting the prognostic state of those women.Keywords: Iraq, PETN gene, Breast cancer.
Molecular Diversity of Bacterial Isolated from Cozy and Cold Spring Water in Mosul / Iraq Mohammed Abdul_Razak Ibraheem Al-Qatan
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

The study involved determining the phenotypic and genotypic characterizations of the bacterial isolates from cozy springing water. Three bacterial species were elite supported on morphological bacterial, physiological and biochemical tests. In addition to molecular diagnosis using 16srRNAsequences. The cells were Rod_cocci, non-motile and their colonies appeared pigment red, yellow-orange and white, the range of their growth was at ph 4-8, temperature range 10-40 and the range of growth in NaCl 2-15%. All isolates were aerobic, positive for  catalase, oxidase, nitrate redaction and negative methyl red, also produced acid from fermentation of (arabinose, fructose, maltose and trehalose), while our  isolates exhibited variable results formation of acid from sugares such as  glucose, galactose, mannose, sorbitole, lactose and sucrose). Also the isolates were resistant for the foiiowing antibiotics amoxicillin, carbencillin, erythromycin, streptomycin and tetracycline but with various resistance to gentamycin and novobiocin. The 16srRNA sequences were performed by the ABI 3130XL gene analysis in Biology Bolumu 21280_Diyarbakir/Turkey. The isolated strains were mainly Serratia nematodiphila, Staphylococcus saprophyticus and Bacillus vietnamensis. Bioinformatic analysis alignment was done by Clustal W program mega 5 and phylogenetic tree analysis was constructed and drawn by Nieghbour_ joining program.Keywords: Phylogenetic tree, Spring water, Bioinformatic.
A Study of Chemical Composition for Muscles in two Species of Marine Teleosts Fishes: Hilsa Shad, Tenualosa Ilisha and Gizarred Shad, Nematolosa Nasus Akeil Jameil Mansour
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

A comparative study was conducted on the chemical composition for muscles in two types of marine teleosts species; Halsa Shad, Tenualosa ilisha (Hamilton, 1822) and gizzard shad, Nematalosa nasus (Bloch, 1795). The study samples were collected from the Faw market in southern Basra - Iraq between November - 2017 and December - 2018. The results showed a difference in the chemical composition for muscles of the studied fish. Moisture content had high averages ranged between 69 - 71% while there were few averages of ash content which ranged between 1.64-1.99 % . Protein content ranged between 15.98 - 18.90 % while fat content ranged between 7.35-12.05% in the studied species. The results showed significant differences (P < 0.05) in the protein, fat and moisture content between the studied species, while the differences were not significant (P > 0.05) when analyzing the results of ash content statistically. Keywords: Hilsa shad, Gizzard shad, Fish muscles, Chemical composition.
Production of Lemongrass (Cymbopogon Citratus) Powder Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Lemongrass (Cymbopogon citratus) is a perennial grass belonging to genus Cymbopogon. The lemongrass has a very wide demand in nutritional, medicinal and flavoring industry. Cymbopogon citratus contains various phytoconstituents such as flavonoids and phenolic compounds, terpenoids and essential oils, which may be responsible for the different biological activities. The demand for lemongrass (Cymbopogon citratus) is for its high citral content. But it is not stored as fresh for long time at ambient condition because it turns brown and rotten quickly. Even processing or preservation, its volatility and susceptibility to degradation are the major drawbacks for the use of Cymbopogon citratus oil. This research studied the feasibility of lemongrass dried powder production by treatment of vapor steaming (140oC in 10s; 130oC in 15s, 120oC in 20s, 110oC in 25s), drying temperature (40oC, 45oC, 50oC, 55oC) in 6 hours to 6.5% moisture content, grinding and coating materials (β-cyclodextrin, sodium alginate, carrageenan, cacboxymethyl cellulose) in different concentration (1.0%, 1.5%, 2.0%, 2.5%). The total chlorophyll content (mg/100g), citral content (%) were estimated. Results revealed that vapor steaming at 130oC in 15s, drying at 50oC in 6 hours to 6.5% moisture content, grinding and coating with 2.0% of β-cyclodextrin were appropriated for lemongrass dried powder production.Keywords: Lemongrass, Dried powder, Chlorophyll, Citral, β‐cyclodextrin, Sodium alginate, Carrageenan, Cacboxymethyl cellulose
Introducing Optosonographic Surgical Monitoring Into Clinical Practice Olga V. Surnina
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Materials and methods: In the period from 2010 to 2017 quite a few people were examined, i.e. a ‘comparison’ group of 200 people and an observation group, i.e. 1667 people. The results were as follows. Optosonographic monitoring in 935 patients (56%) revealed surgical thyroid disease, in 732 patients (44%) revealed a surgical pathology of the mammary glands. Among the identified neoplasms, 741 (79%) were benign ones, and 194 (21%) were malignant ones. The number of patients with mammary neoplasms was 732 patients. Of these, 634 were benign ones (87%) and 95 were malignant ones (13%). Results: The sensitivity in the differential diagnosis by optosonographic method of benign thyroid neoplasms is increased from 63% to 95%, malignant neoplasms from 66% to 96%. Reliability increase from 60% to 98% for the diagnosis of benign breast neoplasms, for malignant ones from 37% to 98%. This allows the use of non-invasive optosonographic monitoring to verify the diagnosis.Keywords: Optosonographic method, Implantation, Mammary gland, Thyroid gland.
Effect of NPK Compound Fertilizer Normal and Nano on Mineral and Protein Content of Three Species of a Piaceae Plants Dhafir A. Jameel
Journal of Global Pharma Technology Volume 09 Issue 12
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Abstract

An experiment was conducted under the conditions of Al-Diwaniya governorate in a special nursery was specially constructed for the experiment during the autumn season (2016 - 2017) in order to determine the effect of adding the different levels of balanced NPK fertilizer (20-20-20) normal and nano to the soil of three species ‎of A piaceae (cumin, anise and sweet fennel) and their interference in mineral and protein content of seeds. The factorial experiment that consist of two factor and with three replicates was designed by Randomized Complete Blocks Design (RCBD); the first factor consisted of three species of A piaceae plant that above-mentioned, while second factor included seven levels of the NPK compound fertilizer balanced (control, normal NPK at recommended level, nano NPK at recommended level, normal NPK at double recommended level, nano NPK at double recommended level, Mixture NPK (Normal + Nano) at recommended level, Mixture NPK (Normal + Nano) at double recommended level).The means of the treatments was compared with a significant difference in the use of the least significant difference (LSD) at the probability level (p ≤ 0.05). The results showed the superiority of sweet fennel plant in seeds content of total phosphorus and potassium versus the superiority of cumin plant in total seeds content of nitrogen and protein. The significant effect of soil-additive fertilizers from normal and nano compound fertilizer in the increase of the majority of the studied traits and recording the highest mean in the NPK mixture at the double recommended or recommended level. The interference between factors gave the same significant effect to the superiority of the individual factors, as well as the improvement traits of more than double in some of them and the difference of response between plants depending on the type of fertilizer.Keywords: NPK; nano; a piaceae; mineral; protein.
Effect of Ballistic Exercises in Explosive Capacity, Accuracy of Service and Spike of the Volleyball of the Physically Disabled-Sitting Ammar Khaleel Ebrahim Al-Ezzi
Journal of Global Pharma Technology .
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Abstract

The study aimed to: Identify the effect of ballistic exercises in the explosive ability, accuracy of service and the spike of the volleyball of the physically disabled - sitting. The researcher used the experimental method in the style of the two equal groups. The research society was determined by the players of the national team in the 12-player volleyball team. They were divided into two equal groups (control and experimental). Ballistic exercises included moderate and moderate exercises similar to the skill performance, the course lasted for (8) weeks by (3) training units per week and the main findings of the researcher after the extraction of the results of Posttests the following conclusion:Ballistic training used has a positive effect on the development of exploding explosive capability, accuracy of service and spike of the ball off the disabled for movement-sitting.Keywords: Ballistic exercises, Explosive capacity, Accuracy and physically disabled.
Clinical Use of Ultrasound in Obstetrics Saba Kamal Mahmood
Journal of Global Pharma Technology Volume 11 Issue 6.
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Abstract

During the past three years, ultrasound diagnostic procedures have been important and useful means in clinical practice of obstetrics and gynecology. Ultrasound images of the flow, whether color flow or spectral Doppler, are obtained from motion measurements. In ultrasound scanners, a series of pulses are transmitted to detect blood movement. Echoes of fixed tissues are the same from pulse to pulse. The echoes of the transition from scatter to slight differences appear at the time of signal return to the receiver. These differences can be measured as a direct time difference, or usually, in terms of the phase shift from which the Doppler frequency is obtained. It is then processed to produce either a color flow display or Doppler ultrasonography.
Analysis of Behavioral Factors on Medications in Gout Patients with Health belief Model Theory Ika Ratna Hidayati
Journal of Global Pharma Technology Volume 12 Issue 08
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Abstract

Objective : To identify behavioral factor associated with medication adherence using the Health Belief Model theory. Methods : This study used a cross sectional approach with accidental sampling technique. The number of samples used 64 people. The instruments were used the adherence to refills medication scale and the Health Belief Model questionnaire which had been tested for validation and reliability on the questionnaire. Data were analysed using multiple linear regression analysis. Conclusions : Each Health Belief Model theory variables which are perceived susceptibility, perceived severity, perceived benefits, and perceived barriers had a significant effect on medication adherence in gout patients (p 0.05). The Health Belief Model Theory had coefficient determination (R2) 59.7%. This indicates that the Health Belief Model can predict the behavior of patients who adhere to treatment well. Keywords : Adherence, Health Belief Model, Gout, Community Health Center, Behavior
Evaluation of Antimicrobial Activity OF Acalypha Indica Against Various Enteric Gut Pathogens Richard Lobo
Journal of Global Pharma Technology Volume 09 Issue 08
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Abstract

The present study aimed to identify the photochemical constituents and possible microbicidal potential of ethanol and aqueous extract of Acalyphaindica leaf extract on various gut pathogens. Shade dried leaves of Acalyphaindicawere extracted with solvents of increasing polarity. In vitro anti microbial activity of the water and alcoholic extracts of A. indica was performed by agar punch well diffusion method on selected gut pathogens. Photochemical study of the extracts of A. indicareveals the presence of phytoconstituents like alkaloids, phytosterols, carbohydrates and gums and mucilage’s. Both the aqueous and ethanol extracts showed good to moderate activity against Plesiomonasshigelloide, Shigellaflexineri, Klebsiella pneumonia, Vibrio cholera and Staphylococcus aureus. From the about results we conclude that, the traditionally used medicinal plant A.indica can be useful against the disease causing gut pathogens Keywords: Antimicrobial activity, Acalyphaindica, Gut pathogens, Agar diffusion method, Photochemical screening. 

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