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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Some Technical Parameters Influenced to Production of Baked Purple Sweet Potato (Ipomoea Batatas) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Purple sweet potato possesses a high content of anthocyanins and has an abundant amount of phytochemicals beneficial to human health. The high perishability of sweet potato roots during storage remains a major constraint. This study was carried out to assess value addition of purple sweet potato (Ipomoea batatas) processed in forms of baked strip. This present research aimed to optimize the production parameters as well as come out with an acceptable product. Different parameters affecting to the production of baked purple sweet potato were examined. The results revealed that blanching the purple sweet potato strip in 1.4 cm thickness in 0.15% CaCl2 solution, coating 0.2% xanthan gum, baking at 155oC in 2 minutes, and packing in PET/AL/PE bag were appropriated to maintain the physicochemical properties of baked strips as well as extend product shelf life. From this approach, the biological value of purple sweet potato tubers could be accelerated.Keywords: Purple sweet potato, Blanching, Coating, Baking, Shelf life, Anthocyanin, Xanthan gum.
Effect of Substrate Temperature on Optical Properties of Cu2ZnSnS4 Thin Films Preparing by Chemical Spray Pyrolysis Technique Alaa Ali Diwan
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The optical properties of thin films of Cu2ZnSnS4 have been studied by deposited on glass substrate by chemical  splash spray pyrolysis method (CSP) ,with constant concentration and different substrate temperatures of (350, 400 and 450) °C. CZTS films were prepared by chemical spray pyrolysis by dissolving of copper (II) chloride (CuCl2), zinc (II) Zn (CH3COO).2H2O, tin (IV) chloride (SnCl4), and Thiourea (CS (NH2)2 ,were utilized as sources of Copper particles, Zinc particles, Tin particles and Sulfur particles individually. The UV-Vis study showed high optical absorption coefficient and wide direct band gap for solar region. Further the optical constants such as refractive index, extinction coefficient and dielectric constant have been calculated for all samples. The optical energy gap for permitted direct electronic progress was determined utilizing Tauc's equation.  It is discovered that the band gap diminishes as the substrate temperature increments and the optical permitted energy gap for the direct electronic transitions was in the range of (2-2.2) eV.  The optical absorption coefficient is found to be larger than (10 4 cm-1), which respectively these films have a direct transition.Keywords: CZTS thin Films, Spray pyrolysis Technique, Optical properties, Еnеrgy gap.
Assessment of Health Protective Behaviors among Patient with Thalassemia at the Women's and Children’s Hospital in Al-Muthanna City Radha M. Lefta
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Background: Thalassemia is one of the most common disorders in the world, mostly in the region located around and nearby the Mediterranean Sea. People who are under 30 are most likely to have this disease and that's because of short life expectancy for thalassemia patients, due to life threatening complications and possibly the lack of health protective. Objectives: The study aimed to identify the health Protective behaviors through utilization (Nutrition, Drug, follow up, and Socio-Psychology) domains and to determine correlation between overall health protective behaviors and demographics data. Methodology: The study design a quantitative research by a descriptive study, the sampling it is non-Probability "purposive" sample  was conducted on 70 people with Thalassemia at the Women's and Children’s Hospital in Al-Muthanna City for the period from September 7, 2016 to February 16, 2017. A questionnaire it has used as a tool of data collection to fulfill the study, which consist of three parts, include demographic characteristics, medical history, and the health Protective behaviors. A content validity, which is carried out through 13 panels of experts .A panel of experts determines validity, while reliability use split half. A descriptive and inferential statistics are used to analyze the data. Results: The study indicates that the majority of patients have major thalassemia of the study sample are 60% and most   are male. The study sample are most age 5-10 year within age groups  (37.1%) with limited and average income its mild 54%. The study results indicate for assessment for health behaviors health follow-up and levels of drug use is inadequate. The study results depict that there is a significant between overall health protective behaviors and gender. Conclusions: The Study Sample conclusions have inadequate in health protective drug and follow-up domains due to inability to payment the cost of healthcare services because the majority of the study sample is income mild. Recommendations: To establish educational and awareness campaigns for patients and their patients about Thalassemia and to confirm the role of the nurse in actively participating in the guidance of patients.Keyword: Health Protective Behavior, Thalassemia, Drug use, Health follow-up.
Analysis of Lethal Outcomes in the Cases of Sefere Acute Pneumonia Associated with Influenza A (H1N1) Pdm09 Sergeeva IV
Journal of Global Pharma Technology .
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Abstract

The article analyzes 9 pathology records of deaths from severe complicated influenza A (H1N1) pdm09.It was found that among the deceased were predominantly young women aged 25 to 40 years with a burdened premorbid background, 77.8% of cases. Risk factors were: metabolic syndrome in 77.8% of cases and cardiovascular diseases, chronic viral hepatitis, chronic pyelonephritis was diagnosed in 11.1% of cases, respectively. Lethal outcome follows as a result of ARF and acute respiratory distress syndrome. Severe total injury of the trachea, lungs, and bronchi associated with internal organs plethora was detected morphologically. Clinical manifestations of ARF and ARDS were combined morphologically with alveolar damage. In all cases of lethal outcome, diffuse alveolar damage and polyorganism changes were diagnosed.Keywords: Influenza A (H1N1) pdm09, Community-acquired pneumonia, Lethal outcome.
Clinical and Laboratory Analysis of the Efficiency of Hirudotherapy in Complex Treatment of Endodontal Diseases Andrei Sevbitov
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

To date, teeth with inflammation in the periapical tissues, including destructive ones, often give non-abating exacerbations by conservative treatment, and they are removed. The article displays the clinical and laboratory results of a study of the effectiveness of hirudotherapy in combination therapy of inflammatory diseases of the endodontic. In recent years, a number of new drugs and methods for the treatment of chronic apical periodontitis have been proposed. The arsenal of new drugs for endodontic practice is extensive, but the result of treatment is often not optimistic.  The purpose of the study was to conduct a clinical and laboratory analysis of the method of hirudotherapy to increase the effectiveness of treatment of chronic apical periodontitis. Based on clinical and laboratory data, the local course of the inflammatory process was studied, including cases when using hirudotherapy in patients with acute exacerbation of chronic apical periodontitis. Hirudotherapy allows one to stop inflammatory syndrome in earlier periods and reduce the time of treatment.  The use of hirudotherapy in the combination with conventional endo therapy of patients with chronic apical periodontitis result in pronounced anti-inflammatory, analgesic, and vasoconstrictor effect that increases the effectiveness of treatment of chronic apical periodontitis.Keywords: Inflammation, Apical periodontitis, Hirudotherapy, Cytomorphology, Protocooperation.
Synthesis, Characterization and Spectroscopic Studies of a6, 6’-((1E, 1’E)-(1, 2-phenylene bis (azanylylidene)) bis (methanylylidene)) bis (3-(phenyldiazenyl) phenol) and their Complexes Saher Al-Shamkhawy
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

A new ligand 6, 6’-((1E, 1’E)-(1, 2-phenylenebis (azanylylidene)) bis (methanylylidene)) bis(3-(phenyldiazenyl)phenol) (L2) was prepared and characterized by UV-visible, FT-IR, 1H-NMR and Mass spectra. Two complexes with Cu (II) and Co (II) ions were prepared. The preparation has demeanor after limitation the optimum conditions through (UV-Vis) spectrophotometric study of these complex solutions have been studied such as determination wavelength (λmax), volume reagent, effect of time, effect of temperature and effect of pH .Also study determination of dissociation degree and stability constant under wavelength (λmax) and optimum pH values. The structures of complexes are Evidenced approbate to job method  which were gained from the spectroscopic studies of the complex solutions and characterized by molar conductance measurements, infrared spectra and mass spectra at room temperature. The infrared spectra of the chelating complexes have been studied, this may suggest that coordination between the metal ions and the prepared ligand takes place. The analytical data show that the metal to ligand ratio [M: L] in two complexes is (1:1) (metal: ligand) stoichiometry. depending on these results, the ligand acts as a bidentate ligand coordination through –C=N and –OH groups, the proposed geometrical structures of the complexes of Cu(II) and Co(II) ions are octahedral.Keywords: Azo-azomethine, Metal complexes, Synthesis, Spectral Studies.
Impact of Ischemic Heart Disease on Serum Visfatin, Chemerin and High Sensitivity C - reactive protein in Iraqi Patients with T2 DM Namir I. A. Haddad
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Objectives: Ischemic heart disease is a major cause of mortality among diabetic patients leading to about three-quarters of deaths among them. The study aimed to estimate serum visfatin, chemerin and hsCRP levels and other biochemical parameters in Iraqi diabetic patients with ischemic heart disease and compares it with newly diagnosed diabetic patients and control individuals. Methods: This study was carried out between October 2016 and March 2017 in Baghdad, Iraq, and involved 66 subject divided equally into three groups; 22 diabetic patient without IHD (P1), 22 diabetic patients with IHD (P2) and 22 non-diabetic healthy subjects (C). Serum visfatin, chemerin, hsCRP and other biochemical parameters were measured. Results: The results clarified that diabetic with IHD group had the highest levels of serum visfatin, chemerin and hsCRP in comparison with diabetic without IHD and control groups with means of (67.68±4.38 ng/ml, 59.73±9.42 ng/ml and 52.46±14 ng/ml respectively), (130.87±5.34 ng/ml, 127.85±4.30 ng/ml and 63.98±14.74 ng/ml respectively) and (8.37±1.03 mg/L, 7.54±1.19 mg/L and 4.55±2.31 mg/L respectively). These adipokines were found to be significantly correlated with some biochemical parameters. Conclusion:  High levels of serum visfatin among diabetic patients indicate that there is an association between visfatin and hyperglycemia and it may be an independent risk factor for CHD. Although, both of the two inflammatory markers chemerin and hsCRP can be considered as markers of subclinical atherosclerosis and IHD, and they may be utilized for the early detection of macrovascular disease in type 2 diabetics.Keywords: CHD, Chemerin, Hscrp, IHD, T2DM, Visfatin.
Isolation and Identify the Antibiotic from the Local Isolates of the Streptomyces antibiotics and Test their Antifungal Activity against Plant Pathogens Safaa Ismail Rashid Al-Obaidi
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

A bacterial isolates of (80) from (17) soil samples has been collected from the rhizosphere of different plants of many regions Mosul city; the isolates were initially identified as a Streptomyces genus according to the chalky appearance and the odor of the moist earth. Antagonistic activity against fungi isolated from the soil rhizosphere of plantshas been tested. Only (49) isolates (i.e. 57.64%) proved their antagonized ability against one or more of the tested fungi. The best isolation  that gave antifungal efficacy against all fungi, and was the largest diameter of the inhibition area against A. flavus (48 mm) followed by M. Phaseolina (27 mm), the least inhibition zonewas (12 mm)  of Sclerotiumcepivorum (12 mm). The isolation elected to the level of the species was identified by the morphological, physiological and hematological tests and was found to belong to the species of Streptomyces lydicus. The identification of the antibiotic extracted by ethyl acetate was done using three solutions that are butanol: pyridine: water (6:3:4), methanol: dichloromethyne: water (1:1:1) and butanol: acetic acid: water (6:4:3). A single spot appeared on a thin-layer chromatography plate (TLC) indicating the production of one type of antibiotic. It was noticed that Rf for the spot in the 3 solvents was 0.82, 0.47, and 0.80 respectively. The solvent with Rf 0.86 was the best hence it gave the highest inhibition for the growth of at least 2 fungi. Ultra violet absorption for the antibiotic was (286) and appeared that this compound was a Macrolides. Also Infra red (IR) was measured suggesting that the expected structure of the antibiotic is Oleandomyein.Key words: Streptomyces antibiotics, Bacteria, Antifungal, TCL plate.
Physicochemical, Antibacterial Studies of Some New Transition Metal Complexes of Chelating Active Compound Mahasin. F. Alias
Journal of Global Pharma Technology .
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Abstract

Metal (II) complexes of Co, Ni, and Cu with Amoxicillin derivative [Methyl-6-[2-(benzyl ideneamino) 2-(4-hydroxy phenyl) actamido]-2,2-dimethyl-5-oxo-L-thio-4-azabicyclo[3.2.0] heptan-3-carboxylate], (L) were synthesized and identification by phesio. Chemical procedures i.e (elemental analysis CHNS, metal analysis AA, Uv-Vis, FTIR, TGA, magnetic susceptibility and conduct metric measurement. From analysis the ligand behaves as a bidentate through oxygen carbonyl group of amide and nitrogen atom of imine group. Tetrahedral geometry was suggested for the cobalt ion and a six coordination octahedral geometry for nickel and copper complexes has been proposed. The ligand and its metal complexes were also tested for the Candida albicans .c., and as antibacterial activity to assess their inhibiting potential against two selected microorganism, staphylococcus aureus and Escherichia Coli using two different concentration (10 and 5 mm) in nutrient agar medium.Keywords: Schiff base, Metal complexes, Physico-chemical, Microorganism, Amoxicillin.
THE ROLE OF TISSUE OXYMETRY AND DIGITAL DYNAMOMETRY IN THE PREVENTION OF INTERSPINOUS FIXATORS INSTABILITY Chertkov Kuzma Alexandrovich
Journal of Global Pharma Technology Volume 08 Issue 08
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Abstract

The work describes the results of intraoperative tissue optical oxymetry when implanting interspinous fixators in 17 patients with instability in the lumbar spinal segments with the use of a dynamometric digital device. The aim of the study was to develop preventive measures against vascularization disorders in the bone structures as a basic condition for successful osseointegration. The parameters of safe compression (25-27 N/m) of interspinous processes with fixation devices when implanting stabilizing fixators were determined in the course of the study.  Keywords:  Instability, Tissue optical oxymetry, Implants, Digital dynamometry, Spinal motor segment

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