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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Immunohistochemical Protein Tracing of p15 INK4B Gene Expression in Latent Membrane Protein-1-Epetein Barr Virus Oncoprotein Infected Tissues from Ovarian Tumors Patients Ruqaya M.J. Awadh
Journal of Global Pharma Technology .
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Abstract

This study was designed as a retrospective case-control study research. A total number of (150) formalin-fixed, paraffin embedded ovarian tissues was included. These tissues  were including 45 malignant ovarian tumors (which including Serous epithelial  (32 cases : 71.11%), Mucinous (9 cases :20%) and Endometrium (4 cases :8.89 %)  ,  45 benign ovarian tumors), 20 borderline tumors and 40 of apparently healthy ovarian sections which were included as baseline control .The mean age of the patients with ovarian carcinoma was higher (42.58±8.083years) than the mean age of the borderline ovarian tumor (41.90±10.126 ) and benign tumors group (39.82± 7.646 years), followed by mean age of those females in the group of apparently healthy control  (35.64± 10.183). The results of immunohistochemistry staining of LMP1-EBV gene expression  showed that  57.8% ( 26 out of 45 tissues) was positive in malignant ovarian tumors .While, in benign ovarian tumors the positive results was 40 % (18 out of 45 tissues) of LMP1-EBV. Whereas, the positive results in borderline ovarian tumor group was 40% (8 out of 20 tissues), followed by the apparently healthy ovarian control tissues was 15% (6 out of 40 tissues).
Synthesis, Spectral Characterization and Biological Activity of 2- [2‾ - (1-Amino -1, 5- Dinitrophenyl) azo]-Imidazole Abd Al-Sadda HK
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

The preparation and spectral identification of ligand 2-[1‾-(1-Amino- 1,5-Dinitrophenyl) azo]-Imidazole (ADNPAI) were prepared by reacting a dizonium chloride salt solution of 2,4-Dinitrophenylhydrazine with imidazole in alkaline ethanol solution. Azo dye ligand Prepared have been characterized by analytical data, Infrared, Electronic spectral data, XRD, SEM, Thermal analysis (TG-DSC-DTG), UV-Vis, and magnetic susceptibility. The biological activity azo dye ligand were tested invitro against the sensitive organisms Staphylococcus aureus (Gram-positive) and Escherichia coli, Pseudomonas aeruginosa (Gram-negative) by agar plate different technique. The activity data show appearance the ligand azo dyes prepared apparent highly active against to all the bacteria species tested.Keywords: Azo imidazole, ADNPAI, Thermal analysis, SEM, Antibacterial.
Theoretical Justification of Structure and Development of Capsule Technology with Cerebroprotective Activity Oleh S. Shpychak
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Treatment of brain remains an urgent problem in the health system in Ukraine, due to the wide prevalence of the most common as a result of this disease causes cerebrovascular diseases, including atherosclerosis and hypertension, leading to a narrowing of the blood vessels of the brain and decreased cerebral blood flow. An alternative method of treatment of cerebrovascular diseases (CVD) it is expected pharmacological effect, which is achieved through use in medicines herbal drug that exhibits antyarytmichal, sedative, tranquilizing, antispasmodic, antiseptic hypotensive effects. According to literature data types such therapeutic activity black horehound grass, the grass dead-nettle herb wormwood and compatible whose presence leads to a potentiation of pharmacological action due to the fact that the components of the content biologically active substances (BAS) show a complex impact on different parts of body systems and increase reliability and predictable therapeutic effect. This complex of action reduces the possibility of side effects of display. The aim of this work is the theoretical basis structure and development of technology for rational drug cerebroprotective action in the form of hard gelatin capsules based on dry extracts medical plant material (MPM), namely black horehound grass, herb nettle deaf, sage herb. On the basis of experimental studies, we have proved the composition of masses for encapsulation of drug in the form of hard gelatin capsules number 0. Composition per capsule: a mixture of dry extracts MPM-400 mg; aerosol-50 mg; lactose monohydrate -50 mg. The weight of the contents of the capsule-500 mg. Keywords: Dry extracts, Development composition and technology, Gelatin capsules, Cerebroprotective activity.
Aspects of Health-Improving and Sports-Mass Work Students Valery Panachev
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Currently sports-mass and health-improving work appears to be one of the most important directions in social students’ self-government as well as effective force of persuasion in necessity of students’ physical training and teachers’ professional activity improvement. New era states new innovative problems before all generations. These problems include improvement of life quality, of human health, active way of life, maintenance of peace in the world. One of the basic problems of future social development of state is the quality life improvement, improvement of people’s health and of demographic situation. Today the problems of population’s health, especially of students’ health are the most pressing ones. Up till now the problem of students’ health strengthening by means of physical culture remains acute. In this article we tried to study the peculiarities of dynamic improvement of students’ physical motion in the last decades. The results of students’ motive behavior received during our study predetermined the real interest to active physical culture and sports training. Special students’ interest was provoked by their own model of self-development during the education at university. The decisive role played the stimulation of students’ self-government in motive activity improvement, healthy life-style, systematic physical culture and sports training. All these facts were connected with greater independence in self-development and preparation to the future professional activity. Keywords: Healthy life-style, Students’ self-government, Health strengthening study, Development of physical culture and sport, Health-improving, Sports-mass work.
Comparison of the Changes of D-Dimer and FDP Serum Levels in Ischemic Brain stroke Patients with and without Malignancy Mohammad Reza Amiri-Nikpour
Journal of Global Pharma Technology .
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Abstract

Introduction: Cerebral artery diseases are the third cause of death in the U.S. proceeded only by the heart diseases and cancer. It is the most prevalent neurological disorder leading to illness and death. Stroke is a syndrome characterized by the initiation of acute neurological disorders lasting at least for 24 hours. It reflects the focal involvement of central nervous system induced by blood circulation disorders in brain. This study was designed to study D-Dimer and FDP serum levels in ischemic brain stroke patients with and without malignancy. Method of study: This is a randomized clinical trial in the form of a case-control study. The population of study consists of all cases admitted in the neurology department of Imam-Khomeini Hospital in Urmia who included in the study via randomized allocation after obtaining their consent. Cases with underlying malignancy were grouped in case group and those with no malignancy were grouped in control group. Results: In this study, 60 and 120 cases were studied in the case and control groups, respectively. There was a significant difference in mean D-Dimer (P=0.01), mean FDP (P=0.02), mean ESR (P=0.01) and mean CRP (P=0.01) between case and control groups. Lung cancer was the most prevalent cancer (31.7%) in the case group. In addition, diabetes mellitus, hyperlipidemia and hypertension risk factors were reported in the case group with a frequency of 28.3%, 33.3% and 30%, respectively. Conclusion: In patients with ischemic stroke and malignancy, the serum levels of D-dimer and ESR was elevated and risk factors such as DM, HLP, and HTN had a high rate in these patients, so in patients with cancer, occurrence of cerebral ischemia is higher compared to patients without malignancy. So knowing mechanisms, type and stage of cancer is critical for survival of these patients.Keywords: Diabetes mellitus, D-Dimer, ESR, Hyperlipidemia, Hypertension, Ischemic stroke.
Immuno-Molecular Diagnosis of Toxoplasma gondii in Blood and Meat of Indigenous Chickens in Some Rural Regions of Iraq Amal Hassan Abd Al-Shabbani
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

Herein the object was to detect the prevalence rate of the parasite Toxoplasma gondii (T. gondii) in blood and meat samples of indigenous chickens. Total of 92 chickens of both sexes of more than one year old were selected from some rural areas of Iraq during a period of February to August / 2017 and tested by using indirect-ELISA and PCR techniques. Overall results showed that 19.57% and 14.13% of sera and meat samples respectively were seropositive for anti-T. gondii-antibodies. In meat samples, the sero-prevalence was 7.61% and 14.13% in tissues of skeletal and cardiac muscles respectively. Regarding PCR technique, the total results showed that 5.44% and 1.09% of blood clots and meat extracts respectively were positive for DNA reaction of T. gondii. In addition, although the PCR results were found to be positive in cardiac muscles (1.09%) only, no significant differences had been detected regarding the results of skeletal muscles that lack positive cases. According to the diagnostic assays, significant differences in positive results were reported between indirect-ELISA and PCR technique among the tested samples of sera and meat as well as skeletal and cardiac muscles.Keywords: Toxoplasma gondii, Chickens, Blood, Meat, Serology, Molecular, Iraq.
The Relationship between of Some Pathogens and Gallstones Formation Maytham Abas Makki
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The study was conducted from October 2016 to February 2017 at Al Hussein Educational Hospital in Samawah city. Forty-five patients diagnosed with gallstones which removed by surgical operation the gallbladder,then the bacterial implantation of all the isolated grits from the residual gallbladder.Most of the factors related to diseases of the infected were also recorded. Forty-five percent of the men and women aged 2-43 , 20 - 54 yearsrecpectivly .Three types of gravel were identified depending on appearance, size and color. Cholesterol stone (15.55%), pigmentedstone  (33.33 %) and mixed stone (51.11%).The results showed that all of these species were positive for bacterial culture and recorded species:Enterococcus faecales (88.88%), Klebsiella pneumonia (22.22%), Enterobacteraerogenes (28.88 %), Pseudomonas aerugenosa (77.7%) Vibrio alginolyticus (20%),Vibrio valunificus (46.6%), Escherichia coli (55.55%),Vibrio parahemolyticus (15.55%),،( Proteus merabilis (66.6%) Listeria monocytogenes (60 %   ( Staphylococcus aureus (42.22%), Staphylococcus epidermidis (4.44 %), Staphylococcus saprophyticus (6.66%), Proteus vulgaris (2.22%) ,Citrobacterfreundii (51.55%),Salmonella typhi (37.77 %), Salmonella entritidis 13.33% , Coliform bacteria (15.55 %).Keywords: Pathogens;  Gallstones formation; Enterococcus faecales.
Palynological Study of the Genus Arabis l. (Brassicaceae) in Iraq Khazal Dh. Wadi Al-Jibouri
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Pollen morphology of 4 species (A. aucheri , A. auriculata, A. caucasica, A. nova) belonging to the genus Arabis L. in Iraq was examined by light microscope and scanning electron microscope to determine the significance of pollen features as a taxonomic characters. The results showed pollen grains of the species were monades, homopolar, tricolpate, and with medium size, but the species varied in shapes (polar and equatorial view), colpus length and width, exine thickness and exine ornamentation. Pollen colors were brown convert to brownish yellow.Keywords: Arabis, Cruciferae, Palynology, Pollen grain.
Arterial Pedal Arch Revascularization Impact on the Clinical Results in Critical Lower Limb Ischemia Igor I. Katelnitskiy
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Background: There are still many unresolved problems that reduce frequency of clinical and technical success of angioplasty of lower limb arteries. One of such problems is impact of the arterial pedal arch revascularization on the clinical result of angioplasty in patients with IV class critical lower limb ischemia according to Pokrovsky-Fontaine classification. Material and methods: The results of treatment of 98 patients with peripheral arterial disease (PAD), complicated by critical lower limb ischemia of IV class according to Pokrovsky-Fontaine classification were analyzed in the early postoperative period and 1 year later after the completed angioplasty. Patients were divided into two comparable groups: the first group-the patients with the arterial pedal arch revascularization, the second group – the patients whom it had been impossible to revascularize the arterial arch. Results: “Good result” in patients of the first group in the early postoperative period and one year later was 23.1% and 22.7% respectively. In the patients of the second group-9.2% and 5.6%. The both group patients avoided amputations in the early postoperative period, but one year later 53.3% of the second group patients with the “unsatisfactory result” underwent amputation. Conclusions: According to the results, the arterial pedal arch revascularization influences on the clinical results and decreases the quantity of amputations in patients with purulent-necrotic changes in the lower limb. Keywords: Critical low limb ischemia; Arterial pedal arch; Revascularization; Transluminal balloon angioplasty.
Role of Testosterone on Waist to Hip Ratio in Women with Hirsutism Abdulsamie H. Alta'ee
Journal of Global Pharma Technology Volume 09 Issue 12
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Hirsutism is a series problem faced women in the present days. It is usually associated with elevated levels of androgen hormones.  This study aims to investigate the role of testosterone in the waist-to-hip ratio (WHR), and body mass index (BMI) of 54 women with hirsutism and 54 healthy women match in age, in a case control study. Free testosterone and thyroid stimulated hormone (TSH) were determined using ELISA technique. WTR, BMI and hirsutism score were examined in the study groups. Free testosterone, TSH, WTR, BMI and hirsutism score found to be significantly increased when compared with control group. The result of the present study may hypothesize that testosterone has a central role in the path physiological changes occur in hirsutism, such as fat storage pattern and as consequence the HWR and the stimulation effect to induce TSH and its effect on hair growth. Keywords: Hirsutism, WTR, Testosterone, TSH, BMI.

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