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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Administrative Possibilities of Academic Institutions and Their Correlation with Sports Tendencies of Students and Attitudes towards Practicing Sports Salam Hantosh Rashed
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

The research aims to identify the availability of the administrative possibilities of academic institutions, sports and their correlation with the wishes and preferences of students, the sample included current research (367) students were chosen randomly stratified where they were taking the sample from the Department of Physical Education and Sports Science for the academic year (2017/2018), where the researchers developed a questionnaire consisting of (3) areas and (20) is distributed when the sample data analysis was used arithmetic averages and standard deviations using the bag statistical (SPSS). The most important results of the research, most sports establishments in the department of physical education and sports sciences neglected, as well as there is no supervisor for every sport activity of the programs of sports in the department of physical education and Sports sciences. There is no fitness related to health because of the lack of sports activities in the department of physical education and sports sciences, and the most important recommendations: The head of the department of Physical Education and Sports Sciences must provide all possibilities for students to exercise sports activities, and must provide supervisors of various activities for students in all disciplines and sports activities, and provide effective administrative possibilities through interest in the institutions of the department of physical education and mathematical sciences.Keywords: Administrative possibilities, Sports tendencies and practicing sports.
Different Technical Variables Affecting Noni (Morinda Citrifolia L.) Wine Fermentation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Noni (Morinda citrifolia L.) is one of the most important fruit which was widely used for its health restorative properties. It has been used an herbal medicine in various ailments. This fruit is considered a natural antioxidant. It can prevent cancer, heart disease, diabetes, cognitive dysfunction, hypertension etc., and maintain overall good health. Over the years, its popularity has been diminished due to unpleasant smell from the ripened fruit. There is limited study mentioning to processing of this functional fruit. Therefore we explored a wine fermentation from noni fruit by focusing on the effect of different variables such as sugar supplementation, yeast ratio inculation, fermentation time and temperature in the primary fermentation, and fermentation time and temperature in the secondary fermentation to noni wine quality (%v/v alcohol; g/l acidity; oBrix residual sugar; sensory score). Our results proved that the primary fermentation should be conducted with 15% sugar supplementation, 0.15% Sacchromyces cerevisiae at temperature 29.0oC in 10 days. The secondary fermentation was adequate in 9.5oC for 3 weeks to get a pleasant flavor and aroma. Noni wine also evaluated the antioxidant capacity and total phenolic content. Noni wine could be considered as a good source of antioxidants and phenolics ideal for daily healthy consumption.Keywords: Noni, Wine, Fermentation, Sacchromyces cerevisiae, Antioxidant, Phenolic.
Reliminary Antibacterial and Phytochemical Evaluation of Dryopteris Cochleata (D.DON) C.CHR Toji Thomas
Journal of Global Pharma Technology Volume 03 Issue 06: (2011) June 2011
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Abstract

Ryopteris cochleata Dryopteridaceae is one of the important plants of traditional systems of medicine. Fronds (leaves) of Dryopteris cochleata were evaluated for its antibacterial potential and phytochemical contents in various solvent extracts in increasing polarity towards pathogenic bacterial species. Antibacterial activity was tested by disc diffusion method. Petroleum ether, acetone, methanol and water extracts of Dryopteris cochleata were tested for antibacterial activity towards some pathogenic bacterial strains. Both acetone and methanol extracts exhibited antibacterial activity; maximum activity was shown by acetone extract compared to others. Antibacterial activity was confirmed by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). MIC and MBC values of acetone extract of 12.5mg/ml and 25mg/ml were observed towards Staphyococcus albus while MIC and MBC values of 25mg/ml and 50mg/ml were observed towards Pseudomonas aeruginosa. Flavonoids, phenols, steroids were detected in acetone and methanol extracts. The study proves that Dryopteris cochleata possesses antibacterial principles, soluble in acetone, which hinder the growth and multiplication of some multidrug resistant bacterial strains. Keywords: Dryopteris cochleata, yopteridaceae, Tibacterial, Dsc diffusion.
Virtual Screening of Sulphonyl Urea Derivative and In-silico, In Vitro Anticoagulant Evaluation of Lead Molecules K. Chaithanya Veena
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Objective: The objective of present study is the virtual screening of sulphonylurea analogues followed by the insilico and in vitro evaluation for its anticoagulant activity. Method and result: the method of virtual screening selected is the structure based virtual screening using Ch EMBL database. The in silico analysis was performed using auto dock tools 4.2.The docking was performed using 1TA2 (thrombin) and 1FJS(clotting factor Xa) as the binding proteins which are drawn from the protein data bank. The sulphonyl urea analogues obtained from virtual screening are allowed to dock with the clotting proteins, the binding energies and docking positions were determined using auto dock tools 4.2.the in vitro evaluation of anticoagulant activity were performed, the prothrombin time(PT) and activated thromboplastin time(APTT) were determined. Conclusion: The sulphonylurea analogues are capable of producing the anticoagulant activity. Keywords: Virtual screening, Sulphonyl urea analogues, Anticoagulant activity, Gliclazide, glimepiride, War far in, In silico analysis.
Two Class Classification of Breast Lesions using Statistical and Transform Domain features shreya sharma
Journal of Global Pharma Technology Volume 9 Issue 07
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Abstract

In breast cancer the breast lesions are differentiated into two classes: Benign and Malignant. In this paper Computer- Aided Detection (CAD) system is designed for detecting lumps which may indicate presence of breast cancer. This paper presents the  classification of breast ultrasound images using Statistical and Transform domain feature extraction techniques were data is partitioned by hold-out method and classified using Support Vector Machine (SVM) classifier. The aim of this paper is to achieve higher accuracy in classification of the lesions. SVM trains a model that assigns unseen new objects into a specific category. The best obtained result out of all the features used is calculated using Fourier Power Spectrum (FPS) with 91.5 % overall accuracy and 81.2 % and 92.8 % individual class accuracies for benign and malignant class respectively .
Synthesis, Characterization and Antibacterial Study of Selected Metal Complexes Derived from Modified of PVA Ruwaidah S. Saeed
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

A new ligands(modifier polymers) L1, L2, L3 , L4 and L5 were prepared according to method [8]  by reaction of polyvinyl alcohol(PVA) withi(acid chloride)[1]a or [2,3]a,b in dimethyl formamide. The Ligands were characterized by (FT-IR), (UV- Vis) and (1H-NMR) spectra some of them. Synthesis some transition metals complexes of these ligands and described via (FT-IR, UV-Vis) spectra, [Thermo gravimetric analysis (TGA), Differential Scanning Calorimetry (DSC)], (SEM) and antibacterial activity was screened thought two types of bacteria. The octahedral geometrical was suggested for Co+2, square Planer geometrical was suggested for Ni+2and tetrahedral geometrical was suggested for Cd+2Keywords: PVA; Metal complexes; Antibacterial.
Microwave Vacuum Drying Variables Affecting to Processing of Dried Gomphrena globosa Floral Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Microwave vacuum drying is one of the most energy demanding processes. Water evaporation takes place at lower temperatures under vacuum, and hence the product processing temperature can be significantly lower, offering higher product quality. Gomphrena globosa is one of the traditional medicinal plants widely distributed in Vietnam. It’s considered as a valuable source for pharmaceuticals against various ailments. Gomphrena globosa L. flowers are a promising source of natural antioxidants. Objective of this study focused on the influence of processing parameters such as the microwave power (100, 150, 200, 250, 300 W), system pressure (20, 25, 30, 35, 40 kPa) and drying time (15, 20, 25, 30, 35 min) on shrinkage coefficient, rehydration ratio, color change, total phenolic, flavonoid, betacyanin of dried herbal during the microwave vacuum (MV) drying of Gomphrena globosa. At the end of drying process, we also monitored the stability of dried Gomphrena globosa flower during 12 months of preservation. Our results showed that the optimal drying process should be conducted at microwave power 250 W at 35 kPa within 30 min to get the best quality of dried Gomphrena globosa flower. From this approach, shelf-life of dried Gomphrena globosa flower could be last for 12 months without any deterioration. The low temperature and fast mass transfer conferred by vacuum combined with rapid energy transfer by microwave heating generates very rapid, low temperature drying and thus it has the potential to improve energy efficiency and product quality.Keywords: Gomphrena globosa, microwave vacuum drying, Shrinkage coefficient, Rehydration ratio, Color change, Total phenolic, Flavonoid, Betacyanin.
Studying the Effect of Purified Lectin Producing from E. coli on Multidrug Resistance Pantoea Agglomerans Istabreq Muhammed Ali Salman
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

In this study, an isolate of E coli E2 isolated from diarrhea gave the upmost production level of lectin by microscopic glass slide and microtiter plate methods. The results revealed that human erythrocytes O+ gave hem agglutination activities with all E coli isolates and sheep erythrocyte gave hem agglutination activities with all isolates but with lower activity and the isolate coli E2 appeared higher hem agglutination level with O+ blood group by both methods. Purification of the lectin was achieved by45% saturation ammonium sulfate followed by affinity ion-exchange chromatography on DEAE -cellulose column with a yield of 10%, specific activity 754,477 and a purification fold of 6.059.  Thirteen isolates  of  P. agglomerans  were isolated  from blood specimens from infants patients with blood stream infections and surface swab in neonatal intensive care unit (NICU)  in  Child’s Central Teaching Hospital in Baghdad ,that showed resistance to cefazolin, cefepime,cefotaxime,gentamicin and ampicillin-sulbactum in different ratio while Purified lectin with concentration 200 µg/ml had antibacterial activity against clinical and environmental bacteria  more than other concentration and crud lectin .  Keywords: Pantoea  agglomerans, Lectin,  Antibacterial activity.
Nuclear in Situ Hybridization of High –Risk and Low-Risk Human Papilloma Virus DNA in Tissues from a Group of Iraqi Patients with Sino Nasal and Nasopharyngeal Benign and Malignant Tumors Saad Hasan Mohammed Ali
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Background: Human papilloma viruses (HPV) are well known viruses that can induce tumor genesis in proliferative epithelial tissues.  Many studies implicated HPV in progression of head and neck benign and malignant tumors by affecting cell cycle proteins expression. Objectives This study was designed to determine the rates of detection high- risk HPV16/18 and low -risk HPV6/11 genotypes in tissues from nasal cavity, par nasal sinuses and nasopharyngeal lesions that include apparently healthy tissue, nasal polyps (NP), sin nasal papillomas (SNP) , nasopharyngeal carcinomas(NPC) and sin nasal carcinomas (SNC).Methods: This study is a retrospective one. Total 125formalin -fixed paraffin embedded tissue blocks including: 35 nasal polyps, 35 sin nasal papilloma S, 29 nasopharyngeal carcinomas 6 sin nasal carcinomas and nasal apparently healthy tissues. After his to pathological confirmation Viral DNA localization performed using chromomeric in situ hybridization (CISH).  Results: In sin nasal papillomas and nasal polypsHPV6/11was detected in 54.3% and 22.9% respectively and in sin nasal and nasopharyngeal carcinomas (SNC+NPC) group was detected in 14.3% where the results have revealed highly significant differences (P<0.01).Percentage of HPV16/18 genotypes in SNC+NPC  group was 31.4 %, in sin nasal papilloma tissues was detected in 25.7% and in nasal polyps tissues was detected in 11.4 %where such results have revealed non-significant differences (P>0.05).Conclusions: The present results point for a possible association between  high on cogenic-risk HPV genotypes with sin nasal papillomas as well as SNC and NPC in the way of their pathogenesis and /or tumor genesis where as a low association was observed between high and low- risk HPV genotypes with nasal polyps lesions.Keywords:  Low- riskHPV-6/11, High- riskHPV-16/18, CISH, Sino nasal and Nasopharyngeal lesions.
2D QSAR, PHARMACOPHORE AND DOCKING STUDIES OF MYCOBACTERIUM TUBERCULOSIS ENOYL ACYL CARRIER PROTEIN REDUCTASE INHIBITORS Haripriya Munipalli
Journal of Global Pharma Technology Volume 02 Issue 05: (2010) May 2010
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Abstract

InhA, the enoyl acyl carrier protein reductase is one of the key enzymes involved in the type II fatty acid biosynthesis pathway of M. tuberculosis. Discovery Studio 2.5 was used to carry out the current work. Different training sets and test sets were taken for QSAR and pharmacophore studies from a total of 116 molecules. In the present work, classical 2D QSAR (r2 = 0.913, Adj. r2 = 0.95 and cross-validated r2 = 0.90) models were developed for a series of 95 enoyl acyl carrier protein reductase inhibitors. This model was applied to successfully estimate activities of 14 test set molecules. Hiphop showed best fit with five features namely one hydrogen bond donor, three hydrophobic and one hydrophobic aromatic. The best hypothesis of hypogen run with 28 molecules consisting of four features namely two hydrophobic aromatic, one hydrophobic aliphatic and one hydrophobic, has a correlation coefficient of 0.914, a root mean square deviation of 1.166 and a cost difference of 80.23, suggesting that a highly predictive pharmacophore model was successfully obtained. The application of the model showed success in predicting the activities of few molecules in 54 known Mt EACP reductase inhibitors in our test set with a correlation coefficient of 0.847(r). The CDOCKER energies of two highly active inhibitors were -27.723 and -18.668, that of one moderately active inhibitor was -27.191 and of two low active inhibitors were and -2.581, -3.807. From 2D-QSAR, pharmacophore and docking studies the results have shown that Triclosan derivatives were proved to be highly potent inhibitors against Mycobacterium tuberculosis enoyl acyl carrier protein reductase.Keywords: Common feature pharmacophore; 3D-QSAR pharmacophore generation; Hip-hop; Hypogen; CDOCKER; Mycobacterium tuberculosis enoyl acyl carrier protein reductase (Mt EACPR); and 2D-QSAR.

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