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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Antioxidant Potential, Total Phenolic and Flavonoids Content of Aerial Parts of Ethanolic Extract of Cordia Obliqua S. Sivakrishnan
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: The aim of this work was to estimate the total phenolic and flavonoids content, and to evaluate in-vitro antioxidant activity of ethanolic extract of Cordia obliqua.Methods: The ethanolic extract of Cordia obliqua was examined by Iron chelating activity, Total antioxidant activity, Total phenol and flavonoids with reference standard EDTA (Ethylenediaminetetraacetic acid), Ascorbate and catechol respectively through in vitro models.Results: The antioxidant activities of the extract were positively associated with the total phenolic and flavonoid contents of the ethanolic extract of cordia obliqua.Conclusion: Ethanolic extract of Cordia obliqua. showed strong scavenging activity. These in vitro assays indicate that this plant extract is a better source of natural antioxidants. The presence of antioxidants such as phenolics, flavonoids, tannins and proanthocyanidins in plants may provide protection against a number of diseases including cancer, neurodegeneration and inflammation. 
Temporary Loop Occlusion using Vessel Loops on Bilateral Common iliac Arteries to Reduce Blood Loss in Total Abdominal Hysterectomy on Adherent Placenta Patient at Sanglah General Hospital, Bali-Indonesia I Nyoman Semadi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: In pregnancy, there may be an invasion of the placenta into uterine wall, causing post-partum haemorrhage. This Hemorrhage may cause maternal death. Therefore a total abdominal hysterectomy (TAH) needs to be done to stop the bleeding. Temporary loop occlusion (TLO) is an additional procedure to reduce blood loss when doing TAH. This study aims to determine the intraoperative outputs of TLO when doing TAH on adherent placenta patient. Material & Method: This research is a retrospective study conducted at Sanglah Hospital from January 1st to 31st December 2019. There were two groups consist of four patients each, namely TLO intervention and non-intervention. Each group was analyzed based on the estimated blood loss, the number of packed red cell (PRC) transfusion, operating time, length of intensive care unit (ICU) and ward stay. Result: Intraoperative blood loss revealed a statistically significant difference in results (p=0.037), with mean 2125 ± 853.9 ml in TLO intervention and 3750 ± 866 ml in non-intervention. Comparison between both groups on other variables such as PRC transfusion were 694.75 ± 394.18 ml and 1298.5 ± 716.19 (p=0.384), operating time were 220,05 ± 39,5 minutes and 264,5 ± 69,84 minutes (p=0.468), length of ICU stay were 2.75 ± 0.95 days and 3.25 ± 0.96 days (p=0.488), length of ward stay were 2.25 ± 0.5 days and 2.75 ± 1.5 days (p=0.85). Conclusion: TLO is an additional procedure that can be performed on TAH because it provides good output. Keywords: Temporary loop occlusion, Hysterectomy, Adherent placenta, Haemorrhage, outcome.
Self-care Maintenance of Heart Failure Patients in Babylon Teaching Hospitals Ameer Hassan
Journal of Global Pharma Technology .
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Abstract

Heart failure (HF) is currently one of the major public health problems in world, and its complex and gradual nature often results in reverse proceedings, such as high rate of  rehospitalization and mortality, which could be reduced if there were appropriate self-care, therefore, Self-care is one of the most significant aspects of the treatment of patients with heart failure  through  using special activities to reduce and relieve symptoms and maintain and promote health in patients. Quantitative research, descriptive design cross sectional study Non-probability purposive sample consisted of (100)  heart failure patients who admitted to the Babylon teaching hospitals were selected .The finding out of the study show most of the patient with heart failure have moderate self-care management  a high significant difference between the self-care ability  and their body mass index levels. a significant difference between this disease  and their chronic diseases, hypertension, diabetes mellitus  and duration of disease.Keywords: Self-care, Management, Heart failure patients, Babylon teaching Hospitals.
Isolation and identification of Steroids from Different Parts of Prosopis Cineraria Preeti Khandelwal
Journal of Global Pharma Technology Volume 09 Issue 04
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Abstract

Prosopis cineraria are a tree of remarkable importance and a rich   source of secondary metabolites. The present study was carried out to investigate   the steroid content   present in the leaves, stem and pods of Prosopis cineraria. The   method of Tomita et al., was used   for isolation of steroids.  The  structure  of  the  isolated  compound  was  established  on  the  basis  of  physical  and  chemical  test   and  spectroscopic  evidences (TLC, IR and  GC- MS). The study concluded   that a single type of steroid Diosgenin was found in all the parts of the selected plant species.Keywords: Prosopis cineraria; Steroids; Diosgenin; Thin Layer Chromatography.
Photo Catalyst Degradation of Methylene Blue Dye by Synthesized TiO2/Graphene Oxides Composites Mayada Talib Al-Zubaedi
Journal of Global Pharma Technology .
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Abstract

A ternary nanocomposites of TiO2-Fe2O3/graphene oxide (GO) and TiO2-Fe2O3/reduced graphene oxide (RGO) were prepared from TiO2-Fe2O3 successfully and by precipitation method and graphene oxide (GO) has been prepare from graphite by Hummers method. The ternary nanocomposite possessed enhanced charge separation efficiency. The comparison studied between the three catalysts resulted in the presence of different decomposition data that were affected differently; pH, H2O2, concentration, pollutant concentration, temperature, irradiation time, also the morphology of the ternary nanocomposite and the average diameter which was studied by Atomic Force Microscopy (AFM). The photocatalytic degradation efficiency for methylene blue on the nanocomposites were scanned and the efficiency of photocatalytic degradation of ternary composite was best than that of pure TiO2. Show the result that the photocatalytic efficiency of ternary nanocomposite was obtained and reach 90.8% in 30 min. It is suggested that the ternary composite of TiO2/Fe2O3/RGO can be an efficient multifunctional.Keywords: Photo degradation, TiO2/Fe2O3, composite, Methylene Blue, Fenton's reaction.
Herbal Tea Production from Mimosa Pudica N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Drying is the most popular and basic method for post-harvest storage of herbs because it permits for the quick preservation of the herbal qualities of the herb material in a simple manner. Mimosa pudica is considered as a promising herbal candidate to undergo further exploration as evident from its pharmacological properties. Objective of this study focused on the effect of blanching temperature and time; oven drying temperature and storage condition to total phenolics (mg/g), total flavonoids (mg/g), ferric reducing/antioxidant power (FRAP or TE, mg/g), radical-scavenging activity DPPH (IC50, mg/mL) and sensory score of the dried Mimosa pudica tea. Results showed that Mimosa pudica should be blanched in hot water 95oC at 5 seconds in the present of citric acid 0.5% and then beeing dried by oven dryer at 50oC until 10.0% moisture. The final herbal tea could be preserved under vacuum in aluminum foil at 28oC to maintain flavonoid content for 12 months.Keywords: Blanching, Drying, Ferric reducing power, Flavonoids, Herbal, Mimosa pudica, Phenolics, radical-scavenging activity.
Human sperm DNA integrity : A difference of storage temperature and period of freeze-drying process silvia werdhy lestari; ahmad silalahi; hamdani lunardi; agustinus agustinus
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

The cryopreserve technique using liquid nitrogen is used to preserve human sperm. Nevertheless, this technique has several disadvantages, such as bacterial/viral contamination and its expensive cost. Freeze-drying process offers more simple and cheaper of sperm storage technique. This study aimed to investigate the effect of storage temperature and period of freeze-dried human sperm on DNA integrity. Human sperm samples of 15 donors were prepared with simple washing techniques. Post-washing samples (T0) were divided into 4 groups with the same volume. The four group of samples carried on the freeze-drying process and stored based on different temperature and period: 4°C for 1 week (T1), room temperature (24-25ºC) for 1 week (T2), 4°C for 3 months (T3), and room temperature for 3 months (T4). Sperm DNA integrity was analyzed before and after the storage period of each group. There was a statistically significant difference of sperm DNA integrity of freezes - dried at 4°C in 1 week versus 3 months (T1 vs T3), at room temperature in 1 week versus 3 months (T2 vs T4) (p
GENTAMICIN MODULATES THE GENE EXPRESSION OF HLA IN METHICILLIN RESISTANCE STAPHYLOCOCCUS AUREUS BIOFILM Nihad Taha Mohammed Jaddoa; Harith Jabbar Fahad Al-Mathkhury
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
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Abstract

Objective: The present work was undertaken to investigate the impact of sub inhibitory concentration of gentamicin on hla gene expression in methicillin resistant Staphylococcus aureus isolates. Methods: The bacterial isolates used in this study represent 33 MRSA strains, previously isolated form patients visiting several hospitals in Baghdad. Gentamicin, vancomycin, and oxacillin MIC were determined using broth dilution method. Microtiter plate method was adopted to investigate the biofilm forming capacity. Alpha hemolysin was detected by culturing MRSA isolates on rabbit blood agar. Furthermore, hla gene was detected in MRSA isolates using conventional PCR technique; while, qRT-PCR method was performed to assay the hla expression in planktonic and biofilm cells in presence and absence of gentamicin. Results: the present results demonstrated that 12 (36.36%) isolates were gentamicin-resistant; whereas, all isolates were resistant to oxacillin and sensitive to vancomycin. Out of 33 MRSA, 3, 23, and 7 isolates formed a weak, moderate, and strong biofilm, respectively. Phenotypically, 30 isolates produced alpha hemolysin on rabbit blood agar plates; nevertheless, hla gene was located in 29 isolates. Of considerable interest, the addition of gentamicin significantly (P < 0.05) reduced the hemolysis activity; while, insignificant fold change (less than two) of hla gene was observed in all tested isolates in the presence of sub MIC of gentamicin (16 µg/ml). Conclusion: gentamicin upregulated the hla gene expression in biofilm cells; hitherto, this increment was isolate specific.
Removal of Celestine Blue Dye From Textile Wastewater by Adsorption over the Mixed Oxide NiO –MgO Huda Salam Ghani
Journal of Global Pharma Technology .
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Abstract

This study was carried out for the purpose of estimating the adsorption kinetics and removal of Celestine Blue Dye from textile wastewater by adsorption over mixed oxides NiO–MgO that prepared in our laboratory. The optimum conditions for removal  were studied which includes the appropriate concentration of dye as well as weight of adsorbent, temperature ,pH effect, speed of shaking  and optimum time for the removal  where the best concentration of the adsorption process is ( 100 ppm), the best economic weight is( 0.025 gm)at( 45 min) shaking time at the acidity of the dye which is( pH = 5) and shaking speed of( 175 cycle per minute) at the temperature of the laboratory (25oC ).Keywords: Adsorption, Mixed oxides, Celestine blue B dye.
The Polymorphism of rs2549782 gene Endoplasmic Reticulum aminopeptidase-2, high Concentration of Free Fetal DNA, and Cystatin C as Risk Factors of Preeclampsia I Nyoman Hariyasa Sanjaya
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Background: Recently, the mechanism of the preeclampsia (PE) occurrence has not gained widespread agreement. This is related to the variations intreatment, maternal factor, and fetal morbidities as well as mortality. However, the studies of the placenta associated with PE mechanism have derived serious attention. This study aims to determine the role of rs2549782 ERAP 2 gene polymorphism, extracellular fetal DNA content, and high-level C cystatin in maternal serum as a risk factor for PE Methods: A matched case-control study among 62 maternal over 20 weeks of gestation was conducted in the Department of Obstetrics and Gynecology, Faculty of Medicine, Sanglah General Hospital, Biomolecular Laboratory of Medical Faculty, Universitas Udayana, Bali, Indonesia andProdia Laboratory Denpasar.A 12 months-period of the study was enrolled from August 1st 2016-2017. The polymorphism examination of rs2549782 ERAP 2 gene, extracellular fetal DNA content and C cystatin respectively were evaluated among 31 maternal with PE as case and 31 maternal as control (Normal). Data were analyzed using SPSS version 16 for Windowsto determine the association of rs2549782 ERAP2 genepolymorphism, extracellular fetal DNA level, and maternal serum cystatin C level using Chi-square Test and Odds Ratio (OR). Discriminant tests with logistic regression were displayed in table and narrative form.Results: The ERAP2 gene polymorphism in the case was found 7.5 times (OR = 7.50 IK95%: 3.53-15.92; p = 0.002) higher significantly compared to the control. The cell-free fetal (cff) DNAlevel in the case was 6.67 times (OR, 6.67 IK; 95% 2.67-26.33, p; 0.001) higher significantly than the control. In addition, the level of cystatin C in the case was also 6.5 times (OR, 6.5 IK; 95% 3.04-13, 89, p; 0.007) higher significantly when compared to the control. However, there wasno significant difference in the polymorphism of rs2549782 ERAP2 gene, extracellular fetal DNA, and cystatin C between groups (P>0.05).Conclusion: In can be concluded that the polymorphism of rs2549782 ERAP2 gene, extracellular fetal DNA, and high maternal serum C cystatin increase the risk of PE.Keywords:Preeclampsia, Rs2549782 polymorphism, ERAP2, DNA, cystatin C.

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