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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Effect of Carrageenan as Edible Coating on Storage of Manilkara Zapota Fruit Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

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Abstract

Manilkara zapota fruits which belong to the family Sapotaceae have been widely cultivated in Vietnam. Immature fruits are hard, gummy and rich in tannin (astringent), while the ripe fruits are soft and, juicy, with a sweet taste and an attractive orange color, which makes them a wonderful dessert fruit. The pulp is sweet and melting. They are normally consumed fresh. Manilkara zapota is a climacteric fruit that ripens shortly after harvest. Objective of this study focused on the carrageenan edible coating affected to weight loss, protein, total soluble solid, vitamin A and vitamin C Manilkara zapota fruits. Different concentrations of carrageenan (0%, 0.5%, 1.0%, 1.5%, and 2.0%) were examined. Results demonstrated that Manilkara zapota fruits which were coated with 1.5% carrageenan could prolong Manilkara zapota shelf-life until 15 days of preservation. So the use of carrageenan coating was one promising method to improve stability of Manilkara zapota fruits during storage.Keywords: Manilkara zapota, Carrageenan, Coating, Shelf-life, Preservation, Stability.
Potential Of Biological Activities From Chemical Compounds Of Nigella Sativa As Anti-Osteoporosis, An Insilico Study Mohammad Kuntadi Syamsul Hidayat
Journal of Global Pharma Technology Volume 11 Issue 04.
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Abstract

Objective: The objective of the study was to investigate the potential of biological activities from chemical compounds of Nigella sativa (NS) as anti-osteoporosis using the computational chemistry insilico study. Methods: Database search from KnapSack was conducted to find out NS active compounds. Next, explore using the PASS Server database to find out compounds that have anti-osteoporosis potential. Exploration with STITCH to analyze the interaction of NS active compounds with cell proteins related to anti-osteoporosis, then docking using PyRx to determine the bond affinity that occurs between NS active compounds and cell proteins. Result: There were 36 active NS compounds, 28 of which had anti-osteoporosis potential. One active compound that has a probability to be active value (Pa)> 0.7 and 21 active compounds that have Pa: 0.3 - 0.7. Found 6 active compounds that have interactions and play a major role in the anti-osteoporosis process. With the docking process, binding affinity longifolene is obtained with estrogen receptors: -8.2 kcal / mol, compared to Bazedoxifene -9.6 kcal / mol Conclusion: From the study of insilico, Nigella sativa has the potential as an anti-osteoporosis Keywords : Osteoporosis, Nigella sativa, insilico, anti-osteoporosis
Efficacy of Chitosan as Clarifying Agent to Physico-chemical and Organoleptic Attributes of Pineapple Juice during Clarification Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

Turbidity is a major obstacle in preservation of fruit juice and concentrate. This phenomenon is also not acceptable in handling and distribution of commercial beverage. Fruit juice is a complex of soluble and insoluble multi components in suspension. Clarification is a crucial step to remove pectin, carbohydrate, metal ion as well as solid particles existing in fruit juice to achieve a clear and stable status. As a natural abundant polymer, chitosan has been proven as an alternative approach for juice clarification with diversified manipulations in appropriate cost. Our study focused on the feasibility of chitosan as clarifying agent to physico-chemical and organoleptic properties of pineapple juice during clarification. Different concentrations of chitosan (0.05, 0.075, 0.1, 0.125, 0.15%) and agitation speeds (40, 60, 80, 100, 120 rpm) have been investigated fruit juice to evaluate turbidity (NTU), viscosity (cP), total soluble solid (oBrix), total phenolic (mg GAE/g), flavonoid (mg GE/g) and sensory score after clarification. Our results revealed that 0.125% chitosan; agitation speed 80 rpm were adequate and efficient for juice clarification. As being nontoxic and biodegaradable, chitosan could be effectively utilized as an alternative agent for refining of fruit juice.Keywords: Pineapple juice, Clarification, Chitosan, Turbidity, Viscosity, Total soluble solid, Total phenolic, Flavonoid, Sensory score.
Epidemiological survey of intentional and non- intentional poisoning cases in iraq during 2014-2016 Wrood Salim Alkhfajy; Inam Sameh Arif; Munaf Hashim Zalzala
Journal of Global Pharma Technology Volume 09 Issue 11
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Abstract

Background:  Poisoning is a major global public health problem and one of the most common deaths in many societies. The goal of this study was to detect the percentage of patients with intentional and unintentional poisonings, and to define demographic factors, major toxic agents related to the occurrence of poisoning recorded by The Poisoning Consultation Center (PCC).Methods: This was a retrospective -epidemiological study covering data collected between 2014 and 2016 records of The Poisoning Consultation Center (PCC) / the Ghazi Hariri Specialized Surgery Hospital in the Baghdad medical city, Baghdad, Iraq.Results: Totally, 3213 cases associated with poisoning were evaluated. Among these cases, 3181 were reported as unintentional and only 32 cases as intentional poisoning. Females predominated among intentional cases (81%), and the majority of them belonged to the age group of 15-24 years. While, the 0-9-year age group was the most common among accidental cases. Metal poisonings, mostly copper, were found most frequently within accidental poisoning cases (74%). Carbamazepine ingestion was found to be the major toxic agent for committing suicides, followed by Paracetamol.Conclusion: Females had a greater propensity to commit intentional poisoning, and the housewives, the age group of 15–24 years and drug medications were more related with suicidal poisonings. A large scale of metal accidental poisoning are appearing in Iraqi cities where, bombing, military events, and waste incineration have led to increased public exposures. The results of this study may serve as evidence for new strategies in Iraq to prevent poisoning. Keywords: Accidental poisoning, Suicide, Epidemiology, retrospective analysis, public health.
A Centralized Automated System of Monitoring Adverse Events of Medications- “Medreminder” Serikzhan Berdakhovich Sydykov
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Research ObjectiveTo develop and test the methodology of the centralized automated system of monitoring adverse events of medications in the Republic of Kazakhstan.Research TasksThe analysis of the existing practice of monitoring adverse events of medication in the Republic of Kazakhstan, the identification of problems and the directions to improve the situation.Testing the models of an automated system collecting information about adverse events of medications and the evaluation of effectiveness of the developed system collecting information about adverse events of medications, identifying patients/consumers’ roles of Kazakhstan medical products in the system of pharmacovigilance.Keywords: pharmacovigilance, monitoring the safety of medications, patients, consumers, monitoring adverse events, “yellow card”, consumer reporting.
A Case of Proceeding Polycystic Kidney Progress to the End Stage Renal Failure Khayati Moudgil
Journal of Global Pharma Technology Volume 11 Issue 10 (2019) October 2019
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Abstract

Polycystic Kidney Disease (PKD) commonly an inherited monogenic disease, associated with severe morbidity and mortality. It is categorized by renal cyst formation and renal enlargement. Autosomal dominant polycystic kidney (ADPKD) causes end stage kidney disease and is most commonly seen in adults. Worldwide overall incidence is 1-2% and mutations in both the genes PKD1 and PKD2 causes ADPKD. Most of the ADPKD patients shows decline in renal function where as 70% leads to end- stage renal disease. An alarming non-communicable disease conditions currently with no cure causing a major public health concern as well as the economic burden on healthcare system. Here with we report a case of preceding polycystic kidney progress to the end stage renal failure, along with our understanding towards the management involved in the disease.Keywords: Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease, End Stage Renal Failure, Hypertension.   
The Role of Lipopolysaccharide and Tight Junction Protein-1 (Zo-1) Levels and Symbiosis of Black Rice Extract in Obese Patients Armanto Makmun
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Excessive fat accumulation, which is commonly known as obesity, causes health problems for the community, such as metabolic disorders. Recent studies have shown that the gut micro biota is involved in the occurrence of metabolic disorders in obesity. The gut micro biota can regulate body weight by influencing metabolic processes, regulating the expression of host genes, increasing the ability to extract and store energy. Intestinal micro biota imbalance and increased plasma lipopolysaccharide (LPS) contribute to inflammation in obesity. The latest safe approach in cases of obesity is to use active ingredients from local foods. In South Sulawesi, Indonesia and also in other Asian countries found black rice as the local product that is very good for health because the high level of bioactive compounds that are important for health such as anthocyanin, proteins, amino acids, and phenolic acids. The ingredients in black rice play a role in modulating the composition of the intestinal micro biota as indicated by the increasing composition of Bifid bacterium and Lactobacillus. The increase in the composition of Bifid bacterium causes improvement in the expression of tight junction proteins in the intestinal epithelium, thereby contributing to prevent the translocation of LPS into the circulation. Apart from its role in modulating the composition of bacteria, it can also function to influence intracellular signaling.
The Effectiveness of Intervention of Treatment Based on Acceptance-Commtment Therapy with drug control on the Rate of Parent, s Acceptance of Autistic Children and Their Denial-Defense Mechanism Maryam Khorasani Dehshotoran
Journal of Global Pharma Technology .
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Abstract

The purpose of this study was to measure the efficiency of intervention of treatment based on acceptance-commitment therapy (ACT) with drug control on the rate of parent,s acceptance of autistic children and their denial defense mechanism. The present study consisted of pre-test and post test with control group. The subjects of this study were comprised of Atypical Children Centers in Esfahan in the first three months in 1394. Based on convenient sampling, 40 women, having at least one autistic child, were selected. The instruments of the study were Defense Styles Questionnaire (DSQ) and Acceptance and Action Questionnaire-2 (AAQ-2) and also Ways of Coping Questionnaire (WOCQ). Participants were randomly classified in to control and experimental groups. Also Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Automatic Thoughts Questionnaire(ATQ) were used for mental health assessment in depression-anxiety domain of participants. The experimental group had 8 training sessions, each 90 minutes, and participants were exposed to commitment acceptance therapy. Defense Styles, Acceptance and Action and Ways of Coping Questionnaire were applied again for two groups. The results of the study illustrate that maximal and minimal average number of coping strategy was for avoidant/ escap. And the dominant defense mode in mother’s experimental group was with regard to undeveloped mode. The result of covariance analysis revealed that acceptability of mothers being under the treatment of commitment- acceptance therapy significantly increased (p=0.032<0.05). Whereas there were on significant differences between the scores of mothers experiencing commitment domain in both groups (p=0.147>0.05). Based on the findings, it can be conclude that commitment acceptance therapy had positive effects on the increase of the level of mothers acceptance having auutistic children and with regard to the decrease of eruptional/denial fact in parents, it increased the improvement of the adaptation and family relationship.Keywords: autism, Denial defense machanism, Acceptance commitment therapy.
Development and Evaluation of Felbamate Loaded Solid Lipid Nanoparticles Ramanuj Prasad Samal
Journal of Global Pharma Technology Volume 12 Issue 01 (2020) Jan. 2020
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Abstract

Solid lipid nanoparticles (SLN’s) or lipid nano particles is typically sphere-shaped, with an average diameter of 1nm to 1000nm.  They are alternative carrier systems to tradition colloidal carriers, such as, emulsions, liposomes, and polymeric micro and nanoparticles. The main aim of the current research work is to prepare and optimize the Felbamate loaded solid lipid nanoparticles using by placket and burman design of experiments. SLN’s were prepared by microemulsion technique. Based on preliminary experiments and on literature, the influence of independent variable parameters selected were lipid (X1), surfactant (X2), and co-surfactant concentration(X3),aqueous phase volume(X4),magnetic stirrer rate (X5), probe sonication duration (X6), volume of beaker used for sonication (X7), volume of cold aqueous phase (X8) on the dependent variable such as average particle size (Y1) was studies. Other parameters, i.e., magnetic stirrer rate and probe sonication duration were not having a significant impact on particle size and their levels were kept constant for all the experiments. Magnetic stirrer rate has an impact on particle size and was included in the design. It was concluded from the study that the composition prepared with lipid concentration of 50 mg, surfactant concentration of 75 mg, Co-surfactant concentration of 0.75 ml, aqueous phase volume of 5 ml, magnetic stirring speed of 400 rpm, probe sonication duration 30 minutess, volume of beaker used for sonication 500 ml and volume of cold aqueous phase 30 ml has shown the smallest particle size of 165 nm
Metformin and Insulin Treatment Influence on Monoamine Oxidase Activity in Diabetes Mellitus Type 2 Ruaa Hassan K. Alani
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

The influence of anti-hyperglycemic drugs (Metformin, insulin) on the activity of Monoamine oxidase in the sera of diabetes millets type2 .This study included 54 volunteers, 36 with diabetes millets type 2, treated with Metformin, and metformin + insulin, and18 healthy volunteers without endocrinal diseases represent the control group. Activity of Monoamine oxidase, body mass index, fating blood glucose, glycosylate haemoglobin, and lipid profile levels respectively were examined in this study. The results revealed significant decrease in the levels of BMI, FBG, and lipid profiles in the two groups as compared to control.  Monoamine oxidase showed different in the patients groups as compared to healthy group. As conclusion this study showed different effect of treatment on the biochemical parameters and enzyme activity and this effect may decrease the occurrence of diabetes complication including neuropathy (neurodegredation diseases (Parkinson, and Alzheimer diseases) and increases patients life.

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