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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Modified Atmosphere Packaging on Physico-Chemical Characteristics of Star Apple (Chrysophyllum cainito) Fruit during Post-harvest Storage Minh Phuoc Nguyen
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Star apple (Chrysophyllum cainito) is popularly cultivated in Mekong region. Its pulp has strong sweet taste with antioxidant constituents contributing to various phytochemical and functional advantages. However this fruit has a short shelf life due to its perishable nature. It’s necessary to have appropriate way to extend its commercial distribution. Modified atmosphere packaging can be considered as a proper alternative to store this perishable fruit. Purpose of this research focused on the application of modified atmosphere packaging (MAP) to prolong shelf-life of star apple fruit. Weight loss (%), firmness (N), total soluble solid (oBrix), and vitamin C (mg/100g) were the main variables applied to observe this valuable fruit during 21 days of storage. Under MAP (30% CO2, 15% O2, 55% N2), star apple fruit could be extended to 18 days regarding to the weight loss, firmness, total soluble solid, and vitamin C values. Our finding contributed a basic foundation for more further studies on other tropical fruits and vegetables. Keywords: Chrysophyllum cainito, Modified atmosphere packaging, Weight loss, Firmness, Soluble solid, Vitamin C.
The Effect of Cirprofloxacin (CPX) on the Histological Structure of Albino Rabbit Ovary Jabbar Ebadi Mohammad
Journal of Global Pharma Technology .
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Abstract

The study was conducted in the Animal House of the Department of Biology / Faculty of Education for Women / University of Kufa from October 2016 to May 2017. The study included 72 lab albino rabbit eggs of the type Oryetolagus cuniculus.L divided into four groups of 18 rabbits. They were injected with ciprofloxacin at a concentration of 1 mg / kg bw. The bacteria dose was (1 mg / kg bw) for a week, two weeks, and four weeks respectively. After infusion and injections of all experiment animals, they were sacrificed and dissected for the histological study, which included the female reproductive system. As well, blood samples were taken for blood and chemical indices. The results of the statistical analysis at the probability level (P <0.05) showed that the antibiotic (ciprofloxacin) caused changes in weight by significant decrease (P <0.05) in the total body weight and ovarian weight in females. The results of the statistical analysis of the study showed that the single therapeutic injection of ciprofloxacin and bacterial injection were different in their effect on some blood parameters. The groups of drug and bacterial treatment did not show changes in the first and second weeks, while there was a significant decrease and below the probability level (P <0.05) in the fourth group by number of WBCs, RBCs and hemoglobin (Hb) compared to the control group. Under optical microscopy, the histological study of tissue sections showed patho-histological changes of different intensity and appearance in the female ovaries between the drug and bacteria compared to the control group. The results of the microscopic examination showed clear effects on ovarian tissue structure in females compared with control group.Keywords: Ciprofloxacin; Biochemical tests; Biology; Histopathology; Ovary ; Albino female rabbits.
Molecular Analysis of Genetic Elements Responsible for XDR in Highly Successful Pathogen Acinetobacter Baumannii Isolated from Clinical Samples of Iraqi Patients Rawa Abdul Redha Aziz
Journal of Global Pharma Technology Volume 09 Issue 04
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Abstract

Objective(s): A. baumannii infections have gained attention due to the high number of infected soldiers serving in Iraq and Afghanistan. Current study focus on the phenotypic and genotypic detection of antibiotic resistant genes among Iraqi A. baumannii isolates to classify them into appropriate antibiotic resistant level.Material and methods: Antibiotic resistant genes were screened among 24 A. baumannii isolates collected from Baghdad and Al- Najaf hospitals using different phenotypic methods. Genotypic detection was done using PCR. Results: All isolates showed positive results to recA gene at 425bp. Antimicrobial susceptibility testing revealed 100% resistance towards Ceftazidime, Amoxicillin-clavulanic acid, Ticarcillin-clavulanic acid, and Cefepime. Also, 50% isolates were resistant to Colistin sulphate, while 66.7% isolates were resistant to tigecycline. The MIC test for polymyxin B revealed that 83.3% isolates were resistant to ˃32µg/ml. Results showed 16.7% of A. baumannii isolates was MDR, 70.8% was XDR, and 12.5% of isolates was PDR. Also, 87.5% of isolates were carbapenemase producers; while 33.3% were ESBLs producers. PCR studies showed among 22 antibiotic resistant genes tested, there was 100% and 70.8% for aac(6)-Ib, ant(4)IIb-, and aac(3)-I, respectively. Also, 13% of the isolates were harbored mexX gene. Results showed 50% had rmtD followed by rmtA and rmtF 45.83%. Some of the isolates encode ParC2 and GyrA2 (75% and 91.67%, respectively). The OXA 23 and OXA 51 were detected among 29.17% and 75%, respectively. Conclusion: Current study found most A. baumannii isolates were MDR, XDR, and even PDR pathogens among wound infected patients in Baghdad and Al-Najaf hospitals.Keywards: ESBLs, Modified Hodge test, carbapenemase, Pan drug resistant (PDR), multiple resistant (MDR), extremely resistant (XDR).
A Study of Adsorption of Malachite Green from Aqueous Solution on Graphene Oxide/Polyvinyl Pyrrolidone/Acrylic Acid Layth S. Jasim Al-Hayder
Journal of Global Pharma Technology .
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Abstract

Graphene oxide/polyvinyl pyrrolidone/acrylic acid (GO / PVP / AAc) was prepared. It is a composite hydro gel. They were synthesized by the self-assembly of polyphinylpyrolydone (PVP), acrylic acid (AAc), and Graphene oxide (GO). This composite hydro gel , GO- based , were used to remove two types of dyes , Malachite Green (MG) of its aqueous solutions. It was found that the composite hydrogel prepared have a high surface area. Various experimental variables were studied, such as, contact time (1-180 min), adsorbent surface mass (0.01-0.1 g), the initial concentration of the absorbat material (10-1000mg / L) for both two types of dyes. Also studied were the effect of each temperature, ionic strength, and pH. The experimental isotherm data were also analyzed using the linear forms of Langmuir, Freundlich, and Temkin equations, in order to determine the maximum adsorption capacity. Thermodynamic functions of Adsorption process were also studied, Gibbs free-energy (DG), Entropy (ΔS), and Enthalpy (∆H).Keywords: Adsorption, Composite, Malachite Green, Isotherms, Thermodynamic.
Antimicrobial Action of Allium Sativum and Elettaria Cardamomum against Streptococcus mutans and Lactococcus Raffinolactis Detachment of Tooth Rot Ashraf Sami Hassan
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Twenty specimen from individuals endure tooth rot in various age from Hospitals of the city of Baghdad, segregate analyze of the phenotypic qualities by development of these microorganisms on the way of life media, minute determination and tests biochemical depending on a framework vitek 2 ,where the outcomes demonstrated the microscopic organisms that cause tooth rot is Streptococcus mutans and Lactococcus raffinolactis in equivalent extents, natural adequacy of watery concentrates of Allium sativum and Elettaria cardamomum against the microbes, from the outcomes demonstrate that disengages of Streptococcus mutans was the most touchy to the fluid concentrate comparator with microbes Lactococcus raffinolactis that indicated less impact towards our concentrates under review, On the other hand, the outcomes demonstrated that the fluid concentrate of the Elettaria cardamomum it is best against the development of bacterial species under review contrasted and fluid concentrate of Allium sativum.Keywords: In vitro, Herbal extracts, Antimicrobial activity, Dental pathogens.
Hepatoprotective Effect of Vitamin C and E on Antitubercular Drugs Induced Hepatotoxicity in Albino Rats Babul Kumari
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Objective- The hepatoprotective effects of Vitamin C and E were investigated in anti tubercular drugs induced hepatotoxicity in albino rats. Methods- Liver necrosis was induced by a combination of three anti tubercular drugs [isoniazid (I) 7.5mg/kg, Rifampin (R) 10 mg/kg and Pyrazinamide (P) 35mg/kg] given orally as a suspension for 30 days in rats. The liver damage was evidenced by the histological architectures of the liver tissues and the elevated levels of the liver enzymes like SGOT, SGPT, ALP, Total bilirubin, and unconjugated bilirubin. Results- Treatment with Vitamin C (250 mg/kg) and E (250 mg/kg,) significantly (P<0.05-P<0.001)  reduces the anti tubercular drugs induced elevations of the liver enzymes like SGOT, SGPT, ALP, Total bilirubin, and unconjugated bilirubin. Histological architectures of the liver tissues become normal in vitamin -treated group a comparison to the hepatotoxic group. Conclusion-The results of this study suggest that Vitamin C and E have a hepatoprotective effect against anti tubercular drugs induced hepatotoxicity in albino rats.Keywords:  Vitamin C, Vitamin E, Isoniazid, Rifampicin, Pyrazinamide, liver enzymes.
The Relationship of Mental Fatigue (Flim) With the Level of Hormone Cortisone and the Performance of Running (100) Meters for Young Players Hayder Naji Habash Alshawi
Journal of Global Pharma Technology .
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Abstract

Mental fatigue works to produce cortisone, which causes a series of reactions in the body, including weakness of the immune system and tension in the large muscles ,high blood pressure, and the recurrence of the high rate of cortisone, which leads to the death of brain cellsespecially in the area which is called the hippocampus, an area necessary for memory .(1)The events of the track and the field require special requirements of physical specifications and physical abilities in addition to the training methods for each of the effectiveness of the success and from these events that require a high level of the effectiveness of running 100 meters .(2)The problem of research was that the work of hormones in the body of the important topics in the field of sports physiological psychology in general and in the track and field activities, especially the activity of 100 meters .(3)The problem of looking for the work of hormones in the body of important topics in the field of sports physiological psychology in general and in the arena and field activities, especially the effectiveness of 100 meters ,As the interest of researchers focused on the development of physical abilities, planning and skill and lack of attention to the psychological aspect, which greatly affects the achievement, despite its importance, which is considered the dominant side of the rest of the capacity and mental fatigue of the nervous system and its relationship to achievement and its effects on the secretion of cortisol is considered these variables that affect The players of the effectiveness of the 100 m and therefore affect the results of achievement because the fatigue that gets to the players during fatigue will reduce the activity of the nervous system and therefore cannot show the player all his abilities and do not reach the desired achievement and poor performance So wanted researchers conducting this study, an attempt to achieve the best results using a test of the tests Vienna system (mental fatigue FLIM) and its relationship to the level of the hormone cortisol, and the aim of the research to identify the relationship between mental fatigue and the level of the hormone cortisone and the performance in the 100 meters running for young player. The researchers used the descriptive approach in the method of interrelationships to suit the nature of the problem on the players of the 100 meters advanced to the clubs of Iraq and were selected in a comprehensive inventory, tests used in research, test (mental fatigue) .The researchers concluded that there was a significant correlation between mental fatigue (frequency of fusion) (VF) and cortisone concentration as well as performance ,in addition, there is a significant correlation between mental fatigue (frequency of flashes) (FF) and the level of hormone cortisone and performance . The researchers recommend that the coach to pay attention to knowledge of the values of mental fatigue to the players in addition to knowing the levels of hormones in order to be able to address the problems facing players and how to overcome them ,as the high rate of cortisone evidence of tension in the player and the duty of the coach to address the excitement and tension of the players being a negative impact on their performance .Keyword: Mental fatigue, Hormone cortisone, Performance and running
The Differences in the Stimulation and Personal Social Development of School-Aged Children between Children WHO Raised by their Grandparents and Parents Respectively Praba Diyan Rachmawati
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Introduction: Indonesia is a country that has a cultural feature related to child care. Grandparents can act as a parent because of unexpected factors such as the parents dying, accidents, illness, the parents being dependent on drugs, imprisonment, studying abroad or the parents still being adolescents. The aim of this research was to determine the difference between the stimulation and personal-social development of school-aged children taken care of by their grandparents and parents respectively. Method: The sample used consisted of 20 children taken care of by their grandparents and 30 children taken care of by their parents in one of the Elementary Schools in Surabaya. The independent variable was stimulation and the dependent variable was personal-social development. The data was collected using a questionnaires that was analyzed using Chi-Square and Spearman rho’s with significance α<0.05.  Results: The results showed there to be a significant difference in stimulation between grandparents and parents (p=0.007) and the same in personal social development between the grandparents and parents (p=0.000). There was no correlation between grandparent stimulation (p = 0.209) and parental stimulation (p= 0.244) with the personal social development of the school-aged children. Discussion: The personal social development of school-age children who are cared for by their grandparents was lower than those cared for by their parents. However, there was no relationship between the stimulation carried out by the grandparents and the personal social development as well as the stimulation given by their parents on the personal social development. Further research is suggested to analyze the factors that influence the stimulation and personal-social development of school-aged children by comparing the results of the grandparents’ children and those of the parents.Keywords: Grandparents, Parents problems of early childhood, Personal social development, School-aged children, stimulation.
The Effect of Exercises in the use of Interactive Video in the Development of Learning Motivation and the Performance of Some Basic Skills for Free Swimming for Beginners Hassanien Abdul-Wahid Abbas Shuaila
Journal of Global Pharma Technology Volume 10 Issue 10: 2018
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Abstract

The educational process is not simple, but it is a complex process and needs to make a lot of effort, which makes it face many challenges, perhaps the most obvious are the methods and tools used in the teaching of various subjects. In their work as swimmers for age groups, the researchers noted that the new players do not have the motivation to learn when performing skills and fear of access to water, which is reflected negatively on the level of learning and performance of these skills. The educational process is based on modern technologies to transfer information from teacher to learner, The learning process was done better, faster and with less effort, the preparation of exercises using interactive video in the development of learning motivation and the performance of some basic skills for free swimming for beginners. The aim of the research was to identify the effect of interactive video in the development of learning motivation and the performance of some basic skills in free swimming for beginners. The researchers used the two-group experimental approach to suit the nature of the study. The research community was identified by the Waves Swimming Academy in the province of Bebel (73), who's ages ranged from 12 to 16 years. The study sample was selected in a random way by (30) beginner and 41.09% of the research community. They were divided into two groups (experimental and control) for each group (15). The results reached the following conclusion: The development of learning motivation has a positive impact on learning some free swimming skills for beginners and that the special exercises have had a positive impact on the use of interactive video in teaching some basic skills of free swimming for beginners. Interactive video has a clear role in developing learning motivation and performing some basic skills for free swimming for beginners.Keywords: Exercises, Interactive video, Learning motivation and basic skills.
Potential Role of Titanium Dioxide (TiO2) Nanoparticles against the Toxicity of Leishmania Tropica in Adult Albino Male Rats Ahmed Hamad Saleh
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

The present study was designed to show the role of green Tio2 nanoparticles against toxicity of Leishmania tropica. The present study used 15 adult albino male rats that divided randomly to following groups (each group consist 5 rats); control group received ad libidium, second group infected with Leishmania tropic, third group treated with 50ug/kg green Tio2 nanoparticles. Oxidative stress and antioxidant parameters in positive group injected show significant increased (P < 0.05) in levels of MDA (malonedialdehyied) and significant decreased (P < 0.05) in levels of glutathione (GSH) and catalase compared with control group. While, after used green Tio2 nanoparticles, the results showed non-significant changes (P < 0.05) in MDA, GSH and catalase levels showed non-significant changes (P < 0.05) compared with control group. Histological study of skin in positive group show severs lymphocytes infiltration between collagen fibers in dermis layer with oedema. On other hand, skin in treated group show  epidermis layers normal with dermis appear normal with normal distributed of collagen fibers and hair follicles. It was concluded that green Tio2 nanoparticles has been potential role against toxicity of Leishmania tropica in male rats.Keywords: Tio2 nanoparticles; Leishmania tropica; Oxidative stress; Antioxidant factors.

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