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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Synthesis, Spectral and Biological Studies of Metal Complexes with Heterocyclic Ligand Derived from Thaizolylazo Dye Khalid J. Al-Adilee
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

Metal (II) complexes have been synthesized with new azo dye ligand 2-[2--(4, 5-dimethyl thiazolyl) azo]-4-benzyl phenol (DMeTABP=HL) derived from coupling reaction between 4, 5–di methy thiazaolylazonium chloride and 4 – benzyl phenol in alkaline alcoholic solution. Azo dye ligand and metal complexes have been characterized by elemental analysis (C.H.N.S), 1H-NMR , mass, Electronic, IR , XRD spectral data , SEM ,thermal analysis (TGA,DSC and DTG) , magnetic susceptibility , metal contents and molar conductance .The elemental analysis of the metal chelate complexes confirms the stoichiometry of the type [ M(L)2 ] , where M =Ni(II) , Cu(II) , Zn(II) and [M(L)2]Cl and where M = Co (III) and L = azo dye ligand. The spectra and analytical data indicated that the ligand (DMeTABP) behaves as tridentate chelating agent with l: 2 [M: L] complexes and octahedral geometry.  Conductance measurement suggests the l:l electrolytic nature of Co(III) complexes but non- electrolytic nature of the rest metal complexes. The biological activity of azo dye ligand and its metal complexes against the pathogenic activities was tested against the sensitive organisms Escherichia coli (gram negative), streptococcus, staphylococcus (gram positive) as antibacterial and Alternaria spp as antifungal. The activity data show that the metal complexes were of higher antibacterial and antifungals activity than the free ligand. The results are discussed. The biological activity also conducted cells viability and cytotoxicity assay on Cu (II) and Zn (II) _complex by using the lines of cancerous liver cells of the type HePG2 and compared with line of the ordinary cellsKeywords: Thiazolyl azo ligand, Metal complexes Characterization, Antibacterial, Antifungal and anticancerious.
Detect Heat Shock Protein 70 and Tumor Necrosis Factor Alpha in Obese Breast Cancer Patients Moaed E. Al-Gazally; Alaa S. Al-Awad; Sheerin H. Abbas
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
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Abstract

This study include the measurement of heat shock protein 70 (Hsp 70) and tumor necrosis factor alpha (TNF-α) in breast cancer(BC) by Enzyme-linked immunosorbent assay(ELISA) method. In addition, study the relationship between both (HSP-70 and TNF-α) with obesity≥ 30 Kg/M2 for patients (No.58) and controls (No.30) with age (20-50 years).Hsp-70 elevated while TNF-α decreased in obese BC patients. BC incidence is very low before age 25 and increases in age up 40 years. Increasing of BMI lead to increasing in the breast cancer incidence. Result Hsp-70 elevated statically significant where mean of Hsp-70(56.32 ± SD =18.78, p-value= 0.0001) while TNF-α decreased significantly where mean of TNF-α (163.81pg/ml ± SD = 64.94, p-value= 0.0001) in obese BC patients. The concentration of TNF insignificant decreased where), there is significant the obesity significant with BC patients (p-value = 0.048).Conclusion: Obesity is risk factor for BC. Concentration of Hsp-70increased while TNF-α decreased after Chemotherapy. 
Study the Role of Anti-Mullerian Hormone in Polycystic Ovarian Syndrome and its Correlation with Thyroid Disorder Taghreed H. Al-Sadoon
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

Many biochemical changes were associated with PCOS, the search for new parameters that affect by PCOS and vice versa is still an interesting field of research. In the present study, the level of serum antimüllerian hormone (AMH) level was studied and compared with many descriptive (age, body mass effect (BMI), waist/hip ratio (WHR). Thyroid stimulation hormones  anti -thyroid peroxidase auto antibodies ,anti-TPO and anti -thyroglobulin antibodies Tg is performed by means of immunoassay sandwich with a final fluorescent detection (ELIFA)    anti-thyroglobin.  One hundred and five     PCOS women patients were participated in the study. Their age was (31.35±6.61) year. The samples were collected from PCOS was diagnosed by specialist gynecologist doctors. Hormonal analysis was performed by using ready kit in accordance with the manufacturer's instruction (Biomerieux SA Etoile-France)AMH were measured by ELISA TSH and auto antibodies were performed by minividas full automated system  method with a final fluorescent detection (ELIFA).
Factors Associated With Interprofessional Collaboration for Handling Stunting In Children Nursalam .
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Objective: An estimated in every 4 (25%) infants and toddlers were stunted in Surabaya. With slow progress in stunting reduction in this many regions is not due to insufficient diet alone, it needs interprofessional collaboration (IPC) which will improve the performance of health workers in the management of stunting. The aimed of this study is to understand the knowledge, attitude, self-efficacy, collaboration, communication about interprofessional collaboration to handle children aged < 5 years were stunted. Methods: The research used a cross-sectional study. The population in this study was 128 health workers. Samples were taken by simple random sampling. Independent variables were knowledge, attitude, self-efficacy, collaboration communication. The dependent variable was interprofessional collaboration. The instrument used a questionnaire. Data were analyzed by using correlation and logistic regression with a significance level of p <0.05. Results: The focus of this study is to understand the knowledge, attitude self-efficacy, collaboration communication in interprofessional collaboration as a way to handle stunting aged < 5 years; for self-efficacy p=0,027. A health worker who had good knowledge, attitude self-efficacy, collaboration communication, impacted and improve interprofessional collaboration as a prevention effort against stunting. Conclusion: From this study, we can conclude that the knowledge, attitude, self-efficacy, collaboration communication improve interprofessional collaboration in handling stunting in children under five. The better knowledge, attitude and belief about interprofessional collaboration, the better the implementation of interprofessional collaboration.Keywords: Factor personal, Interprofessional collaboration, Stunting, Children.
Vaccination of Lambs with Killed Vaccine from E. Coli O157:H7 to Induce Cellular Immune Responses against Challenge with Virulent Type Ali Hussein Fadhil
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

This study was aimed to estimate the immune responses of lambs immunized with heat-killed E. coli O157:H7 in two different doses to induce cellular immune responses against challenge with virulent type. Twenty lambs of both sexes were randomly divided into four equal groups (5 animals in each group).  Group A: were immunized subcutaneously with 2 ml of heat killed vaccine with a dose of 1X108 CFU/ml mixed with equal volume of adjuvant twice (primary and booster dose) at two week intervals. Group B- five lambs were immunized with a same manner of group A but with a vaccine containing 1X1010 CFU/ml with adjuvant. Group C- lambs were injected S/C with 2 ml of sterile PBS mixed with equal volume of adjuvant twice in two weeks. Group D – lambs were left without any treatment. Post immunization all lambs examined for clinical signs, Moreover serum at 0, 7,14 ,21 , 28, 42, 56, and 70 days for estimation of Interferon gamma (INF-Y) and IgG levels by ELISA test. Results  showed  increases in Interferon gamma (INF-Y) values significantly in the two immunized groups  at 7,14, 28, and 48 days (0.270± 0.0052, 0.0.310± 0.0076, 0.365± 0.007, 0.428± 0.0089,  0.263± 0.007 ,0.268± 0.005, 0.339± 0.0035 ,0.409 ±0. 0035 ,0.489± 0.003)  respectively, compared with control groups,  while  results revealed  that the interferon values in group B which immunized   with  dose 1×1010  CFU/ml  was significantly  increased  compared with  its value in  lambs immunization  with dose  1×108   CFU/ml  at days  14 as well as 28, and 42.Keywords: Killed vaccine, E. coli O157:H7, Interferon gamma (INF-Y), IgG.
Growth of Different Zinc Oxide Nanostructures for Hydrogen Gas Sensing Thamir A.A. Hassan
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

This work describes the synthesis of various Zinc Oxide (ZnO) nanostructures by a hydrothermal technique. The structures achieved included nanotubes, a lettuce leaf nanostructure and nanosticks, all starting from a ZnO nanostructure of 20 -30 nm and produced by thermal treatment in 6 M NaOH. The process did not use any catalyst or buffer layer and was carried out inside a purpose-built Teflon lined stainless steel autoclave, maintained at a temperature of 70 °C for 24, 48 and 72 hours. The reaction time had a significant influence on the morphology of the resulting products, whose crystallinity and structural properties were studied using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and atomic force microscopy (AFM). The FE-SEM images clearly show diffraction peaks associated with the Wurtzite hexagonal-shaped ZnO structure whilst AFM results show that the films produced have a high surface roughness, especially for the intermediate 48 h synthesis time. Nanostructures ultra-selective detection in gas phase lead to application of artificial sensing intelligence. In this paper, we show that fined the H2 gas concentrations on deliberately controlled sensor device toward specific prepare with ZnO nanostructure.  Keywords: ZnO, Nanostructure, Hydrothermal, IDE, Artificial intelligence.
Change of Hepatobiliary System under the Influence of Hydrazine Derivatives Saspugayeva G.Y.
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

Hydrazine derivatives are used in different spheres, in aero-space activity, medical practice, laboratory-diagnosis practice, that is why environment is polluted with hydrazines in big areas. The question about influence of hydrazine derivatives, used as the rocket fuel, on the human organism and ways of its detoxication is very actual. In connection with appeared situations, we set the goal: to study the negative influence of hydrazine derivatives-hydrazine sulphur, nitrosodimethylamine (NDMA), phenylhydrazine, isonicotinic acid hydrazide (IAH) on several biochemical features of blood and correction of functional damages of organism with “Salsocollin” preparation.Keywords: Isonicotinic acid hydrazide (IAH), N-nitrosodimethylamine (NDMA), AlAT-alanine aminotransferase, AsAT-aspartate aminotransaminase, Salsocollin.
The Effect of Intrathecal Fentanyl on Bispectral Index during Spinal Anesthesia in Patients with Lower Limb Orthopedic Surgery Shahryar Sane
Journal of Global Pharma Technology .
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Objective The addition of opioids to local anesthetics in spinal anesthesia modulates some aspects of anesthesia and analgesia. Accordingly, this study sought to evaluate the effect of adding intrathecal fentanyl on bispectral index (BIS) during spinal anesthesia. Materials and Methods According to prospective clinical trial studies, the patients undergoing lower limb orthopedic surgery were randomly divided into 2 groups. Group 1 received 12.5 mg of 0.5% hyperbaric bupivacaine (HBB), while Group 2 received 12.5 mg of HBB plus 20 µg of intrathecal fentanyl. After the induction of spinal anesthesia, a bispectral index (BIS) monitor was connected and baseline values were recorded for each patient. BIS, vital signs, nausea and vomiting and shivering were recorded for each group. Results A total of 54 subjects participated in the study and underwent analysis. The recorded BIS was different between the two groups at all the time points. At all the times, BIS values were lower in the fentanyl group compared to those in the other group. After spinal anesthesia, the changing trend of BIS reduced until the 45th minute for fentanyl group. In 30th and 45th minute after spinal anesthesia, BIS had the highest reduction in fentanyl group (P= 0.01).Conclusions Although the BIS scores began to decrease during spinal anesthesia using hyperbaric bupivacaine alone or with intrathecal fentanyl, the greatest reduction from baseline BIS values occurred adding intrathecal fentanyl. Moreover, maximum reductions of BIS scores appeared at 30 and 45minutes after the induction of spinal anesthesia.Keywords: Spinal anesthesia, Bispectral index, Fentanyl, Bupivacaine.
Pharmacokinetic Modification of Colon Targeted Delivery systems of Tegaserod Maleate based on Osmotic Technology R. Margret Chandira
Journal of Global Pharma Technology Volume 10 Issue 12.
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Abstract

Colon targeted delivery systems of Tegaserod maleate based on osmotic technology were developed. The developed systems consisted of osmotic core (drug, osmotic agent and wicking agent), coated with semipermeable membrane (spm) containing guar gum as pore former, coated core were then further coated with enteric coating to protect the system from acidic environment of stomach. the effect of various formulation variables namely the level of wicking agent (sodium lauryl sulphate), osmotic agent in the osmotic core, the level of pore former (guar gum) in spm, were studied on physical parameters and drug release characteristics of developed formulations. Tegaserod maleate release of drug is directly related to the level of pore former, wicking agent and osmotic agent. The drug release from the developed formulations was independent of pH.  The thickness of enteric coating could prevent formation of delivery pores before contact with simulated colonic fluid, but had no effect on drug release. Result of spm studies showed the formation of in-situ delivery pores in the membrane from where the drug release occurred, and the number of pores formed were directly related to the initial level of pore former (guar gum) in spm. the manufacturing procedure was found to be reproducible and formulations were found to be stable during 3 months of accelerated stability studies.
Some Biochemical Parameters in Congestive Heart Failure Patients in Baghdad City Suha A. Al-Jowari
Journal of Global Pharma Technology Volume 11 Issue 05.
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The present study was designed to study the changes on some biochemical parameters in males with congestive heart failure (CHF). Ninety males with age ranges from (27-73) years have been involved in this study, divided into two groups; the first group involved 65 males with CHF and the second group involved 25 males without CHF from Teaching Baghdad Hospital. The patient's groups were divided according to their age into three groups (less than 40, 40-50 and more than 50 years). Blood samples were collected from each patient and control and used for analysis of renal function parameters, potassium, calcium and liver function. The results of the current study showed a highly significant (p < 0.01) increase in the concentration of blood urea, serum creatinine in HF patients as compared with the control group. While there is non-significant difference in the level of potassium in HF patients compared with the control group. Further, there was a highly significant (p < 0.01) decrease in concentration of calcium in patients group compare with the control. This study also illustrates a highly significant (p<0.01) increase in the liver function parameters which include alanine aminotransferase (ALT) and aspartate aminotransferases (AST) of HF patients compared with the control group. While there is non-significant difference in alkaline phosphatases (ALP) of HF patients compared with control group. There was also significant (P< 0.05) increase in total serum bilirubin (TSB) concentration of HF patients compared with the control group.Keywords: Congestive heart failure, Urea, Creatinine, ALT, AST, ALP, TSB.

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