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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,439 Documents
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Role of Sintering, Co-particles on Properties of Milled Al-Zn-Mg-Cu Matrix Produced via PM Haider T. Naeem
Journal of Global Pharma Technology Volume 09 Issue 12
Publisher : Journal of Global Pharma Technology

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Abstract

In the current study, mechanically alloying has done to synthesizing Aluminum-Zinc-Magnesium-Copper-Cobalt powders via high-energy ball milling. The green compacts milled Al-Zn-Mg-Cu-Co powders were compacting using hydraulic press uniaxial at 300 MP a. The milled mixtures Al-compacts were conducted by the sintering treatments at various temperatures of 400-600 °C for 1-1.5 hours. Over all ball-milling route turn on: a ratio weight of ball-to-powder about 10:1, the speed of rotation 350 rpm; and the milling time of 8 hours. The assessment of the precipitates particles and intercom pounds of the milled Al-matrixes PM undergone conditions of sintering process were examined using the X-ray diffraction (XRD) and scanning 'electron microscopy-(SEM) with energy-dispersive X-ray spectroscopy (EDS).Outcomes of micro structural the sintered Al-PM alloys investigated having a precipitations and cobalt-compounds in the matrix during several treatments. The highest Vickers hardness recorded of Al-Zn-Mg-Cu-Co PM alloy under sintering at 600 °C.Keywords: Aluminium-Cobalt Alloys; Sintering; Hardness.
PHYTOCHEMICAL SCREENING OF MALLOTUS PHILIPINESIS FOR ITS ANTIBACTERIAL ACTIVITY Patani M.N
Journal of Global Pharma Technology Volume 03 Issue 04: (2011) April 2011
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Abstract

Mallotus philippinensis Muell. Arg. belongs to the family Euphorbiaceae is also known as kamala powder which was extracte with methanol and ethyl acetate. Present study shows that both the extracts of kamala powder have good antibacterial activity, but when compared to Gram negative bacteria, Gram positive bacteria are more susceptible to the extracts. The mechanism of antibacterial action appears to be loss of control over cell membrane permeability. Keywords: Mallotus philippinensis, Antibacterial activity, Methanol, Ethylacetate.
Serine and Alanine as Corrosion Inhibitors for 5083 AA in Aqueous Solutions Zainab W. Ahmed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

By means of potentiodynamic polarization methods, inhibiting the influence of serine and alanine on 5083 AA corrosion in 0.1 mol.dm-3 sodium hydroxide and 140.6 mol. dm-3 NaCl">  over temperature range (298-313) K was investigated. Potentiodynamic polarization results specified that these amino acids functioned as a functional inhibitor in an alkaline environment. The inhibiting efficiency raises as the inhibitor concentration raises. However, it drops as temperature rises. The maximum efficiency value found with alanine was 73 under 298 k and 1410-2 mol. dm-3">  alanine concentration. The adsorption of the amino acids complies with Langmuir adsorption isotherm. Some thermodynamic parameter 14∆Gads">  and activation energy 14Ea">  have been computed to demonstrate the process of corrosion inhibition. The kinetic limitations have been evaluated by means of Arrhenius theorem. An appropriate mechanism has projected for 5083 AA corrosion in alkaline medium. The surface morphology of uninhibited and inhibited samples was investigated using an optical microscope.Keyword: Corrosion inhibition, 5083AA, Amino acids, Free energy of adsorption, Adsorption mechanism.
Physical Stability of Commonly Used Medication Administered by Parenteral Nutrition Admixtures in Hospital: A Systematic Review Erza Genatrika
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Background: Inpatients requiring parenteral nutrition (PN) often need to receive intravenous medication, but physical instability can occur between medications and PN. This review aimed to bring together the available literature on the physical stability of medication with PN used in hospitals. Methods: We conducted a systematic electronic literature search of PubMed, Science Direct, and SpringerLink during the period 2009-2019 for all English language research publications evaluating the physical stability of commonly used medication administered by PN in hospital. Results: Out of 88 studies, 7 studies selected for this review. From all studies conducted in this review found 14 combinations of drugs that are not compatible with PN admixtures, including levetiracetam, albumin, amoxicillin, cefepime, esomeprazole, fluorouracil, pantoprazole, tropics, trace elements, vitamins, and vancomycin. For adding medications directly to the PN solution, specific criteria should be considered, such as physicochemical properties of the ingredients and drug concentration. Conclusion: The stability of IV medications and PN is an important concern in delivering safe and effective medication and nutritional therapy. The role of healthcare professionals is needed to avoid this incident so that patient safety can be guaranteed. Keywords: Parenteral nutrition, Drug, Medication, Stability, Physical.
Application of Proniosomal Powder Technology to Prepare Fast Water Dissolving Tablets for Dutasteride Nidhal K. Maraie
Journal of Global Pharma Technology .
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Abstract

Objective: The aim of the study is to prepare fast water dissolving dutasteride tablets containing a pronisomal powder that yield niosomal dispersion of dutasteride upon dissolving in hot water. The niosomes derived from dissolved tablets may improve the dissolution and permeability of dutasteride since it is loaded in the niosomal vesicles and avoid the high cost and other disadvantages of the soft gelatin capsules commercially available. Method: Ten formulas of dutasteride proniosomal gels were prepared by coaservation method and niosomes derived from them were evaluated for their loading capacity, particle size, particle size distribution , zeta-potential and in-vitro drug release in order to determine the optimum type and quantity of proniosomal contents that will be used to prepare maltodextrin based proniosmal powder formulas which were evaluated and the optimum proniosomal powder formula was used to prepare dutasteride tablet. Results: Thickness, , hardness, disintegration time and in-vitro drug release for the optimum dutasteride tablet T5 were 5.57±0.08 mm, 3.1±0.11 Kg/cm2, 2.9±0.03 and reaches 100% release after 30 min. Particle size, polydispersity index (PDI), and zeta potential of niosomes derived from dissolving dutasteride tablet (T5) were ~263±3.8 nm, 0.225, and -5.43±0.436 mV Conclusion: This results indicating the contribution niosomes derived from proniosomal powder in improving the dutasteride solubility and gave higher dissolution rate compared to the conventional soft gelatin capsule of the same drug . Therefore presenting an oral dosage form that is more convenient and having all the advantage of tablets. Keywords: Cholesterol, Dutasteride, Niosomes, Proniosomes, Span 60, and Tween 20.
Patterns of Mucocutaneous Disorders in HIV-seropositive Patients and Relations with CD4 Counts at Sanglah General Hospital, Denpasar, Bali Made Wardhana; Nila Wardani; Ivana Sugiarto; Made Puspawati; Elis Indira; Wiraguna, Swastika Adiguna
Journal of Global Pharma Technology .
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Abstract

Background: It is well known that more than 90% of HIV-infected patients will develop at least one type of dermatologic disorder during their HIV infection. As a result of the acquired immunodeficiency or the effect of the treatment, with an increased risk infectious skin condition which caused by viral, bacterial, and fungal infections, as well as inflammatory skin disease, have all been reported to increase as CD4+ T cells depleted.Objective: Our purpose was to evaluate the cutaneous manifestation in HIV/AIDS patients in dermatology-venerology polyclinic, Sanglah Hospital Denpasar. Subjects and Methods: Data was collected from medical records of HIV/AIDS patient whose came to the dermato-venerology department, Sanglah Hospital period 2007-2009.Results: During the three years period, noted 260 HIV/AIDS patients with cutaneous manifestation, 183 males, and 77 females. Those patients mostly in the age group 21-30 years old. Five most common cutaneous manifestation was condyloma acuminate for 59 patients (22,7%), dermatitis 27 patients (10,4%), drug eruptions 26 patients (10,0%), prurigo 24 patients (9,2%) and seborrheic dermatitis 23 patients (8,8%). Conclusion: Cutaneous manifestation in HIV/AIDS patients which dominated by males gender and age group 21-30 years old was very varied, in which the most common cutaneous manifestation is condyloma acuminate.Keywords: Cutaneous manifestations, HIV/AIDS.
Mathematical Modeling Applications in Medical Cases: An Essential Tool for Discovery: A Review Dunia Alawi Jarwan
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

This paper discusses the important role that mathematics and mathematical models play in the current revolution of learning, together with the resource regarding science and computational power. The delivery note outlines the reasons in the back of thinking about the utility on mathematics after the field of Biology or Medicine namely an urgent need. The bill also highlights the ambitions or goals over its department over disciplines indicating that mathematics is a wealthy location regarding examination ranging out of coherent abstractions in imitation of concrete applications. The pointed out examples prove that: The sound over mathematics is remarkably powerful or flexible, then the modes of thinking discovered within mathematics perform spawn inconceivable insight within many phenomena as take up current life. In it review, we furnish quick records yet spotlight half concerning the necessary features regarding modeling between organic systems together with an emphasis over the lesson on excitable cells. We finish along with dialogue in relation to possibilities yet challenges because of mathematical modeling going forward. In a large sense, the comment is designed after help answer an easy however necessary query that theoreticians oft rear from interested however skeptical colleagues about the empirical side.Keywords: Mathematical modeling, Medical Cases, Biochemical signals
Effectiveness of Lactobacillus acidophilus as Probiotic in Cantaloupe (Cucumis Melo) Juice Fermentation N. P. Minh
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

Cantaloupe is one of the most consumed fruit crops worldwide specially in Viet Nam due to its pleasant flavour and nutritional value. Cantaloupe is highly perishable, due to its high moisture content.  Lots of cantaloupes rot away in the farmland. The production of freshly cantaloupe juice is a best way to raise the merchandise rate of cantaloupe and to prolong its product shelf-life during consumption. Lactic acid fermentation increases the shelf life of cantaloupe juice and also enhances various beneficial properties, including nutritive value and flavours. Objective of this study focused on the effect of Lactobacillus acidophilus as probiotic in cantaloup (Cucumis Melo) juice production. Different technical parameters such as the initial soluble solid content (8.0, 8.5, 9.0, 9.5, 10.0 oBrix), Lactobacillus acidophilus innoculum size (1.0, 1.5, 2.0, 2.5, 3.0 g/L), fructo-oligosaccharide (0.5%, 1.0%, 1.5%, 2.0%, 2.5%) were examined during fermentation at 37oC in 48 hours. Results showed that the best fermented juice quality would be achieved by the initial soluble solid content 9.5oBrix, Lactobacillus acidophilus innoculum size 2.0 g/L, fructo-oligosaccharide 2.0%.Keywords: Cantaloup, Lactobacillus acidophilus, Probiotic, Juice, Fructo-oligosaccharide, Innoculum.
Biodegradation of Crude Oil Contaminated Soil in Kirkuk/ Iraq by using Pseudomonas Aeruginosa and Klebsiella Pneumoniae Aqeel Mohammed Majeed Al-Ezee
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

The aim of present study was to show crude oil biodegradation by Pseudomonas aeruginosa, K. pneumoniae. The samples of oil were obtain from tanks of crude oil belonging to Kirkuk city/Iraq. The present research was study crude oil biodegradation at a different condition (temperature and pH). The results show the, typical conditions of biodegradation, of crude oil were, temperature 37,0C and. Under typical condition, consumption level reported, P. aeruginosa and K.pneumoniae, at fourth day, (pH 7: 39.7; 37.5 and, temperature 37 0C: 43.1; 30.1 respectively). Also, cell numbers reported, P. aeruginosa and K. pneumoniae, at fourth, day (pH 7: 11.9; 11.3 X log 10 and, temperature 37 0C: 11.8; 10.4, respectively). It was, included from this study that ideal conditions of P. aeruginosa and K. pneumoniae to oil biodegradation were temperature 37 and pH 7.Keywords: Crude oil, Bio-degradation; P. aeruginosa; K. pneumoniae.
Effect of Different Immobilizing Methods on L- Asparaginase Activity for Monitoring Leukemia Hadi Sajed Abd-Al-Abbas
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Purified L-asparagines from Portulacaoleracea L. plant was immobilized by three immobilizing methods (agar , agarose and gelatin ) ,the  activity of immobilized enzyme was determined  and compared with free enzyme ,where immobilizing efficiency of agar , agarose and gelatin techniques was ( 72 %,78 % and 70 % ) respectively, all immobilizing technique proved an significant activity  increasing of enzyme in compaction of free enzyme, where agar and gelatin methods showed more stability of enzyme at alkaline PH (PH 9) , whereas only agarose method get the enzyme more heat stability than other immobilizing methods. there are significant elevation level of asparagine concentration in leukemic human blood samples than normal  human blood samples , where reached to 〖10〗^(-4)-〖10〗^(-7)M of asparagine in normal  human blood samples while it was  〖10〗^(-2)-〖10〗^(-3)  M of asparagine in leukemic human blood samples.

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